Article
Public, Environmental & Occupational Health
Karen Walker-Bone, Geza Benke, Ewan MacFarlane, S. Klebe, Ken Takahashi, Fraser Brims, Malcolm Ross Sim, Tim R. Driscoll
Summary: Mesothelioma, a rare and deadly cancer associated with asbestos exposure, continues to be diagnosed in Australia despite the ban on asbestos since 2003. The Australian Mesothelioma Registry was established to gather comprehensive data on incidence, mortality, and asbestos exposure. Results show a decline in incidence and mortality rates due to effective control of occupational asbestos use, but the rates among women remain stable, suggesting other sources of exposure.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Alessandro Marinaccio, Davide Di Marzio, Carolina Mensi, Dario Consonni, Carmela Gioscia, Enrica Migliore, Carlo Genova, Roberta Rossetto Giaccherino, Silvia Eccher, Stefano Murano, Vera Comiati, Veronica Casotto, Corrado Negro, Lucia Mangone, Lucia Miligi, Sara Piro, Alessia Angelini, Iolanda Grappasonni, Gabriella Madeo, Ilaria Cozzi, Laura Ancona, Tommaso Staniscia, Francesco Carrozza, Domenica Cavone, Luigi Vimercati, Michele Labianca, Federico Tallarigo, Giuseppe Cascone, Massimo Melis, Michela Bonafede, Alberto Scarselli, Alessandra Binazzi
Summary: Mesothelioma incidence surveillance and individual research on asbestos exposure are important for monitoring health effects and preventing exposure risks. Young mesothelioma cases with non-occupational asbestos exposure signal potential clusters of cases.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Respiratory System
Job P. van Kooten, Robert A. Belderbos, Jan H. von der Thusen, Mieke J. Aarts, Cornelis Verhoef, Jacobus A. Burgers, Paul Baas, Arend G. J. Aalbers, Alexander P. W. M. Maat, Joachim G. J. Aerts, Robin Cornelissen, Eva V. E. Madsen
Summary: The incidence of malignant mesothelioma in the Netherlands is declining, especially in male patients under 80 years old. The use of systemic chemotherapy has increased since 2003, which may contribute to improved overall survival. However, the majority of patients do not receive antitumor treatment, and prognosis remains poor.
Article
Oncology
Asad Ullah, Abdul Waheed, Jaffar Khan, Ankita Mishra, Bisma Tareen, Noor Nama, Nabin Raj Karki, Muhammad Saleem Panezai, Luis Velasquez Zarate, Joseph White, Frederick D. Cason, Nathaniel Matolo, Subhasis Misra, Nagla Abdel Karim
Summary: Primary peritoneal mesothelioma (PPM) is a rare and aggressive tumor that arises from the peritoneum. This study investigated the factors affecting patient prognosis and survival in PPM. The majority of PPM patients were male and Caucasian, and the prognosis was worse for patients with poorly differentiated tumors, tumor size > 4 cm, Caucasian race, and distant spread of disease.
Article
Medicine, Research & Experimental
Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos
Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Environmental Sciences
Suresh Moolgavkar, Ellen T. Chang, E. Georg Luebeck
Summary: The current understanding is that cancer is caused by mutations in a few crucial genes, which has implications for the epidemiology of cancer. These include the impact of age on cancer risk, the role of inherited tumor predisposition syndromes, and the interaction of genetics and environmental exposures on cancer risk.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Laura Kurth, Jacek M. Mazurek, David J. Blackley
Summary: This study examines the burden of malignant mesothelioma and therapy patterns among Medicare beneficiaries using claims data from 2016 to 2019. The results show that mesothelioma is prevalent among Medicare beneficiaries, but only a small proportion receive all three therapy modalities. This study provides important insights into the burden of mesothelioma and its treatment patterns.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Wing Sze Pang, Shui Hang Chow, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluates the global disease burden of mesothelioma and its trends by age, sex, and geographic locations. The findings show a substantial declining incidence trend of mesothelioma in the past decade, possibly related to the restriction of asbestos use in some countries, although an increase was observed in Bulgaria and Korea.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Joelle S. Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele, Jin-Hee Kim, Alicia A. Zolondick, Jiaming Xue, Ronghui Xu, Mai Saito, Sandra Pastorino, Michael Minaai, Yasutaka Takanishi, Mitsuru Emi, Ian Pagano, Andrew Wakeham, Thorsten Berger, Harvey I. Pass, Giovanni Gaudino, Tak W. Mak, Michele Carbone, Haining Yang
Summary: Asbestos is found to be the main cause of malignant mesothelioma, and HMGB1 plays a crucial role in its development. HMGB1 is mainly released by mesothelial cells during the early stages of inflammation after asbestos exposure, leading to an inflammatory response and atypical mesothelial hyperplasia. Knocking out HMGB1 in mesothelial cells significantly reduces the inflammatory response and the incidence of mesothelioma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Environmental Sciences
Yuhe Gao, Jacek M. Mazurek, Yaming Li, David Blackley, David N. Weissman, Shirley V. Burton, Waqas Amin, Douglas Landsittel, Michael J. Becich, Ye Ye
Summary: This study examines the work histories and survival time of patients with suspected exposure to asbestos. The most frequent cases of mesothelioma occurred in patients working in manufacturing, construction, and education services. Males or individuals over 40 tended to work in traditionally asbestos-associated industries, while females or individuals aged 20-40 tended to work in non-traditionally associated industries. The results highlight the importance of considering all potential sources of asbestos exposure when evaluating mesothelioma patients.
ENVIRONMENTAL RESEARCH
(2023)
Review
Oncology
Fraser Brims
Summary: Mesothelioma is a cancer of the lining of the lungs caused by breathing in asbestos fibres, which remains a challenge in terms of treatment and has an uncertain survival time. The disease mainly occurs in males, with a clear risk associated with exposure to asbestos. There have been significant advances in diagnosis, but further research and treatment are still needed.
Article
Oncology
Pietro Gino Barbieri, Dario Consonni, Anna Somigliana
Summary: The study found no significant relationship between asbestos lung burden and survival, with histologic subtype being the strongest prognostic determinant.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Phillip Munson, Arti Shukla
Summary: This review summarizes the role of exosomes in the development of malignant mesothelioma (MM), and discusses their potential in detection and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Maya-Liliana Avramescu, Christian Potiszil, Tak Kunihiro, Kazunori Okabe, Eizo Nakamura
Summary: This study investigates the growth of asbestos fibers in the lungs of smokers and non-smokers. It is found that smokers have denser and more iron-rich asbestos fiber structures, possibly due to a more uniform supply of iron from smoking. In addition, asbestos fibers may accrete mucopolysaccharides to accumulate iron and form asbestos ferruginous bodies. The results suggest that oxidative stress may not be the main driver for the onset of malignant mesothelioma.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Nathan L. DeBono, Hunter Warden, Chloe Logar-Henderson, Sharara Shakik, Mamadou Dakouo, Jill MacLeod, Paul A. Demers
Summary: The study analyzed detailed patterns of mesothelioma and asbestosis incidence in the Ontario workforce as part of an occupational disease surveillance program. The findings indicated that construction trades workers had the highest adjusted incidence rates of both diseases, with insulators, pipefitters, plumbers, and carpenters showing particularly elevated rates. In addition, workers in welding, flame cutting, boiler making, mechanic and machinery repair occupations, as well as in industrial chemical and primary metal manufacturing industries, had significantly elevated rates of mesothelioma and asbestosis.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2021)