期刊
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
卷 31, 期 5, 页码 365-405出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevTherDrugCarrierSyst.2014010123
关键词
Glaucoma; iontophoresis; microneedle; anterior and posterior segments; ocular inserts
资金
- IYBA [BT/01/IYBA/2009]
- Department of Biotechnology (DBT), New Delhi, India
- Punjab Technical University, Jalandhar, India
Glaucoma is a common cause of blindness worldwide, and the development of treatments is difficult for pharmaceutical scientists because successful delivery of drugs to the anterior and posterior segments of eye is challenging due to anatomical and physiological constraints. Conventional treatments use various dosage forms (solutions, suspensions, and ointments) that are hindered by poor intraocular penetration and/or rapid ocular elimination. Therefore, effective, safe, and comfortable methods of drug delivery are needed. One approach to improving ocular therapy is the use of nanotechnology for drug delivery. Recent drug delivery approaches using gels, liposomes, niosomes, ocular inserts, contact lenses, microparticles, nanoparticles, nanosuspensions, and other materials have produced exciting new therapies for ocular diseases, especially glaucoma. In this review, we discuss the importance of nanotechnology in novel drug delivery systems and the future possibilities for an effective treatment of glaucoma.
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