Review
Biotechnology & Applied Microbiology
Yongjun Deng, Chao Zhou, Lifeng Fu, Xiaogang Huang, Zunyong Liu, Jiayi Zhao, Wenqing Liang, Haiyan Shao
Summary: An emerging application of nanotechnology in medicine involves using nanoparticles to deliver drugs or other substances to specific types of cells, such as cancer cells. Engineering and manipulating matter at the molecular level has many advantages in the field of medicine. However, it is unclear how much of this technology will ultimately improve patient care.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Environmental Sciences
Divya Singh, Bhola Ram Gurjar
Summary: Nanotechnology has great potential in agriculture, but its environmental impact and risks are still not well understood. The effects of nanoparticles on soil life and their fate in the environment require further study. There is a need for more knowledge on factors such as adsorption/desorption, dissolution, and biological degradation of nanoparticles. Additionally, detailed decision criteria and international consensus are necessary to ensure the safety of nanotechnology.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Polymer Science
Pierluigi Stipa, Stefania Marano, Roberta Galeazzi, Cristina Minnelli, Giovanna Mobbili, Emiliano Laudadio
Summary: Biodegradable polymeric nanoparticles are promising non-toxic vehicles for drug delivery, but lack of regulatory guidance in assessment and characterization delays their clinical success. Understanding drug-polymer interactions is crucial for optimizing drug delivery systems.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Muhanad Ali, Miriam E. van Gent, Amy M. de Waal, Bjorn R. van Doodewaerd, Erik Bos, Roman I. Koning, Robert A. Cordfunke, Jan Wouter Drijfhout, Peter H. Nibbering
Summary: The formulation of SAAP-148 in PLGA nanoparticles improves its selectivity index and enables sustained release of the peptide. The nanoparticles exhibit favorable physiochemical properties and demonstrate increased activity against antimicrobial resistant bacteria and biofilms over time. This suggests that SAAP-148 nanoparticles have promising potential as a treatment for bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nurul Alyani Zainol Abidin, Faridah Kormin, Nurul Akhma Zainol Abidin, Mohd Fadzelly Abu Bakar, Iqbal Ahmed Moujdin
Summary: A breakthrough in cosmeceuticals using insects as major ingredients and chitosan extracted from O. rhinoceros as a drug carrier has been achieved. Curcumin-loaded chitosan-gold nanoparticles (CCG-NPs) were successfully synthesized, providing a stable, spherical, nano-sized, non-toxic, and homogeneous solution.
Review
Pharmacology & Pharmacy
Weina Ke, Rachael M. Crist, Jeffrey D. Clogston, Stephan T. Stern, Marina A. Dobrovolskaia, Piotr Grodzinski, Mark A. Jensen
Summary: Cancer nanotechnologies have great potential as therapeutic and diagnostic treatments and have seen significant advancements in recent years. Data sharing and reanalysis are crucial for utilizing this complex interdisciplinary information effectively. caNanoLab, a repository for cancer-related nanotechnology data, offers opportunities for data mining, artificial intelligence, and tracking trends in nanomedicine research.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Mohammad Reza Malekpour, Saereh Hosseindoost, Fatemeh Madani, Morteza Kamali, Masood Khosravani, Mahdi Adabi
Summary: This study explores the use of Poly(lactic co-glycolic acid) nanoparticles loaded with Paclitaxel (PTX) and Doxorubicin (DOX) to improve the treatment of glioblastoma tumors. The results show that these nanoparticles enhance cytotoxicity and decrease tumor size. MRI results also demonstrate a longer median survival rate for the combination therapy. Additionally, the combination therapy has a positive effect on rat movement, as indicated by behavioral tests.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Ju-Ro Lee, Bong-Woo Park, Jae-Hyun Park, Songhyun Lim, Sung Pil Kwon, Ji-Won Hwang, Hyeok Kim, Hun-Jun Park, Byung-Soo Kim
Summary: This study demonstrates that local injection of senolytic drug-loaded nanoparticles can selectively kill stress-induced senescent cells in infarcted heart, reducing inflammatory cytokines and promoting normal cell survival. Further efferocytosis of apoptotic senescent cells by macrophages leads to restoration of cardiac function after myocardial ischemia-reperfusion injury. Importantly, local injection of senolytic drug does not cause systemic toxicity, unlike systemic administration, highlighting the therapeutic potential of senolysis in infarcted myocardium.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Physical
Jaya Baranwal, Brajesh Barse, Amalia Di Petrillo, Gianluca Gatto, Luca Pilia, Amit Kumar
Summary: The use of tailored medication delivery holds great potential for improving cancer treatment outcomes by increasing efficacy and reducing side effects. Currently, chemotherapy remains a challenging topic for researchers seeking to improve clinical outcomes. Nanotechnology has revolutionized medical research by providing new and improved materials for biomedical applications, particularly in therapy and diagnostics. Metal nanoparticles are increasingly being explored as alternative chemotherapy drugs, as they possess inherent or surface-induced anticancer properties. The rapid development of metal nanoparticles offers alternative therapeutic strategies and improved outcomes for cancer treatments.
Article
Pharmacology & Pharmacy
Basak Simitcioglu, Isik Didem Karagoz, Sibel Ilbasmis-Tamer, Ugur Tamer
Summary: This study found that the molecular weight of the polymer and the terminal groups can affect the surface morphology of nanoparticles and the drug encapsulation efficiency. Resomers with acid terminal function showed higher encapsulation and reaction efficiency. High molecular weight Resomers exhibited selective cytotoxicity, especially in the treatment of prostate cancer, suggesting potential for extended-release drug delivery systems.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Xin Yuan Lim, Sharah Mae Capinpin, Nagarjun Bolem, Aaron Song Chuan Foo, Wai-Cheong George Yip, Alan Prem Kumar, Daniel Boon Loong Teh
Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited treatment options due to the difficulty of drugs crossing the blood-brain barrier (BBB) and tumor heterogeneity. Nanoparticle (NP) drug carriers have shown promise in targeting cells beyond the BBB. This review focuses on biomimetic NPs in GBM therapy and their potential in overcoming physiological and anatomical challenges.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Rolle Rahikainen, Pramila Rijal, Tiong Kit Tan, Hung-Jen Wu, Anne-Marie C. Andersson, Jordan R. Barrett, Thomas A. Bowden, Simon J. Draper, Alain R. Townsend, Mark Howarth
Summary: The challenge of matching symmetry at interfaces in molecular assembly is overcome by coupling virus-like particles (VLPs) to diverse antigen symmetries using SpyCatcher003. This approach enables efficient VLP conjugation and extreme thermal resilience, allowing for the display of antigens with varying symmetries. The nanodisplay of different symmetries through SpyCatcher003 conjugation shows promise for the generation of potent vaccines.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Cell Biology
Daniyah A. Almarghalani, Sai H. S. Boddu, Mohammad Ali, Akhila Kondaka, Devin Ta, Rayyan A. Shah, Zahoor A. Shah
Summary: This review discusses the obstacles to siRNA delivery for intracerebral hemorrhage (ICH) treatment, including the advantages and disadvantages of viral and nonviral vectors. Efficient delivery of siRNA via nanoparticles is emerging as a viable and effective therapeutic tool for ICH.
NEURAL REGENERATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Hashem O. Alsaab, Fatima D. Alharbi, Alanoud S. Alhibs, Nouf B. Alanazi, Bayan Y. Alshehri, Marwa A. Saleh, Fahad S. Alshehri, Majed A. Algarni, Turki Almugaiteeb, Mohammad N. Uddin, Rami M. Alzhrani
Summary: Research on the use of biodegradable polymers for drug delivery, particularly PLGA, has been ongoing for several decades. PLGA, a family of FDA-approved biodegradable polymers, possesses high biocompatibility and tunability. This paper explores the manufacturing processes, characteristics, and applications of PLGA in drug release.
Review
Pharmacology & Pharmacy
Supandeep Singh Hallan, Maddalena Sguizzato, Elisabetta Esposito, Rita Cortesi
Summary: Nano-sized drug transporters are efficient and have commercial values. Nanomedicine has a wide range of applications in drug delivery and other areas. The design of suitable protocol for physical evaluation of nanoparticles is still controversial, and comparing different techniques can help overcome this obstacle.
