Article
Public, Environmental & Occupational Health
Kazumitsu Nawata
Summary: This study analyzed the relationship between hypertension and heart diseases using a large dataset of medical checkups. The findings suggest that the previously accepted relationship between hypertension and heart diseases may be spurious when accounting for other factors. Moreover, the study found that taking antihypertensive medications significantly increases the probability of developing heart diseases in the next year, highlighting the need for further research and caution in their use.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Food Science & Technology
Seyed Mohammad Mousavi, Ahmad Jayedi, Yahya Jalilpiran, Maryam Hajishafiee, Azadeh Aminianfar, Ahmad Esmaillzadeh
Summary: Previous findings on the association between long-term protein intake and cardiovascular diseases are inconsistent. This study summarized previous investigations and found no significant association between dietary protein intake from different sources and the risk of coronary heart disease and hypertension.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Chike C. Nwabuo, Duke Appiah, Henrique T. Moreira, Henrique D. Vasconcellos, Yuichiro Yano, Jared P. Reis, Ravi Shah, Venkatesh L. Murthy, Norrina B. Allen, Stephen Sidney, Paul Muntner, Cora E. Lewis, Donald M. Lloyd-Jones, Pamela J. Schreiner, Samuel S. Gidding, Joao A. C. Lima
Summary: The study found that cumulative blood pressure in young adults is associated with the risk of heart failure, coronary heart disease, stroke, and cardiovascular diseases. Cumulative blood pressure provides incremental prognostic value and improves risk reclassification for cardiovascular diseases when compared to single blood pressure assessments or changes in blood pressure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jenifer M. Brown, Wunan Zhou, Brittany Weber, Sanjay Divakaran, Leanne Barrett, Courtney F. Bibbo, Jon Hainer, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Marcelo F. Di Carli
Summary: Insufficient myocardial perfusion to match global metabolic demand may be a risk marker for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Nutrition & Dietetics
Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: Oxysterols are believed to contribute to the development of cardiovascular diseases, and their serum levels are positively associated with cholesterol absorption and synthesis. However, the regulation of different oxysterols in the body is largely unknown. This study aimed to investigate the relationship between clinical factors and cholesterol metabolism markers, as well as identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease.
Article
Endocrinology & Metabolism
Jie Wang, Qi Sun, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: This study found that elevated remnant cholesterol is associated with a higher risk of hypertension in the Chinese population, especially among individuals with diabetes. However, with ideal management of remnant cholesterol, glucose, and other cardiovascular risk factors, the risk of hypertension can be minimized for diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yahui Liu, Binbin Zhu, Weicen Zhou, Yao Du, Datun Qi, Chenxu Wang, Qianqian Cheng, You Zhang, Shan Wang, Chuanyu Gao
Summary: This study found that the elevated TyG index may serve as a potential marker for adverse prognosis in patients with coronary heart disease (CHD) and hypertension.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Weiqiang Wu, Guanzhi Chen, Kuangyi Wu, Huancong Zheng, Yanjuan Chen, Xianxuan Wang, Zegui Huang, Zefeng Cai, Zhiwei Cai, Zhichao Chen, Yulong Lan, Shuohua Chen, Shouling Wu, Youren Chen
Summary: This study aimed to investigate the relationship between cumulative remnant-cholesterol (Cum-RC) concentration and the risk of cardiovascular disease (CVD) in patients with hypertension. The study found that a consistently high Cum-RC concentration increases the risk of CVD in individuals with hypertension. Therefore, achieving blood pressure and RC concentration targets should be prioritized to reduce the risk of CVD in these individuals.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Peripheral Vascular Disease
Hui-Wen Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Rui-Xia Xu, Qi Hua, Yan-Fang Li, Chuan-Jue Cui, Qian Dong, Jing Sun, Jian-Jun Li
Summary: This study found that sdLDL-C levels are associated with disease severity and worse outcomes in hypertensive patients with CAD. In hypertensive patients with poorly controlled hypertension, higher sdLDL-C levels were independently associated with CVEs. Paying more attention to sdLDL-C in these patients may be warranted.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Julian Jakob, Odile Stalder, Tali Kali, Etienne Pruvot, Mark J. Pletcher, Jamal S. Rana, Stephen Sidney, Reto Auer
Summary: Recent current cannabis use is associated with lower resting heart rate, but this association appears to be transient as past cumulative exposure to cannabis was not related to heart rate.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Peripheral Vascular Disease
Nonhlanhla Mthembu, Gavin R. Norton, Vernice R. Peterson, Ravi Naran, Suraj M. Yusuf, Grace Tade, Hamza Bello, Adamu Bamaiyi, Carlos D. Libhaber, Patrick Dessein, Ferande Peters, Pinhas Sareli, Angela J. Woodiwiss
Summary: The study explores the mechanisms of the relationship between heart rate and central pulse pressure and its dependence on age. It finds that the increased central pulse pressure associated with a lower heart rate is mainly attributed to the enhanced backward wave rather than the prolonged ejection or filling duration. These findings have clinical implications, especially in older adults.
Article
Multidisciplinary Sciences
Pan Zhuang, Xiaohui Liu, Yin Li, Yuqi Wu, Haoyu Li, Xuzhi Wan, Lange Zhang, Chengfu Xu, Jingjing Jiao, Yu Zhang
Summary: This study investigated the relationship between fatty acids, genetic predisposition, and coronary artery disease. The results showed that monounsaturated fatty acids were positively associated with CAD risk, while polyunsaturated fatty acids were associated with a decreased risk. Individuals with high genetic risk should reduce saturated fatty acid levels for CAD prevention.
Article
Medicine, Research & Experimental
Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh, Hamid Soori
Summary: The study identified seven distinct multi-trajectories of blood lipid levels and found that individuals with rising triglyceride levels over time, even with optimal LDL-C levels, faced a significantly increased risk of cardiovascular disease. Despite the decline in LDL-C levels, there remained a considerable residual risk for CVD, emphasizing the importance of monitoring and potentially lowering triglyceride concentrations to reduce this risk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Vibhu Parcha, Gargya Malla, Rajat Kalra, Peng Li, Ambarish Pandey, Khurram Nasir, Garima Arora, Pankaj Arora
Summary: The study evaluated the use of coronary artery calcium (CAC) score to guide hypertension therapy in individuals without cardiovascular disease. Results showed that among those with CAC>0, there was a higher risk of incident cardiovascular events in individuals with elevated BP or low-risk stage 1 hypertension, as well as in those with high-risk stage 1 or stage 2 hypertension. The study suggests that utilizing CAC score may help personalize cardiovascular risk reduction strategies in individuals where current guidelines do not recommend treatment.
Article
Medicine, General & Internal
Jaskanwal Deep Singh Sara, Elad Maor, Diana Orbelo, Rajiv Gulati, Lliach O. Lerman, Amir Lerman
Summary: This study found a significant association between a noninvasive voice biomarker and incident CAD events at follow-up, which may have important clinical implications for the remote and noninvasive screening of patients to identify those at risk of coronary disease and its complications.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Biochemistry & Molecular Biology
Raffaele Pugliese, Martina Bartolomei, Carlotta Bollati, Giovanna Boschin, Anna Arnoldi, Carmen Lammi
Summary: Food bioactive peptides are widely used in food products and functional biomaterials, but their practical applications are limited due to their instability and low bioavailability. In this study, the self-assembling peptide RADA16 was functionalized with two synthetic analogues of food bioactive peptides to improve their nanostructures and biological features. The co-assembly of the functionalized food bioactive peptides with RADA16 was found to enhance their bioactivity and potential for the prevention of metabolic syndrome.
Article
Pharmacology & Pharmacy
Carmen Lammi, Enrico M. A. Fassi, Jianqiang Li, Martina Bartolomei, Giulia Benigno, Gabriella Roda, Anna Arnoldi, Giovanni Grazioso
Summary: By utilizing a computational approach, we optimized the primary structure of P5 and obtained new analogs with improved affinity to PCSK9. Biological assays were then conducted to fully characterize the dual cholesterol-lowering activity of these P5 analogs using both biochemical and cellular techniques.
Article
Nutrition & Dietetics
Carlotta Bollati, Ruoxian Xu, Giovanna Boschin, Martina Bartolomei, Fabrizio Rivardo, Jianqiang Li, Anna Arnoldi, Carmen Lammi
Summary: This study characterized the potential pleotropic activity of two commercially available soybean and pea protein hydrolysates, revealing their ability to inhibit DPP-IV and ACE activity. These findings suggest that these hydrolysates could be used in the development of innovative multifunctional foods and nutraceuticals for the prevention of metabolic syndrome.
Article
Chemistry, Multidisciplinary
Yuhui Zhang, Li Wang, Benjamin J. Tombling, Carmen Lammi, Yen-Hua Huang, Yue Li, Martina Bartolomei, Bin Hong, David J. Craik, Conan K. Wang
Summary: Optimization of peptide stability is an effective approach for developing peptides as alternatives to approved monoclonal antibodies. It can improve the activity of cholesterol-lowering and is particularly important for targeting proprotein convertase subtilisin-like/kexin type 9 (PCSK9).
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Food Science & Technology
Andrea Cerrato, Carmen Lammi, Anna Laura Capriotti, Carlotta Bollati, Chiara Cavaliere, Carmela Maria Montone, Martina Bartolomei, Giovanna Boschin, Jianqiang Li, Susy Piovesana, Anna Arnoldi, Aldo Lagana
Summary: This study aims to develop a valuable mixture of short-chain peptides from hempseed for the prevention of metabolic syndrome worldwide. A dedicated analytical platform was developed to isolate and characterize over 500 short-chain peptides, which showed higher activity in inhibiting angiotensin-converting enzyme and dipeptidyl peptidase IV, and modulating cholesterol metabolism through low-density lipoprotein receptor.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Martina Bartolomei, Janna Cropotova, Carlotta Bollati, Kristine Kvangarsnes, Lorenza d'Adduzio, Jianqiang Li, Giovanna Boschin, Carmen Lammi
Summary: The study aimed to investigate the biological activities of low molecular weight peptides isolated from rainbow trout obtained by enzymatic hydrolysis. The fish protein hydrolysate (FPH) showed antioxidant, ACE inhibitory, and DPP-IV inhibitory activities. In vitro antioxidant activity was evaluated using various assays, while cell-free ACE and DPP-IV inhibitory activity assays were also conducted. The results suggest that peptides derived from Oncorhynchus mykiss may have potential applications as health-promoting ingredients.
Article
Biochemistry & Molecular Biology
Carlotta Bollati, Stefania Marzorati, Lorenzo Cecchi, Martina Bartolomei, Jianqiang Li, Maria Bellumori, Lorenza d'Adduzio, Luisella Verotta, Laura Piazza, Anna Arnoldi, Nadia Mulinacci, Carmen Lammi
Summary: To improve the management of the production chain of PGI Mantua pears, fruits with diseases or defects were used to produce dried rounds of pears, extending the remaining life. The secondary and residual by-products of the pears were then utilized to extract valuable phytocompounds using traditional and green extraction methods. The extracted compounds showed antioxidant activity, suggesting their potential use in dietary supplements and functional foods.
Article
Chemistry, Medicinal
Carmen Lammi, Enrico M. A. Fassi, Marco Manenti, Marta Brambilla, Maria Conti, Jianqiang Li, Gabriella Roda, Marina Camera, Alessandra Silvani, Giovanni Grazioso
Summary: Proprotein convertase subtilisin/kexin 9 (PCSK9) is a key target for the treatment of hypercholesterolemia and cardiovascular diseases. In this study, we discovered Rim13, a polyimidazole derivative that inhibits the interaction between PCSK9 and LDLR. Through computational design, we optimized the shape of PCSK9/ligand complementarity and identified potent diimidazole derivatives. Compound Dim16 showed improved PCSK9 inhibitory activity and some compounds in this series also showed hypocholesterolemic activity by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lorenzo Cecchi, Giulia Ghizzani, Maria Bellumori, Carmen Lammi, Bruno Zanoni, Nadia Mulinacci
Summary: Olives are rich in phenolic compounds that have health-promoting properties. This study analyzed the phenolic composition of olive seeds from Tuscan cultivars over the course of maturation. The most abundant compounds in the seeds were nuzhenide and nuzhenide 11-methyl oleoside. The total amount of phenols in the seeds was significant, reaching approximately 100 g/kg.
Article
Food Science & Technology
Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Ana Isabel Alvarez-Lopez, Justo Pedroche, Patricia Judith Lardone, Anna Arnoldi, Carmen Lammi, Antonio Carrillo-Vico
Summary: In the past 20 years, the demand for meat-free food has increased, leading to research on vegetable compounds as beneficial agents for human health. Particularly, protein hydrolysation has gained much interest as it releases peptides with biological activities. Lupinus spp. protein hydrolysates (LPHs) have been extensively studied for their biological activities, and they have shown antioxidant, immunomodulatory, hypotensive, hypoglycemic, and hypolipidemic effects. LPHs could potentially be used as nutraceuticals to prevent or treat chronic diseases, and the development of nanonutraceuticals to enhance their stability and bioactivity has been discussed.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guillermo Santos-Sanchez, Gilda Aiello, Fabrizio Rivardo, Martina Bartolomei, Carlotta Bollati, Anna Arnoldi, Ivan Cruz-Chamorro, Carmen Lammi
Summary: Hempseed is a promising source of plant proteins, with approximately 24% protein content, and edestin makes up the majority of its proteins. Two hempseed protein hydrolysates (HH1 and HH2) were produced using enzymes from different strains for different time periods. These hydrolysates exhibited strong direct antioxidant activity and certain peptides within them were found to be transported across intestinal cells, retaining their antioxidant activity. This suggests that these hempseed hydrolysates could be utilized as sustainable antioxidant ingredients in nutraceutical and/or food industries.
Article
Biochemistry & Molecular Biology
Silvia Badini, Stefano Regondi, Carmen Lammi, Carlotta Bollati, Giordana Donvito, Raffaele Pugliese
Summary: This study uses 3D printing technology to design and fabricate two lattice structures inspired by silkworm cocoons, for the production of hand-wrist orthosis to assist MND patients with muscle atrophy. Finite element method analysis is used to study mechanical behavior and stress distribution of the lattice structures, and biocompatibility with human skin fibroblasts is confirmed. Semi-structured interviews with patients are conducted to gather feedback and develop form-fitting prototypes of 3D-printed orthosis.
Article
Food Science & Technology
Carmen Lammi, Carlotta Bollati, Laura Fiori, Jianqiang Li, Melissa Fanzaga, Lorenza d'Adduzio, Martina Tosi, Alberto Burlina, Gianvincenzo Zuccotti, Elvira Verduci
Summary: Phenylketonuria is the most common genetic disorder affecting amino acid metabolism. Early diagnosis and proper diet can lead to positive neurological outcomes. However, the restricted diet may cause oxidative stress in PKU patients. It is believed that mitochondrial impairment and oxidative stress contribute to the development of PKU. There is a potential correlation between PKU and the risk of developing noncommunicable diseases.
FOOD RESEARCH INTERNATIONAL
(2023)
