Article
Biochemistry & Molecular Biology
Eva Juengel, Pascal Schnalke, Jochen Rutz, Sebastian Maxeiner, Felix K. -H. Chun, Roman A. Blaheta
Summary: Axitinib significantly suppressed the growth of sunitinib-resistant HUVECs and induced cell cycle arrest at the G0/G1 phase. Both axitinib and sorafenib reduced HUVEC tube length and prevented wound closure in sunitinib-resistant HUVECs after six weeks of treatment, with sorafenib showing slightly better results.
Article
Endocrinology & Metabolism
Wanting Wang, Zhaoqiang Feng, Jinghui Bai
Summary: This study aimed to evaluate the risks of cardiovascular toxicity in cancer patients taking sunitinib. The findings showed that the use of sunitinib increased cardiovascular toxicity, including hypertension and bleeding. Therefore, doctors should regularly monitor cardiovascular health in patients taking sunitinib.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Clea Tardy, Alicja Puszkiel, Pascaline Boudou-Rouquette, Sixtine De Percin, Jerome Alexandre, Marion Berge, Guillaume Ulmann, Benoit Blanchet, Rui Batista, Francois Goldwasser, Audrey Thomas Schoemann
Summary: This report focuses on the feasibility of pharmacokinetics-guided dose escalation of pazopanib in patients with gastrointestinal reconstructions (GIR) and the clinical implications for their management. According to a retrospective data collection on three patients with GIR treated with pazopanib, optimal exposure to pazopanib cannot be achieved in patients with GIR, and other therapeutic strategies should be encouraged. Pretherapeutic assessment and therapeutic drug monitoring could be helpful to optimize pazopanib response in these patients.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Oncology
Annemarie Uhlig, Johannes Uhlig, Lutz Trojan, Michael Woike, Marianne Leitsmann, Arne Strauss
Summary: This study evaluated the association between axitinib, sunitinib, and temsirolimus toxicities and patient survival in metastatic renal cell cancer patients. Specific toxicities of each drug were found to predict patient outcomes in terms of overall survival and progression-free survival, providing potential insights for better treatment strategies.
Review
Gastroenterology & Hepatology
Xuehui Jiang, Fangfang Xiong, Qun Fu, Hongwei Peng, Yan Jing, Kaisaner Rexiti, Xiaohua Wei, Song Tao
Summary: This meta-analysis assessed the incidence and risk of sunitinib-induced hematologic toxicities in patients with imatinib-resistant gastrointestinal stromal tumors (GIST). The results showed that sunitinib had a relatively high incidence of anemia, neutropenia, and thrombocytopenia in GIST patients, as well as a substantial increased risk of high-grade neutropenia.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Dermatology
Xiaoyun Liu, Xia Wu, Wenjun Fan
Summary: This study evaluated the effectiveness and safety of endoscopic submucosa dissection (ESD) compared with endoscopic mucosal resection (EMR) in treating early-stage stomach cancer. The meta-analysis results showed that there was no significant difference between EMR and ESD in terms of postoperative hemorrhage, but EMR had a lower rate of postoperative perforation.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Dailong Li, Sha Wan, Wanqiang Li, Chunlai Cheng, Lu Xu, Peng Gu
Summary: Sorafenib demonstrates comparable efficacy to sunitinib as a first-line treatment for mRCC, but with lower toxicity.
Review
Oncology
Dezhi Lin, Yangxu Ou, Longlong Li, Kexin Wu, Qiang Zhang, Jiayin Yan, Kunlin Kuang, Dezhong Peng
Summary: This study evaluated the efficacy and safety of acupuncture for postoperative gastrointestinal dysfunction (PGD) in cancer based on eight randomized controlled trials. The results showed that acupuncture effectively reduced the time to first flatus (TFF) and time to first defecation (TFD). Acupuncture was also effective in reducing TFF and TFD in patients with different types of cancer, and no adverse events were reported.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Lijuan Xiang, Sihan Wu, Qingling Hua, Chuyang Bao, Hu Liu
Summary: Through systematic searches and meta-analysis of related studies, this article demonstrates the feasibility and potential of utilizing exhaled volatile organic compounds (VOCs) for diagnosing gastrointestinal cancers. The results show promising sensitivity and specificity of VOC analysis in diagnosing colorectal cancer (CRC) and gastroesophageal cancer (GEC), indicating that VOCs could serve as valuable tumor biomarkers for gastrointestinal cancer diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wanting Wang, Zhaoqiang Feng, Jinghui Bai
Summary: The study aimed to evaluate the risk of cardiovascular toxicities in cancer patients taking sunitinib. It found that the use of sunitinib can increase the cardiovascular toxicity of patients, such as hypertension and bleeding, but does not increase the risk of thromboembolism. Doctors should be aware of these risks and regularly monitor the cardiovascular health of patients.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
Review
Medicine, General & Internal
Yuming Yao, Xiang Zhu, Weixin Liu, Jiayi Jiang, Han Jiang
Summary: Detecting circulating tumor cells (CTCs) can predict the prognosis of patients with gastrointestinal tumors and contribute to personalized treatment plans.
Review
Pharmacology & Pharmacy
Yan Wang, Yan Cai, Qi-Ming Wang
Summary: This study evaluated the efficacy and safety of cediranib in cancer patients through a comprehensive analysis. The results showed that cediranib treatment had significantly better progression-free survival (PFS) and overall survival (OS) compared to noncediranib therapy. However, cediranib treatment also increased the risk of specific treatment-related toxicities.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2023)
Review
Oncology
Hua-Yang Pang, Xiu-Feng Chen, Meng-Hua Yan, Li-Hui Chen, Zhi-Xiong Chen, Shou-Ru Zhang, Hao Sun
Summary: This study investigated the value of the advanced lung cancer inflammation index (ALI) in evaluating postoperative complications (POCs) and survival outcomes in patients with gastrointestinal (GI) cancer. The results showed that patients in the low ALI group had an increased incidence of POCs, worse overall survival, and decreased disease-free survival compared to those in the high ALI group. Therefore, ALI could serve as a valuable predictor of POCs and long-term outcomes in patients with GI cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jing Xu, Li'e Sun, Song Luo, Guoqing Zhu, Yilang Zhou, Mei Jiang, Min Wang
Summary: This study evaluated the efficacy and safety of recombinant human endostatin combined with chemotherapy in advanced gastrointestinal tumors in China. The results showed that the short-term efficacy of rh-ES combined with chemotherapy was better, with fewer adverse reactions.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Oncology
De Luo, Fei Kuang, Juan Du, Mengjia Zhou, Xiangdong Liu, Xinchen Luo, Yong Tang, Bo Li, Song Su
Summary: Based on our meta-analysis, artificial intelligence showed high accuracy in the diagnosis of early upper gastrointestinal cancer (EUGIC).
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wei-Xiang Qi, Zan Shen, Li-Na Tang, Yang Yao
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2014)
Review
Pharmacology & Pharmacy
Wei-Xiang Qi, Zan Shen, Li-Na Tang, Yang Yao
CLINICAL DRUG INVESTIGATION
(2014)
Review
Gastroenterology & Hepatology
W. -X. Qi, Z. Shen, L. -N. Tang, Y. Yao
COLORECTAL DISEASE
(2014)
Review
Medicine, General & Internal
Wei-Xiang Qi, Zan Shen, Feng Lin, Yuan-jue Sun, Da-liu Min, Li-Na Tang, Ai-Na He, Yang Yao
CURRENT MEDICAL RESEARCH AND OPINION
(2013)
Article
Medicine, General & Internal
Wei-Xiang Qi, Feng Lin, Ai-Na He, Li-Na Tang, Zan Shen, Yang Yao
CURRENT MEDICAL RESEARCH AND OPINION
(2013)
Article
Pharmacology & Pharmacy
Wei-Xiang Qi, Li-Na Tang, Zan Shen, Yang Yao
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2014)
Article
Oncology
Wei-Xiang Qi, Shengguang Zhao, Jiayi Chen
Article
Oncology
Wei-Xiang Qi, Lu Cao, Cheng Xu, Shengguang Zhao, Jiayi Chen
Article
Oncology
Wei-xiang Qi, Shengguang Zhao, Jiayi Chen
Editorial Material
Oncology
Wei-Xiang Qi, Lu Cao, Cheng Xu, Shengguang Zhao, Jiayi Chen
Article
Oncology
Wei Xiang Qi, Lu Cao, Cheng Xu, Jiayi Chen
Summary: The study found that adjuvant radiotherapy significantly improves the survival of patients with primary squamous cell carcinoma of the breast. Further research is needed to investigate the role of adjuvant radiotherapy in PSCC after mastectomy.
JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Wei-Xiang Qi, Lingyan Chen, Lu Cao, Cheng Xu, Gang Cai, Jiayi Chen
Summary: This study aimed to compare the survival outcomes between HER2-low-positive and HER2-0 breast cancer, regardless of hormone-receptor (HR) status, in Asian women. The results showed no significant survival difference between the two groups, but high Ki-67 index was associated with poorer survival outcomes in HER2-0 breast cancer.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Wei-Xiang Qi, Lu Cao, Siyue Zheng, Cheng Xu, Rong Cai, Haoping Xu, Gang Cai, Jiayi Chen
Summary: The IMNI PRECISION trial aims to determine the optimal adjuvant radiation therapy for early-stage breast cancer patients with positive lymph nodes (T1-2N1). The study randomly assigns patients with high clinical risk but low genomic risk to receive either comprehensive regional nodal irradiation with internal mammary node irradiation or to omit the internal mammary node irradiation. The primary endpoint is event-free survival.
Article
Oncology
Wei-Xiang Qi, Xiaoyan Wang, Chengqiang Li, Shuyan Li, Huan Li, Feifei Xu, Jiayi Chen, Shengguang Zhao, Hecheng Li
Summary: This study aimed to analyze the relationship between pretreatment inflammatory biomarkers and survival outcomes for patients with esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and pembrolizumab. The results showed that pretreatment absolute lymphocyte count and platelet count were independent predictors for treatment response and prognosis of ESCC.
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)