期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 89, 期 2, 页码 322-329出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2013.08.012
关键词
Pazopanib; Angiogenesis; Soft tissue sarcoma; Vascular endothelial growth factor (VEGF); Targeted therapy; Tyrosine kinase inhibitor (TKI)
资金
- Regione Calabria on the Behalf of Agenzia Italiana del Farmaco (AIFA)
Soft tissue sarcomas (STS) are rare tumors with mesenchymal origin, accounting for 1% of all human cancer. Local control of STS can be obtained through the use of surgery and radiotherapy. In about 40% of these patients, disease will recur at distant sites, and of these more than 90% will die because of this aggressive malignancy. In advanced and/or metastatic STS patients treated with anthracycline-based regimen the median overall survival is about 12 months, and it has remained unchanged during the last 20 years. Clearly, this strongly suggests the need for discover more active compounds in STS, such as imatinib in GIST or dermatofibrosarcoma patients. In this paper we describe the crucial role of angiogenesis mechanisms in sarcomas development and progression. Consequentially, we focus on pazopanib, a novel multitargeted tyrosine kinase inhibitor with anti-angiogenic activity, mainly due to VEGFR2 pathway interference. We also analyze principal completed trials leading pazopanib approval in sarcomas pretreated patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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