Review
Biochemistry & Molecular Biology
Susana Hernando Polo, Diana Moreno Munoz, Adriana Carolina Rosero Rodriguez, Jorge Silva Ruiz, Diana Isabel Rosero Rodriguez, Felipe Counago
Summary: For metastatic castration-resistant prostate cancer, novel targeted therapies are changing the treatment landscape, with PARPi inhibitors showing significant benefits but being ineffective for resistant tumors and wildtype BRCA tumors.
Review
Oncology
Karin L. Lee, Jeffrey Schlom, Duane H. Hamilton
Summary: Combining neoepitope vaccines with other cancer therapies may improve their clinical efficacies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Anusha Muralidhar, Hemanth K. Potluri, Tanya Jaiswal, Douglas G. McNeel
Summary: Prostate cancer is the most diagnosed malignancy in men in the United States, but targeted radionuclide therapies have shown promise in improving patient outcomes. While immune-based treatments have generally had limited success, radiation therapy may be able to combine with immunotherapy to more effectively eliminate metastases. This review provides an overview of targeted radiation agents approved for prostate cancer and explores their potential combination with immunotherapy.
Article
Immunology
Lauren R. Corulli, Denise L. Cecil, Ekram Gad, Marlese Koehnlein, Andrew L. Coveler, Jennifer S. Childs, Ronald A. Lubet, Mary L. Disis
Summary: Overexpression of proteins in colorectal cancer patients may make them immunogenic, and vaccines targeting these proteins could potentially inhibit tumor development. Further research is needed to develop multi-antigen vaccines for the treatment and prevention of colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Octavia Cadassou, Lars Petter Jordheim
Summary: More and more studies are focusing on the complex metabolic characteristics and plasticity of cancer cells. New metabolism-targeting therapeutic strategies, including classical and promising OXPHOS inhibitors (OXPHOSi), are being developed to address these specificities and vulnerabilities. OXPHOSi show limited efficiency as monotherapy but have potential in combination with conventional therapeutic strategies and other innovative approaches.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ana Belen Azuaga, Julio Ramirez, Juan D. D. Canete
Summary: Psoriatic arthritis is a chronic inflammatory disease associated with psoriasis and other comorbidities. Its complex pathogenesis involves genetic predisposition, environmental factors, and immune system activation. Research has identified therapeutic targets based on immune-inflammatory pathways, but heterogeneous responses remain a challenge. Translational research and integration of omics technologies are needed to improve outcomes and identify new targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Carlo Sorrentino, Emma Di Carlo
Summary: Recent studies have emphasized the importance of molecular targeted therapies in metastatic castration-resistant prostate cancer. These therapies aim to block specific molecules and related pathways in cancer cells or their microenvironment to inhibit their growth and spread while minimizing harm to healthy tissues. The review discusses the characteristics, efficacy, and limitations of these therapies, some of which are already approved for clinical use, while others are still in clinical trials or pre-clinical development. It also explores future research perspectives, including combining traditional drugs and using nanomedicine for selective release at the tumor site, to improve tolerability and efficacy.
Review
Oncology
Sahar F. Bannoura, Husain Yar Khan, Asfar S. Azmi
Summary: KRAS mutations are common in cancer, and recent advancements have shown that small molecule inhibitors can be developed against KRAS G12C, although there is still no agent to target KRAS G12D. However, significant progress has been made in developing compounds that can bind to and inhibit KRAS G12D, including MRTX1133. Additionally, an immunotherapeutic approach using adoptive T-cell transfer has shown promise in targeting G12D in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Yang Yang, Hongyi Li, Christina Fotopoulou, Paula Cunnea, Xia Zhao
Summary: This article reviews the role of Toll-like receptors (TLRs) in immune reactions and their potential in cancer treatment. TLR-targeted strategies have shown the ability to regulate the tumor microenvironment and have become part of standard care in some cases. However, challenges and further research are still needed for the development of TLR-targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zaoqu Liu, Jinxiang Lv, Qin Dang, Long Liu, Siyuan Weng, Libo Wang, Zhaokai Zhou, Ying Kong, Huanyun Li, Yilin Han, Xinwei Han
Summary: Immunotherapy treatments using the immune system have revolutionized personalized medicine and brought significant benefits for cancer patients. Tumor neoantigens, arising from somatic mutations and presented by major histocompatibility complex, play a crucial role in immunotherapy. With advancements in sequencing technology and bioinformatics, the identification of neoantigens has accelerated and is expected to be integrated into clinical practice. Neoantigen vaccines, such as peptides, DNA, RNA, and dendritic cells, have shown great potential in activating specific T cells and enhancing anti-tumor immunity. This review discusses the origin and prediction of neoantigens, compares different types of neoantigen vaccines, and explores strategies for improving their efficacy, while addressing the challenges in their application.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Samantha Gogola, Michael Rejzer, Hisham F. F. Bahmad, Ferial Alloush, Yumna Omarzai, Robert Poppiti
Summary: The standard of care therapy for early prostate cancer includes external beam radiation therapy, brachytherapy, radical prostatectomy, active surveillance, or a combination approach. Androgen deprivation therapy is considered for advanced disease. However, many patients eventually develop castration-resistant prostate cancer, leading to the development of targeted therapies, including prostate cancer stem cell-targeted therapies. In this review, the mechanisms of action of PCSC-targeted therapies are summarized and future development is discussed.
Review
Oncology
Carmelo Laface, Girolamo Ranieri, Felicia Maria Maselli, Francesca Ambrogio, Caterina Foti, Michele Ammendola, Marigia Laterza, Gerardo Cazzato, Riccardo Memeo, Giovanni Mastrandrea, Marco Lioce, Palma Fedele
Summary: One of the most important abilities of a tumor is to establish immunosuppression inside the tumor microenvironment. This is achieved through various mechanisms of tumor immune escape identified in experimental studies. In the liver, the microenvironment is oriented towards immune tolerance, preventing autoimmune reactions. Additionally, hepatocellular carcinoma often develops in the context of chronic inflammation. Due to these factors, different immunotherapeutic strategies have been developed and evaluated for advanced HCC. This review provides an overview of the clinical applications of immunotherapy for advanced HCC, including approved drugs and ongoing clinical trials.
Review
Biochemistry & Molecular Biology
Lifu Long, Zhenjie Yi, Yu Zeng, Zhixiong Liu
Summary: The incidence of brain metastases has been increasing and poses a significant challenge in the medical field. Currently available therapies, such as systemic chemotherapy, targeted therapy, and immunotherapy, face difficulties like drug resistance and low permeability of the blood-brain barrier. Recent research shows that malignant tumor cells can manipulate the brain microenvironment, leading to a pro-tumoral environment. This review compares the characteristics of the brain microenvironment in brain metastases with other sites or primary tumors and evaluates microenvironment-targeted therapies for brain metastases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Oncology
Rille Pihlak, Caroline Fong, Naureen Starling
Summary: Stomach cancer is an aggressive disease with poor survival outcomes, but in the past two decades, clinical research has made significant progress in understanding targets and potential targeted treatments for advanced stomach cancer. This article summarizes the recent advancements in targeted therapies and precision medicine in gastric cancer and discusses new potential treatments.
Article
Multidisciplinary Sciences
Yuxin Guo, Shao-Zhe Wang, Xinping Zhang, Hao-Ran Jia, Ya-Xuan Zhu, Xiaodong Zhang, Ge Gao, Yao-Wen Jiang, Chengcheng Li, Xiaokai Chen, Shun-Yu Wu, Yi Liu, Fu-Gen Wu
Summary: By using HDDT nanoparticles, cancer cells can be converted into micrometer-sized vesicles, which can be utilized as personalized vaccines by producing vesicles in situ to convert primary tumors into antigen depots. HDDT treatment provides long-term protection and induces strong immune memory effect.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Zhi-You Cai, Ming Xiao, Sohel H. Quazi, Zun-Yu Ke
NEURAL REGENERATION RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Jayshree Mishra, Randall Simonsen, Narendra Kumar
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Narendra Kumar, Jayshree Mishra, Gianfranco Alpini, Ceci Ludovica, Kyritsi, Konstantina, Shannon Glaser, Fanyin Meng, Francis Heather
Review
Cell Biology
Narendra Kumar, Longxiang Kuang, Ryan Villa, Priyam Kumar, Jayshree Mishra
Summary: Janus kinases (Jaks) play critical roles in both immune and nonimmune cells, especially in epithelial cells. Emerging information on the roles of Jak3 in gastrointestinal functions and associated diseases is drawing attention.
MEDIATORS OF INFLAMMATION
(2021)
Review
Cell Biology
Jayshree Mishra, Madyson Stubbs, Longxiang Kuang, Nitza Vara, Priyam Kumar, Narendra Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Probiotics and their engineering show great potential in treating chronic inflammatory conditions, including IBD. Personalized probiotic treatment is important due to the diversity of the gut microbiome in different populations.
MEDIATORS OF INFLAMMATION
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Jayshree Mishra
Meeting Abstract
Biochemistry & Molecular Biology
Narendra Kumar, Gianfranco Alpini, Jayshree Mishra
Meeting Abstract
Biochemistry & Molecular Biology
Priyam Kumar, Jayshree Mishra, Narendra Kumar
Article
Nutrition & Dietetics
Premranjan Kumar, Jayshree Mishra, Narendra Kumar
Summary: In this study, we demonstrated the mechanistic role of Jak3 in obesity-associated cognitive impairments. High-fat diet suppressed Jak3 expression, leading to cognitive impairments. We revealed the mechanism of gut dysbiosis, compromised microglial functions, and brain inflammation caused by Jak3 deficiency, which ultimately resulted in cognitive impairments.
Meeting Abstract
Biochemistry & Molecular Biology
Jayshree Mishra, Narendra Kumar
Meeting Abstract
Biochemistry & Molecular Biology
Narendra Kumar, Jayshree Mishra
Meeting Abstract
Biochemistry & Molecular Biology
Narendra Kumar, Jayshree Mishra
Meeting Abstract
Biochemistry & Molecular Biology
Narendra Kumar, Jugal K. Das, Jayshree Mishra
Meeting Abstract
Biochemistry & Molecular Biology
Narendra Kumar, Premranjan Kumar, Jayshree Mishra
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
