Correction
Cell Biology
Daniel Constantin, Christian Widmann
Summary: Correction to the paper has been published.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Mrinal K. Das, Oyvind P. Haugen, Trine B. Haugen
Summary: Testicular germ cell tumour (TGCT) is the most common cancer type among young adults in many parts of the world. MicroRNAs (miRNAs), a class of non-coding RNAs, play important roles in TGCT pathogenesis by regulating gene expression at the post-transcriptional level. They can act as either oncogenes or tumour suppressors by influencing cellular processes such as proliferation, differentiation, and apoptosis. The involvement of miRNAs in TGCT development has been supported by differential expression studies and functional studies that explore individual miRNA targets and downstream pathways. This review summarises the diverse roles and targets of miRNAs in TGCT pathogenesis.
Article
Medicine, General & Internal
Selim Jennane, Mounir Ababou, Mariyam El Haddad, Omar Ait Sahel, El Mehdi Mahtat, Hicham El Maaroufi, Abderrahim Doudouh, Kamal Doghmi
Summary: This study investigated the risk factors for bleomycin-induced lung toxicity in patients with Hodgkin's lymphoma and evaluated the effectiveness of positron emission tomography scan in early detection of this toxicity. The results showed that smoking and treatment regimen were significant risk factors for bleomycin-induced lung toxicity. However, positron emission tomography scans after two and four cycles of therapy were not reliable in predicting the occurrence of this toxicity.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Luz Alonso-Crisostomo, Jennifer Trendell, Marta Ferraresso, Shivani Bailey, Dawn Ward, Zachary G. L. Scurlock, Stephanie C. Wenlock, Carlos A. P. Bastos, Ravin Jugdaohsingh, Nuno J. Faria, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray
Summary: Malignant germ-cell-tumours (GCTs) are characterized by dysregulation of microRNA (miRNA/miR-), specifically overexpression of miR-371, miR-373, and miR-302/367 clusters. These miRNAs are released in extracellular vesicles (EVs) and may serve as potential biomarkers. This study comprehensively investigated the role of EVs and their miRNA cargo in the tumor microenvironment (TME) of testicular GCTs (TGCTs). The results showed that TGCT cells secreted EVs containing miR-371, miR-373, and miR-302/367 miRNAs. Co-culture of TGCT cells with TME cells resulted in increased levels of these miRNAs in TME cells. Fluorescent labeling demonstrated the internalization of TGCT-derived EVs by TME cells. Treatment of TME cells with EVs from different TGCT subtypes led to increased miRNA levels. Overexpression of miR-371a in TME cells resulted in functional changes, including collagen contraction and angiogenesis. These findings suggest that TGCT cells communicate with nontumor stromal TME cells through EVs enriched with oncogenic miRNAs, potentially contributing to tumor progression.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Harshita Dubey, Garima Jain, Chandan Kumar, Amar Ranjan, Atul Batra, Santosh Kumar Chellapuram, Swati Gupta, Harsh Goel, Anil Sharma, Pranay Tanwar
Summary: This article reports a case of an adult male presenting with an intra-abdominal mass, inguinal lymphadenopathy, and deranged kidney function test. Bone marrow aspirate smear showed metastatic tumor cells, while bone marrow biopsy was unremarkable. High serum β-HCG levels indicated a germ cell lesion. Lymph node biopsy and immunomarkers confirmed metastatic foci from a germ cell tumor and were managed according to standard protocol. Rarely, bone marrow aspirate can be positive for malignancy while biopsy turns out to be negative. Additionally, bone marrow metastasis of germ cell tumors should be considered in cases like this.
Article
Multidisciplinary Sciences
Pierre Pinochet, Edgar Texte, Aspasia Stamatoullas-Bastard, Pierre Vera, Sorina-Dana Mihailescu, Stephanie Becker
Summary: The study demonstrates the prognostic value of initial total metabolic tumor volume (TMTV) in predicting outcomes for patients with advanced-stage Hodgkin's lymphoma (HL). TMTV is useful for predicting 5-year progression-free survival and PET response after chemotherapy, and remains a baseline prognostic factor even when considering other treatment variables.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Tianxiang Geng, Catherine Anne Heyward, Xi Chen, Mengxue Zheng, Yang Yang, Janne Elin Reseland
Summary: This study investigated the expression of ameloblastin in testicular germ cell tumour and its relationship with diagnosis and prognosis. Bioinformatic analysis revealed that ameloblastin was associated with tumour recurrence and identified a ceRNA regulatory network and PELATON as an independent prognostic factor.
Article
Oncology
Neha Pathak, Abhishek Raj, Akhil P. Santhosh, Sudhir Kumar, K. P. Haresh, Prabhjot Singh, Brusabhanu Nayak, Shamim Ahmed Shamim, Amlesh Seth, Mukurdipi Ray, Seema Kaushal, Ranjit Kumar Sahoo, Atul Batra
Summary: This study compared the quality of life (QoL) of germ cell tumor (GCT) survivors with healthy controls. The results showed significant differences in emotional, social, and overall QoL between the two groups. GCT survivors had more severe symptoms and financial toxicity. However, no significant predictive variables were found to impact QoL.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Klaus-Peter Dieckmann, Hendrik Isbarn, Francesca Grobelny, Cansu Dumlupinar, Julia Utschig, Christian Wulfing, Uwe Pichlmeier, Gazanfer Belge
Summary: The size of testicular tumours is clinically relevant, with larger tumours having higher frequencies of metastasis and elevation of tumour markers. The novel marker M371 performs better than classical markers, even in subcentimeter tumours. Tumour size is associated with clinical stage, tumour marker expression rates, and histology. It is important to note that 50% of subcentimeter testicular tumours are benign.
Article
Andrology
Yuxuan Song, Xiangjie Qi, Jiaqi Kang, Xiao Wang, Ningjing Ou, Jun Zhu, Shangren Wang, Xiaoqiang Liu
Summary: Our study identified AKAP4, SPA17, and TNP1 as promising biomarkers for TGCT, which may regulate immune cell infiltration in the tumor microenvironment.
Article
Reproductive Biology
S. P. Singh, S. D. Kharche, M. Pathak, Y. K. Soni, R. V. S. Pawaiya, S. A. Quadri, M. K. Singh, M. S. Chauhan
Summary: This study aimed to create a suitable recipient goat model for germ cell transplantation through a single intra-testicular busulfan infusion under ultrasonographic guidance. The results demonstrated a significant suppression of spermatogenesis in the 2 mg/kg-MT group, without significant effects on key hematological variables.
Review
Pathology
Nuno Tiago Tavares, Rui Henrique, Aditya Bagrodia, Carmen Jeronimo, Joao Lobo
Summary: Testicular germ cell tumors (TGCT) are the most commonly diagnosed cancers among young men. This article provides a comprehensive review of the currently available and future prospects in the field of TGCT biomarkers.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Medicine, Research & Experimental
Lin Yang, Qiuling Zhao, Wenbin Liu, Ting Chen, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Dong
Summary: Inhibition of HPK1 enhances the efficacy of anti-PD-1 immunotherapy in non-Hodgkin's lymphoma, suggesting that HPK1 inhibitors are promising drug targets for cancer immunotherapy.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Michal Chovanec, Katarina Kalavska, Jana Obertova, Patrik Palacka, Katarina Rejlekova, Zuzana Sycova-Mila, Zuzana Orszaghova, Peter Lesko, Valentina De Angelis, Lucia Vasilkova, Daniela Svetlovska, Beata Mladosievicova, Jozef Mardiak, Michal Pastorek, Barbora Vlkova, Peter Celec, Michal Mego
Summary: This study found that disruption of the intestinal barrier may contribute to cognitive impairment in survivors of testicular germ cell tumors through the gut-blood-brain axis. Higher levels of plasma sCD14 were associated with worse cognitive function in these patients. These findings provide new insights into understanding and addressing cognitive impairment in survivors of testicular germ cell tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Gabriela G. F. van der Schoot, Harm L. Ormel, Nico-Derk L. Westerink, Johan B. Wempe, Joop D. Lefrandt, Anne M. May, Aline H. Vrieling, Coby Meijer, Jourik A. Gietema, Annemiek M. E. Walenkamp
Summary: Examining the effects of physical exercise on pulmonary and vascular endothelial toxicity in patients with testicular cancer during or after BEP chemotherapy, this post hoc analysis of a randomized clinical trial found that exercising during chemotherapy helps preserve lung function and minimize vascular damage.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Hematology
Ioannis Papakonstantinou, Epameinondas Koumpis, Eugenia Fytsili, Aikaterini Panteli, Haralampos Milionis, Alexandra Papoudou-Bai, Eleni Kapsali, Eleftheria Hatzimichael
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleni Alexandri, Alexandra Primikyri, Georgios Papamokos, Themistoklis Venianakis, Vasileios K. Gkalpinos, Andreas G. Tzakos, Andreas Karydis-Messinis, Dimitrios Moschovas, Apostolos Avgeropoulos, Ioannis P. Gerothanassis
Summary: This study presents a novel approach using STD, Tr-NOESY, INPHARMA NMR techniques, docking calculations, and competitive binding experiments to map the interactions and binding sites of free fatty acids (FFAs) with non-labelled serum albumin (BSA/HSA). The results reveal significant negative inter-ligand NOEs between the FFAs and the drugs ibuprofen and warfarin, suggesting a competitive binding mode. The conformational flexibility of the FFAs in the warfarin binding site hindered the accurate determination of their location and conformational states.
Article
Biochemistry & Molecular Biology
Lenka Hernychova, Eleni Alexandri, Andreas G. Tzakos, Martina Zatloukalova, Alexandra Primikyri, Ioannis P. Gerothanassis, Lukas Uhrik, Marek Sebela, David Kopecy, Lukas Jedinak, Jan Vacek
Summary: This work investigates the interaction between 9/10-nitro-oleic acid (NO2-OA) and human serum albumin (HSA). The study reveals that NO2-OA can non-covalently bind to HSA and has a higher affinity to HSA compared to oleic acid (OA).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pathology
Lydia Kyriazopoulou, Georgia Karpathiou, Eleftheria Hatzimichael, Michel Peoc'h, Alexandra Papoudou-Bai, Panagiotis Kanavaros
Summary: This study investigated the expression of autophagy and cellular senescence in classical Hodgkin lymphoma and found a significant positive correlation between high nuclear p62 expression and disease relapse. Heterogeneous autophagy and cellular senescence patterns were observed in Hodgkin and Reed-Sternberg cells, suggesting biological heterogeneity in classical Hodgkin lymphoma.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Plant Sciences
Antonios D. Tsiailanis, Christos M. Chatzigiannis, Christina D. Papaemmanouil, Maria Chatziathanasiadou, Panagiotis Chaloulos, Isabel Riba, Graham Mullard, Wieslaw Wiczkowski, Apostolos Koutinas, Ioanna Mandala, Andreas G. Tzakos
Summary: Replacing synthetic dyes with natural pigments, such as betalains, is a topic of great interest in the food industry, as consumers are increasingly concerned about non-toxic and natural additives. This study focuses on the identification of betalain phytochemical content in prickly pear cactus from two different Opuntia species in Greece. The use of modern analytical techniques, including UV-Vis spectroscopy, NMR spectroscopy, and LC-HRMS, as well as cell-based assays, enabled the researchers to establish a rapid approach for distinguishing different Opuntia cultivars based on their phytochemical constituents. These findings highlight the potential of Opuntia species as a viable source of natural food colorants.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki D. Kostagianni, Antonis D. Tsiailanis, Thomas Thorne, Maria Chatziathanasiadou, Gregory B. Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie Morse, James J. Choi, Kevin O'Neill, Zoi Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas G. Tzakos, Nelofer Syed
Summary: This study reveals that AT(2)R is a therapeutic target for GBM and AngII promotes proliferation through this receptor. EMA401 and its derivative A3E can inhibit the proliferation and invasiveness of GBM, and show enhanced penetration in the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Theodoros P. Vassilakopoulos, Fotios Panitsas, Zois Mellios, John Apostolidis, Michalis Michael, Ronit Gurion, Burhan Ferhanoglu, Eleftheria Hatzimichael, Stamatios Karakatsanis, Maria Dimou, Christina Kalpadakis, Eirini Katodritou, Theoni Leonidopoulou, Ioannis Kotsianidis, Hara Giatra, Nick Kanellias, Ayman Sayyed, Tamar Tadmor, Olga Meltem Akay, Maria K. Angelopoulou, Netanel Horowitz, Maria Bakiri, Gerassimos A. Pangalis, Panayiotis Panayiotidis, Sotirios G. Papageorgiou
Summary: Central nervous system (CNS) involvement is rare in primary mediastinal large B-cell lymphoma (PMLBCL). Kidney and/or adrenal involvement is strongly associated with CNS relapse. Chemotherapy regimen and established prognostic factors do not predict CNS relapse in PMLBCL. CNS relapse as a first event occurs rarely in PMLBCL.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Panagiotis T. Diamantopoulos, Emmanouil Charakopoulos, Argiris Symeonidis, Ioannis Kotsianidis, Nora-Athina Viniou, Vassiliki Pappa, Charalampos Pontikoglou, Dimitrios Tsokanas, Georgios Drakos, Alexandra Kourakli, Elena Solomou, Eleftheria Hatzimichael, Anastasia Pouli, Maria Kotsopoulou, Evangelos Asmanis, Maria Dimou, Panayiotis Panayiotidis, Sotirios Papageorgiou, Georgios Vassilopoulos, Achilles Anagnostopoulos, Theodoros Vassilakopoulos, Helen Papadaki, Athanasios Galanopoulos
Summary: Monocytopenia is a common finding in patients with myelodysplastic syndrome (MDS), and its presence is associated with excess blasts and higher prognostic scoring system categories. Monocytopenia is a prognostic indicator of lower overall survival and leukemia free survival in MDS patients, even after adjusting for other factors. Monocytopenia can also help differentiate prognostically distinct subgroups in the low and intermediate risk groups of MDS.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Goran Stegnjaic, Milica Lazarevic, Dimitrios A. Diamantis, Neda Djedovic, Bojan Jevtic, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Andreas G. Tzakos, Dorde Miljkovic
Summary: This study evaluated the immunomodulatory properties of a phenethyl ester derivative of rosmarinic acid (PERA) in an animal model of central nervous system autoimmunity. PERA was found to have anti-encephalitogenic effects by shortening disease duration and reducing clinical scores, as well as inhibiting the production of encephalitogenic cytokines and nitric oxide. The study suggests that PERA could be a potential therapy for multiple sclerosis.
IMMUNOLOGY LETTERS
(2022)
Article
Oncology
Konstantinos Liapis, Vasileios Papadopoulos, Charalambos Pontikoglou, George Vrachiolias, Emily Stavroulaki, Alexandra Kourakli, Vasileios Lazaris, Athanasios G. Galanopoulos, Menelaos Papoutselis, Sotirios G. Papageorgiou, Panagiotis T. Diamantopoulos, Vassiliki Pappa, Nora-Athina Viniou, Dimitris Tsokanas, Theodoros P. Vassilakopoulos, Eleftheria Hatzimichael, Eleni Bouronikou, Maria Ximeri, Aekaterini Megalakaki, Panagiotis Zikos, Panayiotis Panayiotidis, Maria Dimou, Stamatis Karakatsanis, Maria Papaioannou, Stavros Papadakis, Anna Vardi, Flora Kontopidou, Nikolaos Harchalakis, Ioannis Adamopoulos, Argiris Symeonidis, Helen A. Papadaki, Ioannis Kotsianidis
Letter
Hematology
Panagiotis T. Diamantopoulos, Elena Solomou, Argiris Symeonidis, Vasiliki Pappa, Ioannis Kotsianidis, Athanasios Galanopoulos, Charalampos Pontikoglou, Achilles Anagnostopoulos, George Vassilopoulos, Panagiotis Zikos, Eleftheria Hatzimichael, Maria Papaioannou, Aekaterini Megalakaki, Theodoros Vassilakopoulos, Maria Dimou, Dimitrios Tsokanas, Menelaos-Konstantinos Papoutselis, Sotirios Papageorgiou, Alexandra Kourakli, Helen Papadaki, Panayiotis Panayiotidis, Nora-Athina Viniou
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Review
Biology
Vasileios Georgoulis, Alexandra Papoudou-Bai, Alexandros Makis, Panagiotis Kanavaros, Eleftheria Hatzimichael
Summary: Hodgkin lymphoma accounts for 10% of new lymphoma diagnoses and has high cure rates, but new treatments are needed for relapsed cases. Neoplastic cells in the tumor microenvironment interact with immune cells and suppress the host's anti-tumor immunity. This review summarizes the role of different cells in the microenvironment, focusing on macrophages, and discusses how tumor cells evade immune surveillance. Novel therapeutic targets have been identified in this microenvironment, providing personalized treatment options for Hodgkin lymphoma patients.
Review
Medicine, Research & Experimental
Theofilos Kanavos, Effrosyni Birbas, Alexandra Papoudou-Bai, Eleftheria Hatzimichael, Aikaterini Kitsouli, Georgia Karpathiou, Panagiotis Kanavaros
Summary: Primary bone lymphoma (PBL) is a rare form of malignant lymphoid cell tumor that presents with bone lesions without nodal or extranodal involvement. The most common histological type is diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), and it primarily occurs in the femur, humerus, tibia, spine, and pelvis. Diagnosis is often delayed due to non-specific clinical presentation, but can be confirmed through clinical examination, imaging studies, and histopathological and immunohistochemical examination. PBL has a favorable prognosis, especially when treated with combined chemoradiotherapy.
Article
Medicine, Research & Experimental
Stamatis J. Karakatsanis, Maria Bouzani, Argyris Symeonidis, Maria K. Angelopoulou, Sotirios G. Papageorgiou, Michail Michail, Gabriella Gainaru, Georgia Kourti, Sotirios Sachanas, Christina Kalpadakis, Eirini Katodritou, Theoni Leonidopoulou, Ioannis Kotsianidis, Eleftheria Hatzimichael, Maria Kotsopoulou, Maria Dimou, Eleni Variamis, Dimitrios Boutsis, Nick Kanellias, Maria N. Dimopoulou, Evridiki Michali, George Karianakis, Pantelis Tsirkinidis, Chryssa Vadikolia, Christos Poziopoulos, Anna Pigaditou, Effimia Vrakidou, Theophanis Economopoulos, Lydia Kyriazopoulou, Marina P. Siakantaris, Marie-Christine Kyrtsonis, Konstantinos Anargyrou, Maria Papaioannou, Evdoxia Hatjiharissi, Elissavet Vervessou, Maria Tsirogianni, Maria Palassopoulou, Ekaterini Stefanoudaki, Panayiotis Zikos, Panayiotis Tsirigotis, Gerassimos Tsourouflis, Theodora Assimakopoulou, Evgenia Verrou, Helen Papadaki, Polixeni Lampropoulou, Meletios-Athanasios Dimopoulos, Vassiliki Pappa, Kostas Konstantopoulos, Themis Karmiris, Paraskevi Roussou, Panayiotis Panayiotidis, Gerassimos A. Pangalis, Theodoros P. Vassilakopoulos
Summary: Both R-CHOP-14 and R-CHOP-21 are likely equally effective in PMLBCL patients, but further studies are needed to determine if dose-dense regimens can provide better disease control and long-term outcomes.
Review
Medicine, Research & Experimental
Georgios Petros Barakos, Eleftheria Hatzimichael
Summary: Bone marrow, as an active organ of the immune system, provides a sanctuary for immune cells and responds to external stimuli. However, chronic immune stimulation is harmful to normal hematopoietic stem cells, while essential for the propagation of dysregulated immune microenvironments in myeloid diseases.
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
