Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Immunology
Ryma Haroun, Sahar Naasri, Ayman J. Oweida
Summary: TLRs are essential for immune responses and can mediate inflammation by recognizing molecular patterns in pathogens and damaged cells. TLR ligands have gained attention in cancer research, especially in combination with cancer treatments like immunotherapy, chemotherapy, and radiotherapy (RT). However, the role of TLRs in cancer, particularly in response to radiation, is still poorly understood. This review examines how TLR signaling affects tumor response to RT and proposes a framework for TLR-based therapies with RT.
Article
Oncology
Louise M. E. Muller, Gemma Migneco, Gina B. Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J. Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais
Summary: The study demonstrates that reovirus can reduce MM tumor burden and myeloma-induced bone disease, increase NK cell and CD8(+) T cell numbers, activate these cells, and upregulate effector-memory CD8(+) T cells. Reovirus is able to kill MM cells by activating NK cells and MM-specific CD8(+) T cells, suggesting that reovirus-induced immunotherapy should be combined with agents that enhance antitumor immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Allison M. Owen, Liming Luan, Katherine R. R. Burelbach, Margaret A. A. McBride, Cody L. L. Stothers, Olivia A. A. Boykin, Kalkena Sivanesam, Jessica F. F. Schaedel, Tazeen K. K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. K. Patil, Edward R. R. Sherwood, Julia K. K. Bohannon
Summary: Immunocompromised populations are at high risk of life-threatening infections, and strategies to protect these patients are urgently needed. This study explores the use of trained immunity, which enhances the immune response to subsequent infections, as a promising approach. The researchers demonstrate that the MyD88-dependent signaling pathway plays a critical role in TLR-mediated trained immunity, providing valuable insights into the mechanisms underlying this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonios Lazaridis, Eleni Gavriilaki, Stella Douma, Eugenia Gkaliagkousi
Summary: Essential hypertension is a highly heterogeneous disease with a complex etiology, where subclinical inflammation and abnormal activation of TLR signaling play crucial roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jinta Asami, Toshiyuki Shimizu
Summary: TLRs are crucial in recognizing pathogenic molecular patterns and initiating immune responses. Recent advances in structural and mechanistic studies have provided insights into the activation and inhibition mechanisms of TLRs, enhancing our understanding of their functional properties.
Article
Fisheries
Hansam Cho, Ki Hoon Park, Yuyeon Jang, Yeondong Cho, Yoon-Ki Heo, Minjee Kim, Young Bong Kim
Summary: Outbreaks of infectious disease in shrimp pose a serious threat to shrimp agriculture worldwide. Shrimp lack adaptive immunity and rely solely on innate immunity for defense against infectious disease. Toll-like receptors play a critical role in the shrimp innate immune system, with the identification of a new Toll-like receptor gene (MnToll) in Macrobrachium nipponense potentially involved in defense against WSSV.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Immunology
Luke S. Uebelhoer, Agnes Gwela, Bonnie Thiel, Sophie Nalukwago, John Mukisa, Christopher Lwanga, Justine Getonto, Emily Nyatichi, Grace Dena, Alexander Makazi, Shalton Mwaringa, Ezekiel Mupere, James A. Berkley, Christina L. Lancioni, Childhood Acute Illness
Summary: Severely ill children in low- and middle-income countries experience high mortality rates from infectious diseases, and the risk of infection-related death is compounded by undernutrition. This study found that T cell function is impaired and innate immune responses are exaggerated in acutely ill children. Nutritional status is associated with the magnitude of cytokine responses. Further research is needed to understand the mechanisms of innate immune dysregulation in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Bettina Hoden, David DeRubeis, Margarita Martinez-Moczygemba, Kenneth S. Ramos, Dekai Zhang
Summary: Innate immune response mechanisms play a crucial role in lung cancer immunity and immunotherapy. TLR signaling can modulate the tumor microenvironment and enhance the immune sensitization of tumor cells to treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yanqin Du, Jun Wu, Jia Liu, Xin Zheng, Dongliang Yang, Mengji Lu
Summary: Chronic hepatitis B virus (HBV) infection is a significant global burden, and Toll-like receptors (TLRs) play a crucial role in immune response. However, HBV has developed strategies to inhibit TLR responses, limiting host immune response and promoting viral persistence. Recent studies indicate that stimulation of TLR signaling pathway enhances host immune response and suppresses HBV replication. These findings provide important insights for the use of TLR agonists as immunomodulators in the functional cure of HBV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ping-Ping Sun, Dan Li, Meng Su, Qing Ren, Wen-Ping Guo, Jiang-Li Wang, Luan-Ying Du, Guang-Cheng Xie
Summary: This study investigated the effects of TLR1/2/4/6 monomers and TLR2 heterodimer on EV71 replication and innate immune activation. It was found that TLR monomers and TLR2 heterodimer inhibited EV71 replication and induced the production of IL-8. Additionally, the EV71 capsid proteins served as pathogen-associated molecular patterns for TLR monomers and TLR2 heterodimer, activating innate immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara
Summary: This review discusses the importance of TLR responses in HCV infection and the mechanisms adopted by HCV to avoid immune surveillance mediated by TLRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Haibo Sun, Thomas G. Martin, John Marra, Denice Kong, Jonathon Keats, Sandrine Mace, Marielle Chiron, Jeffrey L. Wolf, Jeffrey M. Venstrom, Raja Rajalingam
Summary: The study revealed that specific genetic makeup of patients can influence their response to Isa-lenalidomide-dexamethasone therapy, with patients carrying KIR3DL2 and HLA-A3/11 plus high-affinity FCGR3A-158V allele showing improved progression-free survival. Conversely, patients with KIR2DL1 and HLA-C2C2 combination may have a lower response to this treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Ella A. Zuiderwijk-Sick, Celine van der Putten, Raissa Timmerman, Jennifer Veth, Erica M. Pasini, Linda van Straalen, Paul van der Valk, Sandra Amor, Jeffrey J. Bajramovic
Summary: Exposure to IL-4 induces changes in the cell surface protein expression profile of primary rhesus macaque microglia and enhances their potential to induce proliferation of T cells with a regulatory signature. Additionally, IL-4 exposure broadly impairs TLR-induced cytokine production and inhibits microglial innate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jun-Lin Lu, Qi-Dong Xia, Yi Sun, Yang Xun, Heng-Long Hu, Chen-Qian Liu, Jian-Xuan Sun, Jin-Zhou Xu, Jia Hu, Shao-Gang Wang
Summary: The study found that TLR4 expression is decreased in tumor tissues compared to surrounding tissues or normal tissue, and is positively correlated to the overall survival rate and cancer-specific survival rate of bladder cancer patients. Low TLR4 expression is associated with malignant performance in tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Allergy
Daniel Elieh Ali Komi, Frank A. Redegeld
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2020)
Letter
Allergy
Karin Hufnagl, Sheriene Moussa Afify, Nina Braun, Stefanie Wagner, Michael Wallner, Michael Hauser, Markus Wiederstein, Gabriele Gadermaier, Sabrina Wildner, Frank A. Redegeld, Bart R. Blokhuis, Gerlinde Hofstetter, Isabella Pali-Schoell, Franziska Roth-Walter, Luis F. Pacios, Erika Jensen-Jarolim
Article
Cell Biology
Suzanne Abbring, Bart R. J. Blokhuis, Julie L. Miltenburg, Kiri G. J. Romano Olmedo, Johan Garssen, Frank A. Redegeld, Betty C. A. M. van Esch
Article
Multidisciplinary Sciences
Javier Aguilera-Lizarraga, Morgane Florens, Maria Francesca Viola, Piyush Jain, Lisse Decraecker, Iris Appeltans, Maria Cuende-Estevez, Naomi Fabre, Kim Van Beek, Eluisa Perna, Dafne Balemans, Nathalie Stakenborg, Stavroula Theofanous, Goele Bosmans, Stephanie U. Mondelaers, Gianluca Matteoli, Sales Ibiza Martinez, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Karel Talavera, Yeranddy A. Alpizar, Thorsten B. Feyerabend, Hans-Reimer Rodewald, Ricard Farre, Frank A. Redegeld, Jiyeon Si, Jeroen Raes, Christine Breynaert, Rik Schrijvers, Cedric Bosteels, Bart N. Lambrecht, Scott D. Boyd, Ramona A. Hoh, Deirdre Cabooter, Maxim Nelis, Patrick Augustijns, Sven Hendrix, Jessica Strid, Raf Bisschops, David E. Reed, Stephen J. Vanner, Alexandre Denadai-Souza, Mira M. Wouters, Guy E. Boeckxstaens
Summary: Research has shown that bacterial infection and toxins can trigger the production of specific dietary-antigen-specific IgE antibodies in mice, leading to increased visceral pain. Additionally, injecting food antigens into the rectosigmoid mucosa of patients with irritable bowel syndrome can induce local oedema and mast cell activation, revealing new possibilities for treating related abdominal pain disorders.
Article
Cell Biology
Marijke Zonneveld, Martijn J. C. van Herwijnen, Marcela M. Fernandez-Gutierrez, Alberta Giovanazzi, Anne Marit de Groot, Marije Kleinjan, Toni M. M. van Capel, Alice J. A. M. Sijts, Leonie S. Taams, Johan Garssen, Esther C. de Jong, Michiel Kleerebezem, Esther N. M. Nolte-'t Hoen, Frank A. Redegeld, Marca H. M. Wauben
Summary: Maternal milk extracellular vesicles play a crucial role in supporting epithelial barrier function and modulating the immune system. Their unique proteome can target key hotspots of signaling networks in various cell types within the gastrointestinal tract.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Allergy
Mirelle T. A. Kleuskens, Maria L. Haasnoot, Bart M. Herpers, Marleen T. J. van Ampting, Albert J. Bredenoord, Johan Garssen, Frank A. Redegeld, Betty C. A. M. van Esch
Summary: The study investigated the effects of SCFAs acetate, propionate, and butyrate on the esophageal barrier function in EoE, finding that butyrate and propionate can restore the barrier function of esophageal epithelial cells after inflammatory insult. This suggests that these nutraceuticals may have therapeutic benefits in managing EoE.
Article
Cell Biology
Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Summary: The study demonstrates that pretreating MM cells with DHA/EPA before bortezomib significantly enhances chemosensitivity by decreasing GSH levels and altering metabolism, highlighting the role of GSH degradation in overcoming drug resistance. RNA-seq results suggest the NRF2-ATF3/4-CHAC1 signaling pathway as central in GSH degradation and indicate potential connections to various pathways contributing to the tumor suppressive effect. The findings implicate GSH degradation as a promising therapeutic target in MM and provide new insights into combating bortezomib resistance.
Article
Allergy
Sheriene Moussa Afify, Andreas Regner, Luis F. Pacios, Bart R. Blokhuis, Sebastian A. Jensen, Frank A. Redegeld, Isabella Pali-Schoell, Karin Hufnagl, Rodolfo Bianchini, Sonja Guethoff, Matthias F. Kramer, Alessandro Fiocchi, Zdenek Dvorak, Erika Jensen-Jarolim, Franziska Roth-Walter
Summary: The lozenge formulated with catechin-iron complexes effectively masked IgE binding in milk-allergic children and reduced immune reactivity in mice and allergic subjects. By targeting antigen presenting cells, the lozenge dampened immune activation in a non-specific manner, providing immune resilience against allergic symptoms.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Medicine, General & Internal
Agnese Merlo, Pauline A. Hendriksen, Johan Garssen, Elisabeth Y. Bijlsma, Ferdi Engels, Gillian Bruce, Joris C. Verster
Summary: The COVID-19 pandemic in the Netherlands led to significant decreases in alcohol consumption and hangover frequency during lockdown periods, with varying impacts on academic functioning among respondents, particularly heavier drinkers who experienced improved academic performance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Allergy
Xiaoli Zhao, Bart. R. J. Blokhuis, Frank. A. Redegeld, Iris Chang, Diane Dunham, Hongbing Chen, Kari Nadeau, Johan Garssen, Leon M. J. Knippels, Astrid Hogenkamp
Article
Pharmacology & Pharmacy
Jing Chen, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Summary: This study found that ethyl ester-DHA/EPA can induce stronger cytotoxicity in MM cells, even in resistant cells. Pretreating MM cells with ethyl ester-DHA/EPA can enhance the cytotoxicity of bortezomib. Additionally, treatment with ethyl ester-DHA/EPA resulted in increased intracellular ROS levels, reflecting enhanced oxidative stress in treated cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Natasa Vukovic, Samer Halabi, Joan Salvador Russo-Cabrera, Bart Blokhuis, Pedro Berraondo, Frank A. M. Redegeld, Dietmar M. W. Zaiss
Summary: Bispecific antibodies (bsAbs) targeting two different antigens offer a higher level of specificity and improved clinical efficacy in cancer therapy compared to monoclonal antibodies (mAbs). We successfully developed dual tumor-associated antigen-targeting bispecific human IgE antibodies to combine the promising potential of IgE molecules with increased target selectivity. These IgE bsAbs demonstrate potent antibody-dependent cell toxicity and have significant clinical application potential.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Maria Haasnoot, Mirelle Kleuskens, Ingrid Terreehorst, Jaap H. Akkerdaas, Ronald van Ree, Frank A. Redegeld, Betty C. Van Esch, Arjan Bredenoord
Article
Psychology, Clinical
Pauline A. Hendriksen, Johan Garssen, Elisabeth Y. Bijlsma, Ferdi Engels, Gillian Bruce, Joris C. Verster
Summary: The study found that the COVID-19 lockdowns led to an increase in academic activities and improvement in study grades, but also resulted in higher levels of stress, anxiety, depression, fatigue, and loneliness, with decreased levels of optimism and happiness. Gender, living situation, and ethnicity have different effects on the impact of the pandemic, with women, students living alone, and those with a migration background being more negatively affected. Poor sleep quality and reduced quality of life were associated with decreased mood and academic performance. Young age and non-Western migration background predicted improved performance quality, while young age was a significant predictor of improved study grades/output. Increased stress and fatigue were significant predictors of reduced performance quality and poorer study grades/output during the pandemic. For a substantial group of students, academic functioning was reported to be poorer during the COVID-19 pandemic, emphasizing the need for more attention and guidance for successful transition to online education.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2021)
Article
Pharmacology & Pharmacy
Adriana H. van Houwelingen, Rashmi A. Kusurkar, Ferdi Engels
Summary: The course design aimed to stimulate students' autonomy by incorporating autonomy-supportive teaching strategies. Students explored pain from various disciplines and were given freedom of choice in their final assignments, which enhanced their interest and relevance to the topic. The study revealed that the course setup successfully supported students' autonomy and curiosity towards different disciplines.
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)