Review
Nutrition & Dietetics
Mattia Perazzi, Enrico Gallina, Giulia Francesca Manfredi, Filippo Patrucco, Antonio Acquaviva, Donato Colangelo, Mario Pirisi, Mattia Bellan
Summary: This paper reviews the potential role of vitamin D in the pathogenesis and management of systemic sclerosis (SSc). Pre-clinical data suggest that vitamin D and its analogs may suppress fibrogenesis, while clinical data show a high prevalence of hypovitaminosis D and osteoporosis in SSc patients, but inconsistent findings regarding the association with clinical manifestations and phenotypes of SSc.
Review
Immunology
Amirhossein Ghaseminejad-Raeini, Ali Ghaderi, Amirmohammad Sharafi, Behrad Nematollahi-Sani, Maryam Moossavi, Afshin Derakhshani, Gholamreza Anani Sarab
Summary: For many years, vitamin D has been known for its role in maintaining calcium and phosphate balance, but recent research has focused on its immunomodulatory role, which has generated conflicting results. The presence of vitamin D receptors in various immune cell types has allowed for the investigation of its precise role in diseases, specifically autoimmune disorders. Physiologically activated vitamin D not only modulates innate and acquired immune cell responses, but also promotes a tolerogenic immune state. Recent studies suggest that this important micronutrient plays a complex role in immune system pathways and associated disorders. Understanding this field is still relatively new, and some studies indicate that patients with severe autoimmune illnesses often have vitamin D deficiencies. This review aims to provide a clear understanding of the latest research on the immune system-related roles of vitamin D, including the pathophysiology of major disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Giovanni Bonaccorso
Summary: This systematic review found a significant correlation between lower Vitamin D levels and Myasthenia Gravis (MG). The study suggests routine monitoring and potential correction of Vitamin D levels in MG patients based on the current data.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Environmental Sciences
Jutti Levita, Gofarana Wilar, Ika Wahyuni, Lidya Cahyo Bawono, Tiara Ramadaini, Rohani Rohani, Ajeng Diantini
Summary: Intoxication of vitamin D is not commonly seen in pediatrics. This review provides insights into the clinical toxicology of vitamin D in pediatrics, including the mechanism, case reports, and management of vitamin D poisoning.
Article
Medicine, General & Internal
Weronika Galus, Anna Walawska-Hrycek, Michalina Rzepka, Ewa Krzystanek
Summary: This study assessed the vitamin D status and practices among MS patients and professionals in the clinical setting. Results showed that while most patients confirmed vitamin D supplementation, only a small percentage achieved optimal vitamin D levels. Lack of doctor's recommendation was the most common reason for the absence of supplementation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ashvin Kuri, Nicola Vickaryous, Amine Awad, Benjamin Meir Jacobs, Ruth Dobson
Summary: This study demonstrates that vD supplementation is the major determinant of vD levels in people with MS, with genetic factors playing a smaller role.
JOURNAL OF NEUROLOGY
(2023)
Article
Environmental Sciences
Alexandra E. Butler, Edwina Brennan, Daniel S. Drage, Thozhukat Sathyapalan, Stephen L. Atkin
Summary: This study examined the association of polychlorinated biphenyls (PCBs) with vitamin D in non-obese women. The results showed that certain PCBs were associated with vitamin D levels, but these associations could be explained by body mass index (BMI). Therefore, the deleterious effects of PCB accumulation are not mediated by effects on vitamin D levels.
ENVIRONMENTAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Julie Langlois, Damien Denimal
Summary: This systematic review examined the effects of vitamin D supplementation on clinical and imaging outcomes in patients with multiple sclerosis (MS). The results showed no significant impact of vitamin D supplementation on relapse events, disability progression, and magnetic resonance imaging (MRI) lesions. However, recent studies found a significant reduction in new MRI lesions in the central nervous system of MS patients during supplementation with vitamin D3.
Article
Oncology
Atsushi Isoda, Yuri Miyazawa, Tetsuya Ishikawa, Shuhei Kanaya, Keita Nakayama, Masahiro Mihara, Hirono Iriuchishima, Akio Saito, Morio Matsumoto, Morio Sawamura
Summary: This study aimed to determine the prevalence of vitamin D deficiency among Japanese MM patients and its correlation with clinical outcomes. The study identified a considerable number of Japanese MM patients with insufficient serum vitamin D levels, with one-third being deficient. Additionally, vitamin D deficiency predicted poor overall survival in Japanese MM patients. Further investigation is required to determine whether vitamin D supplementation can improve the frailty and survival of vitamin D-deficient MM patients.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Cell Biology
Carsten Carlberg, Marcin P. Mycko
Summary: Environmental factors, such as low vitamin D levels, contribute to the susceptibility of multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. Vitamin D3, through its metabolite 1,25(OH)2D3, modulates the epigenome and transcriptome of immune cells, reducing inflammatory reactions and promoting immunological tolerance in T cells, thus preventing MS.
Article
Nutrition & Dietetics
Mario Flores-Aldana, Marta Rivera-Pasquel, Armando Garcia-Guerra, Jesus Giovanni Perez-Cortes, Juan E. Barcena-Echegollen
Summary: This study aimed to assess the effect of vitamin D supplementation at different doses on serum 25(OH)D concentrations in preschool children. After three months, there was a significant increase in serum concentrations of 25(OH)D and a decrease in the prevalence of vitamin D deficiency. No adverse effects were observed.
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Review
Oncology
Haoyu Zhao, Xiaoqi Wei, Xiuhua Yang
Summary: Vitamin D plays a significant role in immunomodulation in patients with RPL, affecting immune cell activity and cytokine production to reduce the incidence of RPL. It may serve as an important and effective immunotherapeutic agent for RPL patients.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Nutrition & Dietetics
Souzana E. Xyda, Kalliopi Kotsa, Argyrios Doumas, Emmanouil Papanastasiou, Alexandros A. Garyfallos, George Samoutis
Summary: The prevalence of vitamin D deficiency is paradoxically high in both Mediterranean countries, Greece and Cyprus, despite ample sunlight in the region. Only the month and gender were significantly associated with vitamin D levels.
Article
Biochemistry & Molecular Biology
Edwina Brennan, Alexandra E. Butler, Manjula Nandakumar, Daniel S. Drage, Thozhukat Sathyapalan, Stephen L. Atkin
Summary: This study examined the association between organochlorine pesticides (OCPs) and vitamin D deficiency. The results showed a correlation between OCPs and vitamin D-3, as well as the active metabolite 1,25-dihydrovitamin D-3. The study also suggested that OCP effects may be enhanced in cases of vitamin D deficiency.
Article
Immunology
Jade Ghosn, Hendy Abdoul, Soraya Fellahi, Audrey Merlet, Dominique Salmon, Jean-Pierre Morini, Jean Deleuze, Jacques Blacher, Jacqueline Capeau, Jean-Philippe Bastard, Jean-Paul Viard
Summary: People living with HIV are at risk of noninfectious comorbidities, with subclinical atherosclerosis and multimorbidity common in middle-aged, well-controlled PLWH, and the presence of multiple comorbidities is associated with older age and longer exposure to antiretrovirals. Associations between comorbidities and inflammatory/immune activation biomarkers are diverse.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2021)
Article
Environmental Sciences
Brice Faraut, Lorenzo Tonetti, Alexandre Malmartel, Sophie Grabar, Jade Ghosn, Jean-Paul Viard, Vincenzo Natale, Damien Leger
Summary: Persons living with HIV have more fragmented sleep and the severity of HIV infection is associated with increased sleep duration. Better performance scores on prospective memory tasks were associated with several sleep parameters in controls but not in PLWH. Long sleepers within the PLWH group were found to have a greater severity of the disease.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Francis Feldman, Mireille Koudoufio, Yves Desjardins, Schohraya Spahis, Edgard Delvin, Emile Levy
Summary: Polyphenols (PLPs), phytochemicals found in plant-based foods, have shown promising effects on lipid disorders in animal models. However, their effectiveness in human dyslipidemia is still unclear, highlighting the need for further research to clarify their potential role in managing lipid metabolism disorders.
Article
Biochemistry & Molecular Biology
Mathilde Foisy Sauve, Francis Feldman, Mireille Koudoufio, Nour-El-Houda Ould-Chikh, Lena Ahmarani, Alain Sane, Thierry N'Timbane, Ramy El-Jalbout, Nathalie Patey, Schohraya Spahis, Alain Stintzi, Edgard Delvin, Emile Levy
Summary: This study demonstrated that glycomacropeptide (GMP) has the potential to reduce systemic insulin resistance, decrease oxidative stress and inflammation, enhance antioxidant enzyme expression in the liver, and inhibit hepatic inflammatory response, leading to improved hepatic insulin sensitivity and restoration of liver homeostasis.
Review
Endocrinology & Metabolism
Giovanni Lombardi, Edgard Delvin
Summary: Osteoporosis is a prevalent bone disease and circulating microRNAs have shown potential as diagnostic and prognostic markers. However, the lack of standardization and harmonization of methods limits their application.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Infectious Diseases
Amanda Mocroft, Jose M. Miro, Gilles Wandeler, Josep M. Llibre, Anders Boyd, Kathrin van Bremen, Marek Beniowski, Julia Mikhalik, Matthias Cavassini, Fernando Maltez, Claudine Duvivier, Caterina Uberti Foppa, Brygida Knysz, Elzbieta Bakowska, Elena Kuzovatova, Pere Domingo, Alexandra Zagalo, Jean-Paul Viard, Olaf Degen, Ana Milinkovic, Thomas Benfield, Lars Peters
Summary: The study found a significant increase in the incidence of non-liver malignancies in PLWH with HBV infection, particularly in those who were HBV DNA positive and for NHL. These findings suggest the need for increased cancer screening in HIV-positive individuals with chronic HBV infection.
Article
Clinical Neurology
Amelie Bourhis, Valerie Roussel-Robert, Jean-Paul Viard, Matthieu Peyre, Franck Bielle
Summary: This case study reports the occurrence of Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) in the peripheral nerve of a young man infected with human immunodeficiency virus (HIV). Initially misdiagnosed as a schwannoma, the correct diagnosis was made through histological examination. EBV-associated SMTs are commonly found in young adults with poorly controlled HIV infection and can occur in multiple organs. The prognosis is affected by the complications of immunodeficiency.
Article
Infectious Diseases
Myroslava Nikolaichuk, Amanda Mocroft, Gilles Wandeler, Janos Szlavik, Magnus Gottfredsson, Dag Henrik Reikvam, Veronica Svedhem, Hila Elinav, Montserrat Laguno, Kamal Mansinho, Emma Devitt, Nikoloz Chkhartishvili, Georg Behrens, Johannes Bogner, Jean-Paul Viard, Alan Winston, Thomas Benfield, Clifford Leen, Olga Fursa, Juergen Rockstroh, Lars Peters
Summary: This study aimed to determine the usage of antiretroviral drugs (ARVs) according to European AIDS Clinical Society (EACS) guidelines in HIV/HCV coinfected patients treated with direct-acting antivirals (DAAs). The findings showed that more than one-third of patients received DAAs with potential ARV contraindications, but few received a contraindicated ARV. However, patients who received a contraindicated DAA and ARV combination still had a high rate of sustained virological response.
Article
Immunology
Maria Choufany, Laurence Weiss, Alain Makinson, Helene Roul, Jean-Michel Livrozet, Valerie Pourcher, Giovanna Melica, Christophe Rioux, Jean-Paul Viard, Esaie Marshall, Sophie Grabar, Dominique Costagliola
Summary: The study aimed to assess the risk of CD4 T-cell count decline and its association with severe morbid conditions or death in people with HIV infection. The results showed that CD4 decline was rare but associated with a higher risk of severe morbid conditions or death within the first 6 months.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Laurence Slama, Raphael Porcher, Francoise Linard, Catherine Chakvetadze, Agnes Cros, Severine Carillon, Lucille Gallardo, Jean-Paul Viard, Jean-Michel Molina
Summary: This study aimed to understand the perspectives of people with HIV (PWH) and pre-exposure prophylaxis (PrEP) users on long-acting injectable (LAA) antiretroviral drugs. The results showed that a large majority of PWH and PrEP users expressed a high level of interest in LAA, particularly among PrEP users. However, no specific characteristics were associated with acceptance of LAA in both groups, suggesting a need for further studies to identify the targeted individuals.
BMC INFECTIOUS DISEASES
(2023)
Review
Nutrition & Dietetics
Emile Levy, Valerie Marcil, Sarah Tagharist ep Baumel, Noam Dahan, Edgard Delvin, Schohraya Spahis
Summary: Milk-derived bioactive proteins are gaining attention worldwide for their high-quality amino acids and health-promoting attributes. This review focuses on lactoferrin (LF) and osteopontin (OPN), two multifunctional dairy proteins, and their naturally occurring bioactive LF-OPN complex. The review discusses the physiological, biochemical, and nutritional functionalities of these proteins, particularly in the perinatal period. It also evaluates their potential therapeutic applications in cardiometabolic disorders and associated complications.
Meeting Abstract
Infectious Diseases
G. Liegeon, L. Assoumou, J. Ghosn, M. El Mouhebb, C. Katlama, G. Pialoux, J. P. Viard, K. Lacombe, M. Genin, L. Beniguel, J. Lourenco, D. Rojas Castro, D. Costagliola, J. -M. Molina
Meeting Abstract
Infectious Diseases
A. Mocroft, J. M. Miro, G. Wandeler, J. M. Llibre, A. Boyd, K. van Bremen, M. Beniowski, J. Mikhalik, M. Cavassini, F. Maltez, C. Duvivier, C. Uberti Foppa, B. Knysz, E. Bakowska, E. Kuzovatova, P. Domingo, A. Zagalo, J. -P. Viard, O. Degen, A. Milinkovic, T. Benfield, L. Peters
Meeting Abstract
Infectious Diseases
M. Nikolaichuk, A. Mocroft, G. Wandeler, J. Szlavik, A. Yakovlev, M. Gottfredsson, D. H. Reikvam, V. Svedhem-Johansson, H. Elinav, M. Laguno, K. Mansinho, E. Devitt, N. Chkhartishvili, G. Behrens, J. Bogner, J. -P. Viard, A. Winston, T. Benfield, C. Leen, V. M. Mitsura, J. Rockstroh, L. Peters
Article
Infectious Diseases
David Lebeaux, Eve Jablon, Cecile Flahault, Fanny Lanternier, Jean-Paul Viard, Barbara Pace, Jean-Luc Mainardi, Cedric Lemogne
Summary: Utilizing Moodle for blended learning in Infectious Diseases and Microbiology resulted in improved student satisfaction and attendance at face-to-face courses.
INFECTIOUS DISEASES NOW
(2021)
