期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 53, 期 6, 页码 596-606出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2018.1508411
关键词
Long noncoding RNA; lncRNA; snoRNA; sno-lncRNA; SPA; Prader-Willi syndrome; nucleolus; RNA polymerase I
资金
- Chinese Academy of Sciences [XDB19020104]
- Ministry of Science and Technology of China [2016YFA0100701]
- National Natural Science Foundation of China [31725009, 31730111]
- Howard Hughes Medical Institute [55008728]
Small nucleolar RNAs (snoRNAs) are a family of conserved nuclear RNAs that function in the modification of small nuclear RNAs (snRNAs) or ribosomal RNAs (rRNAs), or participate in the processing of rRNAs during ribosome subunit maturation. Eukaryotic DNA transcription and RNA processing produce many long noncoding RNA (lncRNA) species. Although most lncRNAs are processed like typical mRNAs to be 5' capped and 3' polyadenylated, other types of lncRNAs are stabilized from primary Pol II transcripts by alternative mechanisms. One way to generate stable lncRNAs is to co-operate with snoRNA processing to produce snoRNA-ended lncRNAs (sno-lncRNAs) and 5' snoRNA-ended and 3'-polyadenylated lncRNAs (SPAs). Rather than silently accumulating in the nucleus, some sno-lncRNAs and SPAs are involved in the regulation of pre-rRNA transcription and alternative splicing of pre-mRNAs. Here we provide a mini-review to discuss the biogenesis and functions of these unusually processed lncRNAs.
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