期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 44, 期 5, 页码 343-351出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409230903232618
关键词
Chromosome domain; epigenetics; histone acetylation; nuclear position; replication timing
资金
- Spanish Ministry of Science and Innovation [BFU2007-65326, CSD2007-0015]
- European Union [IRG FP6-031129]
- Fundacion Caja Madrid
Eukaryotic cells follow a temporal program to duplicate their genomes. Chromosomes are divided into domains with a specific DNA replication timing (RT), not dictated by DNA sequence alone, which is conserved from one cell cycle to the next. Timing of replication correlates with gene density, transcriptional activity, chromatin structure and nuclear position, making it an intriguing epigenetic mark. The differentiation from embryonic stem cells to specialized cell types is accompanied by global changes in the RT program. This review covers our current understanding of the mechanisms that determine RT in mammalian cells, its possible biological significance and how unscheduled alterations of the RT program may predispose to human disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据