Article
Public, Environmental & Occupational Health
Miki Matsui, Yoshinori Katayama
Summary: Decolonization of MRSA in the oral cavity and tracheal aspirates was observed in 85% and 58% of neonates, respectively, with nasal mupirocin treatment. Recurrent MRSA colonization occurred in 45% of neonates whose MRSA was detected in the oral cavity at a mean of 19 days. Recurrent MRSA colonization occurred in 58% of neonates whose MRSA was detected in tracheal aspirates at a mean of 23 days.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Dermatology
Mohamed S. Imam, Randa M. Abdel-Sattar, Faisal Alqarni, Saad Yousef S. Aljumayi, Ibrahim Altukhais, Abdullah Saad Altukhays, Mohamed E. A. Abdelrahim
Summary: This meta-analysis evaluated the relationship between nasal colonization of methicillin-resistant Staphylococcus aureus (MRSA) and surgical site infection (SSI) after spine surgery (SS). The results showed that MRSA-positive individuals had a significantly higher SSI rate, while methicillin-susceptible Staphylococcus aureus and Staphylococcus aureus had no significant effect on SSI in SS patients.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Sanjam S. Sawhney, Eric M. Ransom, Meghan A. Wallace, Patrick J. Reich, Gautam Dantas, Carey-Ann D. Burnham
Summary: This study discovered a high prevalence of Staphylococcus aureus isolates with a borderline oxacillin resistance phenotype (BORSA) in the neonatal intensive care unit (NICU). By analyzing mutations and truncations and using a random forest classification model, BORSA and methicillin-susceptible S. aureus were distinguished among clinical isolates collected from two continents. This work highlights the need for improved MRSA screening methods and the presence of the non-mecA-mediated BORSA phenotype.
Article
Microbiology
Sanjam S. Sawhney, Eric M. Ransom, Meghan A. Wallace, Patrick J. Reich, Gautam Dantas, Carey-Ann D. Burnham
Summary: In this study, researchers discovered a high prevalence of Staphylococcus aureus isolates exhibiting a borderline oxacillin resistance phenotype (BORSA) in their neonatal intensive care unit (NICU). They found that the current MRSA screening methods misclassified BORSA, and identified specific markers that can distinguish BORSA from methicillin-susceptible S. aureus (MSSA). The findings have implications for epidemiological reporting of MRSA rates and can help improve MRSA screening methods.
Article
Multidisciplinary Sciences
Carolin Boehne, Leonard Knegendorf, Frank Schwab, Ella Ebadi, Franz-Christoph Bange, Marius Vital, Dirk Schlueter, Gesine Hansen, Sabine Pirr, Corinna Peter, Bettina Bohnhorst, Claas Baier
Summary: This study investigated MRSA colonization and infection in a mixed tertiary neonatal intensive and intermediate care unit in Germany over an 8-year period. The study found that the burden of MRSA was low and emphasized the importance of a comprehensive infection control concept.
Article
Infectious Diseases
Hanzada T. Nour El-Din, Aymen S. Yassin, Yasser M. Ragab, Abdelgawad M. Hashenn
Summary: In this study, it was found that infectious MRSA isolates showed a higher tendency for biofilm formation and borderline minimum inhibitory concentrations. A positive correlation was observed between susceptibility to protein synthesis inhibitors and cell wall inhibitors. Additionally, nasal samples were enriched in rifampicin-resistant isolates, while urine and blood samples were enriched in susceptible ones.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Chemistry, Multidisciplinary
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: The study shows that high-dose diclofenac inhibits the growth of MRSA without inducing drug-resistant mutations easily, while low-dose diclofenac can resensitize bacteria to beta-lactams and inhibit biofilm formation. Transcriptomic and proteomic analyses indicate that diclofenac reduces the expression of genes and proteins associated with antibiotic resistance and biofilm formation. Murine implant infection models suggest that diclofenac combined with beta-lactams can substantially alleviate MRSA infections in vivo, offering promising applications for preventing perioperative infections.
Article
Public, Environmental & Occupational Health
Sharline Madera, Nicole McNeil, Paula Hayakawa Serpa, Jack Kamm, Christy Pak, Carolyn Caughell, Amy Nichols, David Dynerman, Lucy M. Li, Estella Sanchez-Guerrero, Maira S. Phelps, Angela M. Detweiler, Norma Neff, Helen Reyes, Steve A. Miller, Deborah S. Yokoe, Joseph L. DeRisi, Lynn Ramirez-Avila, Charles R. Langelier
Summary: This study investigated a MRSA outbreak in a neonatal intensive care unit (NICU) using epidemiologic review and whole-genome sequencing (WGS). The results revealed silent transmission of MRSA between healthcare personnel (HCP) and infants and guided the implementation of infection prevention interventions that prevented further transmission. Whole-genome sequencing coupled with epidemiologic analysis can be used to detect transmission events and prompt early implementation of control strategies.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Moxi Yu, Yachen Hou, Meiling Cheng, Yongshen Liu, Caise Ling, Dongshen Zhai, Hui Zhao, Yaoyao Li, Yamiao Chen, Xiaoyan Xue, Xue Ma, Min Jia, Bin Wang, Pingan Wang, Mingkai Li
Summary: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are difficult to treat due to antibiotic resistance, posing a significant threat to public health. A study examined the antibacterial activity of novel squaric amide derivatives against MRSA strains. The results showed that one derivative, squaric amide 2 (SA2), exhibited strong bactericidal activity, reduced infection size and bacterial count in an animal model.
Article
Infectious Diseases
Melissa R. Gitman, Bremy Alburquerque, Marilyn Chung, Adriana van de Guchte, Mitchell J. Sullivan, Ajay Obla, Jose Polanco, Irina Oussenko, Melissa L. Smith, Flora Samaroo, Debbie Barackman, Deena R. Altman, Emilia Mia Sordillo, Harm van Bakel
Summary: Through whole genome sequencing, we identified a modified Staphylococcus aureus (MODSA) methicillin-resistance phenotype with unique truncating mutations in the gene encoding the enzyme GdpP or a non-synonymous substitution in the gene encoding PBP2. These findings highlight the challenges in identifying non-mecA, non-mecC-mediated MRSA isolates in clinical microbiology laboratories, which impacts the implementation of appropriate therapy and infection control measures.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Eric T. Lofgren, Matthew Mietchen, Kristen V. Dicks, Rebekah Moehring, Deverick Anderson
Summary: The study suggests that there is significant room for improvement in anti-MRSA disinfectants, including both the compounds themselves and their delivery mechanisms. Despite the decolonization estimates found in this study, these agents have robust outcomes even after delays in administration, which may help alleviate concerns over patient comfort and toxic effects.
Article
Pharmacology & Pharmacy
Masakazu Kitahara, Shin Takayama, Tetsuya Akaishi, Akiko Kikuchi, Tadashi Ishii
Summary: This study demonstrated that administration of HET in acute stroke patients can effectively prevent MRSA colonization and reduce the incidence of infectious diseases, leading to improved rehabilitation outcomes within three months.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Lorry G. Rubin, Joanna Beachy, Tara Matz, Archana Balamohan, Linda Jendresky, Jill Zembera, Medini K. Annavajhala, Anne-Catrin Uhlemann
Summary: This study describes an outbreak of mupirocin-resistant MRSA that lasted for 31 months. Through molecular epidemiology analysis, it was discovered that contact with carriers and potential environmental or personnel reservoirs were associated with MRSA acquisition.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Cheston B. Cunha, Steven Z. Kassakian, Ryan Chan, Fred C. Tenover, Panos Ziakas, Kimberle C. Chapin, Leonard A. Mermel
AMERICAN JOURNAL OF INFECTION CONTROL
(2016)
Article
Medicine, General & Internal
Panayiotis D. Ziakas, Nina Joyce, Ioannis M. Zacharioudakis, Fainareti N. Zervou, Richard W. Besdine, Vincent Mor, Eleftherios Mylonakis
Article
Immunology
Elina Eleftheria Pliakos, Nikolaos Andreatos, Panayiotis D. Ziakas, Eleftherios Mylonakis
CLINICAL INFECTIOUS DISEASES
(2019)
Review
Microbiology
Elina Eleftheria Pliakos, Nikolaos Andreatos, Fadi Shehadeh, Panayiotis D. Ziakas, Eleftherios Mylonakis
CLINICAL MICROBIOLOGY REVIEWS
(2018)
Article
Immunology
Aigli G. Vakrakou, Sorina Boiu, Panayiotis D. Ziakas, Evangelia Xingi, Haralabia Boleti, Menelaos N. Manoussakis
JOURNAL OF AUTOIMMUNITY
(2018)
Article
Multidisciplinary Sciences
Panayiotis D. Ziakas, Irene S. Kourbeti, Loukia S. Poulou, Georgios S. Vlachogeorgos, Eleftherios Mylonakis
Article
Critical Care Medicine
Elina Eleftheria Pliakos, Nikolaos Andreatos, Giannoula S. Tansarli, Panayiotis D. Ziakas, Eleftherios Mylonakis
Article
Medicine, General & Internal
Panayiotis D. Ziakas, Eleftherios Mylonakis
Article
Medicine, General & Internal
Katerina Tori, Giannoula S. Tansarli, Diane M. Parente, Markos Kalligeros, Panayiotis D. Ziakas, Eleftherios Mylonakis
Article
Multidisciplinary Sciences
Panayiotis D. Ziakas, Eleftherios Mylonakis
Article
Immunology
Elina Eleftheria Pliakos, Panayiotis D. Ziakas, Eleftherios Mylonakis
Summary: The study compares the cost-effectiveness of cefazolin and antistaphylococcal penicillins for treating MSSA bacteremia, finding that cefazolin is a cost-effective strategy with considerable healthcare cost-savings.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Panayiotis D. Ziakas, Irene S. Kourbeti, Eleftherios Mylonakis
Summary: This study analyzed the relationship between COVID-19 mortality and vaccination coverage in European Union countries. The study found that countries with higher vaccination coverage had lower mortality rates, and expanding vaccination coverage may help improve the death toll of COVID-19.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Oncology
Panayiotis D. Ziakas, Eleftherios Mylonakis
Summary: The study found that oncologists' drug costs in Medicare Part D payments have been steadily increasing, surpassing all other providers. There are regional variations in costs, partially influenced by the oncology workforce and quality of cancer care.
JCO ONCOLOGY PRACTICE
(2021)
Article
Oncology
Loukia S. Poulou, Loukas Thanos, Panayiotis D. Ziakas, Emmanouel Merikas, Apostolos Achimastos, Constantine Gennatas, Konstantinos N. Syrigos
Article
Oncology
Panayiotis D. Ziakas, Loukia S. Poulou, Elias Zintzaras