Article
Microbiology
Nikki Bortell, Elizabeth R. Aguilera, Laurel L. Lenz
Summary: Pulmonary coinfections can impair the host's ability to control systemic Lm, increasing susceptibility to severe infection. Exposure to microbial products can render hosts more susceptible to severe infection through an increase in IL-10 production. This increase in susceptibility correlates with a dampening of myeloid cell function in infected tissues.
Article
Biochemistry & Molecular Biology
Ildefonso Sanchez-Cerrillo, Diego Calzada-Fraile, Ana Triguero-Martinez, Marta Calvet-Mirabent, Olga Popova, Cristina Delgado-Arevalo, Mariel Valdivia-Mazeyra, Marta Ramirez-Huesca, Enrique Vazquez de Luis, Alberto Benguria, Teresa Acena-Gonzalo, Roberto Moreno-Vellisca, Magdalena Adrados de Llano, Hortensia de la Fuente, Ilya Tsukalov, Pablo Delgado-Wicke, Elena Fernandez-Ruiz, Emilia Roy-Vallejo, Reyes Tejedor-Lazaro, Almudena Ramiro, Salvador Iborra, Francisco Sanchez-Madrid, Ana Dopazo, Isidoro Gonzalez Alvaro, Santos Castaneda, Enrique Martin-Gayo
Summary: This study reveals the increased proportion of CD16(+) CD56hi NK cell subset and CD64(+) conventional dendritic cells (cDC2) in pSS patients, suggesting their involvement in the progression of the disease. The cDC2 can activate NK cells ex vivo and are found in proximity to NK cells in the salivary glands. The expression of NKG2D ligands on cDC2 from pSS patients is regulated by the IFN signatures associated with the RIG-I/DDX60 pathway. Injection of poly I:C leads to increased proportions of CD64hi RAE-1(+) cDC2 and NKG2D(+) CD11b(+) CD27(+) NK cells in the salivary glands.
Letter
Medicine, General & Internal
Jan O. Friedrich, Elisa Gouvea Bogossian
Summary: In a trial evaluating the efficacy of hydrocortisone in treating community-acquired pneumonia, researchers found a nearly 50% lower 28-day mortality rate in the hydrocortisone group compared to the placebo group. They also observed a higher incidence of septic shock in the placebo group. The trial did not allow the use of open-label glucocorticoids, which may have contributed to the higher mortality rate in the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Israel Martinez-Espinosa, Jose A. Serrato, Blanca Ortiz-Quintero
Summary: NK cells have the ability to produce both pro-inflammatory and anti-inflammatory cytokines, playing a crucial role in regulating inflammation during systemic infection. Understanding the factors driving the production of IL-10 by NK cells and its impact is important for therapeutic advancements in diseases like sepsis.
Editorial Material
Hematology
Robin Parihar
Summary: In this study, memory-like natural killer (ML NK) cells were evaluated for their potential in treating relapsed acute myeloid leukemia (AML) patients after transplantation. The results show that ML NK cells hold promise in AML therapy, and serial assessments of blood and bone marrow provide new insights into their biology.
Article
Immunology
Shigeki Shimada, Hiroki Sakamoto, Norifumi Iijima, Atsushi Fukui, Yutoku Shi, Masashi Deguchi, Hideto Yamada
Summary: Regulatory B cells (Bregs) have a crucial role in maintaining human pregnancy. This study found that the cell percentages of CD24hiCD38hi Bregs and CD24hiCD27+ Bregs, which have the potential to produce IL-10, are increased in human decidua compared with the mid-luteal phase endometrium. The study also revealed positive correlations between Bregs and the expression of dendritic cells (DCs) and natural killer (NK) cells.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Siqi Liu, Lanlan Yang, Shengnan Jia, Rui Zhao, Zhenjing Jin
Summary: In patients with hepatocellular carcinoma (HCC), the levels of NKB cells and IL-18 secretion were decreased in both peripheral blood and liver-infiltrating sites. Elevated IL-35 levels were negatively correlated with the percentage of NKB cells and IL-18 production in HCC, suggesting a suppressive role of IL-35 on NKB cell activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Y. Aizaki, H. Yazawa, K. Sato, T. Mimura
Summary: The study found that IL-6 and IL-18 were the main cytokines increased in the serum of AOSD patients. When NK cells were cultured with IL-10 and IL-18, it significantly induced the production of IFN-gamma, while IL-10 inhibited the production of proinflammatory cytokines by monocytes. These findings suggest that IL-10 has dual effects on NK cells and monocytes in AOSD patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Review
Immunology
Nurul Izza Ismail
Summary: As the placenta is semi-allogenic, it is expected that maternal immune cells would attack the invading trophoblast, but studies have shown that they cooperate with the trophoblast to disrupt the arterial wall. uNK cells, unique immune cells, play a role in pregnancy. The interaction between HLA class 1b genes and maternal uNK cells in humans is described in this review.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Debora Basilio-Queiros, Eva Mischak-Weissinger
Summary: Natural Killer (NK) cells have evolved significantly since their initial discovery in the 1970s. Recent research has revealed adaptive-like behavior in NK cells, challenging the traditional categorization of the immune system. This subpopulation of NK cells exhibits characteristics of both innate and adaptive immunity, with clonal-like expansion and enhanced cytotoxic response upon antigen exposure. The implications of these findings are highly relevant in clinical settings, particularly in adoptive immunotherapies where NK cells offer distinct advantages. This review provides an overview of the discovery and current understanding of adaptive NK cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mitch Ganley, Lauren E. Holz, Jordan J. Minnell, Maria N. de Menezes, Olivia K. Burn, Kean Chan Yew Poa, Sarah L. Draper, Kieran English, Susanna T. S. Chan, Regan J. Anderson, Benjamin J. Compton, Andrew J. Marshall, Anton Cozijnsen, Yu Cheng Chua, Zhengyu Ge, Kathryn J. Farrand, John C. Mamum, Calvin Xu, Ian A. Cockburn, Katsuyuki Yui, Patrick Bertolino, Stephanie Gras, Jerome Le Nours, Jamie Rossjohn, Daniel Fernandez-Ruiz, Geoffrey I. McFadden, David F. Ackerley, Gavin F. Painter, Ian F. Hermans, William R. Heath
Summary: Malaria, caused by Plasmodium species transmitted by mosquitoes, can be prevented by inducing liver-resident memory T cells through mRNA vaccines. Addition of an agonist that recruits T cell help improved the efficacy of the vaccine. This strategy shows potential in malaria-endemic regions.
Article
Microbiology
Sara Nunes, Rafael Tiburcio, Icaro Bonyek-Silva, Pablo Rafael Oliveira, Ricardo Khouri, Viviane Boaventura, Aldina Barral, Claudia Brodskyn, Natalia Machado Tavares
Summary: Skin ulcers in cutaneous leishmaniasis (CL) are influenced by the interaction between dendritic cells (DCs) and natural killer (NK) cells. This study identified the crosstalk between DCs and NK cells pathway as a potential pathway involved in the pathogenesis of CL, with molecules such as TLR4, TNFRSF1B, IL-15, IL-6, CD40, CCR7, TNF, and IFNG playing significant roles. The expression of CCR7, in particular, was found to be correlated with lesion development.
Review
Cell Biology
Mohamed Khalil, Dandan Wang, Elaheh Hashemi, Scott S. Terhune, Subramaniam Malarkannan
Summary: The article discusses the differences between the innate and adaptive immune systems, including signaling pathways and cytokine-mediated effects. The functional relevance of the 'third' signal in NK cells remains elusive.
Article
Immunology
Ye Zhang, Wei Kuang, Danfeng Li, Yu Li, Yi Feng, Xinwei Lyu, Gao-Bo Huang, Jian-Qi Lian, Xiao-Fei Yang, Cheng Hu, Yajuan Xie, Song Xue, Jiali Tan
Summary: NKB cells play a crucial role in periodontitis by secreting IL-18 to promote inflammation and bone resorption. Elevated levels of NKB cells and IL-18 were observed in periodontitis patients and correlated with attachment loss. Additionally, IL-18 stimulation led to proinflammatory cytokine production in periodontal ligament cells, suggesting a potential target for immunotherapies in periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Antoine Roquilly, Justine D. Mintern, Jose A. Villadangos
Summary: Macrophages and conventional dendritic cells are crucial for maintaining tissue homeostasis, coordinating immune responses, and fighting against infections and cancer. They acquire spatiotemporal adaptations in response to different environmental challenges, but these adaptations can also lead to immunosuppression. Understanding their development and adaptation mechanisms can help harness their beneficial outcomes and minimize their adverse effects.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Article
Oncology
Tony Yao, Patrick T. Rudak, Celine M. Laumont, Alex R. Michaud, Rasheduzzaman Rashu, Natasha N. Knier, Paula J. Foster, Hamish E. G. McWilliam, Jose A. Villadangos, Brad H. Nelson, Gabriel E. DiMattia, Trevor G. Shepherd, S. M. Mansour Haeryfar
Summary: Research on mucosa-associated invariant T (MAIT) cells in epithelial ovarian cancer (EOC) reveals their low frequency in tumors but potential immunomodulatory and cytotoxic properties. In a mouse model, MAIT cells showed IL-17A and IFN-gamma production in the peritoneal cavity but lost these functions with tumor progression. Ascitic MAIT cells in EOC patients exhibit inducible effector functions, suggesting potential modifications for future immunotherapeutic strategies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Cell Biology
Rebecca Seneviratna, Samuel J. Redmond, Hamish E. G. McWilliam, Rangsima Reantragoon, Jose A. Villadangos, James McCluskey, Dale Godfrey, Nicholas A. Gherardin
Summary: Recent studies have shown that MR1-restricted T cells can react to a variety of antigens, including tumor cells and tumor-derived self-antigens. By using TCR gene transfer and engineered MR1-expressing antigen-presenting cells, researchers further investigated the reactivity of MR1-restricted TCRs and found differential dependence on MR1 position and competitive inhibition by ligands. However, TCR-expressing reporter cell lines failed to fully replicate the previously reported tumor specificity, suggesting the importance of accessory molecules in MR1-dependent tumor reactivity.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Immunology
Shivam K. Purohit, Carolyn Samer, Hamish E. G. McWilliam, Renee Traves, Megan Steain, Brian P. McSharry, Paul R. Kinchington, David C. Tscharke, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Summary: This study demonstrates that varicella zoster virus suppresses the expression of antigen presentation molecule MR1, highlighting the intricate temporal relationship between infection and ligand availability. The study also suggests that VZV likely encodes multiple viral genes targeting MR1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Patrick Schriek, Alan C. Ching, Nagaraj S. Moily, Jessica Moffat, Lynette Beattie, Thiago M. Steiner, Laine M. Hosking, Joshua M. Thurman, V. Michael Holers, Satoshi Ishido, Mireille H. Lahoud, Irina Caminschi, William R. Heath, Justine D. Mintern, Jose A. Villadangos
Summary: Marginal zone B cells acquire dendritic cell-like properties through the trogocytic acquisition of MHC II-C3 complexes from conventional dendritic cells.
Article
Critical Care Medicine
Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly
Summary: Brain injury induces immunosuppression, increasing the risk of viral reactivations and impairing neurological recovery. This study found that lung replication of herpesviridae is associated with poor recovery after brain injury, and a specific monocyte signature can predict the neurological outcome at 6 months.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemical Research Methods
Vanta J. Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K. Mackay, Axel Kallies, Jose A. Villadangos, Hamish E. G. McWilliam, Alexis Perez-Gonzalez
Summary: Understanding the impact of autofluorescence on signal resolution in cytometry is crucial for experimental design and data quality. This study provides mathematical predictions and empirical evidence to support the importance of autofluorescence extraction through full spectrum unmixing. The study also presents a novel method for isolating pure cell subset-specific autofluorescence profiles based on high dimensionality reduction algorithms.
Article
Multidisciplinary Sciences
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Summary: This study reveals the critical role of ubiquitin-like protein 3 (UBL3) in the trafficking process controlled by MARCH1. UBL3 has wide-ranging immunological consequences and is essential for immune responses.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Sothea Touch, Emmanuelle Godefroy, Nathalie Rolhion, Camille Danne, Cyriane Oeuvray, Marjolene Straube, Chloe Galbert, Loic Brot, Iria Alonso Salgueiro, Sead Chadi, Tatiana Ledent, Jean-Marc Chatel, Philippe Langella, Francine Jotereau, Frederic Altare, Harry Sokol
Summary: The abundance of Faecalibacterium prausnitzii is decreased in patients with inflammatory bowel diseases (IBD). This study found that DP8 alpha Treg cells were reduced in IBD patients. Using a humanized mouse model, researchers demonstrated a protective effect of a HLA-DR*0401-restricted DP8 alpha Treg clone combined with F. prausnitzii administration in a colitis model. The frequency of circulating DP8 alpha cells was found to be independently associated with disease activity in IBD patients. Furthermore, a positive correlation was found between F. prausnitzii-specific DP8 alpha Tregs and the amount of F. prausnitzii in fecal microbiota in healthy individuals and patients with ileal Crohn's disease.
Article
Cardiac & Cardiovascular Systems
Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish E. G. McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N. Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A. Villadangos, Karim Asehnoune
Summary: This study found that transfusion of packed red blood cells with high levels of MRP_14 may increase the incidence of AKI after cardiac surgery. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Meeting Abstract
Hematology
Emmanuelle Godefroy, Patrice Chevallier, Fabienne Haspot, Caroline Vignes, Veronique Daguin, Sylvia Lambot, Thierry Guillaume, Margaux Verdon, Pierre Peterlin, Alice Garnier, Maxence Mougon, Amandine Le Bourgeois, Maxime Jullien, Francine Jotereau, Frederic Altare
Article
Immunology
Francine Jotereau, Joudy Alameddine, Raluca Teusan, Annabelle Pedron, Nicolas Jouand, Frederic Altare, Emmanuelle Godefroy
Summary: In this study, a unique subset of Tregs called DP8 alpha Tregs was identified in humans. These Tregs secrete IL-10, co-express CD4 and CD8 alpha, and react against the symbiotic bacterium Faecalibacterium prausnitzii. They exhibit a mixed Tr1-like/cytotoxic CD4(+) T cell-profile and share master genes with mouse gut microbiota-induced Tregs. DP8 alpha Tregs possess potent cytotoxic, chemotactic, and IgA-promoting abilities. The discovery of their complete signature and novel functional properties provides important insights into their physiological roles and clinical applications in inflammatory bowel diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Caroline L. Ashley, Brian P. McSharry, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Summary: This study reveals that human cytomegalovirus (HCMV) inhibits the MR1 pathway and disrupts the MR1:MAIT cell axis through the viral protein gpUS9. The interaction between this virus and MAIT cells in the context of viral infection is not well characterized.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Patrick Schriek, Jose A. Villadangos
Summary: Antigen-presenting cells capture or synthesize antigens and present them on their plasma membrane through major histocompatibility complex (MHC) molecules. Trogocytosis is a mechanism where cells acquire fragments from other cells and incorporate them into their own plasma membrane, including intact antigens and MHC molecules. Trogocytosis expands cellular immunological functions with both beneficial and deleterious consequences.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Remy Char, Zhuangzhuang Liu, Cedric Jacqueline, Marion Davieau, Maria-Graciela Delgado, Clara Soufflet, Mathieu Fallet, Lionel Chasson, Raphael Chapuy, Voahirana Camosseto, Eva Strock, Rejane Rua, Catarina R. Almeida, Bing Su, Ana-Maria Lennon-Dumenil, Beatrice Nal, Antoine Roquilly, Yinming Liang, Stephane Meresse, Evelina Gatti, Philippe Pierre
Summary: This study shows that iRUFY3 plays a role in perinuclear positioning, phagocyte migration and antigen presentation during Salmonella infection. iRUFY3 controls macrophages migration, MHC II presentation and responses to Interferon-γ, while being important for intracellular Salmonella replication.
NATURE COMMUNICATIONS
(2023)