Review
Engineering, Biomedical
Diana Alves, Tania Grainha, Maria Olivia Pereira, Susana Patricia Lopes
Summary: Ventilator-associated pneumonia (VAP) is a persistent problem in hospitals, resulting in inadequate treatment, high mortality, and prolonged hospital stays. The endotracheal tube (ETT) is the main cause of VAP due to microbial colonization and biofilm formation by various pathogens. Research on antimicrobial ETT surface coating/modification approaches has been conducted to address this issue. This review provides an overview of the relevance of the ETT biofilms in VAP and the technological advancements in antimicrobial ETT materials. Rating: 8/10
ACTA BIOMATERIALIA
(2023)
Review
Nanoscience & Nanotechnology
Xuemeng Chen, Xiaomei Ling, Gaowang Liu, Jinfang Xiao
Summary: Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in mechanically ventilated patients. Recent studies have shown that tracheal intubation plays a key role in the pathogenesis of VAP, primarily through rapid colonization of the tracheal intubation surface by microbiota. Antibiotics are ineffective against microbial airway colonization, thus antimicrobial coating materials offer new solutions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Fang Jung, Shang-Shing P. Chou, Shih-Hsing Yang, Jau-Chen Lin, Guey-Mei Jow
Summary: This study evaluates the use of closed suctioning system in mechanical ventilation, conducting experiments on patients with compromised pulmonary mechanics to determine related parameters, providing reference for clinical treatment.
APPLIED SCIENCES-BASEL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roshan Dsouza, Darold R. Spillman, Ronit Barkalifa, Guillermo L. Monroy, Eric J. Chaney, Mark A. Johnson, Karen C. White, Stephen A. Boppart
Summary: This study found that the standard-of-care suctioning procedure is inefficient at clearing secretions or preventing the formation of biofilms in endotracheal tubes. The in situ imaging method used in the study was sensitive to the presence of secretions and biofilms, and can be useful for investigating different suctioning protocols in the future.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Review
Chemistry, Physical
Lavinia Marcut, Veronica Manescu (Paltanea), Aurora Antoniac, Gheorghe Paltanea, Alina Robu, Aurel George Mohan, Elena Grosu, Iuliana Corneschi, Alin Danut Bodog
Summary: Ventilator-associated pneumonia is a common hospital infection that has a high mortality rate and prolonged hospitalization time. The endotracheal tube is a major cause of this pneumonia due to its surface being colonized by different pathogens. This paper discusses the definition, economic burdens, and outcomes of ventilator-associated pneumonia, as well as the latest technological solutions for endotracheal tube surfaces. The analysis concludes by identifying research gaps and exploring future possibilities for reducing ventilator-associated pneumonia cases and improving patient comfort.
Article
Biotechnology & Applied Microbiology
Yue Wang, Bingyue Cai, Dalong Ni, Yu Sun, Gang Wang, Hong Jiang
Summary: This study developed a new coating method for endotracheal tubes, which can achieve both antibacterial and antifouling effects. The experiments demonstrated the inhibitory effect of the coating on various bacteria and its ability to prevent biofilm formation. The results also showed good stain resistance and biocompatibility of the coating.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Microbiology
Marta Palau, Estela Munoz, Nieves Larrosa, Xavier Gomis, Ester Marquez, Oscar Len, Benito Almirante, Joan Gavalda
Summary: Biofilm-producing microorganisms are medically crucial and cause 80% of human infections. This study evaluated the efficacy of hyperthermia in preventing biofilm formation in vitro and in a rabbit model. The results showed that hyperthermia can effectively prevent biofilm formation under specific temperature and time conditions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pediatrics
Ajaya Kumar Gahan, Suksham Jain, Supreet Khurana, Deepak Chawla
Summary: This study compared the effect of closed versus open endotracheal tube suction on the occurrence of ventilator-associated pneumonia in mechanically ventilated neonates. The results showed that the choice of suction method did not significantly impact the incidence of ventilator-associated pneumonia in a unit with a low incidence of this condition.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Jian Zhou, Jingqian Zhou, Yan Hong, Youcheng Wang, Hailong Lin, Leting Huang
Summary: The study evaluated the diagnostic value of ETT-aspirate sTREM-1 and serum C-reactive protein concentrations in neonatal ventilator-associated pneumonia (NVAP) among preterm and full-term neonates on mechanical ventilators. The results showed that these indicators may be useful for diagnosing NVAP, especially when combined. Changes in these indicators over ventilation days were also observed, providing valuable insights into neonatal recovery processes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nursing
Ozlem Soyer Er, Meryem Yavuz Van Giersbergen, Sefa Celik
Summary: This study aims to analyze the effect of endotracheal tube cuff pressure control measures on the microaspiration of stomach contents by measuring the level of pepsin in deep tracheal aspiration. Through a single-blind, randomized controlled trial with 56 patients, the impact of different control measures on microaspiration and the incidence of ventilator-associated pneumonia will be examined, as well as identifying the most appropriate cuff pressure control method. The results of this study are significant for future applications of pepsin level as a biomarker in the treatment and follow-up of mechanically ventilated patients and highlight the importance of multidisciplinary research.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Respiratory System
Erika Alejandra Cifuentes, Maria A. Sierra, Andres Felipe Yepes, Ana Margarita Baldion, Jose Antonio Rojas, Carlos Arturo Alvarez-Moreno, Juan Manuel Anzola, Maria Mercedes Zambrano, Monica G. Huertas
Summary: This study investigated the microbiome of the endotracheal tube (ETT) and found that it mainly consists of Proteobacteria, Firmicutes, and Bacteroidetes. The composition of the microbiome was associated with the ICU where the patients were hospitalized, but not with the duration of intubation or the diagnosis of ventilator-associated pneumonia (VAP). These findings suggest that the ICU environment or medical practices may influence the colonization of microbial communities in patients requiring mechanical ventilation.
RESPIRATORY RESEARCH
(2022)
Article
Polymer Science
Manar Fathy Al-Sayed, Mohamed Tarek El-Wakad, Mohammed A. Hassan, Ahmed M. Soliman, Amal S. Eldesoky
Summary: This study prepared silver nitrate sol-gel with different concentrations and pH values, and evaluated its antimicrobial activity and biocompatibility. The results showed that a concentration of 0.03496% exhibited the highest effectiveness in inhibiting bacterial colonization, indicating that silver nitrate sol-gel may be a potential preventive measure against VAP.
Article
Multidisciplinary Sciences
Thomas Maldiney, Valentin Pineau, Catherine Neuwirth, Linda Ouzen, Isabelle Eberl, Geraldine Jeudy, Sophie Dalac, Lionel Piroth, Mathieu Blot, Marc Sautour, Frederic Dalle, Caroline Abdulmalak, Romain Ter Schiphorst, Paul-Simon Pugliesi, Thomas Poussant, Agathe Ogier-Desserrey, Isabelle Fournel, Melchior de Giraud D'Agay, Marine Jacquier, Marie Labruyere, Francois Aptel, Jean-Baptiste Roudaut, Thibault Vieille, Pascal Andreu, Sebastien Prin, Pierre-Emmanuel Charles, Mael Hamet, Jean-Pierre Quenot
Summary: Biofilm growth is important in the development of ventilator-associated pneumonia in intensive care units. The study reveals two different morphological aspects of endotracheal tube-deposited biofilm, as well as higher acquired resistance compared to other colonization sites. These findings have significant clinical implications for antimicrobial treatment in critically ill patients.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Olympia E. Anastasiou, Fotis Theodoropoulos, Christian Taube, Melanie Fiedler, Ulf Dittmer
Summary: Data analysis on cases tested with bilateral BAL samples and EA showed that there was no significant improvement in diagnostic efficiency for detecting common viral respiratory pathogens. Discrepant results were observed in a small percentage of cases, indicating comparable diagnostic quality between EA and BAL samples for detecting common viral respiratory infections.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Vu Quoc Dat, Lam Minh Yen, Huynh Thi Loan, Vu Dinh Phu, Nguyen Thien Binh, Ronald B. Geskus, Dong Huu Khanh Trinh, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Nguyen Phu Huong Lan, Tran Phuong Thuy, Nguyen Vu Trung, Nguyen Trung Cap, Dao Tuyet Trinh, Nguyen Thi Hoa, Nguyen Thi Thu Van, Vy Thi Thu Luan, Tran Thi Quynh Nhu, Hoang Bao Long, Nguyen Thi Thanh Ha, Ninh Thi Thanh Van, James Campbell, Ehsan Ahmadnia, Evelyne Kestelyn, Duncan Wyncoll, Guy E. Thwaites, Nguyen Van Hao, Le Thanh Chien, Nguyen Van Kinh, Nguyen Van Vinh Chau, H. Rogier van Doorn, C. Louise Thwaites, Behzad Nadjm
Summary: The study found that continuous cuff pressure control (CPC) using an automated electronic device did not reduce the incidence of ventilator-associated respiratory infection (VARI) in intubated patients compared to intermittent CPC.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Engineering, Biomedical
Elena Spinelli, Tommaso Mauri, Eleonora Carlesso, Stefania Crotti, Daniela Tubiolo, Alfredo Lissoni, Nicola Bottino, Mauro Panigada, Paola Tagliabue, Nicola Rossi, Eleonora Scotti, Federica Conigliaro, Luciano Gattinoni, Giacomo Grasselli, Antonio Pesenti
Article
Critical Care Medicine
Alberto Zanella, Pietro Caironi, Luigi Castagna, Emanuele Rezoagli, Domenico Salerno, Eleonora Scotti, Vittorio Scaravilli, Salua A. Deab, Thomas Langer, Tommaso Mauri, Michele Ferrari, Daniele Dondossola, Manuela Chiodi, Francesco Zadek, Federico Magni, Stefano Gatti, Luciano Gattinoni, Antonio M. Pesenti
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Engineering, Biomedical
Giacomo Grasselli, Luigi Castagna, Nicola Bottino, Vittorio Scaravilli, Nadia Corcione, Amedeo Guzzardella, Matteo Bonifazi, Nicola Rossi, Alberto Zanella, Antonio Pesenti
Review
Critical Care Medicine
Elena Spinelli, Tommaso Mauri, Jeremy R. Beitler, Antonio Pesenti, Daniel Brodie
INTENSIVE CARE MEDICINE
(2020)
Letter
Critical Care Medicine
Tommaso Mauri, Elena Spinelli, Jeremy R. Beitler, Antonio Pesenti, Daniel Brodie
INTENSIVE CARE MEDICINE
(2020)
Article
Anesthesiology
Andrea Coppadoro, Roberto Rona, Giacomo Bellani, Giuseppe Foti
Summary: The study shows that PEI can be reliably measured by a brief end-expiratory occlusion maneuver, allowing for real-time measurement by the ventilator.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Editorial Material
Medicine, General & Internal
Giacomo Grasselli, Antonio Pesenti, Maurizio Cecconi
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella, Massimo Antonelli, Luca Cabrini, Antonio Castelli, Danilo Cereda, Antonio Coluccello, Giuseppe Foti, Roberto Fumagalli, Giorgio Iotti, Nicola Latronico, Luca Lorini, Stefano Merler, Giuseppe Natalini, Alessandra Piatti, Marco Vito Ranieri, Anna Mara Scandroglio, Enrico Storti, Maurizio Cecconi, Antonio Pesenti
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Hematology
Mauro Panigada, Nicola Bottino, Paola Tagliabue, Giacomo Grasselli, Cristina Novembrino, Veena Chantarangkul, Antonio Pesenti, Flora Peyvandi, Armando Tripodi
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Respiratory System
Tommaso Tonetti, Alberto Zanella, Giacinto Pizzilli, Charlene Irvin Babcock, Sergio Venturi, Stefano Nava, Antonio Pesenti, V. Marco Ranieri
Letter
Engineering, Biomedical
Marco Giani, Clarissa Forlini, Benedetta Fumagalli, Roberto Rona, Antonio Pesenti, Giuseppe Foti
Editorial Material
Critical Care Medicine
Gianni Tognoni, Luigi Vivona, Antonio Pesenti
INTENSIVE CARE MEDICINE
(2021)
Article
Engineering, Biomedical
Jacopo Fumagalli, Sebastiano Maria Colombo, Vittorio Scaravilli, Francesca Gori, Antonio Pesenti, Alberto Zanella, Giacomo Grasselli
Summary: Evaluation of donor lung function using PaO2/FiO2 measurement is influenced by various factors. Increased FiO2 and reduced mixed venous oxygen saturation during brain dead observation and EVLP can elevate the PaO2/FiO2 ratio. Extrapulmonary factors should be taken into account when assessing graft suitability for transplantation.
Article
Critical Care Medicine
Antonio Pesenti, Douglas Slobod, Sheldon Magder
INTENSIVE CARE MEDICINE
(2023)
Article
Hematology
Fabrizio Semeraro, Concetta T. Ammollo, Pietro Caironi, Serge Masson, Roberto Latini, Mauro Panigada, Antonio Pesenti, Nicola Semeraro, Luciano Gattinoni, Mario Colucci