☆ 4.6 Editorial Material

Mesenchymal stromal cells: Cautious optimism for their potential role in the treatment of acute lung injury

CRITICAL CARE MEDICINE (2012)

期刊

CRITICAL CARE MEDICINE

卷 40, 期 4, 页码 1373-1375

出版社

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1097/CCM.0b013e31824317f7

关键词

acute respiratory distress syndrome; endotoxemia; experimental sepsis; mesenchymal stem cells; mesenchymal stromal cells; sepsis; septic shock

类别

Critical Care Medicine

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Biochemistry & Molecular Biology

Endotoxic Septic Shock: Diagnosis and Treatment

Debra M. Foster, John A. Kellum

Summary: Endotoxin, also known as lipopolysaccharide (LPS), induces inflammatory response and can lead to sepsis and septic shock. Quantifying endotoxin and removing it using extracorporeal methods may be beneficial for patients with endotoxic septic shock.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Clinical and biological markers for predicting ARDS and outcome in septic patients

Jesus Villar, Ruben Herran-Monge, Elena Gonzalez-Higueras, Miryam Prieto-Gonzalez, Alfonso Ambros, Aurelio Rodriguez-Perez, Arturo Muriel-Bombin, Rosario Solano, Cristina Cuenca-Rubio, Anxela Vidal, Carlos Flores, Jesus M. Gonzalez-Martin, M. Isabel Garcia-Laorden, Ramon Adalia, Gerard Sanchez-Etayo, Alfonso Ambros, Carmen Martin-Rodriguez, Elena Gonzalez-Higueras, Rosario Solano, Laura Martinez-Garcia, M. Isabel Garcia-Laorden, Jesus Villar, Jesus M. Gonzalez-Martin, Aurelio Rodriguez-Perez, Angel Becerra, Lucia Valencia, Demetrio Carriedo, Francisco Javier Diaz Dominguez, Anxela Vidal, Jose M. Anon, Pablo Millan, Domingo Martinez, Miryam Prieto-Gonzalez, Cristina Cuenca-Rubio, Ana Isabel Garcia-Sanchez, Braulio Alvarez-Martinez, Perfectino Fernandez-Perez, Efren Otero-Alvarin, Carlos Flores, Gerardo Aguilar, Nasara Segura, Marina Soro, Ruben Herran-Monge, Arturo Muriel-Bombin, Marta M. Garcia-Garcia, Concepcion Tarancon, Teresa Alvarez

Summary: This study found that certain biomarkers can help predict the risk of septic patients developing acute respiratory distress syndrome (ARDS), and can improve the accuracy of clinical markers in predicting ARDS. Panels including indicators such as RAGE, CXCL16, and Ang-2 show good performance in predicting ARDS. The presence of ARDS, need for invasive mechanical ventilation, and pulmonary/extrapulmonary origin of sepsis are factors related to ICU death in septic patients.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Critical Care Medicine

Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome

Declan Byrnes, Claire H. Masterson, Antonio Artigas, John G. Laffey

Summary: Sepsis and ARDS are devastating conditions with high morbidity and mortality rates. Both diseases involve abnormal immune responses causing host injury and inflammation. Both conditions result in immune cell dysfunction in later stages and increased susceptibility to superinfections. Therapeutic strategies for these conditions face challenges due to overlapping pathophysiologic mechanisms and lack of specific treatments.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Dose-specific efficacy of adipose-derived mesenchymal stem cells in septic mice

Kui Li, Tao Wang, Rui Li, Fulai Xue, Guodan Zeng, Jingyao Zhang, Yuan Ma, Li Feng, Y. James Kang

Summary: This study aimed to investigate the efficacy and mechanism of action of mesenchymal stem cells (MSCs) in rescuing mice with sepsis. The results showed that allogeneic adipose-derived MSCs had a significant therapeutic effect on septic mice, but the dose-related effects were substantial. An appropriate dose significantly reduced mortality and alleviated infection and organ damage, while a higher dose could cause early death and exacerbated liver injury.

STEM CELL RESEARCH & THERAPY (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs)

Matthieu Daniel, Yosra Bedoui, Damien Vagner, Loic Raffray, Franck Ah-Pine, Berenice Doray, Philippe Gasque

Summary: The treatment of sepsis and septic shock remains a major public health issue. Mesenchymal stem cells (MSCs) are emerging as a potential approach for cell therapy in sepsis, but the mechanisms underlying their beneficial effects are still unclear.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Overexpression of FoxM1 optimizes the therapeutic effect of bone marrow mesenchymal stem cells on acute respiratory distress syndrome

Yuling Luo, Shanhui Ge, Qingui Chen, Shan Lin, Wanmei He, Mian Zeng

Summary: This study explored whether overexpression of FoxM1 promotes the therapeutic effect of BMSCs on ARDS. The results showed that FoxM1 overexpression significantly decreased pathological variations, protein concentration, oxidative stress, and cytokine levels. Furthermore, FoxM1 enhanced the protective effect of BMSCs on endothelial cell injury through the activation of the Wnt/beta-catenin signaling pathway.

STEM CELL RESEARCH & THERAPY (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells

Mitsutoshi Ishii, Tomoshi Tsuchiya, Ryoichiro Doi, Yoichi Morofuji, Takashi Fujimoto, Hideki Muto, Takashi Suematsu, Ryoichi Mori, Keitaro Matsumoto, Takuro Miyazaki, Koichi Tomoshige, Hironosuke Watanabe, Mayumi Iwatake, Takeshi Nagayasu

Summary: The study found that adipose-derived MSCs enhanced the intercellular barrier function of lung epithelial cells, possibly through both direct adhesion and indirect paracrine effects, suggesting a strengthening of the barrier function of lung alveolar epithelium in vitro.

PHARMACEUTICS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment

Wendi Wang, Wei Lei, Lina Jiang, Siqi Gao, Shijun Hu, Zi-Gang Zhao, Chun-Yu Niu, Zhen-Ao Zhao

Summary: MSCs, derived from various sources and with low immunogenicity, have been widely used for the treatment of ARDS. Recent studies suggest that MSCs can ameliorate ARDS through multiple mechanisms, such as modulating immune/inflammatory cells, attenuating endoplasmic reticulum stress, and inhibiting pulmonary fibrosis.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model

Josep Bringue, Raquel Guillamat-Prats, Maria Luisa Martinez, Eva Torrents, Marta Camprubi-Rimblas, Lluis Blanch, Antonio Artigas

Summary: The study showed that a single, low dose of MTX can protect against sepsis-induced lung damage by reducing pro-inflammatory cytokines, decreasing infiltration of inflammatory cells in the lung, and regulating adenosine receptor A2aR and metalloproteinases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Immunology

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges, and opportunities

Susan Moradinasab, Atieh Pourbagheri-Sigaroodi, Parisa Zafari, Seyed H. Ghaffari, Davood Bashash

Summary: The emergence of novel coronavirus in Wuhan in 2019 has caused a worldwide pandemic, leading to an unprecedented public health crisis. Mesenchymal stromal/stem cells (MSCs) have shown therapeutic potential against COVID-19 due to their immunomodulatory and anti-inflammatory effects, but challenges like malignant transformation and coagulopathy need to be addressed for successful application. Research has shown promising results in the use of MSCs for acute respiratory distress syndrome (ARDS) and viral infections, suggesting MSC therapy could be a valuable approach in treating COVID-19.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

添加到收藏夹

Article Polymer Science

Bone Marrow Mesenchymal Stromal Cells on Silk Fibroin Scaffolds to Attenuate Polymicrobial Sepsis Induced by Cecal Ligation and Puncture

Ok-Hyeon Kim, Jun-Hyung Park, Jong-In Son, Ok-Ja Yoon, Hyun-Jung Lee

Summary: The study demonstrates that silk fibroin scaffolds can enhance the anti-inflammatory and immunomodulatory functions of mesenchymal stromal cells, showing potential benefits for the treatment of inflammatory disorders.

POLYMERS (2021)

添加到收藏夹

Article Critical Care Medicine

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial)

Ellen A. Gorman, Jennifer Rynne, Hannah J. Gardiner, Anthony J. Rostron, Jonathan Bannard-Smith, Andrew M. Bentley, David Brealey, Christina Campbell, Gerard Curley, Mike Clarke, Ahilanadan Dushianthan, Phillip Hopkins, Colette Jackson, Kallirroi Kefela, Anna Krasnodembskaya, John G. Laffey, Cliona McDowell, Margaret McFarland, Jamie McFerran, Peter McGuigan, Gavin D. Perkins, Jonathan Silversides, Jon Smythe, Jacqui Thompson, William S. Tunnicliffe, Ingeborg D. M. Welters, Laura Amado-Rodriguez, Guillermo Albaiceta, Barry Williams, Manu Shankar-Hari, Daniel F. McAuley, Cecilia M. O'Kane

Summary: This study investigated the safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) in COVID-19-related ARDS. The results showed that ORBCEL-C did not improve surrogate outcomes of pulmonary organ dysfunction. Evaluation: 7/10.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

添加到收藏夹

Review Immunology

Acute respiratory distress syndrome heterogeneity and the septic ARDS subgroup

Huikang Xu, Shiying Sheng, Weiwei Luo, Xiaofang Xu, Zhaocai Zhang

Summary: Acute respiratory distress syndrome (ARDS) is a serious condition characterized by inflammatory lung injury and immune system disturbance. Researchers have used latent class analysis and targeted treatment to improve ARDS therapy, and sepsis-induced ARDS is particularly difficult to treat.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Fresh and Cryopreserved Human Umbilical-Cord-Derived Mesenchymal Stromal Cells Attenuate Injury and Enhance Resolution and Repair following Ventilation-Induced Lung Injury

Shahd Horie, Hector Gonzalez, Jack Brady, James Devaney, Michael Scully, Daniel O'Toole, John G. Laffey

Summary: The experiments compared the efficacy of umbilical-cord-derived MSCs and bone-marrow-derived MSCs in treating ventilator-induced lung injury, with results showing that umbilical-cord-derived MSCs comparably retained their efficacy in preserving injury resolution.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

Mesenchymal Stromal Cells in Ischemic Brain Injury

Beverly Brooks, Dominique Ebedes, Ahsan Usmani, Joaquin Vega Gonzales-Portillo, Daniel Gonzales-Portillo, Cesario Borlongan

Summary: Ischemic brain injury is a major cause of death worldwide with limited treatment options. Stem cell-based regenerative therapies, specifically mesenchymal stromal cells, show promise in stroke treatment, but further research is needed to fully understand their cell function.

CELLS (2022)

添加到收藏夹

Article Critical Care Medicine

An international comparison of the cost of fluid resuscitation therapies

Colman Taylor, Li Yang, Simon Finfer, Flavia R. Machado, An YouZhong, Laurent Billot, Frank Bloos, Fernando Bozza, Alexandre Biasi Cavalcanti, Maryam Correa, Bin Du, Peter B. Hjortrup, Lauralyn McIntyre, Manoj Saxena, Frederique Schortgen, Nicola R. Watts, John Myburgh, Kelly Thompson, Naomi E. Hammond

Summary: This study investigated the cost of fluid resuscitation fluids in different countries, showing significant variations in costs between countries and fluid types. Saline was found to be consistently less costly than colloid preparations and certain buffered salt solutions, providing valuable information for future economic evaluations.

AUSTRALIAN CRITICAL CARE (2021)

添加到收藏夹

Letter Cell & Tissue Engineering

A systematic approach to enhance transparency in mesenchymal stromal cell research

Laurent Renesme, Kelly D. Cobey, Manoj M. Lalu, Bernard Thebaud

CYTOTHERAPY (2022)

添加到收藏夹

Review Cell & Tissue Engineering

Definition and Characteristics of Mesenchymal Stromal Cells in Preclinical and Clinical Studies: A Scoping Review

Laurent Renesme, Maria Pierro, Kelly D. Cobey, Rhea Mital, Kennedy Nangle, Risa Shorr, Manoj M. Lalu, Bernard Thebaud

Summary: This study conducted a scoping review on original MSC preclinical and clinical studies to investigate the current definitions and characterizations of MSCs. The results showed inconsistent descriptions of MSC products and incomplete reporting of MSC characteristics and culture conditions. Only a small percentage of articles referred to the minimal criteria provided by ISCT. Clinical studies were inconsistent in reporting relevant information on MSC characterization and cell manufacturing processes. These findings suggest the need for further development and implementation of consensus definitions and reporting guidelines for MSCs to improve rigor, reproducibility, and transparency in MSC research.

STEM CELLS TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Cell Biology

Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta-analysis

Alvin Tieu, Kevin Hu, Catherine Gnyra, Joshua Montroy, Dean A. Fergusson, David S. Allan, Duncan J. Stewart, Bernard Thebaud, Manoj M. Lalu

Summary: Preclinical studies show that MSC-EVs have the potential to reduce inflammation and improve organ function in lung diseases, but greater transparency and direct comparisons of different methods and EV subtypes are needed to generate robust evidence.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

添加到收藏夹

Article Anesthesiology

Home-based prehabilitation with exercise to improve postoperative recovery for older adults with frailty having cancer surgery: the PREHAB randomised clinical trial

Daniel I. McIsaac, Emily Hladkowicz, Gregory L. Bryson, Alan J. Forster, Sylvain Gagne, Allen Huang, Manoj Lalu, Luke T. Lavallee, Husein Moloo, Julie Nantel, Barbara Power, Celena Scheede-Bergdahl, Carl van Walraven, Colin J. L. McCartney, Monica Taljaard

Summary: Home-based prehabilitation does not significantly improve postoperative recovery or other outcomes in older adults with frailty undergoing cancer surgery. Program adherence may be a key factor in the efficacy of prehabilitation.

BRITISH JOURNAL OF ANAESTHESIA (2022)

添加到收藏夹

Article Medicine, General & Internal

Assessing the impact of predatory journals on policy and guidance documents: a cross-sectional study protocol

Olivier Brandts-Longtin, Manoj M. Lalu, Euan A. Adie, Marc A. Albert, Elham Almoli, Faris Almoli, Gregory L. Bryson, Christophe Dony, Daniel Dunleavy, Agnes Grudniewicz, Christian Lehmann, Remy Lhoest, David Moher, Joshua Montroy, Mallory Pitts, Alicia Ricketts, Paul Thirion, Kelly D. Cobey

Summary: This study aims to investigate whether predatory journals have impacted public policy by analyzing citations of articles from the predatory publisher OMICS in policy documents and other epidemiological details.

BMJ OPEN (2022)

添加到收藏夹

Editorial Material Cell & Tissue Engineering

An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells Committee editorial on overcoming limitations in clinical trials of mesenchymal stromal cell therapy for coronavirus disease-19: time for a global registry

Daniel J. Weiss, Anthony Filiano, Jacques Galipeau, Maroun Khoury, Mauro Krampera, Manoj Lalu, Katarina Le Blanc, Jan Nolta, Donald G. Phinney, Patricia R. M. Rocco, Yufang Shi, Karin Tarte, Sowmya Viswanathan, Ivan Martin

CYTOTHERAPY (2022)

添加到收藏夹

Review Biology

Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: A pre-clinical systematic review

Chintan Dave, Shirley H. J. Mei, Andrea McRae, Christine Hum, Katrina J. Sullivan, Josee Champagne, Tim Ramsay, Lauralyn McIntyre

Summary: The majority of preclinical in vivo efficacy and in vitro potency outcomes were not significantly different between freshly cultured and cryopreserved MSCs.

ELIFE (2022)

添加到收藏夹

Article Economics

Engaging Patients and Caregivers in an Early Health Economic Evaluation: Discerning Treatment Value Based on Lived Experience

Mackenzie Wilson, Kednapa Thavorn, Terry Hawrysh, Ian D. Graham, Harold Atkins, Natasha Kekre, Doug Coyle, Manoj M. Lalu, Dean A. Fergusson, Kelvin K. W. Chan, Daniel A. Ollendorf, Justin Presseau

Summary: This study aimed to identify patient priorities for an early economic evaluation of chimeric antigen receptor T-cell therapy for relapsed or refractory B-cell acute lymphoblastic leukemia in adults. The findings revealed that patients and caregivers recognized both the direct costs related to clinical care and indirect treatment costs, as well as the emotional and physical toll of treatment and its impact on employment and education. The treatment benefits prioritized by participants included treatment efficacy, manageable side effects, improved quality of life, accessibility of treatment, and short treatment duration.

PHARMACOECONOMICS (2022)

添加到收藏夹

Article Medicine, General & Internal

FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate

Lauralyn Ann McIntyre, Dean A. Fergusson, Tracy McArdle, Alison Fox-Robichaud, Shane W. English, Claudio Martin, John Marshall, Deborah J. Cook, Ian D. Graham, Steven Hawken, Colin McCartney, Kusum Menon, Raphael Saginur, Andrew Seely, Ian Stiell, Kednapa Thavorn, Charles Weijer, Akshai Iyengar, John Muscedere, Alan J. Forster, Monica Taljaard, Canadian Crit Care Trials Grp

Summary: This pilot trial aimed to evaluate the effect of normal saline and Ringer's lactate on clinically important outcomes. The study found a higher adherence rate with normal saline, but also observed more adverse events associated with it. Overall, conducting a large-scale trial in the future is feasible, but addressing logistical challenges during the planning stages will be crucial.

BMJ OPEN (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies

Manoj D. Lalu, Justin C. Presseau, Madison Foster, Victoria Hunniford, Kelly Cobey, Jamie Brehaut, Carolina S. Ilkow, Joshua A. Montroy, Analyssa Cardenas, Ayni Sharif, Matthew Jeffers, Dean Fergusson

Summary: The use of rigorous study design methods and transparent reporting is proposed to improve the reproducibility of preclinical research, but there is low uptake in practice. Interviews with 30 preclinical scientists revealed that they are motivated to adopt these methods but there is varied awareness and implementation of guidelines. Researchers also noted disadvantages such as increased sample sizes, expenses, and time required for implementation.

PLOS BIOLOGY (2023)

添加到收藏夹

Article Biology

A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies

Victoria T. Hunniford, Agnes Grudniewicz, Dean A. Fergusson, Joshua Montroy, Emma Grigor, Casey Lansdell, Manoj M. Lalu

Summary: Multicentric approaches are not only widely used in clinical trials, but also in laboratory-based experimentation. Multilaboratory studies demonstrate greater rigor in study design and smaller effect sizes compared to single lab studies. This provides a robust method to assess interventions and the generalizability of findings between laboratories.

ELIFE (2023)

添加到收藏夹

Article Anesthesiology

Association of preoperative anaesthesia consultation prior to elective noncardiac surgery with patient and health system outcomes: a population-based study

Jake S. Engel, Weiwei Beckerleg, Duminda N. Wijeysundera, Sylvie Aucoin, Julien Leblanc, Sylvain Gagne, Gregory L. Bryson, Manoj M. Lalu, Anna Wyand, Daniel I. Mcisaac

Summary: This study aimed to evaluate the association between preoperative anesthesia consultation and patient outcomes. The results showed that preoperative anesthesia consultation did not have a significant impact on days alive and at home (DAH(30)) for the overall study population, but potential benefits were observed among high-risk subgroups.

BRITISH JOURNAL OF ANAESTHESIA (2023)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

A call to implement preclinical study registration in animal ethics review

Matthew S. Jeffers, Aileen Maclellan, Marc T. Avey, Julia M. L. Menon, Janet Sunohara-Neilson, Dean A. Fergusson, Manoj M. Lalu

Summary: Protocol registration is necessary in clinical trials, and extending it to animal studies can enhance transparency and reduce redundancy. Integrating study registration into institutional approval of animal use protocols is a promising strategy to increase uptake.

PLOS BIOLOGY (2023)

添加到收藏夹

Review Cell & Tissue Engineering

Mesenchymal Stromal Cell-derived Extracellular Vesicles in Preclinical Animal Models of Tumor Growth: Systematic Review and Meta-analysis

Adrian J. M. Bailey, Alvin Tieu, Manika Gupta, Mitchell Slobodian, Risa Shorr, Tim Ramsay, Rosendo A. Rodriguez, Dean A. Fergusson, Manoj M. Lalu, David S. Allan

Summary: MSC-EVs have mixed effects on tumor growth, with some studies showing inhibition and others showing progression. EVs containing anti-tumor RNAs lead to a significant reduction in tumor growth.

STEM CELL REVIEWS AND REPORTS (2022)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.