Review
Engineering, Biomedical
Diana Alves, Tania Grainha, Maria Olivia Pereira, Susana Patricia Lopes
Summary: Ventilator-associated pneumonia (VAP) is a persistent problem in hospitals, resulting in inadequate treatment, high mortality, and prolonged hospital stays. The endotracheal tube (ETT) is the main cause of VAP due to microbial colonization and biofilm formation by various pathogens. Research on antimicrobial ETT surface coating/modification approaches has been conducted to address this issue. This review provides an overview of the relevance of the ETT biofilms in VAP and the technological advancements in antimicrobial ETT materials. Rating: 8/10
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Physical
Lavinia Marcut, Veronica Manescu (Paltanea), Aurora Antoniac, Gheorghe Paltanea, Alina Robu, Aurel George Mohan, Elena Grosu, Iuliana Corneschi, Alin Danut Bodog
Summary: Ventilator-associated pneumonia is a common hospital infection that has a high mortality rate and prolonged hospitalization time. The endotracheal tube is a major cause of this pneumonia due to its surface being colonized by different pathogens. This paper discusses the definition, economic burdens, and outcomes of ventilator-associated pneumonia, as well as the latest technological solutions for endotracheal tube surfaces. The analysis concludes by identifying research gaps and exploring future possibilities for reducing ventilator-associated pneumonia cases and improving patient comfort.
Review
Nanoscience & Nanotechnology
Xuemeng Chen, Xiaomei Ling, Gaowang Liu, Jinfang Xiao
Summary: Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in mechanically ventilated patients. Recent studies have shown that tracheal intubation plays a key role in the pathogenesis of VAP, primarily through rapid colonization of the tracheal intubation surface by microbiota. Antibiotics are ineffective against microbial airway colonization, thus antimicrobial coating materials offer new solutions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yue Wang, Bingyue Cai, Dalong Ni, Yu Sun, Gang Wang, Hong Jiang
Summary: This study developed a new coating method for endotracheal tubes, which can achieve both antibacterial and antifouling effects. The experiments demonstrated the inhibitory effect of the coating on various bacteria and its ability to prevent biofilm formation. The results also showed good stain resistance and biocompatibility of the coating.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nursing
Ozlem Soyer Er, Meryem Yavuz Van Giersbergen, Sefa Celik
Summary: This study aims to analyze the effect of endotracheal tube cuff pressure control measures on the microaspiration of stomach contents by measuring the level of pepsin in deep tracheal aspiration. Through a single-blind, randomized controlled trial with 56 patients, the impact of different control measures on microaspiration and the incidence of ventilator-associated pneumonia will be examined, as well as identifying the most appropriate cuff pressure control method. The results of this study are significant for future applications of pepsin level as a biomarker in the treatment and follow-up of mechanically ventilated patients and highlight the importance of multidisciplinary research.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Medicine, General & Internal
Clementine Levy, Alexandre Gaudet, Emmanuelle Jaillette, Jean Reignier, Guillaume Lassailly, Malika Balduyck, Emeline Cailliau, Anahita Rouze, Saad Nseir
Summary: The aim of this study was to determine the relationship between cirrhosis and abundant gastric-content microaspiration in intubated critically ill patients. The results suggest that cirrhosis is not associated with abundant gastric-content microaspiration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Jian Zhou, Jingqian Zhou, Yan Hong, Youcheng Wang, Hailong Lin, Leting Huang
Summary: The study evaluated the diagnostic value of ETT-aspirate sTREM-1 and serum C-reactive protein concentrations in neonatal ventilator-associated pneumonia (NVAP) among preterm and full-term neonates on mechanical ventilators. The results showed that these indicators may be useful for diagnosing NVAP, especially when combined. Changes in these indicators over ventilation days were also observed, providing valuable insights into neonatal recovery processes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Microbiology
Marta Palau, Estela Munoz, Nieves Larrosa, Xavier Gomis, Ester Marquez, Oscar Len, Benito Almirante, Joan Gavalda
Summary: Biofilm-producing microorganisms are medically crucial and cause 80% of human infections. This study evaluated the efficacy of hyperthermia in preventing biofilm formation in vitro and in a rabbit model. The results showed that hyperthermia can effectively prevent biofilm formation under specific temperature and time conditions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pediatrics
Ajaya Kumar Gahan, Suksham Jain, Supreet Khurana, Deepak Chawla
Summary: This study compared the effect of closed versus open endotracheal tube suction on the occurrence of ventilator-associated pneumonia in mechanically ventilated neonates. The results showed that the choice of suction method did not significantly impact the incidence of ventilator-associated pneumonia in a unit with a low incidence of this condition.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Immunology
Vu Quoc Dat, Lam Minh Yen, Huynh Thi Loan, Vu Dinh Phu, Nguyen Thien Binh, Ronald B. Geskus, Dong Huu Khanh Trinh, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Nguyen Phu Huong Lan, Tran Phuong Thuy, Nguyen Vu Trung, Nguyen Trung Cap, Dao Tuyet Trinh, Nguyen Thi Hoa, Nguyen Thi Thu Van, Vy Thi Thu Luan, Tran Thi Quynh Nhu, Hoang Bao Long, Nguyen Thi Thanh Ha, Ninh Thi Thanh Van, James Campbell, Ehsan Ahmadnia, Evelyne Kestelyn, Duncan Wyncoll, Guy E. Thwaites, Nguyen Van Hao, Le Thanh Chien, Nguyen Van Kinh, Nguyen Van Vinh Chau, H. Rogier van Doorn, C. Louise Thwaites, Behzad Nadjm
Summary: The study found that continuous cuff pressure control (CPC) using an automated electronic device did not reduce the incidence of ventilator-associated respiratory infection (VARI) in intubated patients compared to intermittent CPC.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Haibei Liu, Rong Luo, Shuangjiao Cao, Bixing Zheng, Ling Ye, Wensheng Zhang
Summary: This meta-analysis examined the difference between sugammadex and neostigmine in reducing postoperative pulmonary complications. The results showed that using sugammadex to reverse neuromuscular blockade can reduce the risk of compound postoperative pulmonary complications, pneumonia, and respiratory failure. However, the evidence is limited by confounding factors and small-scale randomized controlled trials.
CHINESE MEDICAL JOURNAL
(2023)
Article
Respiratory System
Erika Alejandra Cifuentes, Maria A. Sierra, Andres Felipe Yepes, Ana Margarita Baldion, Jose Antonio Rojas, Carlos Arturo Alvarez-Moreno, Juan Manuel Anzola, Maria Mercedes Zambrano, Monica G. Huertas
Summary: This study investigated the microbiome of the endotracheal tube (ETT) and found that it mainly consists of Proteobacteria, Firmicutes, and Bacteroidetes. The composition of the microbiome was associated with the ICU where the patients were hospitalized, but not with the duration of intubation or the diagnosis of ventilator-associated pneumonia (VAP). These findings suggest that the ICU environment or medical practices may influence the colonization of microbial communities in patients requiring mechanical ventilation.
RESPIRATORY RESEARCH
(2022)
Article
Critical Care Medicine
Saad Nseir, Amelie Le Gouge, Olivier Pouly, Jean-Baptiste Lascarrou, Jean-Claude Lacherade, Jean-Paul Mira, Emmanuelle Mercier, Pierre-Louis Declercq, Michel Sirodot, Gael Piton, Francois Tinturier, Elisabeth Coupez, Stephane Gaudry, Michel Djibre, Didier Thevenin, Malika Balduyck, Jean Reignier
Summary: The study found no significant association between obesity and the incidence of VAP in patients receiving mechanical ventilation and vasopressor support in the ICU. Although there was no significant difference in VAP incidence between obese and nonobese patients, 90-day mortality was significantly lower in obese patients. Additionally, there was no significant difference in the rate of microaspiration of gastric contents or oropharyngeal secretions between obese and nonobese patients.
Review
Medicine, General & Internal
Min Gan, Zhuming Bao, Juan Han
Summary: This systematic review evaluates the therapeutic effect of the Venner-PneuX endotracheal tube system (VPXETS) in preventing ventilator-associated pneumonia (VAP), with outcome measures including the incidence and side effects of VAP. The findings will be disseminated through peer-reviewed publication, and ethical approval is not required as only published data is used, ensuring anonymity in the data analysis process.
Article
Multidisciplinary Sciences
Thomas Maldiney, Valentin Pineau, Catherine Neuwirth, Linda Ouzen, Isabelle Eberl, Geraldine Jeudy, Sophie Dalac, Lionel Piroth, Mathieu Blot, Marc Sautour, Frederic Dalle, Caroline Abdulmalak, Romain Ter Schiphorst, Paul-Simon Pugliesi, Thomas Poussant, Agathe Ogier-Desserrey, Isabelle Fournel, Melchior de Giraud D'Agay, Marine Jacquier, Marie Labruyere, Francois Aptel, Jean-Baptiste Roudaut, Thibault Vieille, Pascal Andreu, Sebastien Prin, Pierre-Emmanuel Charles, Mael Hamet, Jean-Pierre Quenot
Summary: Biofilm growth is important in the development of ventilator-associated pneumonia in intensive care units. The study reveals two different morphological aspects of endotracheal tube-deposited biofilm, as well as higher acquired resistance compared to other colonization sites. These findings have significant clinical implications for antimicrobial treatment in critically ill patients.
SCIENTIFIC REPORTS
(2022)