Article
Agriculture, Dairy & Animal Science
Rafael E. Martinez, Jessica L. Leatherwood, Amanda N. Bradbery, Brittany L. Silvers, Jennifer Fridley, Carolyn E. Arnold, Erin A. Posey, Wenliang He, Fuller W. Bazer, Guoyao Wu
Summary: Our study found that regardless of age, equine enterocytes cannot convert ornithine into citrulline and arginine, which has important implications for the nutrition, performance, and health of horses.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Peng Zhang, Zhangxing Wang, Huixian Qiu, Wenhao Zhou, Mingbang Wang, Guoqiang Cheng
Summary: By analyzing metabolite markers in serum and cerebrospinal fluid, this study identified changes in arginine and creatinine metabolism as the main characteristics of neonatal sepsis with meningoencephalitis. Additionally, abnormal oxidative stress was indicated by significant increases in antioxidants taurine and proline in the serum. The lasso algorithm combined with XGBoost was successful in predicting concentration of homo-L-arginine in CSF based on serum metabolite markers.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Daniela B. Surrer, Martin F. Fromm, Renke Maas, Joerg Koenig
Summary: This study reveals an unknown link between NaCT/Nact transporter protein and L-arginine and its cardiovascular important derivatives, and demonstrates that arginine and its derivatives are substrates of NaCT/Nact. This finding is of significance for further investigation into the role of arginine and its derivatives in energy metabolism and brain development.
Article
Chemistry, Multidisciplinary
Nataliya Stasyuk, Galina Gayda, Olha Demkiv, Lyubomyr Darmohray, Mykhailo Gonchar, Marina Nisnevitch
Summary: Limited data exist on amperometric biosensors for L-arginine determination based on oxidases producing H2O2 and artificial peroxidases. This study proposed three types of ABS for direct measurement of Arg, showing high sensitivity, selectivity, and good storage stability. The ABSs demonstrated high correlation and accuracy when tested on real samples, indicating their potential for Arg analysis in various fields.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Liming Wang, Licen Li, Bingzhe Wang, Jun Wu, Yupeng Liu, Enshan Liu, Huiqi Zhang, Bohan Zhang, Guichuan Xing, Qinglin Li, Zikang Tang, Chuxia Deng, Songnan Qu
Summary: A facile method using L-arginine-functionalized carbon dots (L-Arg@CDots) to suppress lipogenesis and obesity is reported. The L-Arg@CDots form stronger bonds than D-arginine and lysine with L-Arg in water, and they offer a high photoluminescence quantum yield of 23.6% in the red wavelength region.
Review
Immunology
Rebecca R. Crowther, Joseph E. Qualls
Summary: This article provides a summary of the current knowledge on anti-Mtb immunity, focusing on immune cell amino acid metabolism, specifically discussing the roles of L-arginine and L-tryptophan in TB patients. By uncovering the immune cell contribution during Mtb infection and how amino acid utilization regulates their functions, novel host-directed therapies may be developed and refined to help eradicate TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Hiep Thi Dao, Nishchal K. Sharma, Emma J. Bradbury, Robert A. Swick
Summary: The study examined the effects of reduced protein diet, arginine deficiency, and the addition of arginine substitutes on Hy-Line Brown laying hens. It was found that while an arginine deficient diet decreased performance, the addition of guanidinoacetic acid or citrulline allowed birds to perform similarly or better than with added arginine.
Article
Pharmacology & Pharmacy
Ji Huang, Diogo Ladeiras, Yi Yu, Xiu-Fen Ming, Zhihong Yang
Summary: The study found that long-term L-arginine supplementation has negative effects on kidney aging, leading to increased inflammation and fibrosis markers, enhanced albuminuria, and mortality particularly in females.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. Qualls
Summary: Macrophages rely on L-arginine for anti-Mtb defense, not only for NO production but also for regulating metabolism and other host defense mechanisms. Inhibition of glycolysis or mTOR reduces macrophage control of Mtb, as well as macrophage number and viability in the presence of L-arginine. L-arginine is essential for macrophage function in combating intracellular pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Pengqi Bao, Li Chen, Yu Wang, Yue Hu, Yan Wang, Hongmei Fang, Huamei Yang, Bao Zhang, Bin He, Cunliu Zhou
Summary: The study found that both L-arginine and L-lysine can improve water holding capacity, texture, color, and protein denaturation of frozen porcine Longissimus lumborum. They decrease losses and hardness, increase resistance and pH values, and help maintain the integrity of tissue structure.
Article
Biochemistry & Molecular Biology
Nam Ah Kim, Shavron Hada, Seong Hoon Jeong
Summary: This study improved the role of arginine hydrochloride in biopharmaceutical industry by using compound N-Acetyl-L-arginine (NALA), which can significantly minimize the decrease in T-m at different pH, enhance colloidal stability, reduce agitation stress of protein, and cooperate with glycine buffer to maintain monomer content and suppress larger particle formation. The study suggests that the decrease in protein T-m caused by arginine hydrochloride is due to the amide group in the alpha-carbon chain.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Vinothini Arunagiri, Hsieh-Chih Tsai, Haile Fentahun Darge, Endiries Yibru Hanurry, Chang Yi Lee, Juin-Yih Lai, Szu-Yuan Wu
Summary: Fucoidan, a marine sulfated polysaccharide extracted from brown macroalgae, has been widely used in various industrial applications. Research shows that by using an L-arginine uptake enhancer, the uptake of fucoidan can be improved.
Article
Agriculture, Multidisciplinary
Daojing Zhang, Yinyin Zhang, Yajun Huang, Li Chen, Pengqi Bao, Hongmei Fang, Cunliu Zhou
Summary: L-arginine and L-lysine effectively alleviated the destructive effects of hydroxyl radicals on the emulsifying properties and structure of myosin, enabling myosin to maintain its emulsifying capacity under oxidative stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Hiep Thi Dao, Nishchal K. Sharma, Emma J. Bradbury, Robert A. Swick
Summary: Supplementing broilers with arginine and citrulline may improve performance under warm temperature conditions. Feeding broilers with normal protein diets is necessary to maintain growth performance.
Article
Pharmacology & Pharmacy
Andjelika Kalezic, Aleksandra Korac, Bato Korac, Aleksandra Jankovic
Summary: L-arginine supplementation induces browning of white adipose tissue, characterized by the appearance of multilocular adipocytes and increased expression of thermogenic and beige adipocyte-specific genes. This browning effect is associated with increased inducible nitric oxide protein expression and NO signaling. Additionally, L-arginine treatment also decreases white adipose tissue mass and body weight.
