Article
Pediatrics
Fiona Lynch, Trisha Prentice, Lynn Gillam, Zornitza Stark, Christopher Gyngell
Summary: The clinical utility of rapid genome sequencing (rGS) in critically ill infants has been demonstrated consistently. However, informed decision making regarding rGS in the NICU poses challenges due to the complexity of information and heightened emotions of parents.
Article
Cardiac & Cardiovascular Systems
Enzo Lusebrink, Antonia Kellnar, Clemens Scherer, Kathrin Krieg, Mathias Orban, Tobias Petzold, Sven Peterss, Stefan Kaab, Stefan Brunner, Daniel Braun, Christian Hagl, Jorg Hausleiter, Steffen Massberg, Martin Orban
Summary: Critical care cardiology, a rapidly developing sub-specialization within cardiovascular medicine, requires a multidisciplinary approach to manage complex patients with high burden of critical cardiovascular and non-cardiovascular illnesses. Specialized knowledge and skills in cardiovascular diseases, emergency medicine, critical care, and internal medicine are essential for the successful management of patients in cardiac intensive care units.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Nursing
Stijn Blot, Etienne Ruppe, Stephan Harbarth, Karim Asehnoune, Garyphalia Poulakou, Charles-Edouard Luyt, Jordi Rello, Michael Klompas, Pieter Depuydt, Christian Eckmann, Ignacio Martin-Loeches, Pedro Povoa, Lila Bouadma, Jean-Francois Timsit, Jean-Ralph Zahar
Summary: Patients in intensive care units are highly susceptible to healthcare-acquired infections due to various factors. While the incidence of infections related to invasive procedures and devices has been reduced, ICU-acquired infections remain a significant issue. The emergence of new pathogens and the COVID-19 pandemic add further challenges to prevention and management. ICU nurses play a crucial role in HAI prevention and management. Advances in microbiological techniques and understanding of the patient-microbiota interaction are reshaping the definition and strategies for diagnosing, treating, and preventing infections in the ICU.
INTENSIVE AND CRITICAL CARE NURSING
(2022)
Article
Nursing
Carolyne Stewart
Summary: Learning experiences in ICU for new nurses are challenging due to the large number of skills that need to be developed in a short period. Forming supportive social relationships is crucial for new ICU nurses to adapt to the complex clinical environment. The high-risk culture of ICU makes it especially difficult for internationally educated nurses to learn.
INTENSIVE AND CRITICAL CARE NURSING
(2021)
Review
Infectious Diseases
Alexandre Duong, Chantale Simard, Yi Le Wang, David Williamson, Amelie Marsot
Summary: Aminoglycosides are commonly used for Gram-negative infections, but optimal dosing regimens in ICU patients remain unclear due to significant variability in pharmacokinetics. Pharmacokinetic models for amikacin, gentamicin, and tobramycin show high interindividual variability, with no consensus on dosing regimens. Further research is needed to better understand aminoglycoside pharmacokinetics in ICU patients.
Article
Nursing
Linda R. Gregory, Rimen Lim, Lois MacCullagh, Therese Riley, Karen Tuqiri, Jan Heiler, Kath Peters
Summary: The study found that nurses in ICU had to implement workarounds to ensure safety when using the new eMAR; Nurses were concerned that the eMAR in eRIC diverted their attention from patients and added more screen time to their day.
Review
Psychiatry
Stephen Lee-Cheong, Shabbir Amanullah, Mackenzie Jardine
Summary: Dementia is a condition that causes global cognitive dysfunction, leading to difficulties in daily activities. Without proper support, individuals with dementia are vulnerable. The use of new assistive technologies, such as artificial intelligence systems, can improve quality of life and health equity for dementia patients.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Ronny Klawunn, Urs-Vito Albrecht, Marie-Luise Dierks
Summary: This study investigates patients' attitudes, expectations, worries, and anticipated implementation effects of new assistive technology in nursing care through qualitative, guided, semi-open interviews. The results indicate that patients have nuanced and mixed perspectives on the implementation of new nursing technology, which can inform future implementation strategies.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Critical Care Medicine
Guido Michels, Manuela Schallenburger, Martin Neukirchen, ICU Palliative Study Grp
Summary: A consensus process is underway in Germany to develop recommendations on palliative care in intensive care for non-oncological patients, aiming to address the needs of patients with advanced diseases.
Review
Critical Care Medicine
Victoria Metaxa, Despina Anagnostou, Savvas Vlachos, Nishkantha Arulkumaran, Sherihane Bensemmane, Ingeborg van Dusseldorp, Rebecca A. Aslakson, Judy E. Davidson, Rik T. Gerritsen, Christiane Hartog, J. Randall Curtis
Summary: The study evaluated various types of palliative care interventions implemented in ICUs and their impact on practice, finding that strategies to enhance palliative care involvement were associated with beneficial effects on common outcomes for ICU patients. However, the majority of studies were from North America, limiting the generalisability to other healthcare systems.
INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki, Francesca Rubulotta
Summary: There is a significant gender gap in critical care medicine, with women being underrepresented, but gender diversity has beneficial effects. The article discusses the reasons behind gender imbalance and proposes solutions, emphasizing the need to address and eliminate this issue.
Article
Health Care Sciences & Services
Jan Hoffmann, Alinda Reimer, Laura Mause, Andreas Mueller, Neo-CamCare, Till Dresbach, Nadine Scholten
Summary: This study investigates the readiness for the implementation of a webcam system among lead NICU staff in Germany and identifies technology acceptance as a significant factor associated with the readiness. The findings can be used to manage potential barriers in implementing webcams in NICUs.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Infectious Diseases
Eder Rodriguez-Campos, Ana Belen Guisado-Gil, German Penalva, Beatriz Fernandez-Rubio, Teresa Aldabo, Laura Herrera-Hidalgo, Esperanza Fernandez-Delgado, Marta Mejias-Trueba, Maria Luisa Gascon, Maria Adriaensens, Jose Miguel Cisneros, Maria Victoria Gil-Navarro
Summary: This study assessed the quality of antimicrobial use in ICUs using a bundle of indicators in a teaching hospital in Spain. The indicators were selected based on consumption data and trends were analyzed using segmented regression. The findings showed an increase in the use of certain antimicrobial agents and the detection of patterns that align with local guidelines and antibiogram reports. The use of these novel indicators provides additional information for analysis and improvement within antimicrobial stewardship programs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Health Care Sciences & Services
Camille Guinemer, Martin Boeker, Daniel Fuerstenau, Akira-Sebastian Poncette, Bjoern Weiss, Rudolf Moergeli, Felix Balzer
Summary: Tele-ICU interventions have diverse use cases that include extending coverage, improving compliance, and facilitating transfer. Current research focuses on the benefits of tele-ICU interventions in centralized systems for expanding critical care capabilities in community settings and improving care compliance in tertiary hospitals. No strong evidence has been found regarding the reduction of patient transfers following tele-ICU interventions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Cell Biology
Karolina Akinosoglou, Georgios Schinas, Maria Panagiota Almyroudi, Charalambos Gogos, George Dimopoulos
Summary: Caring for the elderly in the intensive care unit (ICU) is challenging due to factors like frailty, comorbidities, and polypharmacy. The COVID-19 pandemic has highlighted the importance of addressing specific considerations for elderly populations. Age-related physiological changes and functional status should be taken into account for triage assessment, and special attention should be given to age-related specificities during ICU care. Proper rehabilitation post-ICU can improve long-term outcomes. The pandemic may limit standard care for elderly ICU patients, and socioeconomic factors should be addressed. Tailoring treatment plans to patients' wishes and personalized needs will guide critical care for the elderly.
AGEING RESEARCH REVIEWS
(2023)
Article
Hematology
Elaine Cavalcante dos Santos, Peter Bakos, Jean-Louis Vincent
Editorial Material
Microbiology
Jean-Louis Vincent
FUTURE MICROBIOLOGY
(2021)
Letter
Critical Care Medicine
Jean-Louis Vincent, Jacques Creteur
INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
Wasineenart Mongkolpun, Peter Bakos, Jean-Louis Vincent, Jacques Creteur
Summary: This study included 42 patients with shock, and found that baseline skin blood flow and its early reduction after initiation of fluid removal using CVVH can predict worsened tissue perfusion, reflected by an increase in blood lactate levels.
ANNALS OF INTENSIVE CARE
(2021)
Review
Medicine, General & Internal
Jean-Louis Vincent, Jacques Creteur
Summary: With increasing life expectancy, more elderly patients are being admitted to ICU, representing a unique subgroup with changes in organ function, reduced daily living activities, decreased mobility, and cognitive decline. Ethical decisions regarding intensive care, life-sustaining interventions, life support withdrawal/withholding, and terminal sedation are more common in elderly patients, and should be personalized to consider individual beliefs and wishes.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jean-Louis Vincent
Summary: Intensive care units (ICUs) worldwide have faced significant challenges due to the COVID-19 pandemic, such as resource shortages and ethical dilemmas. Through the discussions prompted by the COVID-19 situation, valuable lessons can be learned about resource allocation, end-of-life decision-making, and staff support.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fabio Silvio Taccone, Fuhong Su, Xinrong He, Lorenzo Peluso, Katia Donadello, Sabino Scolletta, Daniel De Backer, Jean-Louis Vincent
Summary: The effects of correcting hypotension with vasopressors in septic shock may improve cerebral oxygenation but do not reverse the alterations in brain microcirculation or cerebral metabolism.
Review
Virology
Maya Hites, Jean-Louis Vincent
Summary: This article reviews the clinical studies conducted in Belgium on hospitalized patients with COVID-19, showing a limited participation of hospitals, low international collaboration, and a lack of adaptive platform trials.
Article
Neurosciences
Katia Donadello, Fuhong Su, Filippo Annoni, Sabino Scolletta, Xinrong He, Lorenzo Peluso, Leonardo Gottin, Enrico Polati, Jacques Creteur, Olivier De Witte, Jean-Louis Vincent, Daniel De Backer, Fabio Silvio Taccone
Summary: This study investigated the effects of cooling on cerebral microcirculation, oxygenation and metabolism in a healthy swine model. The results showed that during the cooling phase, cerebral functional capillary density and proportion of small-perfused vessels decreased, while oxygenation increased and metabolism decreased. After rewarming, all variables returned to normal values, except for an increased metabolism in the two groups subjected to hypothermia during the rewarming phase compared to the normothermia group.
Review
Biochemistry & Molecular Biology
Jean-Louis Vincent, Tom van der Poll, John C. Marshall
Summary: Sepsis, a life-threatening organ dysfunction caused by an uncontrolled host response to infection, remains a major challenge for clinicians and trialists. The evaluation of therapeutics targeting components of host response anomalies in sepsis patients is complicated by the inability to identify those who are more likely to benefit from a specific intervention. Furthermore, the existence of multiple and diverse host response aberrations in sepsis and limited knowledge of the dysregulated biological organ system or pathway driving sepsis-induced pathology in individual patients further complicate the development of effective therapies.
Article
Infectious Diseases
Jean-Louis Vincent
Summary: Sepsis is an infection associated with organ dysfunction, and early recognition and assessment of severity are crucial.
Correction
Critical Care Medicine
Alberto Fogagnolo, Fabio Silvio Taccone, Jean Louis Vincent, Giulia Benetto, Elaine Cavalcante, Elisabetta Marangoni, Riccardo Ragazzi, Jacques Creteur, Carlo Alberto Volta, Savino Spadaro
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Critical Care Medicine
Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki, Francesca Rubulotta
Summary: There is a significant gender gap in critical care medicine, with women being underrepresented, but gender diversity has beneficial effects. The article discusses the reasons behind gender imbalance and proposes solutions, emphasizing the need to address and eliminate this issue.
Article
Critical Care Medicine
Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi
Summary: The current coronavirus pandemic has heavily impacted ICUs worldwide, putting immense pressure on healthcare systems and staff. It is important to learn from both the positive and negative aspects of the response to improve organization and patient care in the future.