Article
Clinical Neurology
Ana M. Castano-Leon, Marta Cicuendez, Blanca Navarro-Main, Igor Paredes, Pablo M. Munarriz, Amaya Hilario, Ana Ramos, Pedro A. Gomez, Alfonso Lagares
Summary: This study investigates the diagnosis and prognosis assessment of traumatic axonal injury. The results suggest that diffusion tensor imaging and conventional MRI provide complementary prognostic information, and their combination can improve the performance of traditional prognostic models.
JOURNAL OF NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Lara Pankatz, Philine Rojczyk, Johanna Seitz-Holland, Sylvain Bouix, Leonard B. Jung, Tim L. T. Wiegand, Elena M. Bonke, Nico Sollmann, Elisabeth Kaufmann, Holly Carrington, Twishi Puri, Yogesh Rathi, Michael J. Coleman, Ofer Pasternak, Mark S. George, Thomas W. Mcallister, Ross Zafonte, Murray B. Stein, Christine E. Marx, Martha E. Shenton, Inga K. Koerte
Summary: This study analyzed diffusion and structural MRI data of 278 participants with and without military background, and found microstructural alterations at the gray matter/white matter boundary of the brain after mild traumatic brain injury (mTBI) that were associated with post-concussive symptom severity, functional, and cognitive impairment. These findings suggest that microstructural changes at the gray matter/white matter boundary may be sensitive markers of adverse long-term outcomes following mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Sung Ho Jang, You Sung Seo
Summary: Diffusion tensor tractography is a valuable method to evaluate axonal injury in concussion (mTBI) patients. It reveals characteristic features such as tearing, narrowing, and discontinuations of neural tracts, which provide insights into the extent and patterns of axonal injury. Axonal injury in concussion (mTBI) patients is characterized by their occurrence in long neural tracts and multiple injuries. However, the corticospinal tract discontinuation is commonly observed in diffuse axonal injury, while partial tearing and narrowing in subcortical white matter are frequently observed in concussion (mTBI) patients. These differences suggest that the forces causing axonal injury in concussion (mTBI) patients are weaker than those in diffuse axonal injuries. Additionally, the presence of collateral branches in concussion (mTBI) patients indicates a relatively weaker impact on the brain compared to diffuse axonal injury. The characteristics of axonal injury in concussion (mTBI) patients reviewed in this study provide valuable supplementary information for the diagnosis of axonal injury in concussion (mTBI) patients.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Amy E. Jolly, Maria Balaet, Adriana Azor, Daniel Friedland, Stefano Sandrone, Neil S. N. Graham, Karl Zimmerman, David J. Sharp
Summary: This study introduces a pipeline for assessing the presence of axonal injury in traumatic brain injury patients, revealing that the majority of patients have axonal injury in the chronic and subacute phases. Patients with axonal injury exhibit significantly poorer cognitive and functional outcomes.
Review
Health Care Sciences & Services
Sung Ho Jang, Dong Hyun Byun
Summary: This study reviewed traumatic axonal injury (TAI) in patients with concussion. DTI provides valuable data for the diagnosis of TAI in patients with concussion, but further research is needed to find a diagnostic method that does not require a brain biopsy for live confirmation of TAI.
Review
Medicine, General & Internal
Sung-Ho Jang, Min-Jye Cho
Summary: This review paper discusses the application of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in the diagnosis of traumatic axonal injury (TAI) in individuals with concussion or mild traumatic brain injury (mTBI). While several hundred DTI-based studies have reported TAI in concussion or mTBI, there are fewer case studies focusing on individual patients. The summary of these studies suggests that DTI can be used as a non-invasive tool for determining the presence and severity of TAI in individual patients with concussion or mTBI. However, certain conditions need to be met for an accurate diagnosis, and further studies are required to improve the precision of TAI diagnosis in individual patients.
Article
Medicine, General & Internal
Chao Zhang, Wen-Dong You, Xu-Xu Xu, Qian Zhou, Xiao-Feng Yang
Summary: The novel nomogram model combining AEEG parameters showed potential in predicting outcomes in severe TBI coma patients receiving RMNS treatment, effectively classifying patients into prognostic groups and demonstrating good predictive ability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rehabilitation
Clara Debarle, Vincent Perlbarg, Alice Jacquens, Melanie Pelegrini-Issac, Marion Bisch, Amelie Prigent, Blandine Lesimple, Elsa Caron, Muriel Lefort, Eleonore Bayen, Damien Galanaud, Pascale Pradat-Diehl, Louis Puybasset, Vincent Degos
Summary: This study evaluated global volumetric and diffusion parameters related to long-term outcome after TBI, and found that global mean diffusivity is a more promising radiomarker for discriminating good outcome long term after TBI. Further research is needed to understand the evolution of these long-term radiological parameters.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Critical Care Medicine
Rael T. Lange, Sara M. Lippa, Tracey A. Brickell, Ping-Hong Yeh, John Ollinger, Megan Wright, Angela Driscoll, Jamie Sullivan, Samantha Braatz, Rachel Gartner, Elizabeth Barnhart, Louis M. French
Summary: This study found a significant impact of PTSD on neuropsychological outcomes after MTBI, but no relationship between PTSD and white matter integrity. Concurrent PTSD and MTBI should be considered a risk factor for poor neuropsychological outcomes that requires early intervention.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Neha Soni, Rodrigo Medeiros, Khawlah Alateeq, Xuan Vinh To, Fatima A. Nasrallah
Summary: This study is the first to investigate the effects of TBI in tau-transgenic mice using DTI. The results show that changes in the DTI signal are associated with glial activity following TBI and may reflect changes that occur with or without phosphorylated-tau. Additionally, FA may be a promising measure to identify discrete pathological processes such as increased astroglia activation, tau hyperphosphorylation, or both in the brain following TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Sung Ho Jang, Seong Ho Kim, Hyeok Gyu Kwon
Summary: This study found a high diagnostic sensitivity of traumatic axonal injury (TAI) of the spinothalamic tract (STT) in patients with mild traumatic brain injury (TBI) suffering from central pain symptoms using diffusion tensor tractography (DTT). However, the generalizability of the study results may be limited by the small number of subjects who visited the university hospital and the constraints of DTT technology.
Article
Critical Care Medicine
Louis Puybasset, Vincent Perlbarg, Jean Unrug, Didier Cassereau, Damien Galanaud, Gregory Torkomian, Valentine Battisti, Muriel Lefort, Lionel Velly, Vincent Degos, Guiseppe Citerio, Eleonore Bayen, Melanie Pelegrini-Issac
Summary: This study aimed to design a new classification score based on magnetic resonance diffusion metrics measured in the deep white matter between day 7 and day 35 after TBI to predict 1-year clinical outcome. The score achieved a high accuracy in predicting both favorable and unfavorable outcomes, providing objective information for ICU decision-making.
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
Sara M. Lippa, Ping-Hong Yeh, John Ollinger, Tracey A. Brickell, Louis M. French, Rael T. Lange
Summary: The extant literature on the relationship between diffusion tensor imaging (DTI) and cognition following traumatic brain injury (TBI) is limited by small sample sizes and inappropriate control groups. This study examined DTI metric differences between different TBI groups and found a dose-response relationship between TBI severity and the strength of the relationship between white matter integrity and cognitive performance. Unlike previous findings, this study did not find any differences in DTI metrics between controls, mild TBI, and complicated TBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Health Care Sciences & Services
Sungho Jang, Eunbi Choi
Summary: This pilot study investigated the relationship between the Coma Recovery Scale-Revised (CRS-R) and the five subparts of the thalamocortical tract in chronic patients with hypoxic-ischemic brain injury using diffusion tensor tractography (DTT). The results showed a moderate positive correlation between the CRS-R score and the tract volume of the prefrontal cortex part, and the change in the remaining number of neural fibers of the prefrontal cortex part appeared to be related to the change in conscious state.
Article
Clinical Neurology
Joel Frohlich, Micah A. Johnson, David L. McArthur, Evan S. Lutkenhoff, John Dell'Italia, Courtney Real, Vikesh Shrestha, Norman M. Spivak, Jesus E. Ruiz Tejeda, Paul M. Vespa, Martin M. Monti
Summary: The study found that sedation-induced burst-suppression (SIBS) was positively associated with outcomes at 6 months in patients with moderate-to-severe traumatic brain injury (TBI), but did not predict outcomes at discharge. These results suggest that burst suppression may have neuroprotective effects in acute patients with TBI etiologies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
A. W. van der Eerden, T. L. van den Heuvel, V. Perlbarg, P. Vart, P. E. Vos, L. Puybasset, D. Galanaud, B. Platel, R. Manniesing, B. M. Goraj
Summary: In patients with moderate to severe traumatic brain injury, microbleed concentration in the subacute phase is associated with the integrity of normal-appearing white matter in the chronic phase. DTI findings reflect white matter integrity in the chronic phase, but interpretation in the subacute phase is more complex. SWI evaluation for microbleeds is straightforward in both phases.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Rehabilitation
Clara Debarle, Vincent Perlbarg, Alice Jacquens, Melanie Pelegrini-Issac, Marion Bisch, Amelie Prigent, Blandine Lesimple, Elsa Caron, Muriel Lefort, Eleonore Bayen, Damien Galanaud, Pascale Pradat-Diehl, Louis Puybasset, Vincent Degos
Summary: This study evaluated global volumetric and diffusion parameters related to long-term outcome after TBI, and found that global mean diffusivity is a more promising radiomarker for discriminating good outcome long term after TBI. Further research is needed to understand the evolution of these long-term radiological parameters.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Cell Biology
Pauline Perez, Jens Madsen, Leah Banellis, Basak Turker, Federico Raimondo, Vincent Perlbarg, Melanie Valente, Marie-Cecile Nierat, Louis Puybasset, Lionel Naccache, Thomas Similowski, Damian Cruse, Lucas C. Parra, Jacobo D. Sitt
Summary: Recent evidence suggests that conscious processing can affect the timing of the heartbeat. Higher Inter-Subject Correlation of Heart Rate (ISC-HR) predicts better recall of the narrative. Patients with disorders of consciousness have lower ISC-HR, indicating that heart rate fluctuations may represent a simple metric to assess conscious state in unresponsive patients.
Letter
Critical Care Medicine
Louis Puybasset, Vincent Perlbarg, Melanie Pelegrini-Issac
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
Louis Puybasset, Vincent Perlbarg, Jean Unrug, Didier Cassereau, Damien Galanaud, Gregory Torkomian, Valentine Battisti, Muriel Lefort, Lionel Velly, Vincent Degos, Guiseppe Citerio, Eleonore Bayen, Melanie Pelegrini-Issac
Summary: This study aimed to design a new classification score based on magnetic resonance diffusion metrics measured in the deep white matter between day 7 and day 35 after TBI to predict 1-year clinical outcome. The score achieved a high accuracy in predicting both favorable and unfavorable outcomes, providing objective information for ICU decision-making.
INTENSIVE CARE MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arman Avesta, Anastasia Yendiki, Vincent Perlbarg, Lionel Velly, Omid Khalilzadeh, Louis Puybasset, Damien Galanaud, Rajiv Gupta
Summary: This study aimed to assess if quantitative diffusion magnetic resonance imaging analysis would improve prognostication of individual patients with severe traumatic brain injury. The results showed that quantifying severity of injury to white-matter tracts complements qualitative imaging findings and improves outcome prediction in severe traumatic brain injury.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2022)
Article
Critical Care Medicine
Shraddha Mainali, Venkatesh Aiyagari, Sheila Alexander, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Emery Brown, Jeremy Brown, Jan Claassen, Brian L. Edlow, Erika L. Fink, Joseph J. Fins, Brandon Foreman, Jennifer Frontera, Romergryko G. Geocadin, Joseph Giacino, Emily J. Gilmore, Olivia Gosseries, Flora Hammond, Raimund Helbok, J. Claude Hemphill, Karen Hirsch, Keri Kim, Steven Laureys, Ariane Lewis, Geoffrey Ling, Sarah L. Livesay, Victoria McCredie, Molly McNett, David Menon, Erika Molteni, DaiWai Olson, Kristine O'Phelan, Soojin Park, Len Polizzotto, Jose Javier Provencio, Louis Puybasset, Chethan P. Venkatasubba Rao, Courtney Robertson, Benjamin Rohaut, Michael Rubin, Tarek Sharshar, Lori Shutter, Gisele Sampaio Silva, Wade Smith, Robert D. Stevens, Aurore Thibaut, Paul Vespa, Amy K. Wagner, Wendy C. Ziai, Elizabeth Zink, Jose Suarez
Summary: This article summarizes the background, research priorities, panel discussions, and deliverables of the 2nd Curing Coma National Institutes of Health (NIH) symposium. The symposium focused on six major domains related to disorders of consciousness and identified actionable items for the Curing Coma Campaign mission through interactive and inspiring presentations and panel discussions.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Yann Nadjar, Pierre Levy, Vi-Huong Nguyen-Michel, Charles-Edouard Luyt, Louis Puybasset, Vincent Navarro
Summary: This study aimed to identify the features that may predict the outcome of patients with post anoxic coma (PAC) by analyzing electroencephalographic (EEG) patterns. The presence of EEG paroxysms (EP) and their regularity features were strongly associated with poor outcome in PAC patients. A global regularity score derived from visual EEG inspection could be a reliable prognostic tool.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Surgery
Elisabeth Hain, Amine Chamakhi, Charlotte Lussey-Lepoutre, Jerome Bertherat, Christophe Baillard, Gilles Manceau, Louis Puybasset, Jacques Blacher, Bernard Cholley, Anne-Paule Gimenez-Roqueplo, Bertrand Dousset, Laurence Amar, Fabrice Menegaux, Sebastien Gaujoux
Summary: According to the study results, patients with pheochromocytomas/paragangliomas who underwent surgery after presenting with Takotsubo-like cardiomyopathy can be safely operated with low risk of perioperative complications and good postoperative outcomes.
Article
Gastroenterology & Hepatology
Daniel Eyraud, Marine Creux, Diane Lastennet, Louis Lemoine, Jean Christophe Vaillant, Eric Savier, Corinne Vezinet, Olivier Scatton, Benjamin Granger, Louis Puybasset, Yann Loncar
Summary: The study found that restrictive fluid intake strategy in hepatic surgery is a risk factor for postoperative acute kidney injury (AKI), leading to longer hospital stays and higher mortality. Meanwhile, a liberal fluid intake strategy can reduce the risk of AKI.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Anesthesiology
Matthieu Le Dorze, Laurent Martin-Lefevre, Gaelle Santin, Rene Robert, Gerard Audibert, Bruno Megarbane, Louis Puybasset, Didier Dorez, Benoit Veber, Francois Kerbaul, Corinne Antoine
Summary: This study aimed to assess the influence of controlled donation after circulatory death (cDCD) on the withdrawal of life-sustaining therapies (WLST) process. The findings revealed that organ donation did not expedite the WLST decision but rather increased the interval between the decision and its initiation. Most French cDCD donors were associated with post-anoxic brain injury.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Clinical Neurology
Andrew I. R. Maas, David K. Menon, Geoffrey T. Manley, Mathew Abrams, Cecilia Akerlund, Nada Andelic, Marcel Aries, Tom Bashford, Michael J. Bell, Yelena G. Bodien, Benjamin L. Brett, Andras Buki, Randall M. Chesnut, Giuseppe Citerio, David Clark, Betony Clasby, D. Jamie Cooper, Endre Czeiter, Marek Czosnyka, Kristen Dams-O'Connor, Veronique De Keyser, Ramon Diaz-Arrastia, Ari Ercole, Thomas A. van Essen, Eanna Falvey, Adam R. Ferguson, Anthony Figaji, Melinda Fitzgerald, Brandon Foreman, Dashiell Gantner, Guoyi Gao, Joseph Giacino, Benjamin Gravesteijn, Fabian Guiza, Deepak Gupta, Mark Gurnell, Juanita A. Haagsma, Flora M. Hammond, Gregory Hawryluk, Peter Hutchinson, Mathieu van der Jagt, Sonia Jain, Swati Jain, Ji-Yao Jiang, Hope Kent, Angelos Kolias, Erwin J. O. Kompanje, Fiona Lecky, Hester F. Lingsma, Marc Maegele, Marek Majdan, Amy Markowitz, Michael McCrea, Geert Meyfroidt, Ana Mikoli, Stefania Mondello, Pratik Mukherjee, David Nelson, Lindsay D. Nelson, Virginia Newcombe, David Okonkwo, Matej Oresic, Wilco Peul, Dana Pisica, Suzanne Polinder, Jennie Ponsford, Louis Puybasset, Rahul Raj, Chiara Robba, Cecilie Roe, Jonathan Rosand, Peter Schueler, David J. Sharp, Peter Smielewski, Murray B. Stein, Nicole von Steinbuchel, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nancy Temkin, Olli Tenovuo, Alice Theadom, Ilias Thomas, Abel Torres Espin, Alexis F. Turgeon, Andreas Unterberg, Dominique Van Praag, Ernest van Veen, Jan Verheyden, Thijs Vande Vyvere, Kevin K. W. Wang, Eveline J. A. Wiegers, W. Huw Williams, Lindsay Wilson, Stephen R. Wisniewski, Alexander Younsi, John K. Yue, Esther L. Yuh, Frederick A. Zeiler, Marina Zeldovich, Roger Zemek
Article
Critical Care Medicine
Aude Sangare, Clemence Marois, Vincent Perlbarg, Nadya Pyatigorskaya, Melanie Valente, Julie Zyss, Alaina Borden, Virginie Lambrecq, Loic Le Guennec, Jacobo Sitt, Nicolas Weiss, Benjamin Rohaut, Sophie Demeret, Louis Puybasset, Alexandre Demoule, Lionel Naccache
Summary: This retrospective cohort study described the neurological assessment and outcomes of patients with hypoglycemic encephalopathy hospitalized in the intensive care unit. The study found that the overall prognosis of severe hypoglycemic encephalopathy patients was poor, with only a small fraction showing slow improvement after discharge. A multimodal neurological assessment approach using advanced brain imaging and electrophysiology techniques could potentially improve diagnostic and prognostic performance in severe hypoglycemic encephalopathy.
NEUROCRITICAL CARE
(2023)
Article
Rehabilitation
Pierre Simeone, Guillaume Auzias, Julien Lefevre, Sylvain Takerkart, Olivier Coulon, Blandine Lesimple, Gregory Torkomian, Valentine Battisti, Alice Jacquens, David Couret, Lionel Naccache, Eleonore Bayen, Nicolas Bruder, Vincent Perlbarg, Louis Puybasset, Lionel Velly
Summary: This study found a significant decrease in volumes of white matter and deep grey nuclear structures in severe TBI patients. These lesions were associated with lower baseline scores and higher diffusion tensor imaging values, which can be used to predict long-term neurological outcomes.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Critical Care Medicine
Antoine Monsel, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Otriv Nguekap Tchoumba, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clemence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean-Michel Constantin, Bruno Megarbane, Gaetan Plantefeve, Stephanie Malard-Castagnet, Sonia Burrel, Michelle Rosenzwajg, Nicolas Tchitchek, Helene Boucher-Pillet, Guillaume Churlaud, Audrey Cras, Camille Maheux, Chloe Pezzana, Mamadou Hassimiou Diallo, Jacques Ropers, Philippe Menasche, Jerome Larghero
Summary: The efficacy of UC-MSCs in patients with SARS-CoV-2-induced ARDS was assessed in this study. The results showed no significant difference in respiratory indicators between the UC-MSCs and placebo groups. The repeated UC-MSCs infusions did not lead to any serious adverse events during treatment or thereafter.