Review
Biology
Swetha Mohan, Zavier Yongxuan Lim, Kai Siang Chan, Vishal G. G. Shelat
Summary: Obesity is associated with increased risk of intra-abdominal hypertension and abdominal compartment syndrome. This study aims to determine the impact of obesity on the clinical outcomes of patients with these conditions. A systematic review of nine studies involving 9938 patients showed that obesity was associated with a higher risk of intra-abdominal hypertension and correlated with the need for renal replacement therapy, intensive care unit-acquired infections, systemic inflammatory response syndrome, acute respiratory distress syndrome, length of hospital stay, and mortality.
Review
Critical Care Medicine
Jan J. De Waele
Summary: This review focuses on the developing insights in the epidemiology and treatment of patients with intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Recent studies have drawn attention to the impact of IAH and ACS on kidney function and other outcomes. New methods for measuring intra-abdominal pressure (IAP) are being developed, and researchers continue to search for biomarkers to detect IAH or ACS. The findings from recent studies allow for better prevention and treatment of these conditions in IAH and ACS patients.
CURRENT OPINION IN CRITICAL CARE
(2022)
Review
Critical Care Medicine
Edward J. Kimball
Summary: Recent research has improved our understanding of the prevalence of intra-abdominal hypertension (IAH) and its independent association with organ failure. Studies have also clarified the effects of IAH on individual organ systems and specific disease states, contributing to advancements in diagnosing, monitoring, and treating IAH/ACS. There is a significant focus on the impact of IAH/ACS in the ICU setting, with contributions from specialists in various sub-specialties leading to improvements in treatment algorithms.
CURRENT OPINION IN CRITICAL CARE
(2021)
Review
Chemistry, Analytical
Chien-Hung Liao, Chi-Tung Cheng, Chih-Chi Chen, Yu-Hsin Wang, Hsin-Tzu Chiu, Cheng-Chun Peng, Uei-Ming Jow, Yen-Liang Lai, Ya-Chuan Chen, Dong-Ru Ho
Summary: This review article discusses recent advancements in innovative sensors for measuring intra-abdominal pressure (IAP) and highlights the increasing use of wireless sensing systems for monitoring IAP. The inherent advantages of IAP sensors, such as their small size, remote monitoring, and multiplexing capabilities, are also discussed.
Article
Multidisciplinary Sciences
Rui Pereira, Maria Buglevski, Rui Perdigoto, Paulo Marcelino, Faouzi Saliba, Stijn Blot, Joel Starkopf
Summary: This study found a high prevalence of intra-abdominal hypertension and abdominal compartment syndrome in critically ill cirrhotic patients, with risk factors such as alcoholic cirrhosis and infection. Early diagnosis and treatment of these conditions may improve outcomes.
Article
Pediatrics
Paul Wiegandt, Thomas Jack, Alexander von Gise, Kathrin Seidemann, Martin Boehne, Harald Koeditz, Philipp Beerbaum, Michael Sasse, Torsten Kaussen
Summary: The survey reveals inconsistent acceptance of definitions and guidelines among pediatric intensivists in Germany regarding IAH and ACS. The awareness and knowledge of valid definitions of ACS have improved, but a significant number of physicians still have not diagnosed IAH/ACS and have never measured intra-abdominal pressure (IAP).
Review
Biology
Rita Jacobs, Robert D. Wise, Ivan Myatchin, Domien Vanhonacker, Andrea Minini, Michael Mekeirele, Andrew W. Kirkpatrick, Bruno M. Pereira, Michael Sugrue, Bart De Keulenaer, Zsolt Bodnar, Stefan Acosta, Janeth Ejike, Salar Tayebi, Johan Stiens, Colin Cordemans, Niels Van Regenmortel, Paul W. G. Elbers, Xavier Monnet, Adrian Wong, Wojciech Dabrowski, Philippe G. Jorens, Jan J. De Waele, Derek J. Roberts, Edward Kimball, Annika Reintam Blaser, Manu L. N. G. Malbrain
Summary: This review summarizes the current knowledge on the association between fluid administration and intra-abdominal pressure in patients at risk of intra-abdominal hypertension and abdominal compartment syndrome. Most studies confirm the association between fluid resuscitation and intra-abdominal hypertension, but optimal fluid management strategies for these patients remain controversial.
Article
Medicine, General & Internal
Rayan Qutob, Alanoud Hassan A. Alkhannani, Turki Yazeed Alassaf, Saad Othman Alhokail, Ghassan Abdullah Bagazi, Abdulmalak Abdullah Alsaleh, Mashael Kamel Alqarni, Yousef Alammari, Khalid Al Harbi, Alyaa Elhazmi, Abdullah Ibrahim Bukhari, Abdullah Alaryni, Abdullah Alghamdi, Osamah A. Hakami
Summary: This study investigated physicians' knowledge and management of intra-abdominal hypertension and abdominal compartment syndrome in Saudi Arabia. The results showed a low level of knowledge among physicians, highlighting the need for increased awareness and education on the proper diagnosis and management of these conditions.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Surgery
Manxu Zhao, Nicola D'Attellis, Dominic Emerson, Vanessa Moll, Fardad Esmailian
Summary: We present a case study where a patient who underwent mechanical circulatory support during complicated orthotopic heart transplantation developed spontaneous retroperitoneal hematoma, resulting in abdominal compartment syndrome and organ failure. The utilization of a novel monitor measuring real-time intra-abdominal pressures and urinary output allowed for early detection of high intra-abdominal pressures, leading to prompt intervention through decompressive laparotomy and subsequent hemodynamic stabilization.
FRONTIERS IN SURGERY
(2022)
Review
Medicine, General & Internal
Narcis Octavian Zarnescu, Ioana Dumitrascu, Eugenia Claudia Zarnescu, Radu Costea
Summary: Abdominal compartment syndrome is a severe complication of acute pancreatitis, characterized by increased intra-abdominal pressure and new organ dysfunction. It leads to multiple organ failure and higher morbidity and mortality rates. Elevated intra-abdominal pressure has detrimental effects on respiratory, cardiovascular, gastrointestinal, neurologic, and renal functions. Around 15% of severe acute pancreatitis patients develop intra-abdominal hypertension or abdominal compartment syndrome, with a mortality rate of approximately 50%. Treatment involves medical intervention, percutaneous drainage, surgical decompression, vacuum-assisted closure therapy, and early abdominal fascia closure.
Article
Multidisciplinary Sciences
Xuxu Xu, Zhenghui He, Yingchi Shan, Qing Mao, Junfeng Feng, Guoyi Gao
Summary: Intra-abdominal pressure is a crucial physiological parameter with elevated levels associated with organ dysfunction. Monitoring IAP can aid in predicting clinical status and guiding treatment.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Surgery
Jordan Bozer, Brandon Rodgers, Naveen Qureshi, Kristine Griffin, Brian Kenney
Summary: This study evaluated the incidence and mortality of pediatric abdominal compartment syndrome (ACS) in multiple children's hospitals in the United States from 2007 to 2019. The annual incidence and mortality of pediatric ACS remained unchanged during the study period, with a high mortality rate, especially in neonatal intensive care unit patients. There were significant variations in hospital-specific incidence and mortality, suggesting inconsistencies in pediatric ACS care between institutions, possibly related to recognition and diagnosis.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Critical Care Medicine
Steven G. Strang, Quirine L. M. Habes, Ben van der Hoven, Wim E. Tuinebreijer, Michael H. J. Verhofstad, Peter Pickkers, Esther M. M. Van Lieshout, Oscar J. F. Van Waes
Summary: Urinary I-FABP levels were positively correlated with the development of ACS, but did not show significant diagnostic value for identifying individual patients at risk for IAH-associated complications.
JOURNAL OF CRITICAL CARE
(2021)
Article
Biology
Maja Stojanovic, Marko Duric, Irina Nenadic, Nemanja Dimic, Suzana Bojic, Predrag Stevanovic
Summary: Patients with acute pancreatitis develop complications and organ damage due to increased intra-abdominal pressure. Changes in intra-abdominal pressure values can lead to alterations in vital parameters such as mean arterial pressure and diuresis per hour in these patients.
Review
Critical Care Medicine
Zaid Khot, Patrick B. Murphy, Nathalie Sela, Neil G. Parry, Kelly Vogt, Ian M. Ball
Summary: The study found that intra-abdominal hypertension is common in critically ill patients and may be associated with increased mortality, especially at higher grades. However, there were variations in the definition of IAH, frequency and duration of IAP measurement, and reporting of outcomes among studies. Further prospective research is needed to examine the effect of screening and treatment of IAH on patient outcomes.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Anesthesiology
Anneleen S. Staelens, Ann Heymans, Sigrid Christiaens, Niels Van Regenmortel, Wilfried Gyselaers, Manu L. N. G. Malbrain
Summary: Rectal measurement of intra-abdominal pressure is not feasible and lacks reliability for obtaining accurate readings and validations.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Editorial Material
Critical Care Medicine
Xavier Monnet, Manu L. N. G. Malbrain, Michael R. Pinsky
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Isabel Spriet, Jan J. De Waele
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Surgery
Michael T. Meschino, Kelly N. Vogt, Laura Allen, Maisa Saddik, Rahima Nenshi, Rardi Van Heest, Fady Saleh, Sandy Widder, Samuel Minor, Emilie Joos, Neil G. Parry, Patrick B. Murphy, Chad G. Ball, Morad Hameed, Paul T. Engels
Summary: Access to the operating room for emergency general surgery (EGS) services in Canada varies, with some services having dedicated EGS ORs while others have only a shared queue. This study aimed to examine the burden of after-hours EGS operating in Canada and differences associated with OR access. The results showed substantial variation in OR booking priority among EGS patients in Canada, with sites that have dedicated EGS ORs performing more cases during weekday daytime.
CANADIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Paul T. Engels, Jennie Lee, Timothy R. Rice, Rahima Nenshi, Chad G. Ball, Morad Hameed, Sandy Widder, Samuel Minor, Najma Ahmed, Neil Parry, Kelly Vogt, Emilie Joos, Kristin DeGirolamo, Andy Kirkpatrick, Jacinthe Lampron, Najma Ahmed, Cecily Bos, Joao Rezende Neto, Morgan Schellenberg, Rich Hilsden, Chad Ball, Phil Dawe, Mike Kim, Jag Rao, Laura Allen, David Gomez, Jordan Nantais, Erin Sadler, Jeremy Grushka, Sarah Miller, Karan D'Souza, Nori Bradley, Sarah Mueller, Nicole Koloszsvari, Ashlie Nadler, Ken Leslie, Maggie Gordon, Darrell Boone, Morad Hameed, Lily Tung, Brett Mador, Lawrence Gillman, Rardi Van Heest, Stephanie Mason, Tim Rice, Lily Park, Steve Quigley, Sam Minor, Neil Parry, Matt Strickland, Markus Ziesmann, Derek Roberts, Brad Moffat, Eric Walser, Kosar Khwaja, Mary Wells, Rahima Nenshi, Pat Murphy, Erica Lester, Ken Leslie, Shane Smith, Rob Leeper, Shiva Jayaraman, Evan Wong, Emily Roswell
Summary: Acute care surgery (ACS) has become a specialized area within general surgery that has greatly evolved over the past two decades. Canada has both academic and community models of ACS, which help manage patients in need of emergency general surgery (EGS) care, with or without trauma care. The implementation of ACS has had a significant impact on patient care, surgical education, and workforce, allowing some general surgeons to specialize in excluding EGS care from their practice. This has led to the establishment of dedicated ACS fellowship training programs, marking a milestone in the field of general surgery and contributing to the improvement of patient care, surgical education, and scholarly endeavors.
CANADIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Anesthesiology
Wojciech Dabrowski, Philippe Rola, Manu L. N. G. Malbrain
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Multidisciplinary Sciences
Lore Huwel, Joke Van Eessen, Jan Gunst, Manu L. N. G. Malbrain, Veerle Bosschem, Tom Vanacker, Sofie Verhaeghe, Dominique D. Benoit
Summary: This study aims to explore when healthcare professionals consider intensive care as appropriate care. Despite previous attempts to conceptualize appropriate care, there is a lack of understanding on its meaning and implementation. This is important as inappropriate care in the ICU is regularly reported by healthcare professionals, patients, and relatives.
Article
Surgery
Shaun Cowan, Patrick Murphy, Michael Kim, Brett Mador, Eddie Chang, Alison Kabaroff, Emerson North, Cheryl Cameron, Kevin Verhoeff, Sandy Widder
Summary: Handover to the trauma team is crucial and effective handover formats with concise, key details are preferred. A single-blind randomized simulation trial compared ad-lib communication to structured handover formats (ISOBAR and IMIST) with positive results. Factors such as confident delivery, a logical format, and uninterrupted handover by a trauma team leader were identified as contributing to higher quality handovers.
CANADIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Critical Care Medicine
Jan J. J. De Waele, Isabel Leroux-Roels, Pieter Depuydt
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
David Simmons, Jincy Immanuel, William M. Hague, Helena Teede, Christopher J. Nolan, Michael J. Peek, Jeff R. Flack, Mark McLean, Vincent Wong, Emily Hibbert, Alexandra Kautzky-Willer, Juergen Harreiter, Helena Backman, Emily Gianatti, Arianne Sweeting, Viswanathan Mohan, Joanne Enticott, N. Wah Cheung
Summary: The effectiveness of early treatment for gestational diabetes before 20 weeks' gestation on maternal and infant health is not clear. In this study, women at risk of hyperglycemia and diagnosed with gestational diabetes were randomly assigned to receive immediate treatment or deferred/no treatment based on the results of an oral glucose-tolerance test at 24 to 28 weeks' gestation. The results showed that immediate treatment led to a slightly lower incidence of adverse neonatal outcomes, but no significant differences were observed for pregnancy-related hypertension or neonatal lean body mass.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Wim Vandenberghe, Jorien De Loor, Katrien Francois, Kristof Vandekerckhove, Ingrid Herck, Johan Vande Walle, Harlinde Peperstraete, Thierry Bove, Daniel De Wolf, Lieve Nuytinck, Jan J. De Waele, Evelyne Meyer, Eric A. J. Hoste
Summary: This study evaluated serum CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors of acute kidney injury (AKI) after pediatric cardiac surgery. The results showed that these markers could reliably predict the occurrence of AKI within 48 hours and 12 hours, respectively, after adjusting for urine dilution.
Article
Obstetrics & Gynecology
William M. Hague, Annette Briley, Leonie Callaway, Marloes Dekker Nitert, Jessica Gehlert, Dorothy Graham, Luke Grzeskowiak, Angela Makris, Corey Markus, Philippa Middleton, Michael J. Peek, Antonia Shand, Michael Stark, Jason Waugh
Summary: Intrahepatic cholestasis of pregnancy (ICP) is a liver disease during pregnancy characterized by itching and increased levels of total serum bile acids (TSBA), with an incidence of 0.6-0.7% in Australia. ICP is diagnosed by measuring TSBA and bile pigment in a pregnant woman with itching but no known pre-existing liver disorder. Severe and very severe disease are identified by TSBA levels of ≥40 and ≥100 μmol/L, respectively, with severe cases associated with spontaneous preterm birth and stillbirth in very severe cases. The effectiveness and risks of inducing preterm birth in ICP are still uncertain. Ursodeoxycholic acid is the recommended pharmacotherapy for ICP, improving perinatal outcomes and reducing itching, but its ability to reduce stillbirth has not been proven.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Computer Science, Information Systems
Jarne Verhaeghe, Thomas De Corte, Christopher M. Sauer, Tom Hendriks, Olivier W. M. Thijssens, Femke Ongenae, Paul Elbers, Jan De Waele, Sofie Van Hoecke
Summary: This study developed risk models for atrial fibrillation (AF) in intensive care unit (ICU) patients using uncertainty quantification. The models showed good performance and accurate prediction of AF risk in multiple ICU datasets.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Environmental Sciences
Amita Bansal, Nicolas Cherbuin, Deborah L. Davis, Michael J. Peek, Amanda Wingett, Bruce K. Christensen, Hazel Carlisle, Margaret Broom, Danielle A. J. M. Schoenaker, Jane E. Dahlstrom, Christine B. Phillips, Sotiris Vardoulakis, Ralph Nanan, Christopher J. Nolan
Summary: This article emphasizes the impact of climate change on the health of pregnant women and babies, highlighting the limitations of existing evidence on severe heatwaves and wildfires. The authors also emphasize the need for international interdisciplinary collaboration to systematically study the effects of severe climate-related environmental crises on maternal and child health.
LANCET PLANETARY HEALTH
(2023)
Article
Anesthesiology
Jeroen Walpot, Paul Van Herck, Caroline M. Van de Heyning, Johan Bosmans, Samia Massalha, Manu L. N. G. Malbrain, Hein Heidbuchel, Joao R. Inacio
Summary: Over the last two decades, the potential role of epicardial adipocyte tissue (EAT) as a marker for major adverse cardiovascular events has been extensively studied. EAT, unlike other visceral adipocyte tissues, shares the same microcirculation with the myocardium and secretes adipocytokines that directly interact with the heart. This article discusses the three available imaging modalities for evaluating EAT and summarizes the current knowledge on its association with coronary artery disease, high-risk plaque features, atrial fibrillation, aortic stenosis, mitral annular calcification, and heart failure. The potential role of EAT in critically ill patients admitted to the intensive care unit is also discussed.
ANAESTHESIOLOGY INTENSIVE THERAPY
(2023)