Article
Geriatrics & Gerontology
Amjad Bani Hani, Mahmoud Abu Abeeleh, Sondos Al-Najjar, Abdulla Alzibdeh, Shahd Mansour, Isam Bsisu, Nour Awamleh, Randa Farah
Summary: This study investigated the incidence, risk factors, and outcomes of acute kidney injury (AKI) in patients aged 80 years or older in a surgical intensive care unit (SICU). The study found that the incidence of AKI was 32.7%, and it was significantly associated with the use of beta blockers, mechanical ventilation, and inotropes. Further research is needed to assess the incidence of AKI in this population and identify preventive measures and strategies.
Article
Pharmacology & Pharmacy
N. Dereli, M. Babayigit, O. Mentes, F. Koc, O. Ari, E. Dogan, E. Onhan
Summary: COVID-19-related acute kidney injury occurs in a considerable number of hospitalized and ICU patients, leading to prolonged hospital stays, increased treatment requirements, and higher mortality rates.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Dan Liao, Yonghua Deng, Xinchun Li, Ju Huang, Jiayue Li, Ming Pu, Fenglian Zhang, Lijun Wang
Summary: This study found that elevated GNRI in critically ill patients is strongly correlated with a lower risk of unfavorable outcomes.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Article
Medicine, General & Internal
Boxiang Tu, Yuanjun Tang, Yi Cheng, Yuanyuan Yang, Cheng Wu, Xiaobin Liu, Di Qian, Zhansai Zhang, Yanfang Zhao, Yingyi Qin, Jia He
Summary: Patients with acute kidney injury who were administered statins prior to ICU admission may have lower ICU mortality, in-hospital mortality, and shorter ICU length of stay. This association was consistent across different subgroups.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yuan Hong Du, Cheng Jing Guan, Lin Yu Li, Ping Gan
Summary: This study is the first meta-analysis investigating the predictive value of machine learning in assessing the risk of AKI among ICU patients. The results demonstrate that machine learning-based methods have excellent predictive value for identifying AKI risk in ICU patients and could potentially be used for early detection.
Article
Medical Laboratory Technology
Juan Du, Yihui Li, Qiang Sun, Zhihao Wang, Feng Wang, Fangfang Chen, Hao Wang, Yirui Liu, Huimin Zhou, Guokai Shang, Xiaomei Chen, Shifang Ding, Chen Li, Dawei Wu, Wei Zhang, Ming Zhong
Summary: The study indicates that urinary exosomal CD26 is a promising prognosis biomarker associated with renal reversal and recovery in AKI patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Juan Du, Yihui Li, Qiang Sun, Zhihao Wang, Feng Wang, Fangfang Chen, Hao Wang, Yirui Liu, Huimin Zhou, Guokai Shang, Xiaomei Chen, Shifang Ding, Chen Li, Dawei Wu, Wei Zhang, Ming Zhong
Summary: The study found that urinary exosomal CD26 is associated with renal recovery and reversal after acute kidney injury (AKI). A high CD26 level may be related to reversal within 28 days in AKI patients. In survivors of AKI, a high CD26 level is associated with early reversal, recovery, and reversal.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Critical Care Medicine
Kyle C. White, Ary Serpa-Neto, Rod Hurford, Pierre Clement, Kevin B. Laupland, Emily See, James McCullough, Hayden White, Kiran Shekar, Alexis Tabah, Mahesh Ramanan, Peter Garrett, Antony G. Attokaran, Stephen Luke, Siva Senthuran, Philippa McIlroy, Rinaldo Bellomo
Summary: This study aims to describe the epidemiology of sepsis-associated acute kidney injury (SA-AKI). The incidence of SA-AKI reached 18% in 2021, with patients typically being admitted from home via the emergency department (ED) and diagnosed with SA-AKI within 1 day of ICU admission. Compared to other diagnostic criteria, SA-AKI patients diagnosed by low urinary output (UO) only had a lower need for renal replacement therapy and a lower mortality risk.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Hsin-Hung Liu, Yu-Tseng Wang, Meng-Han Yang, Wei-Shu Kevin Lin, Yen-Jen Oyang
Summary: This study developed machine learning models to investigate the interactions between serum creatinine, blood urea nitrogen (BUN), and electrolyte levels in ICU patients without a prior history of AKI or AKI-related comorbidities. The results identified serum creatinine, chloride, and magnesium as the three major factors for monitoring in this patient group. These findings provide valuable insights for developing early intervention and effective management strategies, as well as suggesting directions for future research on the pathophysiological mechanisms involved in AKI.
Article
Pediatrics
Cal Robinson, Erin Hessey, Sophia Nunes, Marc Dorais, Rahul Chanchlani, Jacques Lacroix, Philippe Jouvet, Veronique Phan, Michael Zappitelli
Summary: This study found that nephrology follow-up after pediatric AKI was uncommon, but nearly all survivors received follow-up from non-nephrologist physicians within one year post discharge. This suggests that knowledge translation strategies for AKI follow-up should be targeted at non-nephrology healthcare providers.
PEDIATRIC RESEARCH
(2022)
Article
Geriatrics & Gerontology
Q. Li, P. Hu, H. Kang, Feihu Zhou
Summary: This study revealed that 44.9% of hospitalized COVID-19 patients developed AKI, while 45.8% of AKI cases were not recognized. The findings suggest that AKI has a significant impact on patient outcomes and the protection of kidney function is crucial.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Mark Andonovic, Jamie P. Traynor, Martin Shaw, Malcolm A. B. Sim, Patrick B. Mark, Kathryn A. Puxty
Summary: This retrospective observational cohort study examined patients admitted to intensive care units in Scotland and found that one in four critically ill patients met the criteria for acute kidney disease. These patients had increased risk of short-term mortality and long-term adverse kidney events.
Article
Microbiology
Fabrizio Fabrizi, Carlo M. Alfieri, Paolo Molinari, Francesco Tamborini, Marianna Tangredi, Anna Sikharulidze, Francesco Blasi, Anna Fracanzani, Walter Monzani, Flora Peyvandi, Giuseppe Castellano
Summary: The study reveals that acute kidney injury (AKI) is a common complication among SARS-CoV-2-positive patients who undergo hospitalization. The occurrence of AKI is related to the severity of COVID-19 and factors such as elevated levels of ferritin, IL-6, and azotemia at admission.