Article
Critical Care Medicine
Ravindranath Tiruvoipati, Bindu Akkanti, Kha Dinh, Nicholas Barrett, Alexandra May, Jeremy Kimmel, Steven A. A. Conrad
Summary: This study aims to investigate the effectiveness and safety of a single ECCO2R device (Hemolung) in patients with acute respiratory failure and identify variables associated with survival. The results showed that Hemolung can significantly reduce hypercapnia and improve survival. Non-COVID-19 ARDS, age, and P/F at commencement of ECCO2R were independently associated with survival.
CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Review
Urology & Nephrology
Ranjeeta Chand, Erik R. Swenson, David S. Goldfarb
Summary: Respiratory acidosis is common in patients with respiratory failure, and treatment with sodium bicarbonate remains controversial. The benefits of alkali therapy for mixed acidosis are conflicting, and there is a lack of evidence supporting the net benefit of sodium bicarbonate administration for respiratory acidosis.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Immunology
Chao Cao, Lin Zhang, Jie Shen
Summary: Phosgene gas is a highly toxic chemical intermediate with various industrial applications. Accidental exposure to phosgene can lead to chemical-induced lung injury, which is characterized by initial mild symptoms such as coughing and chest tightness, but can progress to severe respiratory distress and even death. Effective treatments for phosgene inhalation poisoning are currently lacking, highlighting the need to understand the pathophysiology and pathogenesis of this condition in order to develop appropriate therapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Zhan Wu, Rong Zhang, Dongdong Liu, Xuesong Liu, Jierong Zhang, Zhihui Zhang, Sibei Chen, Weiqun He, Yimin Li, Yonghao Xu, Xiaoqing Liu
Summary: This study found that adenovirus is an important cause of virus-related ARDS, with a higher positivity rate in lower respiratory tract secretions than in upper respiratory tract secretions. Age, lower CD3+CD4+ T cells, and higher serum creatinine may be associated with adenovirus-induced ARDS in adults requiring mechanical ventilation. Early identification and intervention to prevent disease progression are essential for reducing the mortality rate in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Review
Critical Care Medicine
Raphael Giraud, Carlo Banfi, Benjamin Assouline, Amandine De Charriere, Maurizio Cecconi, Karim Bendjelid
Summary: ECCO2R aims to eliminate the adverse effects of hypercapnia and related acidosis, providing potential therapeutic benefits for COPD and ARDS patients.
ANNALS OF INTENSIVE CARE
(2021)
Article
Critical Care Medicine
Nadir Yehya, Hossein Fazelinia, Gladys G. Lawrence, Lynn A. Spruce, Mark Mai, G. Scott Worthen, Jason D. Christie
Summary: This study found that plasma nucleosomes are associated with the severity of acute respiratory distress syndrome (ARDS) in children, as well as with nonpulmonary organ failures. Nucleosomes were also linked to higher mortality rates and fewer ventilator-free days in the pediatric ARDS patients. Proteomic analysis further showed elevated levels of core nucleosome histones in septic children with ARDS.
CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Ravindranath Tiruvoipati, Ary Serpa Neto, Marcus Young, Nada Marhoon, John Wilson, Sachin Gupta, David Pilcher, Michael Bailey, Rinaldo Bellomo
Summary: This study investigated the association between hypercapnia and hospital mortality in critically ill patients with sepsis. The results showed that isolated hypercapnia was not associated with increased mortality, while prolonged hypercapnic acidemia was associated with increased risk of mortality.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, Research & Experimental
Ravindranath Tiruvoipati, Jarryd Ludski, Sachin Gupta, Ashwin Subramaniam, Mallikarjuna Ponnapa Reddy, Eldho Paul, Kavi Haji
Summary: This study describes the clinical characteristics, efficacy, and safety of PrismaLung+ in patients with acute hypercapnic respiratory failure. The results showed that PrismaLung+ rapidly improved arterial carbon dioxide and pH levels with a good safety profile, with circuit thrombosis being the only complication.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Qianqian Li, Rui Li, Hanlin Yin, Suli Wang, Bei Liu, Jun Li, Mi Zhou, Qingran Yan, Liangjing Lu
Summary: This study evaluated the potential of IRAK4 inhibitors as a treatment for ARDS-cytokine release syndrome (CRS). The results showed that BAY-1834845 effectively prevented lung injury and improved existing ARDS when combined with dexamethasone. Compared to other drugs, BAY-1834845 reduced inflammatory cell infiltration and neutrophil count. Interestingly, BAY-1834845 preserved the signatures of naive lymphocytes and stromal cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Article
Clinical Neurology
S. Agarwal, J. Conway, V Nguyen, S. Dogra, P. Krieger, D. Zagzag, A. Lewis, K. Melmed, S. Galetta, R. Jain
Summary: This study describes the clinical and imaging features of acute disseminated leukoencephalopathy in critically ill patients with COVID-19, showing short-term evolution into cystic degeneration. Patients exhibited inflammatory cytokine release syndrome and often required prolonged ventilator support, resulting in poor functional outcomes and high mortality rates.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth
Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.
CRITICAL CARE MEDICINE
(2021)
Letter
Anesthesiology
Louise Rose, Luigi Camporota, Gary H. Mills, John Laffey, Gavin D. Perkins, Manu Shankar-Hari, Tamas Szakmany, Danny McAuley, RELEASE Investigators
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Alisa M. Higgins, Lindsay R. Berry, Elizabeth Lorenzi, Srinivas Murthy, Zoe McQuilten, Paul R. Mouncey, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma Van Bentum-Puijk, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Aiden Burrell, Adrian Buzgau, Meredith Buxton, Walton N. Charles, Matthew Cove, Michelle A. Detry, Lise J. Estcourt, Elizabeth O. Fagbodun, Mark Fitzgerald, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, Christopher M. Horvat, David T. Huang, Nao Ichihara, Francois Lamontagne, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Matthew D. Neal, Alistair D. Nichol, Rachael L. Parke, Jane C. Parker, Karen Parry-Billings, Sam E. C. Peters, Luis F. Reyes, Kathryn M. Rowan, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Ary Serpa-Neto, Christopher W. Seymour, Manu Shankar-Hari, Lucy M. Stronach, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Lennie P. G. Derde, Anthony C. Gordon, Steve A. Webb, Patrick R. Lawler
Summary: The longer-term effects of therapies for critically ill COVID-19 patients are unknown. In this study, 4869 patients were randomized to receive different interventions, and it was found that treatment with IL-6 receptor antagonists and antiplatelet agents significantly improved survival rates after 180 days. These findings suggest that most therapies have consistent effects over a 6-month period.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Critical Care Medicine
Mark Dennis, Timothy J. Southwood, Matthew Oliver, Alistair Nichol, Aidan Burrell, Carol Hodgson
Summary: This study conducted a survey among clinicians in Australia and New Zealand and found strong support for further research on optimizing the use of ECMO and ECPR. The results provide a framework for prioritizing future clinical trials and research agendas.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Emma J. Ridley, Lee-anne S. Chapple, Kate Ainscough, Aidan Burrell, Lewis Campbell, Claire Dux, Suzie Ferrie, Kate Fetterplace, Matin Jamei, Victoria King, Ary Serpa Neto, Alistair Nichol, Emma Osland, Eldho Paul, Matthew Summers, Andrea P. Marshall, Andrew Udy
Summary: This study aimed to describe nutrition-related service delivery practices in critically ill patients with COVID-19 admitted to Australian ICUs during the initial pandemic phase. Results showed that approximately half of the patients were seen by a dietitian, with increased malnutrition screening in the ICU associated with higher risk scores and higher likelihood of dietetic consult.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Tai Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, Gaetan Beduneau, Ewan C. Goligher, Giacomo Grasselli, Jon Henrik Laake, Jordi Mancebo, Oscar Penuelas, Lise Piquilloud, Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G. Laffey
Summary: This study investigated the management and outcomes of weaning from invasive mechanical ventilation in patients requiring at least 2 days of ventilation. The results showed that only 65% of patients were successfully weaned at 90 days. Factors such as delayed initiation of weaning and excessive sedation levels were associated with weaning failure. Understanding these factors could improve the success rate of weaning.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Chemistry, Medicinal
Declan Byrnes, Claire H. Masterson, Jack Brady, Senthilkumar Alagesan, Hector E. Gonzalez, Sean D. McCarthy, Juan Fandino, Daniel P. O'Toole, John G. Laffey
Summary: This study investigates the potential of mesenchymal stromal cells (MSCs) for treating pulmonary sepsis caused by antimicrobial-resistant bacterial strains. The results show that pre-conditioning MSCs enhances their therapeutic potential by promoting wound healing, reducing inflammation, preserving metabolic activity, and enhancing bacterial killing. Additionally, the study demonstrates that MSCs pre-activated with cytokines are more effective in attenuating pneumosepsis and improving lung function compared to naive and hypoxia-exposed MSCs.
Article
Critical Care Medicine
Giacomo Grasselli, Carolyn S. Calfee, Luigi Camporota, Daniele Poole, Marcelo B. P. Amato, Massimo Antonelli, Yaseen M. Arabi, Francesca Baroncelli, Jeremy R. Beitler, Giacomo Bellani, Geoff Bellingan, Bronagh Blackwood, Lieuwe D. J. Bos, Laurent Brochard, Daniel Brodie, Karen E. A. Burns, Alain Combes, Sonia D'Arrigo, Daniel De Backer, Alexandre Demoule, Sharon Einav, Eddy Fan, Niall D. Ferguson, Jean-Pierre Frat, Luciano Gattinoni, Claude Guerin, Margaret S. Herridge, Carol Hodgson, Catherine L. Hough, Samir Jaber, Nicole P. Juffermans, Christian Karagiannidis, Jozef Kesecioglu, Arthur Kwizera, John G. Laffey, Jordi Mancebo, Michael A. Matthay, Daniel F. McAuley, Alain Mercat, Nuala J. Meyer, Marc Moss, Laveena Munshi, Sheila N. Myatra, Michelle Ng Gong, Laurent Papazian, Bhakti K. Patel, Mariangela Pellegrini, Anders Perner, Antonio Pesenti, Lise Piquilloud, Haibo Qiu, Marco Ranieri, Elisabeth Riviello, Arthur S. Slutsky, Renee D. Stapleton, Charlotte Summers, Taylor B. Thompson, Carmen Valente Barbas, Jesus Villar, Lorraine B. Ware, Bjoern Weiss, Fernando G. Zampieri, Elie Azoulay, Maurizio Cecconi
Summary: The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM.
INTENSIVE CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas
Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Declan Byrnes, Claire H. Masterson, Hector E. Gonzales, Sean D. McCarthy, Daniel P. O'Toole, John G. Laffey
Summary: Antimicrobial-resistant bacteria, such as Klebsiella species, are a common cause of hospital-acquired pneumonia, leading to high mortality and morbidity. Using mesenchymal stem cells (MSCs) to harness the host immune response to these bacteria shows promise in bypassing antimicrobial resistance mechanisms. This study tested the efficacy of repeated doses and preactivated MSCs in attenuating Klebsiella pneumonia-induced pneumonia in rat models. Two doses of MSCs were effective in improving lung function and reducing bacteria and injury, with preactivated MSCs showing superior results. MSC therapy also affected immune cell populations both locally and systemically. Repeated doses of MSCs, particularly preactivated MSCs, enhance their therapeutic potential in treating antimicrobial-resistant Klebsiella pneumonia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mirjana Jerkic, Katalin Szaszi, John G. Laffey, Ori Rotstein, Haibo Zhang
Summary: Lung macrophages play a crucial role in pulmonary innate immunity and host defense. The interaction between these macrophages and mesenchymal stromal cells (MSCs) has shown potential in treating inflammatory lung diseases and COVID-19. The lung microenvironment facilitates the secretion of factors by MSCs, leading to polarization of macrophages towards an immunosuppressive M2-like phenotype for tissue repair. In turn, M2-like macrophages can affect the immune regulatory function and tissue reparatory effects of MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Peter J. McGuigan, Julia Edwards, Bronagh Blackwood, Paul Dark, James C. Doidge, David A. Harrison, Gareth Kitchen, Izabella Lawson, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar-Hari, Danny F. McAuley
Summary: This study aimed to report the variation in incidence and outcome of in hospital cardiac arrest (IHCA) based on the hour of occurrence. It was found that IHCA occurred more frequently and had poorer outcomes at night. However, this variation was not present in patients admitted to the intensive care unit (ICU).
Article
Hematology
Matthew J. Griffee, Patricia T. Bozza, Luis Felipe Reyes, Devin P. Eddington, Dorothea Rosenberger, Laura Merson, Barbara Wanjiru Citarella, Jonathon P. Fanning, Peta M. A. Alexander, John Fraser, Heidi Dalton
Summary: In this study, the frequency of coagulopathy complications in COVID-19 patients from developing countries (LMICs) was compared to those from high-income countries (HICs), and it was found that complications were more frequent in HICs. Complications were more common in patients receiving advanced treatment, and were associated with increased in-hospital mortality. Moreover, the mortality associated with these complications was higher in LMICs. Therefore, further research is needed to explore timely diagnosis and intervention for coagulation derangements in COVID-19, particularly in limited-resource settings.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Public, Environmental & Occupational Health
Tanya Symons, Janelle Bowden, Anne McKenzie, Julia M. Fallon-Ferguson, Leanne Y. Weekes, James Ansell, Rinki Murphy, Shilpa Jesudason, Manoj Saxena, Alistair Nichol, Nicola Straiton
Summary: This manuscript describes the development of a toolkit to support meaningful consumer involvement in clinical trials in Australia and guide others in creating similar resources. The toolkit aims to enhance consumer participation in prioritizing, designing, and conducting clinical research, and is a comprehensive digital resource derived from best practice literature and international standards.
PUBLIC HEALTH RESEARCH & PRACTICE
(2023)
Article
Critical Care Medicine
Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar-Hari, Markus B. Skrifvars, Karen Thomas, Danny F. McAuley, Peter J. McGuigan
Summary: This retrospective analysis found an association between hypotension and hypertension in the first 24 h in ICU and mortality following OHCA. Patients with a lowest recorded MAP in the range 60-63 mmHg and a highest recorded MAP in the range 95-104 mmHg had the lowest associated mortality. Research into individualized blood pressure targets for survivors following OHCA is needed.
Article
Medicine, General & Internal
G. Eastwood, A. D. Nichol, C. Hodgson, R. L. Parke, S. McGuinness, N. Nielsen, S. Bernard, M. B. Skrifvars, D. Stub, F. S. Taccone, J. Archer, D. Kutsogiannis, J. Dankiewicz, G. Lilja, T. Cronberg, H. Kirkegaard, G. Capellier, G. Landoni, J. Horn, T. Olasveengen, Y. Arabi, Y. W. Chia, A. Markota, M. Haenggi, M. P. Wise, A. M. Grejs, S. Christensen, H. Munk-Andersen, A. Granfeldt, G. O. Andersen, E. Qvigstad, A. Flaa, M. Thomas, K. Sweet, J. Bewley, M. Backlund, M. Tiainen, M. Iten, A. Levis, L. Peck, J. Walsham, A. Deane, A. Ghosh, F. Annoni, Y. Chen, D. Knight, E. Lesona, H. Tlayjeh, F. Svensek, P. J. McGuigan, J. Cole, D. Pogson, M. P. Hilty, J. P. During, M. J. Bailey, E. Paul, B. Ady, K. Ainscough, A. Hunt, S. Monahan, T. Trapani, C. Fahey, R. Bellomo
Summary: In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. There were no significant differences in the incidence of death or adverse events between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)