Article
Immunology
James J. Harrigan, Hatem O. Abdallah, Erik L. Clarke, Arman Oganisian, Jason A. Roy, Ebbing Lautenbach, Emily Reesey, Magda Wernovsky, Pam Tolomeo, Zygmunt Morawski, Jerry Jacob, Michael A. Grippi, Brendan J. Kelly
Summary: Persistent disruption of the lower respiratory tract microbiome, characterized by consecutive days with low Shannon diversity, identifies a high-risk population for lower respiratory tract infection among patients with prolonged critical illness and dependence on mechanical ventilation.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
D-L Pen, G-F Yan, L-Y He, W-L Yan, W-M Chen, J. Liu, J-Y Ying, C-Q Wang, G-P Lu
Summary: This study revealed the significant role of bacterial colonization in ventilator circuits in the development of VAP in mechanically ventilated children. Early identification and decontamination of contaminated ventilator circuits may play a crucial role in preventing VAP.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Pharmacology & Pharmacy
Mingqi Wang, Wen Wang, Xue Jia, Qiao He, Shichao Zhu, Yan Kang, Rui Zhang, Yan Ren, Ling Li, Kang Zou, Zhiyong Zong, Xin Sun
Summary: This study conducted a retrospective cohort study to evaluate the effect of pharmacological thromboprophylaxis on ventilator-associated events (VAEs), ICU stays, and ICU mortality among patients receiving mechanical ventilation. The results showed that pharmacological thromboprophylaxis was associated with a lower risk of VAEs and ICU mortality. Anticoagulants, but not antiplatelet agents, were associated with a decreased risk of VAEs, ICU mortality, and shorter ICU stays. The use of antithrombosis agents may also decrease the risk of VAEs in patients with D-dimer >5 mg/LFEU.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Infectious Diseases
Mariachiara Ippolito, Giovanni Misseri, Giulia Catalisano, Claudia Marino, Giulia Ingoglia, Marta Alessi, Elisa Consiglio, Cesare Gregoretti, Antonino Giarratano, Andrea Cortegiani
Summary: This systematic review and meta-analysis aimed to estimate the occurrence of ventilator-associated pneumonia (VAP) among COVID-19 patients in the ICU and the mortality rate of those who developed VAP. The results showed that the estimated occurrence of VAP in COVID-19 patients was 45.4%, the mortality rate was 42.7%, and the mean ICU length of stay was approximately 28.58 days.
Article
Infectious Diseases
Ayse Akbiyik, Ziynet Hepcivici, Ismet Eser, Mehmet Uyar, Perihan Cetin
Summary: The study aimed to investigate the impact of oropharyngeal aspiration on ventilator-associated pneumonia (VAP) incidence prior to changing patient position. It found that performing oropharyngeal aspiration before patient position changes could effectively prevent the development of VAP. The experimental group had a significantly lower rate of VAP incidence compared to the control group, suggesting the potential benefits of this preventive measure.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Mirella van Duijnhoven, Manon Fleuren-Janssen, Frits van Osch, Jos L. M. L. Lenoble
Summary: The study investigated the incidence and recurrence of ventilator-associated pneumonia (VAP) in patients with COVID-19 and found a high rate of VAP occurrence and recurrence. The most commonly cultured microorganisms in VAP were Pseudomonas, Klebsiella, Escherichia coli, and Staphylococcus aureus. VAP recurrences were frequent, mainly relapses. Extended antibiotic therapy and therapeutic drug monitoring should be considered for VAP caused by Gram-negative microorganisms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Xuetao Kong, Yaozhou Wu, Bingqin Wen, Dongmei Meng, Li Wei, Pengjiu Yu
Summary: This study analyzed the effects of SUP, sedative, statin, and insulin on patients with MV. The results showed that propofol is more recommended as a sedation regimen in ICU patients with MV compared to midazolam. The drugs did not have a protective effect on VAP in MV patients, and no protective effect on death was found in VAP patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Cong Li, Fangjie Lu, Jing Chen, Jiawei Ma, Nana Xu
Summary: This study summarized the research results on various nutritional treatments for the prevention of ventilator-associated pneumonia (VAP) in mechanically ventilated patients. The findings demonstrated that probiotic-supplemented peripheral parenteral nutrition (EPN) had a higher correlation with the alleviation of VAP in critically invasive mechanically ventilated patients, while synbiotic-supplemented EPN was significantly associated with a decreased incidence of nosocomial infection.
FRONTIERS IN NUTRITION
(2022)
Article
Respiratory System
Jeremy Weinberger, Chanu Rhee, Michael Klompas
Summary: This study compares the incidence, causes, and outcomes of ventilator-associated events (VAE) during the COVID-19 pandemic and pre-pandemic years, as well as between COVID-19 positive and negative patients. The results show that COVID-19 positive patients have higher rates of VAE, with over 50% of VAEs being caused by progressive ARDS.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Pediatrics
Soheil Roshanzamiri, Maryam Alemzadeh, Seyyedeh Narjes Ahmadizadeh, Azita Behzad, Seyyedeh Masumeh Hashemi, Jamshid Salamzadeh, Bahador Mirrahimi
Summary: The study demonstrates that the use of probiotics can effectively prevent the occurrence of VAP and diarrhea in children under mechanical ventilation in the PICU.
FRONTIERS IN PEDIATRICS
(2022)
Article
Critical Care Medicine
Ines Gragueb-Chatti, Alexandre Lopez, Dany Hamidi, Christophe Guervilly, Anderson Loundou, Florence Daviet, Nadim Cassir, Laurent Papazian, Jean-Marie Forel, Marc Leone, Jean Dellamonica, Sami Hraiech
Summary: In COVID-19 patients requiring invasive mechanical ventilation, dexamethasone treatment was not associated with increased incidence of ventilator-associated pneumonia or bloodstream infections. Dexamethasone may not explain the high rates of VAP and BSI observed in critically ill COVID-19 patients.
ANNALS OF INTENSIVE CARE
(2021)
Article
Public, Environmental & Occupational Health
Gerard Marshall, Jennifer Sanguinet, Shreya Batra, Mary Jo Foreman, Justin Peruchini, Sarah Lopez, Rian De Guzman, Nancy Rivera, Todd Hightower, Cheryl Malone, Sheri Stucke
Summary: The implementation of an ARDS ventilator weaning protocol has a significant impact on reducing triggers for VAEs and improving patient outcomes.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Critical Care Medicine
Saad Nseir, Amelie Le Gouge, Olivier Pouly, Jean-Baptiste Lascarrou, Jean-Claude Lacherade, Jean-Paul Mira, Emmanuelle Mercier, Pierre-Louis Declercq, Michel Sirodot, Gael Piton, Francois Tinturier, Elisabeth Coupez, Stephane Gaudry, Michel Djibre, Didier Thevenin, Malika Balduyck, Jean Reignier
Summary: The study found no significant association between obesity and the incidence of VAP in patients receiving mechanical ventilation and vasopressor support in the ICU. Although there was no significant difference in VAP incidence between obese and nonobese patients, 90-day mortality was significantly lower in obese patients. Additionally, there was no significant difference in the rate of microaspiration of gastric contents or oropharyngeal secretions between obese and nonobese patients.
Article
Environmental Sciences
Sungjung Kwak, Sujeong Han
Summary: This study developed and validated a tool for measuring VAP prevention behaviors among ICU nurses. The tool was found to be valid and reliable through factor analysis and validity and reliability tests. It can help improve VAP prevention measures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Xinyu Li, Wei Tan, Hongwen Zhao, Wei Wang, Bing Dai, Haijia Hou
Summary: External jet nebulizers had a significant impact on triggering performance in both VC and PC modes, while the effects on control performance and tidal volume varied significantly.
FRONTIERS IN MEDICINE
(2022)