Review
Biochemistry & Molecular Biology
Marcela Kanova, Pavel Kohout
Summary: Skeletal muscle declines under catabolic conditions such as critical illness. Aging leads to gradual muscle loss, especially with decreased physical activity. Intensive care unit-acquired weakness is a serious neuromuscular complication characterized by systemic inflammatory response, metabolic stress, and muscle dysfunction. Mitochondrial dysfunction is a common mechanism in both aging-related decline of muscle mass and function, and in critical illness-induced muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Wei Zhang, Yun Tang, Huan Liu, Li ping Yuan, Chu chu Wang, Shu fan Chen, Jin Huang, Xin yuan Xiao
Summary: Most ICU-AW risk prediction models show good efficacy for high-risk groups, but there is bias in their development and verification processes. Large-sample, multi-center studies are needed in the future to provide a reliable basis for ICU-AW risk prediction models.
Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mustafa Ozdemir, Matthew P. Bomkamp, Hayden W. Hyatt, Ashley J. Smuder, Scott K. Powers
Summary: ICU-acquired weakness is a common result of critical illness that leads to muscle wasting and short-term complications as well as long-term disabilities. There is currently limited understanding of the cellular cause of ICU-acquired weakness and no standard treatment. Therefore, understanding the mechanisms promoting muscle atrophy in critically ill patients is crucial for developing therapeutic strategies.
Review
Urology & Nephrology
J. Pedro Teixeira, Kirby P. Mayer, Benjamin R. Griff, Naomi George, Nathaniel Jenkins, C. Anil Pal, Felipe Gonzalez-Seguel, Javier A. Neyra
Summary: Acute kidney injury (AKI) and intensive care unit-acquired weakness (ICU-AW) are two common complications of critical illness that have recently been found to have a relationship with each other. This review examines the epidemiology and pathophysiological mechanisms linking AKI and ICU-AW, and discusses interventions to mitigate the risk of ICU-AW in patients with AKI. The conclusion suggests the need for further studies to better understand the relationship between AKI, AKI-KRT, and ICU-AW, and to test interventions to improve the long-term functional status and quality of life of AKI survivors.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Medicine, General & Internal
Zi Yang, Xiaohui Wang, Guangming Chang, Qiuli Cao, Faying Wang, Zeyu Peng, Yuying Fan
Summary: This study developed and validated a prediction model for ICU-AW in adult patients in the ICU. The model included five risk factors: gender, shock, mechanical ventilation time, length of ICU stay, and age. The model showed high accuracy and provides an early screening tool for ICU-AW.
FRONTIERS IN MEDICINE
(2023)
Article
Orthopedics
Debora Schmidt, Taila Cristina Piva, Sheila Suzana Glaeser, Daniele Martins Piekala, Paula Pinheiro Berto, Gilberto Friedman, Graciele Sbruzzi
Summary: The study aimed to identify the occurrence and factors associated with ICU-acquired weakness in COVID-19 patients. It found that patients with ICUAW had lower muscle strength and mobility, and factors independently associated with ICUAW included bed rest time and use of corticosteroids.
Article
Medicine, General & Internal
Lilian Jo Engelhardt, Julius J. Grunow, Tobias Wollersheim, Niklas M. Carbon, Felix Balzer, Joachim Spranger, Steffen Weber-Carstens
Summary: This study investigated the sex-specific differences in skeletal muscle metabolism in the context of ICUAW. The results showed that critically ill women had more pronounced impairments in insulin sensitivity and lower MCSA of Type IIa fibers, which may be relevant for sex differences in ICUAW.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Weiqing Zhang, Jun Wu, Qiuying Gu, Yanting Gu, Yujin Zhao, Xiaoying Ge, Xiaojing Sun, Jun Lian, Qian Zeng
Summary: Measuring changes in muscle thickness and cross-sectional area using ultrasound can aid in diagnosing ICU-AW, with particular emphasis on the right rectus femoris muscle. Additionally, SOFA and APACHE II scores have good predictive power for ICU-AW on admission day.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Zi Yang, Xiaohui Wang, Faying Wang, Zeyu Peng, Yuying Fan
Summary: This study conducted a systematic review and meta-analysis to assess the risk factors for ICU-AW. The results indicated that female, mechanical ventilation days, age, length of ICU stay, infectious disease, renal replacement therapy, use of aminoglucoside drugs, SOFA score, and hyperglycemia are independent risk factors for ICU-AW. There was no consistent evidence found for the effects of corticosteroids, neuromuscular blockers, and sepsis on ICU-AW risk.
Article
Medicine, General & Internal
Xinyi Chen, Xiong Lei, Xin Xu, Yu Zhou, Man Huang
Summary: This retrospective study analyzed the frequency and characteristics of intensive care unit-acquired weakness (ICU-AW) in patients with extracorporeal membrane oxygenation (ECMO) support. The prevalence of ICU-AW in the ECMO population was found to be 80%. Mechanical ventilation time, deep sedation time, deep sedation time during ECMO operation, APACHE II, and lowest albumin level were identified as risk factors for ICU-AW in ECMO patients. ECMO itself was not an independent risk factor for ICU-AW.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Masafumi Matsuo, Hiroshi Sakaue, Jun Oto
Summary: Titin, a giant protein functioning as a molecular spring in sarcomeres, can be used as a biomarker for muscle atrophy and weakness, measurable in urine, aiding in the diagnosis of muscle diseases and monitoring patients' conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
M. Raurell-Torreda, S. Arias-Rivera, J. D. Marti, M. J. Frade-Mera, I. Zaragoza-Garcia, E. Gallart, T. R. Velasco-Sanz, A. San Jose-Arribas, E. Blazquez-Martinez
Summary: ICU-acquired muscle weakness has an incidence of 40-46%. In Spain, the incidence is 58%, with older age and more days on renal replacement therapy being predictors for ICUAW. Protective factors include male gender, higher Barthel Index, awake and cooperative days, presence of delirium, and more days with active mobilisation.
AUSTRALIAN CRITICAL CARE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Camille Daste, Fadila Mihoubi, Alexandra Roren, Alina Dumitrache, Nicolas Carlier, Sarah Benghanem, Aude Ruttimann, Jean-Paul Mira, Frederic Pene, Nicolas Roche, Paul Seror, Christelle Nguyen, Francois Rannou, Jean-Luc Drape, Marie-Martine Lefevre-Colau
Summary: This study describes the clinical and early shoulder-girdle MR imaging findings in severe COVID-19-related ICU-AW after ICU discharge. The results showed that within the first month after discharge, all patients exhibited severe proximal bilateral muscular weakness and peripheral muscular edema-like MRI signals of the shoulder girdle. At 3 months, most patients experienced resolution of muscular weakness and MRI signals, but shoulder pain and/or dysfunction were still present in 60% of patients.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Michele Bertoni, Simone Piva, Alessandra Beretta, Federica Bongiovanni, Riccardo Contarino, Ricard Mellado Artigas, Lucia Ceresoli, Mattia Marchesi, Michele Falappi, Marta Belleri, Alberto Goffi, Matteo Pozzi, Frank Antonio Rasulo, Nicola Latronico
Summary: This study is the first to explore the coexistence of ICUAW and DW in both cooperative and uncooperative patients. A lack of association was found between DW and ICUAW when considering both types of patients. We found a strong correlation between ICUAW and VFDs at 28 days and weaning success.
FRONTIERS IN MEDICINE
(2022)