Article
Multidisciplinary Sciences
Yazeed Zoabi, Orli Kehat, Dan Lahav, Ahuva Weiss-Meilik, Amos Adler, Noam Shomron
Summary: This study developed machine learning models to predict patient outcomes of BSI, using electronic medical records to aid in early decision making and effective patient stratification.
SCIENTIFIC REPORTS
(2021)
Review
Infectious Diseases
Anna Maria Peri, Patrick N. A. Harris, David L. Paterson
Summary: This article reviews currently available emerging assays for the diagnosis of bloodstream infections directly from whole blood, including their performance and the available data about their impact on patient outcome.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Public, Environmental & Occupational Health
Dina Hussein Yamin, Azlan Husin, Azian Harun
Summary: Catheter-related bloodstream infection, caused by various nosocomial pathogens, is an important healthcare-associated infection, with Candida parapsilosis emerging as a crucial causative agent in the last two decades. Factors such as ICU admission were found to be significantly associated with non-CRBSI, while TPN was significantly positively associated with CRBSI. Patients admitted in ICU were less likely to develop C. parapsilosis CRBSI, while patients receiving TPN were more likely to have C. parapsilosis CRBSI compared to the non-CRBSI group.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Katarina Rebrosova, Silvie Bernatova, Martin Siler, Jan Masek, Ota Samek, Jan Jezek, Martin Kizovsky, Veronika Hola, Pavel Zemanek, Filip Ruzicka
Summary: Bloodstream infections are a common cause of hospitalizations and are often life-threatening. Timely identification of the causative agent and its antimicrobial susceptibility and resistance profiles is essential for effective therapy. Raman spectroscopy is a potential method that meets the criteria of being reliable, accurate, low-cost, real-time, and easy-to-use.
MICROBIOLOGY SPECTRUM
(2023)
Article
Critical Care Medicine
Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans, Janesh Pillay
Summary: This study evaluated the diagnostic yield of FDG-PET/CT in intensive care patients with BSI, showing a high sensitivity and specificity for identifying infection foci. Poor image quality was significantly associated with decreased likelihood of finding infection foci.
Article
Immunology
Jiaxing Qiu, Alex N. Zimmet, Taison D. Bell, Shrirang Gadrey, Jackson Brandberg, Samuel Maldonado, Amanda M. Zimmet, Sarah Ratcliffe, Pavel Chernyavskiy, J. Randall Moorman, Gilles Clermont, Teague R. Henry, N. Rich Nguyen, Christopher C. Moore
Summary: This study compared the responses to bloodstream infection (BSI) in critically ill transplant and non-transplant recipients and modified the criteria for transplant recipients. The results showed that both transplant and non-transplant recipients had similar responses to BSI.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Robert J. Hart, Lisa A. Morici
Summary: The bacterium Pseudomonas aeruginosa (Pa) is a widespread pathogen causing opportunistic infections in humans and is becoming increasingly difficult to treat due to antibiotic resistance. It is estimated that at least 700,000 people die each year from drug resistant microbial infections and Pa is listed as one of the most critical species in need of novel therapeutics. Current vaccine development efforts have mainly focused on preventing pulmonary infections, but the rise in nosocomial infections, bloodstream infections, and antibiotic resistance poses a major threat to global public health. Therefore, attention should be given to potential Pa vaccine candidates and a renewed effort for prophylactic vaccine development.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Brandon R. Hadfield, Joseph B. Cantey
Summary: Recent advances in causes, diagnosis, management, and prevention of neonatal bloodstream infections (BSI) have led to a decrease in BSI incidence, but challenges such as emerging resistance and the need for novel diagnostics remain. Ongoing efforts to reduce morbidity and mortality caused by neonatal BSI must remain a priority. This review highlights the rapid changes in the field over the past 18 months.
CURRENT OPINION IN INFECTIOUS DISEASES
(2021)
Article
Immunology
Cuihong Qin, Shuguang Zhang, Yingying Zhao, Xianfei Ding, Fei Yang, Yangchao Zhao
Summary: Metagenomic next-generation sequencing (mNGS) demonstrates a higher positive rate and shorter detection period compared to blood culture in the identification of pathogens causing sepsis and bloodstream infection (BSI). Combining routine blood culture with mNGS can significantly reduce the mortality rate of septic patients with BSI.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Gaole Yuan, Yingqiu Tu, Lili Liu, Tiantian Xu
Summary: This study aimed to investigate the efficacy of fluconazole combined with caspofungin in treating Candida bloodstream infection in premature infants. Results showed that the treatment regimen successfully eliminated persistent candidemia without significant adverse effects. While the results were promising, further large-scale clinical trials are needed to validate the safety and efficacy of this treatment approach.
Article
Infectious Diseases
Yan Qiao, Zhaoyu Tao, Feiran Hao, Yongqiang Huang, Hong Sun, Pu Guo
Summary: This study retrospectively collected clinical data of 163 patients with Candida bloodstream infection and found that the distribution of Candida strains, drug susceptibility, clinical characteristics, and certain risk factors are associated with the prognosis of the infection.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Public, Environmental & Occupational Health
X. L. Ruan, X. Qin, M. Li
Summary: Pantoea dispersa, a Gram-negative bacterium, is commonly found in plants, soil, and water. It is a rare pathogen in human infectious diseases, with susceptible populations including infants and immunocompromised patients. This article reports the first case of nosocomial bloodstream infection caused by P. dispersa in China.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Microbiology
Yao-Sheng Wang, Jen-Fu Hsu, Wei-Ju Lee, Shao-Hung Wang, Shih-Ming Chu, Hsuan-Rong Huang, Peng-Hong Yang, Ren-Huei Fu, Ming-Horng Tsai
Summary: This study investigated the clinical characteristics, risk factors, and outcomes of Candida parapsilosis bloodstream infections (BSIs) in pediatric patients in Taiwan. Pediatric patients with C. parapsilosis BSIs were more likely to have previous azole exposure and be on total parenteral nutrition. The duration of C. parapsilosis candidemia was longer, and patients often required a longer duration of antifungal treatment.
Article
Microbiology
Yan-Jun Zheng, Ting Xie, Lin Wu, Xiao-Ying Liu, Ling Zhu, Ying Chen, En-Qiang Mao, Li-Zhong Han, Er-Zhen Chen, Zhi-Tao Yang
Summary: The epidemiology of Candida bloodstream infections has increased steadily over the past 11 years at a large tertiary care hospital in Shanghai. Antifungal therapy was found to influence short-term survival, with a lower mortality risk observed in patients who received treatment compared to those who did not. However, no significant difference in mortality was observed between patients who received early appropriate and targeted antifungal therapy.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Microbiology
Cynthia Ortiz-Roa, Martha Carolina Valderrama-Rios, Sebastian Felipe Sierra-Umana, Jose Yesid Rodriguez, Gerardo Antonio Muneton-Lopez, Carlos Augusto Solorzano-Ramos, Patricia Escandon, Carlos Arturo Alvarez-Moreno, Jorge Alberto Cortes
Summary: Candida auris infection is associated with lower mortality in adult patients with candidemia compared to other Candida species, and it does not affect the length of hospital stay in surviving patients.