Article
Immunology
Andre Bredthauer, Angela Geiger, Michael Gruber, Sophie-Marie Pfaehler, Walter Petermichl, Diane Bitzinger, Thomas Metterlein, Timo Seyfried
Summary: Propofol has been shown to have an impact on the activity of neutrophils, accelerating NETosis and ROS production in sepsis. The drug demonstrates positive effects in improving immune function, but further research is needed to explore its potential benefits in septic patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Shujing Zou, Hongyu Jie, Xinai Han, Jinghong Wang
Summary: Neutrophil extracellular traps (NETs) play a critical role in the inflammatory response and bacterial clearance, but their excessive activation can cause an inflammatory storm and organ dysfunction. Acute lung injury caused by sepsis is the main cause of organ damage. NET formation can accelerate the development of acute lung injury through the release of cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Fuquan Wang, Ming Chen, Chenchen Wang, Haifa Xia, Dingyu Zhang, Shanglong Yao
Summary: Maresin1 plays an important role in regulating neutrophils and has potential value in the treatment of septic lung injury. Using single-cell sequencing technology, this study revealed for the first time the regulatory mechanism of Maresin1 on neutrophils.
Article
Physiology
Chaojin Chen, Zheng Zhang, Fang Tan, Fanbing Meng, Lifei Lai, Xinjin Chi, Qianqian Zhu
Summary: This study found that mast cell activation and polymorphonuclear neutrophil apoptosis were associated with acute lung injury after orthotopic liver transplantation. Delayed polymorphonuclear neutrophil apoptosis was related to the progression of acute lung injury. Inducing polymorphonuclear neutrophil apoptosis may help alleviate acute lung injury after orthotopic liver transplantation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sanjay Pandey, Vandana Anang, Saurabh Singh, Saurabh Seth, Anant Narayan Bhatt, Namita Kalra, Kailash Manda, Ravi Soni, Bal Gangadhar Roy, K. Natarajan, Bilikere S. Dwarakanath
Summary: Pathogen-associated molecular patterns (PAMPs) are known ligands of innate inflammatory receptors that trigger acute inflammation and oxidative stress-driven tissue toxicity. Targeting the metabolism of inflammatory events, using an energy restriction approach, can be an effective strategy to prevent the detrimental effects of bacterial and other pathogenic exposures.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Critical Care Medicine
Jieyan Wang, Yingyi Luan, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Jie Fan
Summary: The study identifies an intra-PMN mechanism that negatively regulates necroptosis mediated through TBK1/IKK epsilon, reducing inflammation by suppressing the formation of the necrosome complex. The LPS-TLR4-TBK1 axis serves as a negative regulator for PMN necroptosis, suggesting it may be a therapeutic target for modulating PMN death and inflammation.
Review
Clinical Neurology
Mahlet Mekonnen, Vera Ong, Timothy J. Florence, Khashayar Mozaffari, Natalie Mahgerefteh, Shivam Rana, Courtney Duong, David S. Plurad, Isaac Yang
Summary: This article reviewed clinical protocols regarding the use of hypertonic saline (HTS) in the treatment of traumatic brain injury (TBI). The study found that 3% and 7.5% concentrations of HTS were the most commonly used and demonstrated efficacy in reducing intracranial pressure (ICP) and improving Glasgow Coma Scale (GCS) score. Lower concentrations of HTS were also found to be more effective in reducing ICP. Therefore, the use of lower concentrations of HTS may be a practical approach in the treatment of TBI.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Ying Luo, Cui Wang, Zhaoxiang Du, Chuan Wang, Yimou Wu, Aihua Lei
Summary: This study found that the number of polymorphonuclear neutrophils (PMN) increased significantly after Chlamydia psittaci infection, accompanied by the expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO) in the lungs of mice. PMN were the main source of NO during pulmonary infection and inhibited the replication of C. psittaci in an iNOS/NO-dependent manner. Therefore, this study highlights the protective role of NO-producing PMN in C. psittaci infection.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Critical Care Medicine
Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. R. Zanier, Fabio Silvio Taccone
Summary: Prognosis after resuscitation from cardiac arrest (CA) is poor, but hypertonic sodium lactate (HSL) infusion may have beneficial effects on brain and cardiac injury. This study aimed to test the effects of HSL infusion in an experimental model of CA.
Article
Biochemistry & Molecular Biology
Silvia Sgambellone, Silvia Marri, Stefano Catarinicchia, Alessandro Pini, Dilip K. Tosh, Kenneth A. Jacobson, Emanuela Masini, Daniela Salvemini, Laura Lucarini
Summary: This study demonstrates the therapeutic potential of the A(3)AR agonist, MRS5980, in lung fibrosis by reducing inflammation, TGF-β expression, and fibrotic remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Shahin Isha, Parthkumar H. Satashia, Siva Naga S. Yarrarapu, Austin B. Govero, Michael F. Harrison, Hassan Z. Baig, Pramod Guru, Anirban Bhattacharyya, Colleen T. Ball, Sean M. Caples, Ami A. Grek, Michael R. Vizzini, Syed Anjum Khan, Katherine J. Heise, Hiroshi Sekiguchi, Warren L. Cantrell, Jeffrey D. Smith, Sanjay Chaudhary, Karthik Gnanapandithan, Kristine M. Thompson, Charles G. Graham, Jed C. Cowdell, Aleksandra Murawska Baptista, Claudia R. Libertin, Pablo Moreno Franco, Devang K. Sanghavi
Summary: In this study, the effectiveness of predominantly using normal saline and lactated ringers in septic shock patients was compared. The results showed no statistically significant differences between the two groups in terms of mortality rates, hospital LOS, ICU admission after diagnosis, mechanical ventilation, oxygen therapy, and RRT. Larger-scale prospective studies are needed to further establish guidelines for the use of balanced crystalloids.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Zhiyuan Ma, Mahesh Krishnamurthy, Vivek Modi, David Allen, Jamshid Shirani
Summary: This retrospective study found a significant association between cardiac troponin release on admission and higher in-hospital mortality and 1-year mortality among septic patients. Further analysis revealed that adequate fluid resuscitation can lower in-hospital mortality in septic patients without cardiac troponin release, but not in those with it.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Critical Care Medicine
Olivier Huet, Xavier Chapalain, Veronique Vermeersch, Jean-Denis Moyer, Sigismond Lasocki, Benjamin Cohen, Claire Dahyot-Fizelier, Kevin Chalard, P. Seguin, Y. Hourmant, Karim Asehnoune, Antoine Roquilly
Summary: The study aimed to evaluate whether increased chloride intake during continuous infusion of 20% hypertonic saline solution is associated with an increase in the incidence of acute kidney injury in traumatic brain injury patients. The results showed that despite the significant increase in chloride intake, continuous infusion of hypertonic saline solution was not associated with acute kidney injury.
Article
Biochemistry & Molecular Biology
Aiping Le, Wei Liu, Chenggao Wu, Piaoping Hu, Juan Zou, Yize Wu, Linju Kuang
Summary: This study found that HLA-A2 antibody activates Src phosphorylation, NF-kappa B, and NLRP3 inflammasome, leading to the activation of PMNs and exacerbation of TRALI. This discovery provides a promising target for the treatment of antibody-mediated TRALI.
MOLECULAR IMMUNOLOGY
(2022)
Article
Anesthesiology
Fang Xu, Yanan Li, Xupeng Wang, Ran Sun, Zilei Zheng, Qi Zhang, Mingyang Gao, Wei Tao, Juan Zhao, Qiujun Wang
Summary: This study found that pre-infusion of hypertonic saline can reduce the incidence of postoperative delirium in elderly patients and alleviate the immune-inflammatory response.
BMC ANESTHESIOLOGY
(2023)
Article
Critical Care Medicine
Yuka Sumi, Carola Ledderose, Linglin Li, Yoshiaki Inoue, Ken Okamoto, Yutaka Kondo, Koichiro Sueyoshi, Wolfgang G. Junger, Hiroshi Tanaka
Article
Biochemistry & Molecular Biology
Koichiro Sueyoshi, Carola Ledderose, Yong Shen, Albert H. Lee, Nathan I. Shapiro, Wolfgang G. Junger
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Severin Muehleder, Christiane Fuchs, Jose Basilio, Dorota Szwarc, Karoline Pill, Krystyna Labuda, Paul Slezak, Christian Siehs, Johannes Proell, Eleni Priglinger, Carsten Hoffmann, Wolfgang G. Junger, Heinz Redl, Wolfgang Holnthoner
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Cell Biology
Yutaka Kondo, Carola Ledderose, Christian J. Slubowski, Mahtab Fakhari, Yuka Sumi, Koichiro Sueyoshi, Ann-Katrin Bezler, Dilan Aytan, Mona Arbab, Wolfgang G. Junger
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Critical Care Medicine
Yutaka Kondo, Koichiro Sueyoshi, Jingping Zhang, Yi Bao, Xiaoou Li, Mahtab Fakhari, Christian J. Slubowski, Soheyl Bahrami, Carola Ledderose, Wolfgang G. Junger
Article
Allergy
Tanya Novak, Mark W. Hall, Douglas R. McDonald, Margaret M. Newhams, Anushay J. Mistry, Angela Panoskaltsis-Mortari, Peter M. Mourani, Laura L. Loftis, Scott L. Weiss, Keiko M. Tarquinio, Barry Markovitz, Mary E. Hartman, Adam Schwarz, Wolfgang G. Junger, Adrienne G. Randolph
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Immunology
Saltanat Ualiyeva, Nils Hallen, Yoshihide Kanaoka, Carola Ledderose, Ichiro Matsumoto, Wolfgang G. Junger, Nora A. Barrett, Lora G. Bankova
SCIENCE IMMUNOLOGY
(2020)
Article
Cell Biology
Carola Ledderose, Sophie Bromberger, Christian J. Slubowski, Koichiro Sueyoshi, Wolfgang G. Junger
Summary: This study demonstrates the importance of P2Y11 receptors in sustaining T cell activation mechanisms by promoting mitochondrial trafficking to the IS through cAMP/PKA signaling.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Correction
Multidisciplinary Sciences
Aiping Bai, Alan Moss, Sonja Rothweiler, Maria Serena Longhi, Yan Wu, Wolfgang G. Junger, Simon C. Robson
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Elizabeth H. Zhong, Carola Ledderose, Paola De Andrade Mello, Keiichi Enjyoji, Justin Mark Lunderberg, Wolfgang Junger, Simon C. Robson
Summary: This study demonstrates the synergistic effects of ectoenzymes such as CD39 and CD73 in reducing inflammatory responses, suggesting that these bifunctional enzymes could serve as therapeutic agents in inflammatory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ana Badimon, Hayley J. Strasburger, Pinar Ayata, Xinhong Chen, Aditya Nair, Ako Ikegami, Philip Hwang, Andrew T. Chan, Steven M. Graves, Joseph O. Uweru, Carola Ledderose, Munir Gunes Kutlu, Michael A. Wheeler, Anat Kahan, Masago Ishikawa, Ying-Chih Wang, Yong-Hwee E. Loh, Jean X. Jiang, D. James Surmeier, Simon C. Robson, Wolfgang G. Junger, Robert Sebra, Erin S. Calipari, Paul J. Kenny, Ukpong B. Eyo, Marco Colonna, Francisco J. Quintana, Hiroaki Wake, Viviana Gradinaru, Anne Schaefer
Article
Biochemistry & Molecular Biology
Carola Ledderose, Sophie Bromberger, Christian J. Slubowski, Koichiro Sueyoshi, Dilan Aytan, Yong Shen, Wolfgang G. Junger
Review
Immunology
Carola Ledderose, Wolfgang G. Junger
FRONTIERS IN IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Saltanat Ualiyeva, Nils Hallen, Wolfgang Junger, Carola Ledderose, Nora Barrett, Lora Bankova
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Critical Care Medicine
Wolfgang Junger