Article
Cardiac & Cardiovascular Systems
Benjamin Grimmer, Adrienn Krauszman, Xudong Hu, Golam Kabir, Kim A. Connelly, Mei Li, Jana Grune, Christian Madry, Brant E. Isakson, Wolfgang M. Kuebler
Summary: This study identifies Panx1 as a novel regulator of HPV, but its role is not necessarily linked to ATP release and downstream signaling via P2Y receptors or TRPV4 activation. Instead, Panx1 appears to modulate the Ca2+ response of PASMC to hypoxia. Furthermore, Panx1 does not affect the development of chronic hypoxic PH.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Juliane Hannemann, Patricia Siques, Lena Schmidt-Hutten, Julia Zummack, Julio Brito, Rainer Boeger
Summary: Chronic intermittent hypoxia leads to high-altitude pulmonary hypertension due to high asymmetric dimethylarginine (ADMA) levels. Genetic variations in the dimethylarginine pathway play a role in determining ADMA concentration and the development of HAPH. Different genes are involved in regulating plasma ADMA levels and impacting altitude-related diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Tyler Kelly, Courtney Brown, Mohini Bryant-Ekstrand, Rachel Lord, Tony Dawkins, Aimee Drane, Joel E. Futral, Otto Barak, Tanja Dragun, Michael Stembridge, Boris Spajic, Ivan Drvis, Joseph W. Duke, Philip N. Ainslie, Glen E. Foster, Zeljko Dujic, Andrew T. Lovering
Summary: This study aimed to investigate the pulmonary vasoreactivity and right heart work in apnoea divers under the stress of hyperbaric, hypercapnic, acidotic, and hypoxic conditions. The findings showed that divers experienced less change in total pulmonary resistance compared to the control group during short-duration isocapnic hypoxia. The administration of sildenafil had a similar effect on reducing pulmonary resistance in both divers and controls. This suggests that divers can maintain normal pulmonary artery tone in hypoxic conditions, which might be a beneficial adaptation for apnoea diving.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mike Stembridge, Ryan L. Hoiland, Alexandra M. Williams, Connor A. Howe, Joseph Donnelly, Tony G. Dawkins, Aimee Drane, Michael M. Tymko, Christopher Gasho, James Anholm, Lydia L. Simpson, Jonathan P. Moore, Damian M. Bailey, David B. MacLeod, Philip N. Ainslie
Summary: The study demonstrates that hemodilution can impact hypoxic pulmonary vasoconstriction (HPV) through increased frictional force and vasoactive signaling from erythrocytes. The balance of these mechanisms is influenced by the duration of hypoxia exposure and hematocrit level. While hemodilution mildly increased pulmonary artery systolic pressure (PASP) and pulmonary vascular resistance (PVR) at sea level, it did not significantly alter these parameters at high altitude, where both remained sensitive to additional acute hypoxia. In Andean high-altitude natives with excessive erythrocytosis, hemodilution lowered PVR but did not change PASP due to compensatory increase in cardiac output.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Pediatrics
Nicolle Fernandez Dyess, Claire Palmer, Roger F. Soll, Reese H. Clark, Steven H. Abman, John P. Kinsella
Summary: This study aimed to describe the treatment practices and outcomes of preterm infants with early hypoxemic respiratory failure and pulmonary hypertension. The results showed that these infants had high early mortality and a high risk of bronchopulmonary dysplasia. Inhaled nitric oxide was commonly used for the treatment of early-onset pulmonary hypertension in preterm infants, but it did not significantly improve patient outcomes.
JOURNAL OF PEDIATRICS
(2023)
Article
Neurosciences
Christopher K. Willie, Alexander Patrician, Ryan L. Hoiland, Alexandra M. Williams, Christopher Gasho, Prajan Subedi, James Anholm, Aimee Drane, Michael M. Tymko, Daniela Nowak-Fluck, Sawyer Plato, Emily McBride, Giovanfrancesco Varoli, Gordon Binsted, Lindsay K. Eller, Raylene A. Reimer, David B. MacLeod, Michael Stembridge, Philip N. Ainslie
Summary: Iron plays an influential role in the modulation of hypoxic pulmonary vasoconstriction at high altitude. Lowerlanders experienced a more significant reduction in iron bioavailability compared to Sherpa during ascent to 5050 m. Iron infusion attenuated PASP at rest, while chelation did not exacerbate PASP during rest or exaggerated hypoxemia.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Review
Chemistry, Multidisciplinary
Dong Liu, Mengmeng Long, Leilei Gao, Yanjun Chen, Fang Li, Yang Shi, Ning Gu
Summary: The respiratory system is crucial in vertebrate biology, but viral infections can cause severe damage. Currently, there are no effective treatments, but nanomedicine shows potential. This review provides a summary of the pathology and clinical treatments of respiratory injuries, focusing on nanomedicine formulations tested in preclinical models.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Physiology
Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala Dakshinamurti
Summary: This study investigated the effects of sodium nitroprusside (NO donor) in treating hypoxic persistent pulmonary hypertension in newborns. The results showed that sodium nitroprusside can reduce reactive oxygen species accumulation, enhance cell relaxation, and inhibit adenylyl cyclase activity. Additionally, sodium nitroprusside can decrease protein nitrosylation levels. These findings provide insights into the reduced effectiveness of NO treatment in hypoxic pulmonary hypertension.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xizhong Cui, Jeffrey Wang, Yan Li, Zoe G. Couse, Thomas F. Risoleo, Mahtab Moayeri, Stephen H. Leppla, Daniela Malide, Zu-Xi Yu, Peter Q. Eichacker
Summary: This study shows that Bacillus anthracis edema toxin can inhibit hypoxic pulmonary vasoconstriction, potentially worsening hypoxemia during invasive anthrax lung infection. The findings suggest that both edema toxin and lethal toxin can contribute to pulmonary pathophysiology during infection, highlighting the importance of antitoxin therapies in managing severe anthrax disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Dermatology
Seyhan Taskin, Hakim Celik, Gokhan Cakirca, Vildan Manav, Abdullah Taskin
Summary: This study found that patients with alopecia areata are exposed to potent nitrosative stress. Specifically, peroxynitrite, acting as a bridge between reactive oxygen species and reactive nitrogen species, triggers the expansion of oxidative stress cascade. Nitrosative stress may play a role in the pathogenesis of alopecia areata. Nitrosative stress parameters, particularly NOS activity, may be potential markers for alopecia areata.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Microbiology
Harrison Dulin, Nathan Hendricks, Duo Xu, Linfeng Gao, Keidy Wuang, Huiwang Ai, Rong Hai
Summary: Influenza virus proteins can be nitrated, which decreases virus infectivity and replication ex vivo, but the inhibitory effect of nitration on virus functions in vivo may be insufficient. Understanding the role of peroxynitrite during influenza virus infections can provide valuable insights.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, Research & Experimental
Qiaoyi Xu, Shuya Mei, Fang Nie, Zhiyun Zhang, Junqi Feng, Jinyuan Zhang, Xiaoqing Qian, Yuan Gao, Zhengyu He, Shunpeng Xing
Summary: The study demonstrates that lipopolysaccharide induces activation of the JNK signaling pathway and TNF-alpha secretion in pulmonary macrophages, leading to interaction between inflammation and metabolism that promotes lung fibroblast glycolysis. This interaction plays a crucial role in lipopolysaccharide-induced pulmonary fibrosis.
LABORATORY INVESTIGATION
(2022)
Article
Critical Care Medicine
Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Mueller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller, Sascha David
Summary: The study identified MIR155 as an upregulated candidate in the endothelium of murine pulmonary cells during endotoxemia. Experimental overexpression of MIR155 induced vascular leakage in zebrafish and HUVECs, while genetic reduction of MIR155 protected against permeability in vitro and in vivo. MIR155 may have potential as a therapeutic target for addressing vascular leakage in systemic inflammatory responses.
Article
Cardiac & Cardiovascular Systems
Marton Vezer, Agota Demeter, Maria Szekeres, Attila Josvai, Balint Banyai, Attila Olah, Fruzsina Balogh, Eszter M. Horvath, Tamas Radovits, Bela Merkely, Nandor Acs, Gyorgy L. Nadasy, Marianna Torok, Szabolcs Varbiro
Summary: Exercise can alter hemodynamics and renal artery function, with sex differences observed. Swim training can mitigate renal artery vasoconstriction in male rats, while depressing elastic fiber and smooth muscle actin density in female rats.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biology
Reka Eszter Sziva, Julia acs, Anna-Maria Tokes, Agnes Korsos-Novak, Gyoergy L. Nadasy, Nandor acs, Peter Gabor Horvath, Anett Szabo, Haoran Ke, Eszter Maria Horvath, Zsolt Kopa, Szabolcs Varbiro
Summary: This study describes a new, accurate, and easy-to-use quantitative computer-based histomorphometric-mathematical image analysis method for evaluating testicular tissue. The method measures quantitatively describable characteristics and immunohistochemical staining intensity on digitized images to improve reproducibility and objectivity in andrological-reproductive medicine research. The technique could be further automated with machine learning and artificial intelligence, and it can be named 'Computer-Assisted or -Aided Testis Histology' (CATHI).
Meeting Abstract
Cardiac & Cardiovascular Systems
A. A. Sayour, M. Ruppert, A. Olah, B. A. Barta, E. Zsary, K. Benke, E. M. Horvath, I Hartyanszky, B. Merkely, T. Radovits
CARDIOVASCULAR RESEARCH
(2022)
Review
Engineering, Biomedical
Marc O. Maybauer, Massimo Capoccia, Dirk M. Maybauer, Roberto Lorusso, Justyna Swol, Joseph M. Brewer
Summary: This study assessed the application of the ProtekDuo cannula for dedicated right ventricular support in COVID-19 ARDS, and found that it had favorable outcomes with lower mortality, incidence of acute kidney injury, and use of continuous renal replacement therapy compared to other respiratory support modalities.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Review
Cardiac & Cardiovascular Systems
Joseph M. Brewer, Massimo Capoccia, Dirk M. Maybauer, Roberto Lorusso, Justyna Swol, Marc O. Maybauer
Summary: This systematic review aimed to describe the patient survival and complications when the ProtekDuo cannula was used as part of a temporary percutaneous right ventricular assist device (RVAD) system. Seven studies with 127 patients were included. The results showed that patients treated with the ProtekDuo cannula had comparable survival rates and complications to other tpRVAD systems.
Article
Engineering, Biomedical
Ahmed M. El Banayosy, Aly El Banayosy, Jennifer G. Smith, Joseph M. Brewer, Mircea R. Mihu, Laura Swant, Robert S. Schoaps, Ammar Sharif, Clayne Benson, Marc O. Maybauer
Summary: This retrospective study examined the outcomes of using extracorporeal membrane oxygenation (ECMO) for pregnant and postpartum patients with COVID-19 acute respiratory distress syndrome (ARDS). The study showed a 100% survival rate for both the mothers and newborns, highlighting the safety and effectiveness of ECMO in this patient population.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Review
Engineering, Biomedical
Massimo Capoccia, Dirk M. Maybauer, Joseph M. Brewer, Marc O. Maybauer
Summary: This study reviewed the role of ECMO in managing burn and smoke inhalation injuries in adult patients. A systematic literature search was conducted to evaluate the effectiveness of this support strategy. Out of 269 articles, 26 were considered suitable for this study. Although there is increasing evidence supporting the use of ECMO for burn injuries in adults, it should only be considered if a likely successful outcome is expected.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Review
Engineering, Biomedical
Marc O. Maybauer, Dirk M. Maybauer, Massimo Capoccia
Summary: A systematic review examined the use of extracorporeal life support (ECLS) in pediatric patients with burn and smoke inhalation injury. Despite limited studies, ECMO was found to provide additional support and positive outcomes in these patients, especially with V-V configuration. Prolonged mechanical ventilation prior to ECMO decreased survival, while good outcomes were reported in scald burns, dressing changes, and pre-ECMO cardiac arrest cases.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph M. Brewer, Jeffrey Sparling, Marc O. Maybauer
Summary: High-risk/massive pulmonary embolism (PE) has a high mortality rate, and venoarterial (V-A) extracorporeal membrane oxygenation (ECMO) can effectively restore and maintain circulation. Catheter-based embolectomy (CBE) is a minimally invasive technique that allows clot removal and resolution of shock. Rapid placement of V-A ECMO prior to CBE can provide circulatory protection throughout the procedure.
Article
Biology
Marton Vezer, Attila Josvai, Balint Banyai, Nandor acs, Marton Keszthelyi, Eszter Soltesz-Katona, Maria Szekeres, Attila Olah, Tamas Radovits, Bela Merkely, Eszter M. Horvath, Gyorgy L. Nadasy, Marianna Toeroek, Szabolcs Varbiro
Summary: This study aimed to investigate the gender differences in adaptation mechanisms of femoral arteries to sports training. An examination of vascular reactivity and histology was conducted following a 12-week swimming training. The results showed that male animals had a significantly higher relaxation reserve capacity compared to females after exercise training.
Article
Cardiac & Cardiovascular Systems
J. Michael Brewer, L. Mikael Broman, Justyna Swol, Roberto Lorusso, Steven A. Conrad, Marc O. Maybauer
Summary: There is poor adherence to standardized nomenclature in describing PPC-PA in publications, indicating the need for a user-guide to ensure proper usage of terminology.
Article
Engineering, Biomedical
Ammar Sharif, J. Michael Brewer, Aly El Banayosy, Mircea R. Mihu, Zachary Reaves, Laura Swant, Robert S. Schoaps, Clayne Benson, Malik Ibithaj Khalid, Marc O. Maybauer
Summary: This retrospective study analyzed the clinical presentation and outcomes of patients with DKA who received ECMO treatment. The results suggest that ECMO is a viable support option for managing these patients and has excellent outcomes.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Meeting Abstract
Peripheral Vascular Disease
Eszter Maria Horvath, Miklos Sipos, Dora Gerszi, Hicham Dalloul, Balint Balint, Reka Eszter Sziva, Reka Kollarich, Peter Magyar, Marianna Torok, Nandor Acs, Maria Szekeres, Leila Hadjadj, Gyorgy L. Nadasy, Szabolcs Varbiro
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Eszter Maria Horvath, Miklos Sipos, Dora Gerszi, Hicham Dalloul, Balint Balint, Reka Eszter Sziva, Reka Kollarich, Peter Magyar, Marianna Torok, Nandor Acs, Maria Szekeres, Leila Hadjadj, Gyorgy L. Nadasy, Szabolcs Varbiro
JOURNAL OF HYPERTENSION
(2022)
Article
Anesthesiology
Marc O. Maybauer, Michael M. Koerner, Mircea R. Mihu, Michael D. Harper, Aly El Banayosy
Summary: This case report presents a COVID-19 patient with ARDS who was treated with V-V ECMO and RVAD. The device configuration was modified to improve oxygenation and blood flow by inserting a femoral drainage cannula and using a Y-connector.
ANNALS OF CARDIAC ANAESTHESIA
(2022)