期刊
CORTEX
卷 108, 期 -, 页码 252-264出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2018.08.002
关键词
Primary progressive aphasia; Functional connectivity; Graph theory; Speech production network; Topological configuration
资金
- National Institutes of Health [NINDS R01NS050915, NIDCD K24DC015544, NIDCD R01DC016291, NIA U01AG052943, NIA P50AG023501, NIA P01AG019724, R01AG038791, U01AG045390, U54NS092089]
- Alzheimer's Disease Research Center of California [03-75271]
- Larry L. Hillblom Foundation [2013-A-029-SUP, 2005/2T]
- John Douglas French Alzheimer's Foundation
- Koret Family Foundation
- Consortium for Frontotemporal Dementia Research
- McBean Family Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U54NS092089, R01NS050915, R01NS100440] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG038791, U01AG052943, P01AG019724, T32AG023481, U01AG045390, P50AG023501, K01AG055698, R01AG058233, K23AG048291] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC016291, K24DC015544] Funding Source: NIH RePORTER
Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neuro-degeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies have exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data from a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neuro-degeneration. We hypothesized that changes in the network architecture would be specific to the affected SPN in nfvPPA, while preserved in the spared default mode network (DMN). Topological configuration was quantified by hub location and global network metrics. Our findings showed a less efficiently wired and less optimally clustered SPN, while no changes were detected in the DMN. The SPN in the nfvPPA group showed a loss of hubs in the left fronto-parietal-temporal area and new critical nodes in the anterior left inferior-frontal and right frontal regions. Behaviorally, speech production score and rule violation errors correlated with the strength of functional connectivity of the left (lost) and right (new) regions respectively. This study shows that focal neurodegeneration within the SPN in nfvPPA is associated with network-specific topological alterations, with the loss and gain of crucial hubs and decreased global efficiency that were better accounted for through functional rather than structural changes. These findings support the hypothesis of selective network vulnerability in nfvPPA and may offer biomarkers for future behavioral intervention. (C) 2018 Elsevier Ltd. All rights reserved.
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