Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Health Care Sciences & Services
Nikolai Shcherbakov, Nataliya Varako, Maria Kovyazina, Yulia Zueva, Maria Baulina, Anatoliy Skvortsov, Daria Chernikova
Summary: This study investigated the effectiveness of group training for executive function disorder rehabilitation in neurological patients. Positive trends were observed in the evaluation methods, although not all reached statistical significance. Results indicated a positive dynamic in the state of executive functions.
Article
Clinical Neurology
Beth K. Rush, Philip W. Tipton, Audrey Strongosky, Zbigniew K. Wszolek
Summary: The neuropsychological profile of CSF1R-related leukoencephalopathy (CRL) is characterized by impaired general cognitive function, processing speed, executive function, speeded visual problem solving, verbal fluency, and self-reported depression and anxiety. Confrontation naming and memory are preserved, distinguishing CRL from other dementia syndromes. Certain measures within cognitive domains show a higher frequency of impairment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Angie A. Diaz Baquero, Manuel A. Franco-Martin, Esther Parra Vidales, Jose Miguel Toribio-Guzman, Yolanda Bueno-Aguado, Fernando Martinez Abad, Maria Perea Bartolome, Aysan Mahmoudi Asl, Henriette G. van der Roest
Summary: This study evaluated the effectiveness of the cognitive rehabilitation program GRADIOR in people with mild cognitive impairment and mild dementia. The results showed that the program improved and maintained cognitive functions in most participants, while the control group showed a worsening trend for most measures at 12 months.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Carel F. W. Peeters, Adriaan W. Hoogendoorn, Rob H. Hagen, Tanja Berk, Odile A. van den Heuvel, Chris Vriend
Summary: This study found no beneficial effect of eight-week computerized cognitive training on the primary outcome (planning accuracy) and only minor improvements on secondary outcomes (processing speed) with limited clinical impact.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Neurosciences
Themis Papaioannou, Alexandra Voinescu, Karin Petrini, Danae Stanton Fraser, Cosimo Tuena
Summary: The study found that VR training has moderate to large effects on cognitive abilities in patients with MCI and dementia, improving global cognition, attention, memory, and construction and motor performance in MCI patients, as well as global cognition, memory, and executive function in dementia patients. Moderators such as immersion and training type significantly influence the effects of VR training.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, General & Internal
Charles R. Joseph, Michael P. Cargill, Chansoon D. Lee
Summary: The study validated a 1-minute timed categorical recall (TCR) method for dementia screening, which involves rapid naming of US cities, and compared it with the Folstein Minimental Status Exam (MMSE). The results showed that TCR has high accuracy, sensitivity, and specificity as a preliminary screening tool for dementia.
Review
Psychology, Multidisciplinary
Paloma E. Fava-Felix, Silvia R. C. Bonome-Vanzelli, Fabiana S. Ribeiro, Flavia H. Santos
Summary: This review investigates the cognitive, functional, and behavioral effects of computerized rehabilitation in stroke patients and considers cognitive reserve proxies. The findings suggest that combining computerized cognitive training with education as a cognitive reserve proxy can improve cognitive abilities in patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Jay A. Olson, Johnny Nahas, Denis Chmoulevitch, Simon J. Cropper, Margaret E. Webb
Summary: This study explores the relationship between semantic distance and creativity, finding that greater semantic distances are associated with higher creativity scores. The method of naming unrelated words as a way to measure divergent thinking can serve as a brief, reliable, and objective tool for assessing creativity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Jean K. Ho, Daniel A. Nation
Summary: This study operationalized neuropsychological decline in older adults and found that it can predict future dementia, providing valuable information for prognosis and clinical decision-making.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Radia Zeghari, Rachid Guerchouche, Minh Tran-Duc, Francois Bremond, Kai Langel, Inez Ramakers, Nathalie Amiel, Maria Pascale Lemoine, Vincent Bultingaire, Valeria Manera, Philippe Robert, Alexandra Konig
Summary: With limited access to diagnosis and care in rural isolated areas, telemedicine platforms have become increasingly important during the pandemic. This study focuses on the feasibility of remote neuropsychological assessment for older adults with cognitive complaints. The results show high agreement between remote and face-to-face assessments, although differences in test performances were observed.
Article
Neurosciences
Seyul Kwak, Hairin Kim, Hoyoung Kim, Yoosik Youm, Jeanyung Chey
Summary: This study identified the optimal combination of functional connectivities that predict neuropsychological test scores, showing that connectivity-based predicted scores can track actual behavioral test scores effectively. Models utilizing most of the connectivity features demonstrated better accuracy than those using focal connectivity features, indicating a largely distributed neural basis across multiple brain systems.
HUMAN BRAIN MAPPING
(2021)
Review
Rehabilitation
Yuanyuan Ren, Qingjie Wang, Houyu Liu, Guodong Wang, Aming Lu
Summary: Virtual reality (VR)-based rehabilitation training has significant effects on cognition, motor function, and daily functioning in patients with mild cognitive impairment and dementia. Immersive VR-based training has greater effects on cognition and motor function, while non-immersive VR-based training is more convenient for patients with limitations. An intervention lasting 5-8 weeks, for >30 min at a frequency of >= 3 times/week achieved the best results.
CLINICAL REHABILITATION
(2023)
Article
Clinical Neurology
Masaki Sonoda, Robert Rothermel, Alanna Carlson, Jeong-Won Jeong, Min-Hee Lee, Takahiro Hayashi, Aimee F. Luat, Sandeep Sood, Eishi Asano
Summary: This prospective study showed that intracranially recorded spectral responses can predict neuropsychological outcomes after epilepsy surgery. The researchers found that high gamma augmentation was associated with a decline in core language scores and expressive language index, while low gamma augmentation and alpha/beta attenuation independently predicted a decline in core language scores. They also developed a machine learning model that accurately predicted patients with postoperative language decline. This study is important for improving neuropsychological predictions in patients undergoing epilepsy surgery.
Article
Psychiatry
Frances Louise Dark, Victoria Gore-Jones, Ellie Newman, Maddison Wheeler, Veronica Demonte, Korinne Northwood
Summary: This study compared the relative effectiveness of Cognitive Compensatory Training (CCT) and Computerized Interactive Remediation of Cognition-Training for Schizophrenia (CIRCuiTs). The results showed no significant difference between the two approaches in terms of cognitive and functional outcomes. This finding has implications for addressing cognitive deficits in schizophrenia spectrum disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Sharon A. Savage, Leonie F. Lampe, Lyndsey Nickels
Summary: This study examined the effects of tailored word retraining on picture naming in individuals with semantic dementia (SD). The results showed that word retraining significantly improved the naming ability of trained vocabulary without increasing word misuse. Although there was an increased tendency for omission errors in untrained items, communication clarity did not significantly change.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Geriatrics & Gerontology
Alinka C. Fisher, Sau C. Cheung, Claire M. C. O'Connor, Olivier Piguet
Summary: This pilot study investigated the acceptability and usefulness of a Positive Behaviour Support (PBS) education program for family carers of individuals with behavioural-variant frontotemporal dementia (bvFTD). The results indicate that the program was helpful in improving the carers' capability in providing behaviour support, with positive changes observed in their approach.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Review
Psychology, Clinical
Jan Van den Stock, Maxime Bertoux, Janine Diehl-Schmid, Olivier Piguet, Katherine P. Rankin, Florence Pasquier, Simon Ducharme, Yolande Pijnenburg, Fiona Kumfor
Summary: Dodich et al. reviewed the clinical use of social cognition assessment in behavioral variant frontotemporal dementia and proposed an initiative to address the limitations in their study.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Psychology
Marianne Jarsch, Olivier Piguet, Manfred Berres, Constantin Sluka, Anna Semenkova, Reto W. Kressig, Andreas U. Monsch, Skye McDonald, Marc Sollberger
Summary: This study aimed to develop the first German-language adaptation of TASIT-SIM, an ecologically valid test for assessing Theory of Mind (ToM) abilities in healthy adults. Thirteen scenes were selected and filmed at different intensities to determine the best materials for the test. Through Rasch analysis, intensity versions were chosen that showed optimal performance in participants with medium ToM abilities. In conclusion, the Basel Version of the Awareness of Social Inference Test - Theory of Mind (BASIT-ToM) was developed, incorporating the strengths of TASIT-SIM and addressing its limitations. Further validation of BASIT-ToM is needed in both healthy and clinical populations.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antony Kaspi, Michael S. Hildebrand, Victoria E. Jackson, Ruth Braden, Olivia van Reyk, Tegan Howell, Simone Debono, Mariana Lauretta, Lottie Morison, Matthew J. Coleman, Richard Webster, David Coman, Himanshu Goel, Mathew Wallis, Gabriel Dabscheck, Lilian Downie, Emma K. Baker, Bronwyn Parry-Fielder, Kirrie Ballard, Eva Harrold, Shaun Ziegenfusz, Mark F. Bennett, Erandee Robertson, Longfei Wang, Amber Boys, Simon E. Fisher, David J. Amor, Ingrid E. Scheffer, Melanie Bahlo, Angela T. Morgan
Summary: This study identified new candidate genes associated with childhood apraxia of speech (CAS) through genome sequencing and bioinformatic analysis. The findings highlight the roles of chromatin organization and gene regulation in CAS, and confirm co-expression of CAS-related genes during brain development.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Sharon A. Savage, Aida Suarez-Gonzalez, Ida Stuart, Iben Christensen
Summary: This study demonstrates the benefits of word retraining programs for individuals with naming difficulties caused by brain damage from alcohol misuse. The results show that a brief and intensive word retraining program can improve naming ability and lead to generalization effects in daily life.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Clinical Neurology
Penelope Monroe, Mark Halaki, Georgina Luscombe, Fiona Kumfor, Kirrie J. Ballard
Summary: This study aimed to determine the feasibility and acceptability of the MuSiCON choir and language/communication assessment protocol for individuals with cognitive impairment. The results showed that most participants had a positive response to MuSiCON, perceiving improved daily functioning and high therapeutic benefit without harmful effects. However, there was no reliable change in communication skills. The MuSiCON protocol was well received by participants and staff at the residential facility.
Correction
Biochemistry & Molecular Biology
Antony Kaspi, Michael S. Hildebrand, Victoria E. Jackson, Ruth Braden, Olivia van Reyk, Tegan Howell, Simone Debono, Mariana Lauretta, Lottie Morison, Matthew J. Coleman, Richard Webster, David Coman, Himanshu Goel, Mathew Wallis, Gabriel Dabscheck, Lilian Downie, Emma K. Baker, Bronwyn Parry-Fielder, Kirrie Ballard, Eva Harrold, Shaun Ziegenfusz, Mark F. Bennett, Erandee Robertson, Longfei Wang, Amber Boys, Simon E. Fisher, David J. Amor, Ingrid E. Scheffer, Melanie Bahlo, Angela T. Morgan
MOLECULAR PSYCHIATRY
(2023)
Article
Neuroimaging
Nga Yan Tse, Martina Bocchetta, Emily G. Todd, Emma M. Devenney, Sicong Tu, Jashelle Caga, John R. Hodges, Glenda M. Halliday, Muireann Irish, Matthew C. Kiernan, Olivier Piguet, Jonathan D. Rohrer, Rebekah M. Ahmed
Summary: Through studying a large sample of 211 participants, it was found that different subregions of the hypothalamus are correlated with cognitive and behavioral impairments. Patients with ALS, mixed ALS-FTD, and bvFTD all showed hypothalamic involvement. Cognitive and behavioral symptoms were correlated with bilateral involvement of the anterior inferior, anterior superior, and posterior hypothalamic subregions. The anterior superior and superior tuberal subregions displayed the greatest volume loss in bvFTD and ALS-FTD, and ALS, respectively, and were associated with specific neuropeptide expression abnormalities.
NEUROIMAGE-CLINICAL
(2023)
Article
Behavioral Sciences
Jessica L. Hazelton, Sol Fittipaldi, Matias Fraile-Vazquez, Marion Sourty, Agustina Legaz, Anna L. Hudson, Indira Garcia Cordero, Paula C. Salamone, Adrian Yoris, Agustin Ibanez, Olivier Piguet, Fiona Kumfor
Summary: This study investigates the disease-specific mechanisms underlying emotion recognition difficulties in bvFTD, AD, and PD patients. The findings suggest that interoceptive accuracy and cognitive abilities may contribute to emotion recognition impairments. In particular, bvFTD patients show worse interoceptive accuracy, while AD and PD patients show worse cognition.
Article
Behavioral Sciences
V. Lenglin, S. Wong, C. O'Callaghan, S. Erzinclioglu, M. Hornberger, T. Lebouvier, O. Piguet, S. Bourgeois-Gironde, M. Bertoux
Summary: Recent evidence from psycho-economics shows that the zero-price effect (ZPE) leads to an increase in subjective utility when the price of an item decreases to zero. This effect is attributed to an affective heuristic where the free status of an item biases choice towards that item. The study explored the role of the ventromedial prefrontal cortex (vmPFC) in the ZPE and found that patients with vmPFC lesion or behavioural-variant frontotemporal dementia showed reduced zero-related changes of preference for gift-cards but not for food items, suggesting altered affective evaluations in these patients.
Article
Psychology, Clinical
Kimberly Gressie, Fiona Kumfor, Her Teng, David Foxe, Emma Devenney, Rebekah M. Ahmed, Olivier Piguet
Summary: The study aims to compare the patterns of errors in facial emotion recognition in frontotemporal dementia (FTD) subtypes with Alzheimer's disease (AD) and healthy controls. The results show that all clinical groups perform worse than controls, with bvFTD and SD-right being particularly impaired. The patterns of errors are similar across all clinical groups.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Clinical Neurology
Anna Semenkova, Olivier Piguet, Andreas Johnen, Matthias L. Schroeter, Jannis Godulla, Christoph Linnemann, Markus Muhlhauser, Thomas Sauer, Markus Baumgartner, Sarah Anderl-Straub, Markus Otto, Ansgar Felbecker, Reto W. Kressig, Manfred Berres, Marc Sollberger
Summary: Based on the revised diagnostic criteria, the Behavioural Dysfunction Questionnaire (BDQ) was developed to discriminate between behavioural variant frontotemporal dementia (bvFTD) and non-bvFTD patients. BDQ-scores without any time criterion were found highly discriminatory between early-stage bvFTD and non-bvFTD groups, suggesting its potential for improving early diagnosis of bvFTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Hiu Chuen Lok, Jared S. Katzeff, John R. Hodges, Olivier Piguet, YuHong Fu, Glenda M. Halliday, Woojin Scott Kim
Summary: Neuroinflammation is a key feature of frontotemporal dementia (FTD), characterized by the degeneration of the frontal and temporal lobes. This study examined 48 cytokines in FTD serum and brain tissues to identify common dysregulation pathways. The results suggest the potential importance of the NLRP3 inflammasome in FTD.
SCIENTIFIC REPORTS
(2023)
Article
Audiology & Speech-Language Pathology
Sharynne McLeod, Grace Kelly, Beena Ahmed, Kirrie J. Ballard
Summary: This study evaluated the effectiveness of SayBananas!, a Mario-style mobile game that provides Australian children with high-dose individualized speech therapy practice. The results showed that most participants were highly engaged with the game and made significant improvements in their treated words and speech production after the intervention. The families also provided high ratings for the game.
INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Article
Behavioral Sciences
Andrea Gajardo-Vidal, Maxime Montembeault, Diego L. Lorca-Puls, Abigail E. Licata, Rian Bogley, Sabrina Erlhoff, Buddhika Ratnasiri, Zoe Ezzes, Giovanni Battistella, Elena Tsoy, Christa Watson Pereira, Jessica Deleon, Boon Lead Tee, Maya L. Henry, Zachary A. Miller, Katherine P. Rankin, Maria Luisa Mandelli, Katherine L. Possin, Maria Luisa Gorno-Tempini
Summary: This study investigates the potential differences in processing speed and neural correlates among the three variants of Primary Progressive Aphasia (PPA). The findings reveal that non-verbal cognitive abilities, such as processing speed, are significantly impacted in nfvPPA and lvPPA patients compared to healthy controls and svPPA patients. Neuroimaging results confirm the importance of fronto-parietal regions associated with processing speed and executive control.
Article
Behavioral Sciences
Holger Wiese, Tsvetomila Popova, Maya Schipper, Deni Zakriev, Mike Burton, Andrew W. Young
Summary: Previous experiments have shown that brief exposure to unfamiliar individuals leads to the formation of new facial representations, which undergo changes and consolidation within the first day after learning.
Article
Behavioral Sciences
Astrid Prochnow, Xianzhen Zhou, Foroogh Ghorbani, Paul Wendiggensen, Veit Roessner, Bernhard Hommel, Christian Beste
Summary: Individuals organize events in their environment by partitioning them into discrete units. This study reveals that the neural activity in the brain plays a critical role in this process, reflecting the key elements of event segmentation.
Article
Behavioral Sciences
Zhenzhen Huo, Zhiyi Chen, Rong Zhang, Junye Xu, Tingyong Feng
Summary: Procrastination has adverse effects on personal growth and social development. Reward sensitivity is positively correlated with procrastination. This study used VBM and RSFC analyses to investigate the neural substrates underlying the association between reward sensitivity and procrastination. The results showed that the functional connectivity of the right parahippocampal gyrus-precuneus mediated the relationship between reward sensitivity and procrastination.
Article
Behavioral Sciences
Stefano Lasaponara, Gabriele Scozia, Silvana Lozito, Mario Pinto, David Conversi, Marco Costanzi, Tim Vriens, Massimo Silvetti, Fabrizio Doricchi
Summary: Cholinergic (Ach), Noradrenergic (NE), and Dopaminergic (DA) pathways are crucial in regulating spatial attention and determining inter-individual differences in temperamental traits. This study found that temperamental traits predict individual differences in the ability to orient spatial attention based on the probabilistic association between cues and targets. These findings highlight the importance of considering temperamental and personality traits in social and professional environments where attention control is essential.
Article
Behavioral Sciences
Darren J. Yeo, Courtney Pollack, Benjamin N. Conrad, Gavin R. Price
Summary: The processing of numerals as visual objects is supported by an Inferior Temporal Numeral Area (ITNA) in the bilateral inferior temporal gyri (ITG). Extant findings suggest some degree of hemispheric asymmetry in how the bilateral ITNAs process numerals. The study found that digit sensitivity did not differ between ITNAs, and digit sensitivity in both left and right ITNAs was associated with calculation skills. The study also revealed a right lateralization in engagement in alphanumeric categorization, and that the right ITNA showed greater discriminability between digits and letters.
Review
Behavioral Sciences
Beste Gulsuna, Abuzer Gungor, Alp O. Borcer, Ugur Ture
Summary: The fiber dissection technique has been used to study the internal structures of the brain, with less focus on white matter. The sagittal stratum, a white matter structure, has not received enough attention and has been a subject of controversy. Recent studies suggest potential functions of the sagittal stratum, emphasizing the importance of understanding this structure accurately.
Article
Behavioral Sciences
Nora Geiser, Brigitte Charlotte Kaufmann, Samuel Elia Johannes Knobel, Dario Cazzoli, Tobias Nef, Thomas Nyffeler
Summary: This study compared the effects of auditory and visual motion stimulation on spatial neglect and found that both interventions were equally effective in improving neglect. Multimodal motion stimulation also improved neglect, but did not show greater improvement than unimodal auditory or visual motion stimulation alone.
Article
Behavioral Sciences
Anna E. Hughes, Anna Nowakowska, Alasdair D. F. Clarke
Summary: This study examines the relationship between search slopes and search efficiency in visual search tasks, introduces the Target Contrast Signal (TCS) Theory, and extends it to a Bayesian multi-level framework. The findings demonstrate that TCS can predict data well, but distinguishing between contrast combination models proves to be difficult.