Article
Clinical Neurology
Roderick P. P. W. M. Maas, Sven Killaars, Bart P. C. van de Warrenburg, Dennis J. L. G. Schutter
Summary: The CCAS-S is effective in identifying cognitive deficits in SCA3 patients, showing a high discriminative ability and correlating with disease severity measures.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Elizabeth Alejandra de la Cruz Cordoba, Juan Antonio Gonzalez Medrano, Patricia Herrera Mora, Gilberto Gomez-Garza, Maria Edith Gonzalez-Serrano, Marco Antonio Yamazaki-Nakashimada, Carmen Alicia Correa-Ramirez
Summary: Ataxia-telangiectasia (A-T) is a disease caused by mutations in the ATM gene, characterized by ataxia, mucocutaneous telangiectasia, immunodeficiency, and malignancy. Patients with A-T also experience neurocognitive and emotional disorders, showing features of cerebellar cognitive affective syndrome (CCAS). This study investigated the neurocognitive and emotional state of 9 pediatric patients with A-T and found impaired executive functioning, visual-motor integration and abilities, language problems, emotional disorders, and ataxia.
Article
Clinical Neurology
Anissa Abderrakib, Noemie Ligot, Gilles Naeije
Summary: This study assessed the prevalence of CCAS after acute cerebellar vascular lesions and found that almost all patients had a definite CCAS. The study also found that CCAS can be efficiently evaluated using the CCAS-S in acute stroke settings.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
V. Destrebecq, C. Comet, F. Deveylder, N. Alaerts, G. Naeije
Summary: This study aimed to assess the main determinant of cerebellar cognitive affective syndrome (CCAS) in individuals with Friedreich's ataxia (FRDA). The study found that CCAS is highly prevalent in adult individuals with FRDA, and the severity of ataxic motor symptoms is an important factor in predicting CCAS.
JOURNAL OF NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Mario Manto, Jan Cendelin, Michael Strupp, Hiroshi Mitoma
Summary: There are multiple etiologies for cerebellar ataxias (CAs) and they exhibit high phenotypic variability. Despite progress in understanding the pathogenesis, there are limited therapeutic options available. This article focuses on preclinical models, cerebellar reserve, therapeutic management of CAs, and suitable surrogate markers. It discusses the need for preclinical studies, standardization of disease evaluation, safety assessment, and demonstration of clinical improvements in the development of therapies for CAs.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Clinical Neurology
Ece Gok-Dursun, Ozge Berna Gultekin-Zaim, Ersin Tan, Isin Unal-Cevik
Summary: The awareness of Cerebellar Cognitive Affective Syndrome (CCAS) is growing, characterized by impaired executive functions, linguistic skills, visuospatial cognition, and personality changes. In cases with features of cognitive and affective disorders, consideration should be given to posterior cerebellar and vermian pathologies. The CCAS Scale is an appropriate screening tool for detecting these patients and guiding evidence-based treatment.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Editorial Material
Behavioral Sciences
Timothy Lawn, Dominic Ffytche
Summary: The study identified structural differences in cerebellar subfields linked to cortical attentional networks in patients with visual hallucinations due to eye diseases or Parkinson's disease. Commentary on the study suggested functional cerebellar changes in Dementia with Lewy bodies. The study reviewed evidence for cerebellar involvement in hallucinations across clinical conditions and sensory modalities, and proposed the potential value of cerebellar subfield differences as predictive biomarkers and treatment targets.
Article
Clinical Neurology
Virginie Destrebecq, Gilles Naeije
Summary: This study aimed to assess the prevalence of cognitive impairment in patients with essential tremor (ET) and determine whether it corresponds to cerebellar cognitive affective syndrome (CCAS). Cognitive functions were evaluated using the CCAS-Scale (CCAS-S) in 20 ET patients and 20 matched controls. The results showed that ET patients performed significantly worse than controls, and the CCAS-S scores correlated with age at onset, disease duration, and tremor severity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Amanda Chirino-Perez, Oscar Rene Marrufo-Melendez, Jose Ignacio Munoz-Lopez, Carlos R. Hernandez-Castillo, Gabriel Ramirez-Garcia, Rosalinda Diaz, Lilia Nunez-Orozco, Juan Fernandez-Ruiz
Summary: The study aimed to compare the effectiveness of the CCAS-S and MoCA tests in evaluating cognitive/affective impairments in patients with chronic acquired cerebellar lesions. While both tests showed adequate discrimination between patients and healthy volunteers, only impairments identified by the CCAS-S were significantly localized within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions exhibited cognitive impairments associated with CCAS. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically significant regions underlying chronic CCAS.
Article
Clinical Neurology
Francesca Puledda, Maria Dolores Villar-Martinez, Peter J. Goadsby
Summary: This article describes a case of intermittent visual snow syndrome that transforms into a persistent form following a posterior circulation stroke. It suggests that visual snow syndrome may be caused by an underlying brain disorder and highlights the importance of the cerebellum in the pathophysiology of this condition.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Brandon T. Craig, Adam Morrill, Britt Anderson, James Danckert, Christopher L. Striemer
Summary: This study investigated the impact of cerebellar damage on spatial, temporal, and sustained attention for the first time. Results showed that cerebellar damage affected reflexive covert attention and attentional blink tasks, but not voluntary covert attention or the sustained attention to response task. Damage to Crus II of the left posterior cerebellum was associated with impaired performance on certain attention tasks. These findings suggest that specific cerebellar regions may play a role in both spatial and temporal visual attention.
Article
Neurosciences
Ruben S. van der Giessen, Djaina Satoer, Peter J. Koudstaal
Summary: This study demonstrates that cerebellar lesions are associated with mild but long-term cognitive impairment in multiple neurocognitive functions. Semantic and phonemic fluency are most affected in patients with cerebellar stroke. Additionally, cognitive deficits after cerebellar stroke are more prominent in women than men.
BRAIN AND COGNITION
(2023)
Review
Cell Biology
Francesco Fabozzi, Stella Margoni, Bianca Andreozzi, Maria Simona Musci, Giada Del Baldo, Luigi Boccuto, Angela Mastronuzzi, Andrea Carai
Summary: Cerebellar mutism syndrome is a common complication following surgical resection of childhood tumors in the posterior fossa. It is characterized by impaired linguistic production, long recovery time, and often results in long-term disabilities. The pathogenic mechanism is likely related to damage to the cerebellar pathway, and the treatment mainly focuses on rehabilitation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Laura Blanco-Hinojo, Laia Casamitjana, Jesus Pujol, Gerard Martinez-Vilavella, Susanna Esteba-Castillo, Olga Gimenez-Palop, Valentin Freijo, Joan Deus, Assumpta Caixas
Summary: The motor system in PWS patients mainly involves neural elements typically associated with motor processing during motor challenge tasks; although there were no significant differences between groups in the simplest task, patients showed weaker activation in the cerebellum during more complex tasks; furthermore, significant interaction between group and correlation pattern with measures of motor function was observed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Juliana J. Schmidt, Guilherme J. Schmidt, Julio C. Tolentino, Eunice N. Simoes, Angela Obongo, Yolanda Tolentino, Francisco A. Coelho, Maria C. P. P. Landesmann, Lea M. B. Fonseca, Glenda C. B. Lacerda, Sergio L. Schmidt
Summary: This case study presented a 31-year-old Caucasian woman with CD who showed improvement in cerebellar perfusion and remission of cerebellar clinical manifestations after a GFD, although psychiatric symptoms persisted due to frontal lobe hypoperfusion.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Stephanie Vanclooster, Johan Bilsen, Lieve Peremans, Jutte Van der Werff Ten Bosch, Genevieve Laureys, Elsie Willems, Sophie Genin, Patrick Van Bogaert, Philippe Paquier, Anna Jansen
DEVELOPMENTAL NEUROREHABILITATION
(2019)
Article
Audiology & Speech-Language Pathology
Hyo Jung De Smet, Philippe Paquier, Jo Verhoeven, Peter Marien
BRAIN AND LANGUAGE
(2013)
Article
Neurosciences
Mathieu Bourguignon, Xavier De Tiege, Marc Op de Beeck, Noemie Ligot, Philippe Paquier, Patrick Van Bogaert, Serge Goldman, Riitta Hari, Veikko Jousmaki
HUMAN BRAIN MAPPING
(2013)
Article
Clinical Neurology
Robbert-Jan Van Hooff, Ann De Smedt, Sylvie De Raedt, Maarten Moens, Peter Marien, Philippe Paquier, Jacques De Keyser, Raf Brouns
Article
Rehabilitation
Stephanie Vanclooster, Katelijne Van Hoeck, Lieve Peremans, Johan Bilsen, Jutte Van Der Werff Ten Bosch, Genevieve Laureys, Philippe Paquier, Anna Jansen
Summary: This study aimed to describe the experiences of childhood brain tumor survivors (CBTS) and key figures in their environment after returning to school, using the International Classification of Functioning, Disability and Health framework. The results showed that school support and professional aftercare were essential to alleviate the child's difficulties, and factors such as teacher attitude, parental involvement, and collaboration practices further influenced the reintegration process.
DISABILITY AND REHABILITATION
(2021)
Review
Geriatrics & Gerontology
Silke Coemans, Esli Struys, Dorien Vandenborre, Ineke Wilssens, Sebastiaan Engelborghs, Philippe Paquier, Kyrana Tsapkini, Stefanie Keulen
Summary: Various tDCS approaches have been used to explore the potential of tDCS in improving language outcomes or slowing down the decline of language competences in PPA cases. While the stimulation protocols and study designs in PPA are similar to post-stroke aphasic populations, differences in pathophysiology require further investigation to establish the optimal stimulation paradigm. Despite heterogeneity in patient populations, stimulation protocols, and study design, tDCS is considered an effective tool for improving language outcomes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Silke Coemans, Stefanie Keulen, Perseverence Savieri, Kyrana Tsapkini, Sebastiaan Engelborghs, Nini Chrispeels, Dorien Vandenborre, Philippe Paquier, Ineke Wilssens, Mathieu Declerck, Esli Struys
Summary: This study conducted a multi-level meta-analysis to investigate deficits in executive functions (EFs) in Primary Progressive Aphasia (PPA) patients. The results showed that PPA patients had poorer EFs compared to age-matched cognitively healthy controls. There were no significant differences between the effect sizes of different EFs components, indicating similar impairments across all components. PPA variant and disease duration were found to be significant moderators of performance.
Review
Linguistics
Anastasia Lada, Philippe Paquier, Christina Manouilidou, Stefanie Keulen
Summary: Idioms have unique semantic dimensions and studying their comprehension in clinical populations, particularly individuals with aphasia, can shed light on the role of the brain in processing idiomatic language. However, there is inconsistency in the literature regarding the existence and effects of certain factors on idiomatic comprehension. This study aimed to explore the impact of idiom stimuli and tasks on language performance in aphasia.
JOURNAL OF NEUROLINGUISTICS
(2023)
Article
Neurosciences
Silke Coemans, Esli Struys, Kyrana Tsapkini, Philippe Paquier, Dorien Vandenborre, Stefanie Keulen
Summary: Transcranial Direct Current Stimulation (tDCS) is a potential tool for enhancing speech and language therapy in individuals with aphasia. This study investigates the effects of applying anodal cerebellar tDCS (ctDCS) combined with language therapy in a bilingual patient with chronic post-stroke aphasia. The results showed that both sham and anodal treatment improved trained picture naming in the treated language (L2), while anodal ctDCS also improved picture naming of untrained items in both L2 and the patient's first language, L1. Picture description abilities improved in both languages after anodal ctDCS, but not after sham.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Cheyenne Svaldi, Philippe Paquier, Stefanie Keulen, Henrieke van Elp, Coriene Catsman-Berrevoets, Annet Kingma, Roel Jonkers, Saskia Kohnen, Vania de Aguiar
Summary: This study aims to identify language processing deficits for four levels of language processing in cerebellar tumour survivors. The results showed inter-individual heterogeneity in spontaneous language outcomes, with impairments observed across all levels of language processing. Moreover, patients with postoperative cerebellar mutism syndrome (pCMS) had predominantly morphosyntactic and semantic impairments.
Article
Psychiatry
S. Keulen, P. Marien, K. van Dun, T. D'aes, L. de Page, L. de Vroege, P. Van Schuerbeek, H. Raeymaekers, J. De Mey, R. Bastiaanse, C. Van der Feltz-Cornelis, P. Paquier, F. Van Overwalle, J. Verhoeven
Summary: This case analysis describes a 28-year-old native Dutch-speaking lady who developed Foreign Accent Syndrome (FAS) and jargon speech after experiencing trauma. The results of neuropsychological tests, fMRI experiment and psychodiagnostic exams indicate a functional etiology for the symptoms, consistent with a DSM-5 conversion disorder.
EUROPEAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Clinical
Stephanie Vanclooster, Johan Bilsen, Lieve Peremans, Jutte Van der Werff Ten Bosch, Genevieve Laureys, Elsie Willems, Sophie Genin, Patrick Van Bogaert, Philippe Paquier, Anna Jansen
JOURNAL OF HEALTH PSYCHOLOGY
(2019)
Meeting Abstract
Oncology
Sophie Genin, Stephanie Vanclooster, Eric Sariban, Patrick Van Bogaert, Philippe Paquier
Meeting Abstract
Oncology
S. Vanclooster, S. Genin, S. Hardonk, L. Peremans, J. Van der Werff Ten Bosch, J. Bilsen, P. Paquier, A. Jansen
PEDIATRIC BLOOD & CANCER
(2015)
Article
Clinical Neurology
Claudine Sculier, Anne-Sophie Tilmant, Xavier De Tiege, Sanda Giurgea, Philippe Paquier, Gabrielle Rudolf, Gaetan Lesca, Patrick Van Bogaert
EPILEPTIC DISORDERS
(2017)
Article
Behavioral Sciences
Andrea Gajardo-Vidal, Maxime Montembeault, Diego L. Lorca-Puls, Abigail E. Licata, Rian Bogley, Sabrina Erlhoff, Buddhika Ratnasiri, Zoe Ezzes, Giovanni Battistella, Elena Tsoy, Christa Watson Pereira, Jessica Deleon, Boon Lead Tee, Maya L. Henry, Zachary A. Miller, Katherine P. Rankin, Maria Luisa Mandelli, Katherine L. Possin, Maria Luisa Gorno-Tempini
Summary: This study investigates the potential differences in processing speed and neural correlates among the three variants of Primary Progressive Aphasia (PPA). The findings reveal that non-verbal cognitive abilities, such as processing speed, are significantly impacted in nfvPPA and lvPPA patients compared to healthy controls and svPPA patients. Neuroimaging results confirm the importance of fronto-parietal regions associated with processing speed and executive control.
Article
Behavioral Sciences
Holger Wiese, Tsvetomila Popova, Maya Schipper, Deni Zakriev, Mike Burton, Andrew W. Young
Summary: Previous experiments have shown that brief exposure to unfamiliar individuals leads to the formation of new facial representations, which undergo changes and consolidation within the first day after learning.
Article
Behavioral Sciences
Astrid Prochnow, Xianzhen Zhou, Foroogh Ghorbani, Paul Wendiggensen, Veit Roessner, Bernhard Hommel, Christian Beste
Summary: Individuals organize events in their environment by partitioning them into discrete units. This study reveals that the neural activity in the brain plays a critical role in this process, reflecting the key elements of event segmentation.
Article
Behavioral Sciences
Zhenzhen Huo, Zhiyi Chen, Rong Zhang, Junye Xu, Tingyong Feng
Summary: Procrastination has adverse effects on personal growth and social development. Reward sensitivity is positively correlated with procrastination. This study used VBM and RSFC analyses to investigate the neural substrates underlying the association between reward sensitivity and procrastination. The results showed that the functional connectivity of the right parahippocampal gyrus-precuneus mediated the relationship between reward sensitivity and procrastination.
Article
Behavioral Sciences
Stefano Lasaponara, Gabriele Scozia, Silvana Lozito, Mario Pinto, David Conversi, Marco Costanzi, Tim Vriens, Massimo Silvetti, Fabrizio Doricchi
Summary: Cholinergic (Ach), Noradrenergic (NE), and Dopaminergic (DA) pathways are crucial in regulating spatial attention and determining inter-individual differences in temperamental traits. This study found that temperamental traits predict individual differences in the ability to orient spatial attention based on the probabilistic association between cues and targets. These findings highlight the importance of considering temperamental and personality traits in social and professional environments where attention control is essential.
Article
Behavioral Sciences
Darren J. Yeo, Courtney Pollack, Benjamin N. Conrad, Gavin R. Price
Summary: The processing of numerals as visual objects is supported by an Inferior Temporal Numeral Area (ITNA) in the bilateral inferior temporal gyri (ITG). Extant findings suggest some degree of hemispheric asymmetry in how the bilateral ITNAs process numerals. The study found that digit sensitivity did not differ between ITNAs, and digit sensitivity in both left and right ITNAs was associated with calculation skills. The study also revealed a right lateralization in engagement in alphanumeric categorization, and that the right ITNA showed greater discriminability between digits and letters.
Review
Behavioral Sciences
Beste Gulsuna, Abuzer Gungor, Alp O. Borcer, Ugur Ture
Summary: The fiber dissection technique has been used to study the internal structures of the brain, with less focus on white matter. The sagittal stratum, a white matter structure, has not received enough attention and has been a subject of controversy. Recent studies suggest potential functions of the sagittal stratum, emphasizing the importance of understanding this structure accurately.
Article
Behavioral Sciences
Nora Geiser, Brigitte Charlotte Kaufmann, Samuel Elia Johannes Knobel, Dario Cazzoli, Tobias Nef, Thomas Nyffeler
Summary: This study compared the effects of auditory and visual motion stimulation on spatial neglect and found that both interventions were equally effective in improving neglect. Multimodal motion stimulation also improved neglect, but did not show greater improvement than unimodal auditory or visual motion stimulation alone.
Article
Behavioral Sciences
Anna E. Hughes, Anna Nowakowska, Alasdair D. F. Clarke
Summary: This study examines the relationship between search slopes and search efficiency in visual search tasks, introduces the Target Contrast Signal (TCS) Theory, and extends it to a Bayesian multi-level framework. The findings demonstrate that TCS can predict data well, but distinguishing between contrast combination models proves to be difficult.