Article
Behavioral Sciences
Davide Quaranta, Naike Caraglia, Federica L'Abbate, Guido Maria Giuffre, Valeria Guglielmi, Giovanna Masone Iacobucci, Paolo Maria Rossini, Paolo Calabresi, Camillo Marra
Summary: Early impairment of semantic memory could predict the progression to Alzheimer's disease before the onset of memory disorders, and the discrepancy between phonological and semantic verbal fluency tests could be able to detect this impairment in advance.
BRAIN AND BEHAVIOR
(2023)
Article
Psychology, Experimental
Cherie Strikwerda-Brown, Siobhan R. Shaw, John R. Hodges, Olivier Piguet, Muireann Irish
Summary: The study used the NExt scoring protocol to investigate profiles of external details generated by patients with Alzheimer's disease and semantic dementia in a future thinking task. The results indicated that AD patients provided more specific episode external details while SD patients displayed various types of external details during future simulation. The increased external details were related to grey matter intensity in different brain regions for each group.
MEMORY & COGNITION
(2022)
Article
Medicine, General & Internal
Athanasios Chatzikostopoulos, Despina Moraitou, Magdalini Tsolaki, Elvira Masoura, Georgia Papantoniou, Maria Sofologi, Vasileios Papaliagkas, Georgios Kougioumtzis, Efthymios Papatzikis
Summary: This study aimed to examine episodic memory in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease dementia (ADD). Statistical analysis with receiver operating characteristic curves (ROC) demonstrated that evaluating episodic memory with the Doors and People tool can effectively distinguish between different groups of patients.
Article
Geriatrics & Gerontology
Aurelien Frick, Gabriel Besson, Eric Salmon, Emma Delhaye
Summary: This study examines the involvement of the perirhinal cortex (PrC) in representing and discriminating confusable objects in individuals with Alzheimer's disease (AD). It found that a decreased volume of the PrC is associated with the ability to disambiguate conceptually confusable items. Therefore, testing recognition memory or conceptual matching of easily conceptually confusable items can serve as a potential cognitive marker of PrC atrophy.
NEUROBIOLOGY OF AGING
(2023)
Review
Psychology, Multidisciplinary
Jeffrey C. Zemla
Summary: The semantic fluency task is commonly used to measure one's ability to retrieve semantic concepts. The ordering of responses can provide insights into how individuals or groups organize semantic concepts within a category. However, there are still many unresolved questions surrounding the validity and reliability of this approach.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Juan Carlos Cejudo, Melissa Samaniego, Marta Almeria, Susana Castrillo, Lidia Medina, Domenec Gil
Summary: This study aimed to create, validate, and normalize a new test called the Ikos test for assessing semantic memory (SM) in Alzheimer's disease (AD) and early AD. The test showed high correlation indexes and met the criteria of validity and reliability. It can be considered a valid and reliable tool for SM assessment in diagnosing AD and the early stages of clinical disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychology, Multidisciplinary
Aino M. Saranpaa, Sasa L. Kivisaari, Riitta Salmelin, Sabine Krumm
Summary: The semantic fluency task is a valuable tool for diagnosing Alzheimer's disease, and this study investigates its use in differentiating between healthy individuals, patients with mild cognitive impairment, and patients with early Alzheimer's dementia. By using word2vec and t-SNE visualization, a multidimensional semantic space is created to effectively analyze semantic categories. The frequency of returning to sub-categories provides additional information for diagnosing early Alzheimer's disease. This research highlights the potential of word2vec and t-SNE as tools for studying the semantic space.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Lin Huang, Yatian Li, Jingnan Wu, Nan Chen, Huanhuan Xia, Qihao Guo
Summary: A voice recognition-based cognitive assessment tool has been developed and demonstrated to have good diagnostic accuracy in detecting MCI and AD dementia. The tool performs well in measuring visual memory, language, and executive function, and has the potential to facilitate large-scale community screening.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Behavioral Sciences
Emma Delhaye, Moreno I. Coco, Mohamed A. Bahri, Ana Raposo
Summary: Concept typicality is crucial for categorical organization based on features, leading to better performance in categorization tasks for typical items and better memory recognition for atypical items. In this study, the neural correlates of typicality in both semantic and episodic memory were investigated, revealing the involvement of anterior temporal lobe (ATL) and inferior frontal gyrus (IFG) in semantic decision tasks, and the activation of core recollection network during correct recognition in episodic memory. Additionally, finer-grained processing and item-specific reinstatement were found to be necessary for the correct retrieval of typical items.
Article
Geriatrics & Gerontology
Geoffroy Gagliardi, Patrizia Vannini
Summary: This study investigates the mechanisms of awareness loss in Alzheimer's Disease, and finds that dysfunction in episodic memory is primarily responsible for the effect of amyloid on awareness.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Eun-Young Lee
Summary: This study investigated the mechanisms underlying memory deficits in Parkinson's disease (PD) and their relationship with brain structural metrics. The findings showed that PD patients had lower memory capacity scores compared to controls in both memory experiments. Additionally, PD patients exhibited reduced cortical thickness in the left superior temporal gyrus, which was associated with lower memory scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Gali H. Weissberger, Anya Samek, Laura Mosqueda, Annie L. Nguyen, Aaron C. Lim, Laura Fenton, S. Duke Han
Summary: This study investigated the cognitive correlates of financial altruism in older adults and found a negative association between financial altruism and cognitive measures sensitive to Alzheimer's disease. The study also highlighted a potential link between financial exploitation risk and Alzheimer's disease in older age.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Kelsey R. R. Sewell, Stephanie R. R. Rainey-Smith, Jeremiah Peiffer, Hamid R. R. Sohrabi, Kevin Taddei, David Ames, Paul Maruff, Colin L. L. Masters, Christopher C. C. Rowe, Ralph N. N. Martins, Kirk I. I. Erickson, Belinda M. M. Brown
Summary: This study examined the association between objectively measured physical activity and cognition in older adults over 8 years. The results showed that higher energy expenditure, physical activity intensity, and total activity were associated with better episodic recall memory and global cognition. These findings suggest that physical activity may preserve cognitive function, with activity intensity playing a significant role.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Dustin Hammers, Sara Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza S. Atri, Gregory Day, Ranjan R. Duara, Neill S. Graff-Radford, Lawrence T. Honig, David C. Jones, Joseph F. Masdeu, Mario Mendez, Erik U. Musiek, Chiadi Onyike, Meghan Riddle, Emily Rogalski, Steve J. Salloway, Sharon J. Sha, Raymond Scott Turner, Sandra S. Weintraub, Thomas A. Wingo, David Wolk, Bonnie C. Wong, Maria C. Carrillo, Bradford D. Dickerson, Gil G. Rabinovici, Liana Apostolova
Summary: This study investigated the limitations of learning slopes in early-onset dementias and aimed to highlight the sensitivity of learning slopes in discriminating disease severity in cognitively normal participants and those diagnosed with early-onset dementia. The results showed that learning slopes are highly sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The rating for the importance of this study is 8 out of 10.
ALZHEIMERS & DEMENTIA
(2023)
Article
Chemistry, Multidisciplinary
Aumm-e-hani Munir, Wajahat Mahmood Qazi
Summary: This paper presents a methodology to develop personal semantic memory in intelligent agents, which allows for the induction of subjectivity. The proposed computational model includes modules for perception, learning, sentiment analysis, knowledge representation, and personal semantic construction. Experimental results demonstrate an increase and evolution of personal semantic knowledge during conversations with humans.
APPLIED SCIENCES-BASEL
(2022)
Article
Neurosciences
Bronson B. Harry, Katja Umla-Runge, Andrew D. Lawrence, Kim S. Graham, Paul E. Downing
JOURNAL OF COGNITIVE NEUROSCIENCE
(2016)
Article
Neurosciences
Carl J. Hodgetts, Natalie L. Voets, Adam G. Thomas, Stuart Clare, Andrew D. Lawrence, Kim S. Graham
JOURNAL OF NEUROSCIENCE
(2017)
Review
Neurosciences
Elisabeth A. Murray, Steven P. Wise, Kim S. Graham
NEUROSCIENCE LETTERS
(2018)
Article
Neuroimaging
Samrah Ahmed, Clare Loane, Sara Bartels, Giovanna Zamboni, Clare Mackay, Ian Baker, Masud Husain, Sian Thompson, Michael Hornberger, Christopher Butler
NEUROIMAGE-CLINICAL
(2018)
Article
Neuroimaging
Samrah Ahmed, Muireann Irish, Clare Loane, Ian Baker, Masud Husain, Sian Thompson, Cristina Blanco-Duque, Clare MacKay, Giovanna Zamboni, David Foxe, John R. Hodges, Olivier Piguet, Christopher Butler
NEUROIMAGE-CLINICAL
(2018)
Article
Neuroimaging
Michele Veldsman, Giovanna Zamboni, Christopher Butler, Samrah Ahmed
NEUROIMAGE-CLINICAL
(2019)
Article
Clinical Neurology
Clare Loane, Georgios P. D. Argyropoulos, Adriana Roca-Fernandez, Carmen Lage, Fintan Sheerin, Samrah Ahmed, Giovanna Zamboni, Clare Mackay, Sarosh R. Irani, Christopher R. Butler
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Neurosciences
Esin Karahan, Alison G. Costigan, Kim S. Graham, Andrew D. Lawrence, Jiaxiang Zhang
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Aida Suarez-Gonzalez, Dilek Ocala, Ivanna Pavisic, Ashley Peacock, Michelle Naessens, Samrah Ahmed, Christopher R. Butler, Alexander P. Lef, Keir X. X. Yong, Sebastian J. Crutch
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Behavioral Sciences
Clare J. Rathbone, Judi A. Ellis, Samrah Ahmed, Chris J. A. Moulin, Alexandra Ernst, Chris R. Butler
Article
Geriatrics & Gerontology
Samrah Ahmed, Siobhan Culley, Cristina Blanco-Duque, John R. Hodges, Christopher Butler, Eneida Mioshi
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2020)
Article
Clinical Neurology
Mario Torso, Samrah Ahmed, Christopher Butler, Giovanna Zamboni, Mark Jenkinson, Steven Chance
Summary: Global cortical DTI derived measures were able to detect differences in both PCA and tAD patients compared to healthy controls. AngleR was the best measure to discriminate HC from tAD (AUC = 0.922), while PerpPD was the best measure to discriminate HC from PCA (AUC = 0.961). Finally, the best global measure to differentiate the two patient groups was ParlPD (AUC = 0.771).
JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Arpita Bose, Niladri S. Dash, Samrah Ahmed, Manaswita Dutta, Aparna Dutt, Ranita Nandi, Yesi Cheng, Tina M. D. Mello
Summary: This study is the first to investigate connected speech production in Bengali speakers with AD, revealing similarities with English speakers in terms of decreased speech rate, simplicity of sentence forms, and reduced semantic content, but differences in Bengali-specific linguistic features, such as fewer pronouns used and simpler inflectional features.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Marie-Lucie Read, Katja Umla-Runge, Andrew D. Lawrence, Alison G. Costigan, Liang-Tien Hsieh, Maxime Chamberland, Charan Ranganath, Kim S. Graham
Summary: Converging evidence from studies of human and nonhuman animals suggests that the hippocampus contributes to sequence learning by using temporal context to bind sequentially occurring items. This study tested the prediction that individual differences in fornix microstructure predict sequence memory. The results showed that greater fornix microstructural complexity is associated with better sequence memory, highlighting the importance of the fornix in aiding memory for objects within a temporal context.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Sebastian J. Crutch, Jonathan M. Schott, Gil D. Rabinovici, Melissa Murray, Julie S. Snowden, Wiesje M. van der Flier, Bradford C. Dickerson, Rik Vandenberghe, Samrah Ahmed, Thomas H. Bak, Bradley F. Boeve, Christopher Butler, Stefano F. Cappa, Mathieu Ceccaldi, Leonardo Cruz de Souza, Bruno Dubois, Olivier Felician, Douglas Galasko, Jonathan Graff-Radford, Neill R. Graff-Radford, Patrick R. Hof, Pierre Krolak-Salmon, Manja Lehmann, Eloi Magnin, Mario F. Mendez, Peter J. Nestor, Chiadi U. Onyike, Victoria S. Pelak, Yolande Pijnenburg, Silvia Primativo, Martin N. Rossor, Natalie S. Ryan, Philip Scheltens, Timothy J. Shakespeare, Aida Suarez Gonzalez, David F. Tang-Wai, Keir X. X. Yong, Maria Carrillo, Nick C. Fox
ALZHEIMERS & DEMENTIA
(2017)
Article
Behavioral Sciences
Andrea Gajardo-Vidal, Maxime Montembeault, Diego L. Lorca-Puls, Abigail E. Licata, Rian Bogley, Sabrina Erlhoff, Buddhika Ratnasiri, Zoe Ezzes, Giovanni Battistella, Elena Tsoy, Christa Watson Pereira, Jessica Deleon, Boon Lead Tee, Maya L. Henry, Zachary A. Miller, Katherine P. Rankin, Maria Luisa Mandelli, Katherine L. Possin, Maria Luisa Gorno-Tempini
Summary: This study investigates the potential differences in processing speed and neural correlates among the three variants of Primary Progressive Aphasia (PPA). The findings reveal that non-verbal cognitive abilities, such as processing speed, are significantly impacted in nfvPPA and lvPPA patients compared to healthy controls and svPPA patients. Neuroimaging results confirm the importance of fronto-parietal regions associated with processing speed and executive control.
Article
Behavioral Sciences
Holger Wiese, Tsvetomila Popova, Maya Schipper, Deni Zakriev, Mike Burton, Andrew W. Young
Summary: Previous experiments have shown that brief exposure to unfamiliar individuals leads to the formation of new facial representations, which undergo changes and consolidation within the first day after learning.
Article
Behavioral Sciences
Astrid Prochnow, Xianzhen Zhou, Foroogh Ghorbani, Paul Wendiggensen, Veit Roessner, Bernhard Hommel, Christian Beste
Summary: Individuals organize events in their environment by partitioning them into discrete units. This study reveals that the neural activity in the brain plays a critical role in this process, reflecting the key elements of event segmentation.
Article
Behavioral Sciences
Zhenzhen Huo, Zhiyi Chen, Rong Zhang, Junye Xu, Tingyong Feng
Summary: Procrastination has adverse effects on personal growth and social development. Reward sensitivity is positively correlated with procrastination. This study used VBM and RSFC analyses to investigate the neural substrates underlying the association between reward sensitivity and procrastination. The results showed that the functional connectivity of the right parahippocampal gyrus-precuneus mediated the relationship between reward sensitivity and procrastination.
Article
Behavioral Sciences
Stefano Lasaponara, Gabriele Scozia, Silvana Lozito, Mario Pinto, David Conversi, Marco Costanzi, Tim Vriens, Massimo Silvetti, Fabrizio Doricchi
Summary: Cholinergic (Ach), Noradrenergic (NE), and Dopaminergic (DA) pathways are crucial in regulating spatial attention and determining inter-individual differences in temperamental traits. This study found that temperamental traits predict individual differences in the ability to orient spatial attention based on the probabilistic association between cues and targets. These findings highlight the importance of considering temperamental and personality traits in social and professional environments where attention control is essential.
Article
Behavioral Sciences
Darren J. Yeo, Courtney Pollack, Benjamin N. Conrad, Gavin R. Price
Summary: The processing of numerals as visual objects is supported by an Inferior Temporal Numeral Area (ITNA) in the bilateral inferior temporal gyri (ITG). Extant findings suggest some degree of hemispheric asymmetry in how the bilateral ITNAs process numerals. The study found that digit sensitivity did not differ between ITNAs, and digit sensitivity in both left and right ITNAs was associated with calculation skills. The study also revealed a right lateralization in engagement in alphanumeric categorization, and that the right ITNA showed greater discriminability between digits and letters.
Review
Behavioral Sciences
Beste Gulsuna, Abuzer Gungor, Alp O. Borcer, Ugur Ture
Summary: The fiber dissection technique has been used to study the internal structures of the brain, with less focus on white matter. The sagittal stratum, a white matter structure, has not received enough attention and has been a subject of controversy. Recent studies suggest potential functions of the sagittal stratum, emphasizing the importance of understanding this structure accurately.
Article
Behavioral Sciences
Nora Geiser, Brigitte Charlotte Kaufmann, Samuel Elia Johannes Knobel, Dario Cazzoli, Tobias Nef, Thomas Nyffeler
Summary: This study compared the effects of auditory and visual motion stimulation on spatial neglect and found that both interventions were equally effective in improving neglect. Multimodal motion stimulation also improved neglect, but did not show greater improvement than unimodal auditory or visual motion stimulation alone.
Article
Behavioral Sciences
Anna E. Hughes, Anna Nowakowska, Alasdair D. F. Clarke
Summary: This study examines the relationship between search slopes and search efficiency in visual search tasks, introduces the Target Contrast Signal (TCS) Theory, and extends it to a Bayesian multi-level framework. The findings demonstrate that TCS can predict data well, but distinguishing between contrast combination models proves to be difficult.