Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Yue-Mei Gao, Shih-Han Chiu, Prabhakar Busa, Chen-Lun Liu, Ranjith Kumar Kankala, Chia-Hung Lee
Summary: This study reports the fabrication of core-shell nanostructures for delivering methylene blue and copper-doxorubicin as model drugs for synergistic photodynamic therapy, chemotherapy, and chemodynamic therapy. The designed architectures demonstrate potent anti-cancer efficacy against skin melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Elisa Bindini, Maria de los Angeles Ramirez, Xabier Rios, Unai Cossio, Cristina Simo, Vanessa Gomez-Vallejo, Galo Soler-Illia, Jordi Llop, Sergio E. Moya
Summary: A novel method was reported to track the in vivo degradation of mesoporous silica nanoparticles, showing that these nanoparticles have fast degradation kinetics in vivo.
Article
Polymer Science
Lili Yu, Lin Yao, Kuan Yang, Wenling Fei, Qingqing Chen, Lan Qin, Shaojing Liu, Min Cao, Qian Liu, Bei Qin
Summary: In this study, a redox-responsive nanocarrier (RGD-MSNs@BSA) was developed by conjugating bovine serum albumin (BSA) to mesoporous silica nanoparticles (MSNs) with a disulfide bond, which showed efficient and stable encapsulation of the anticancer drug doxorubicin (DOX) and redox-responsive drug release in a glutathione (GSH)-containing environment. Moreover, the modification of cRGD peptide on the particle surface enhanced the tumor cell-targeting and cellular uptake of the nanoparticles.
Article
Chemistry, Multidisciplinary
Lucia Garcia, Eneko Garaio, Alberto Lopez-Ortega, Itziar Galarreta-Rodriguez, Laura Cervera-Gabalda, Guillermo Cruz-Quesada, Alfonso Cornejo, Julian J. Garrido, Cristina Gomez-Polo, Jose Ignacio Perez-Landazabal
Summary: Hybrid magnetic nanoparticles consisting of an iron oxide core and a mesoporous SiO2 shell were synthesized. The nanoparticles exhibited high magnetization, large surface area, and efficient drug delivery. The controlled drug release efficiency and heating response of the nanoparticles were achieved using an external AC magnetic field.
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Article
Chemistry, Multidisciplinary
Shan Mohanan, C. Sathish, Kavitha Ramadass, Mingtao Liang, Ajayan Vinu
Summary: This study demonstrates the synthesis of core-shell ordered mesoporous silica nanoparticles (CSMS) with tunable particle size and shape using a dual surfactant-assisted approach. By modifying the synthesis conditions, monodispersed and ordered mesoporous silica nanoparticles with tunable particle size and various morphologies can be obtained. Comparative studies on CBZ-loaded CSMS with hexagonal prism (HP) and spherical shapes reveal better drug delivery efficiency and cellular uptake of CSMS with HP morphology. These unique materials can serve as an excellent drug delivery system and have potential applications for cancer treatment.
Article
Chemistry, Inorganic & Nuclear
Pan-Feng Wu, Qi Xue, Tian-Yu Wang, Shan-Jian Li, Gao-Peng Li, Gang-Lin Xue
Summary: The novel composite Fe3O4@SiO2@mSiO(2)-PW12/Ag exhibits high photocatalytic activity, effectively degrading methyl orange and reducing Cr(vi) under simulated sunlight. The enhanced catalytic activities are attributed to its high specific surface area, synergistic effect among the components, and the formation of a heterojunction of PW12/Ag.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Zehao Zhou, Jian Zhao, Zhenghan Di, Bei Liu, Zhaohui Li, Xuemin Wu, Lele Li
Summary: A mesoporous MOF shell was synthesized on the surface of gold nanorods to capture single AuNRs for combinational phototherapy against solid tumors. The core-shell heterostructures combine a mesoporous structure and photoinduced singlet oxygen generation behavior with plasmonic photothermal conversion characteristic of AuNRs, enabling an efficient tumor treatment strategy. Applications beyond cancer therapy, such as plasmonic harvesting of light energy for catalytic reactions within MOFs and multifunctional nanocarriers for agricultural formulations, are also highlighted.
Article
Polymer Science
Danil D. Kolmanovich, Nikita N. Chukavin, Irina V. Savintseva, Elena A. Mysina, Nelli R. Popova, Alexander E. Baranchikov, Madina M. Sozarukova, Vladimir K. Ivanov, Anton L. Popov
Summary: Layer-by-layer self-assembled polyelectrolyte capsules have great potential in drug delivery and imaging contrast agent applications. This study presents the design of MRI-visible capsules loaded with gadolinium-doped cerium oxide nanoparticles, which showed high biocompatibility and cellular uptake efficiency in cancer cells and normal cells.
Article
Chemistry, Applied
Richard Fiedler, Bastian Beizinger, Paul Walther, Mika Lind
Summary: Superparamagnetic iron oxide nanoparticles, particularly in the form of nanoscopic aggregates, have various applications in contrast agents, biological tools, and sensors. The particle size and refractive index can be modified by coating the nanoparticles with another oxide, typically silica. Additionally, introducing mesoporous silica layers enables the nanoparticles to serve as theranostic nanoparticles and high-capacity adsorbers, as well as colorimetric sensors.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Applied
Ana Garcia, Blanca Gonzalez, Catherine Harvey, Isabel Izquierdo-Barba, Maria Vallet-Regi
Summary: This study developed light-sensitive mesoporous silica nanoparticles with combined photothermal and antimicrobial capabilities for targeting bacterial biofilms. The nanosystems exhibited high therapeutic potential by affecting biofilm architecture and inhibiting its growth. The incorporation of nitrosothiol groups and an antimicrobial molecule such as levofloxacin showed promising results in reducing biofilm dispersion and achieving potent antimicrobial therapy.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Aysenur Pamukcu, M. Baran Karakaplan, Didem Sen Karaman
Summary: A novel nanostructure composed of a cerium oxide core and a porous silica shell (CeO2@pSiO(2)) was found to exhibit synergistic antibacterial action by accommodating curcumin and lectin. The antibacterial potential of this nanocomposite was demonstrated against Escherichia coli, and the mechanisms of action involving the destruction of bacterial cell motility and permeability were identified.
Article
Multidisciplinary Sciences
Yara Kadria-Vili, Oara Neumann, Yage Zhao, Peter Nordlander, Gary Martinez, James A. Bankson, Naomi J. Halas
Summary: A promising clinical trial using gold-silica core-shell nanostructures for near-infrared photothermal therapy of prostate cancer has been reported. In this study, PEGylated Gd2O3-mesoporous silica/gold core/shell nanoparticles were synthesized, which not only have near-infrared photothermal properties but also provide sufficient MRI contrast for visualization at therapeutic doses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Chemical
Fortunato Migliardini, Valeria Califano, Giuseppe Perretta, Carmine Invigorito, Alberto Rubin Pedrazzo, Giovanni Ausanio, Giulio Pota, Aniello Costantini
Summary: The properties and CO2 uptake capability of synthesized and calcined mesoporous silica materials, as well as core-shell nanoparticles, were studied. The core-shell material impregnated with TEPA showed the best performance in CO2 uptake.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Materials Science, Multidisciplinary
A. M. Smirnov, A. V. Kremleva, A. . Yu. Ivanov, A. V. Myasoedov, L. A. Sokura, D. A. Kirilenko, Sh. Sh. Sharofidinov, A. E. Romanov
Summary: This study presents the experimental data on orientation relationships for HVPE-grown K-Ga2O3 film on a-Al2O3 substrate and the theoretical model describing growth orientation dependences of stress-strain state and piezoelectric polarization in K-(AlxGa1-x)2O3 films with orthorhombic crystal structure grown on a-Al2O3 and K-Al2O3 substrates. Two possibilities for variation in films growth orientation for K-Ga2O3/a-Al2O3 and K-(AlxGa1-x)2O3/K-Al2O3 heterostructures are considered. The changes in elastic strain field and piezoelectric polarization in the film caused by differences in values of lattice parameters, elastic, and piezoelectric constants are demonstrated. Growth planes for K-Ga2O3/a-Al2O3 and K-(AlxGa1-x)2O3/K-Al2O3 heterostructures with low internal stresses and low or zero values of piezoelectric polarization are found.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Svetlana A. Kadinskaya, Valeriy M. Kondratev, Ivan K. Kindyushov, Olga Yu. Koval, Dmitry I. Yakubovsky, Alexey Kusnetsov, Alexey I. Lihachev, Alexey V. Nashchekin, Irina Kh. Akopyan, Alexey Yu. Serov, Mariana E. Labzovskaya, Sergey V. Mikushev, Boris V. Novikov, Igor V. Shtrom, Alexey D. Bolshakov
Summary: In this study, ZnO nanostructures with various geometries were grown via hydrothermal synthesis using different surfactants. Photoluminescence spectroscopy was used to study their optical properties, showing that the growth medium composition had a significant impact on the emission characteristics. Therefore, this research revealed the correlation between hydrothermal growth conditions and the optical properties of ZnO nanostructures, opening up new possibilities for their precise control and application in nanophotonics, UV-Vis, and white light sources.
Article
Energy & Fuels
Dmitry Agafonov, Aleksandr Bobyl, Aleksandr Kamzin, Alexey Nashchekin, Evgeniy Ershenko, Arseniy Ushakov, Igor Kasatkin, Vladimir Levitskii, Mikhail Trenikhin, Evgeniy Terukov
Summary: Phase-homogeneous LiFePO4 powders with less than 0.1% impurity crystalline phases were synthesized, as confirmed by SXRD. XRD was used to determine anisotropic crystallite sizes, L-V[hkl]. The use of a low resistance covering layer containing mechanically strong ferric-graphite-graphene composite with impregnated Fe3+ particles < 10 nm in size improves cycleability compared to industrial cathodes.
Editorial Material
Biochemistry & Molecular Biology
Daniil Eurov, Dmitry Kurdyukov
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Alexey Kuznetsov, Eduard Moiseev, Artem N. Abramov, Nikita Fominykh, Vladislav A. Sharov, Valeriy M. Kondratev, Ivan I. Shishkin, Konstantin P. Kotlyar, Demid A. Kirilenko, Vladimir V. Fedorov, Svetlana A. Kadinskaya, Alexandr A. Vorobyev, Ivan S. Mukhin, Aleksey V. Arsenin, Valentyn S. Volkov, Vasily Kravtsov, Alexey D. Bolshakov
Summary: Emerging technologies for integrated optical circuits require novel approaches and materials, such as self-assembled gallium phosphide (GaP) epitaxial nanowires. This research investigates the effects of nanowire geometry on waveguiding properties and demonstrates the fabrication of low-loss and subwavelength cross-section waveguides for visible and near-infrared ranges. The study also reveals the filtering properties of the nanowires and the possibility of developing nanoscale waveguides with a preassigned geometry using GaP nanowires.
Article
Chemistry, Multidisciplinary
Talgat Shugabaev, Vladislav O. Gridchin, Sergey D. Komarov, Demid A. Kirilenko, Natalia V. Kryzhanovskaya, Konstantin P. Kotlyar, Rodion R. Reznik, Yelizaveta I. Girshova, Valentin V. Nikolaev, Michael A. Kaliteevski, George E. Cirlin
Summary: In this study, hybrid nanostructures based on InGaN nanowires with decorated plasmonic silver nanoparticles were investigated. It was found that plasmonic nanoparticles caused the redistribution of room temperature photoluminescence between short-wavelength and long-wavelength peaks of InGaN nanowires. The short-wavelength maxima decreased by 20%, while the long-wavelength maxima increased by 19%. This phenomenon was attributed to energy transfer and enhancement between different parts of the nanowires with varying In content and a proposed Frohlich resonance model was used to explain the enhancement effect.
Article
Chemistry, Multidisciplinary
Maxim K. Rabchinskii, Nadezhda A. Besedina, Maria Brzhezinskaya, Dina Yu. Stolyarova, Sergei A. Ryzhkov, Sviatoslav D. Saveliev, Grigorii A. Antonov, Marina V. Baidakova, Sergei I. Pavlov, Demid A. Kirilenko, Aleksandr V. Shvidchenko, Polina D. Cherviakova, Pavel N. Brunkov
Summary: In this study, the feasibility of aminated graphene for covalently conjugating monoclonal antibodies to human IgG immunoglobulins was thoroughly examined. Core-level spectroscopy methods were applied to investigate the chemistry and electronic structure changes of aminated graphene before and after immobilization of monoclonal antibodies. Electron microscopy techniques were used to assess the morphology alterations of graphene layers during derivatization protocols. Chemiresistive biosensors composed of aerosol-deposited layers of aminated graphene with conjugated antibodies were fabricated and tested, demonstrating selective response to IgM immunoglobulins with a low limit of detection of 10 pg/mL. These findings advance the application of graphene derivatives in biosensing and provide insights into the morphology and physics changes of graphene upon functionalization and covalent grafting by biomolecules.
Article
Materials Science, Multidisciplinary
Daniil A. Eurov, Demid A. Kirilenko, Larisa V. Sharonova, Aleksandr V. Shvidchenko, Alexander N. Smirnov, Maria V. Tomkovich, Maria A. Yagovkina, Dmitry A. Kurdyukov
Summary: An approach for synthesizing stable core-shell V2O5/SiO2 colloidal particles has been proposed, which involves obtaining ammonium vanadate particles as a precursor and coating them with a silica shell. The presence of microporous structure in the SiO2 shell allows efficient removal of decomposition products during conversion and preserves the shape and size of the coreshell particles. The obtained V2O5/SiO2 particles show intense photoluminescence and the shell retains its porous structure, making them promising for use in heterogeneous catalysis.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Nikita A. Leonov, Daniil A. Kozlov, Demid A. Kirilenko, Nikolay A. Bert, Anna O. Pelageikina, Andrey A. Nechitailov, Mikhail B. Alikin, Andrei A. Krasilin
Summary: We investigated the process of obtaining nanostructured halloysite by adjusting the parameters of the initial composition synthesis. Aluminum hydrosilicate with Al2Si2O5(OH)4 composition was synthesized under hydrothermal conditions. The resulting particles had a plate-like morphology with an average length of 100-200 nm and a thickness of 60 nm. Two phases, plate-like kaolinites and a halloysite-like phase, were identified. The synthesized samples also revealed the presence of organic-modified hydrosilicate with a phase transition temperature of approximately 412 degrees C, which holds promise for adsorption and exfoliation studies.
NANOSYSTEMS-PHYSICS CHEMISTRY MATHEMATICS
(2023)
Article
Chemistry, Applied
A. N. Starukhin, D. K. Nelson, D. A. Eurov, D. A. Kurdyukov, S. A. Grudinkin
Summary: The influence of temperature on the fluorescence of carbon dot colloidal solution in glycerol was investigated. Carbon dots were synthesized via pyrolysis of Nile Red laser dye using mesoporous silica as a template. The temperature-dependent intensity of the dominant emission peak was found to be nontrivial: as the temperature increased, the initial fluorescence quenching was replaced by enhancement to the initial value. A three-level model of electronic states was employed to quantitatively describe the observed temperature dependence of fluorescence and estimate the energies of nonradiative deactivation and activation of the emissive state. The solvatochromic effect in the fluorescence spectra of Nile Red-based carbon dots in different solvents was also discussed.
Article
Chemistry, Physical
T. N. Rostovshchikova, D. A. Eurov, D. A. Kurdyukov, M. V. Tomkovich, M. A. Yagovkina, I. A. Ivanin, K. I. Maslakov, O. V. Udalova, M. I. Shilina
Summary: Two types of nanosilicas with different pore structures are synthesized and decorated with cobalt and cerium oxides. The catalytic behavior of the synthesized materials is determined by the interactions among the metal oxides and with the silica surface.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Nanoscience & Nanotechnology
Valeriy M. Kondratev, Ekaterina A. Vyacheslavova, Talgat Shugabaev, Demid A. Kirilenko, Alexey Kuznetsov, Svetlana A. Kadinskaya, Zamir V. Shomakhov, Artem I. Baranov, Svetlana S. Nalimova, Vyacheslav A. Moshnikov, Alexander S. Gudovskikh, Alexey D. Bolshakov
Summary: This work focuses on the development of a highly sensitive silicon-based sensor for the detection and analysis of liquid solutions containing ammonia (NH3) and hydrochloric acid (HCl) using electrochemical impedance spectroscopy (EIS). Three types of sensors were fabricated using as-fabricated Si nanowires, nanowires treated with hydrofluoric acid (HF), and nanowires decorated with silver (Ag) nanoparticles. The best results were obtained with untreated Si nanowires, providing a detection limit of 4 μmol·L-1 for both HCl and NH3. Treatment with HF increased the adsorption sites and showed promise for detecting analyte content up to 1000 μmol·L-1. The study also explored the sensor response to NH3 and HCl vapors, using a dual parameter approach for qualitative analysis of gas mixture composition. These findings contribute to the development of highly sensitive sensors for health monitoring and selective detection of mixed analytes.
ACS APPLIED NANO MATERIALS
(2023)
Article
Crystallography
T. N. Pallaeva, A. V. Mikheev, D. N. Khmelenin, D. A. Eurov, D. A. Kurdyukov, V. K. Popova, E. V. Dmitrienko, D. B. Trushina
Summary: Nanostructured submicron calcium carbonate particles with sizes of 500±90 nm and 172±75 nm have been synthesized through mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO3:Si:Fe nanoparticles 65±15 nm in size have been obtained by template synthesis in pores of silica particles. The crystal structure and polymorphism of these particles are studied, and the influence of the size and structure of particles on the efficiency of their loading with a chemotherapy agent, as well as its release under model conditions at different pH, is determined.
CRYSTALLOGRAPHY REPORTS
(2023)
Article
Physics, Multidisciplinary
D. K. Nelson, A. N. Starukhin, D. A. Kurdyukov, E. Yu. Stovpyaga
Summary: The temperature and viscosity dependences of polarized luminescence of colloidal solutions of MoS2 nanodots in organic solvents were investigated. The ensemble of MoS2 nanodots behaves as a system of linear oscillators under linearly polarized excitation, where the initial orientation is disrupted by the Brownian rotation of the nanodots. The sizes of luminescent nanodots, which change with the radiation wavelength, were estimated within the framework of the Levshin-Perrin model, and the results were consistent with the estimates based on quantum size effect. It was found that the polarization features of radiative transitions in MoS2 nanodots differ from those in MoS2 monolayers.
ST PETERSBURG POLYTECHNIC UNIVERSITY JOURNAL-PHYSICS AND MATHEMATICS
(2023)