Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Yaling Wang, Yonglin Chen, Lingling Meng, Bufan Wu, Ling Ouyang, Rou Peng, Dan Hou, Sitong Liu, Shengfeng Lu, Xinyue Jing, Shuping Fu, Bin Xu
Summary: Electro-acupuncture (EA) is an effective and safe treatment for ischemic stroke, capable of reducing cerebral damage and alleviating intestinal inflammation, although its mechanism is not fully understood.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Urology & Nephrology
Junnan Xu, Xiubin Li, Qing Yuan, Chenfeng Wang, Liang Xu, Xing Wei, Haitao Liu, Bo Yu, Zhekun An, Yuanyu Zhao, Xiang Li, Xu Zhang, Xin Ma, Ming Cai
Summary: The study demonstrates that Sema4A can alleviate kidney ischemia reperfusion injury by enhancing the stability and function of Treg cells, reducing neutrophil and proinflammatory macrophage accumulation.
KIDNEY INTERNATIONAL
(2021)
Article
Cell Biology
Bo Liu, Fengxia Ding, Ding Cao, Jiang Liu, Yaping Wang, Chun Wu
Summary: The study reveals that OMVs preconditioning can ameliorate lung I/R injury by regulating the balance of Tregs and Th17 cells, as well as modulating the Tim-3 and TLR4/NF-kappa B pathways.
INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sebastian Bittner, Brigitte Ruhland, Veronika Hofmann, Lisa Schmidleithner, Kathrin Schambeck, Asmita Pant, Philipp Stueve, Michael Delacher, Bernd Echtenacher, Matthias Edinger, Petra Hoffmann, Michael Rehli, Claudia Gebhard, Nicholas Strieder, Thomas Hehlgans, Markus Feuerer
Summary: In this study, the researchers introduced synthetic biosensors called artificial immune receptors (AIRs) to modulate regulatory T cells (Treg cells). These AIRs enable Treg cells to sense inflammation and activate specific signaling pathways. In animal models, Treg cells expressing AIRs provided better protection against graft-versus-host disease compared to control Treg cells. The expression and signaling of these artificial immune receptors in human Treg cells suggest the potential application of Treg cell-based therapy for various inflammation-driven diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Multidisciplinary Sciences
Christopher T. Turner, Megan Pawluk, Juliana Bolsoni, Matthew R. Zeglinski, Yue Shen, Hongyan Zhao, Tatjana Ponomarev, Katlyn C. Richardson, Christopher R. West, Anthony Papp, David J. Granville
Summary: This study investigated the therapeutic effect of sulfaphenazole (SP) in pressure injuries. The results showed that SP could alleviate the severity of pressure injuries, promote wound closure, and improve wound tensile strength. Additionally, SP rapidly restored tissue perfusion, reduced tissue hypoxia, inflammation, and fibrosis. Moreover, SP demonstrated bactericidal activity through enhanced macrophage activity. The effectiveness of SP in reducing thermal injury severity was also demonstrated. Therefore, SP has the potential to be a therapeutic option for pressure injuries and other ischemic skin injuries.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Selva Rivas-Arancibia, Eduardo Hernandez-Orozco, Erika Rodriguez-Martinez, Marlen Valdes-Fuentes, Vanessa Cornejo-Trejo, Nelva Perez-Pacheco, Claudia Dorado-Martinez, Diana Zequeida-Carmona, Isaac Espinosa-Caleti
Summary: Ozone pollution leads to chronic oxidative stress which disrupts immune response and inflammation regulation. The imbalance in oxidation-reduction equilibrium contributes to the chronic deterioration of degenerative diseases. Studying the relationship between ozone pollution, oxidative stress, and regulatory T cells provides valuable insights into the impact on inflammatory responses and the role of antioxidant systems in various pathologies.
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Abhishek Sahu, Jin Jeon, Min Suk Lee, Hee Seok Yang, Giyoong Tae
Summary: Mesenchymal stem cell (MSC) based therapy shows great potential in treating diseases, but the low viability of transplanted cells in injured tissues due to high oxidative stress levels is a major obstacle. Using a ROS-scavenging nanozyme to protect MSCs from oxidative stress-mediated apoptosis can significantly improve therapeutic potential and survival in high oxidative stress conditions. Incorporating nanozymes into MSCs is a simple and efficient way to enhance MSC-based cell therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Murilo Delgobo, Emil Weiss, DiyaaElDin, Ashour Leon Richter, Lisa Popiolkowski, Panagiota Arampatzi, Verena Stangl, Paula Arias-Loza, Encarnita Mariotti-Ferrandiz, Peter P. Rainer, Antoine-Emmanuel Saliba, Burkhard Ludewig, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: In this study, the researchers investigated how antigen-specific T-helper cells differentiate in the myocardial environment. They used a transgenic T cell receptor model and single-cell transcriptomics to study the cells in the murine infarcted myocardium. The results showed that these cells acquired a regulatory phenotype and influenced tissue repair.
CIRCULATION RESEARCH
(2023)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Aurelie Robin, Claire Mackowiak, Romain Bost, Fanny Dujardin, Alice Barbarin, Antoine Thierry, Thierry Hauet, Luc Pellerin, Jean-Marc Gombert, Ephrem Salame, Andre Herbelin, Louise Barbier
Summary: Over the past thirty years, the complexity of the alpha beta-T cell compartment has been enriched by the identification of innate-like T cells (ITCs). This study reveals the key role of iNKT and MAIT cells in acute sterile inflammation, and their connection with the alarmin/cytokine interleukin (IL)-33 in humans and mice models.
FRONTIERS IN IMMUNOLOGY
(2023)