Review
Pharmacology & Pharmacy
Duoduo Wu, Dawn Ka-Ann Lim, Blanche Xiao Hong Lim, Nathan Wong, Farhad Hafezi, Ray Manotosh, Chris Hong Long Lim
Summary: Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light is a versatile treatment option for a variety of corneal diseases, including keratoconus. Recent advances include PACK-CXL for infectious keratitis and CurV customized protocols, which have generated increased interest in the field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Maryam Eslami, Farhad Ghaseminejad, Paul J. Dubord, Sonia N. Yeung, Alfonso Iovieno
Summary: This study analyzed the long-term topographic and refractive outcomes of corneal cross-linking (CXL) in keratoconus. The results showed improvements in corrected distance visual acuity, spherical and cylindrical refraction, average and steepest keratometry, and corneal aberrations over the follow-up period. The improvement was more pronounced in patients with more severe keratoconus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Eren Aytekin, Sibel Bozdag Pehlivan
Summary: Current treatment approaches for keratoconus include options such as penetrating keratoplasty, deep anterior lamellar keratoplasty, and corneal collagen cross-linking. Early diagnosis and halting the disease with CXL methods are becoming crucial in clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Medicine, General & Internal
Hidenaga Kobashi, Osamu Hieda, Motohiro Itoi, Kazutaka Kamiya, Naoko Kato, Jun Shimazaki, Kazuo Tsubota
Summary: All corneal cross-linking techniques demonstrated attenuation of disease progression in pediatric keratoconus patients for at least one year based on a systematic review and meta-analysis. Both standard and accelerated CXL methods led to significant improvement in visual acuity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Adi Einan-Lifshitz, Asaf Achiron, Shira Hed, Idan Hecht, Biana Dubinsky-Pertzov, Boris Knyazer
Summary: The study demonstrates that accelerated corneal collagen cross-linking (A-CXL) can improve visual function, reduce corneal astigmatism and Kmax, and decrease the thinnest corneal thickness in pediatric patients with keratoconus (KC) after three years of follow-up. A-CXL is non-inferior to standard CXL (S-CXL) in terms of best-corrected and uncorrected visual acuity, thinnest pachymetry, and astigmatism, but non-inferiority cannot be concluded for Kmax.
Article
Ophthalmology
Siddharth Nath, Carl Shen, Alex Koziarz, Laura Banfield, Behnam Nowrouzi-Kia, Mark A. Fava, William G. Hodge
Summary: Transepithelial and epithelium-off corneal cross-linking show significant differences in corneal ectasia treatment, with the latter being more effective but less safe in comparison.
Article
Ophthalmology
Davide Borroni, Chiara Bonzano, Rozaliya Hristova, Rahul Rachwani-Anil, Jose Maria Sanchez-Gonzalez, Carlos Rocha de Lossada
Summary: This study compared the outcomes of standard epithelium-off corneal cross-linking and corneal cross-linking with an epithelial flap for patients with progressive keratoconus. The results showed that the epithelial flap technique was associated with less postoperative pain and anterior stromal haze, with no loss of efficacy at 12 months postoperatively.
JOURNAL OF REFRACTIVE SURGERY
(2021)
Article
Medicine, General & Internal
Magdalena Krok, Ewa Wroblewska-Czajka, Joanna Kokot, Anna Micinska, Edward Wylegala, Dariusz Dobrowolski
Summary: The objective of this paper is to analyze the occurrence of sterile infiltrate in patients with keratoconus after corneal collagen cross-linking (CXL) and evaluate possible risk factors. The study found that the occurrence of sterile infiltrates after CXL was relatively low, but damage to the epithelium and the phototoxic effect of the procedure were significant factors. Appropriate classification and selection of CXL procedures, along with protective measures, can have a significant impact on reducing the incidence of this complication.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
William J. Dupps
Summary: The question of whether to remove the epithelium in corneal cross-linking remains controversial. Most evidence suggests that removal of the epithelium enhances crosslinking effectiveness, but there is still a lack of evidence for a significant reduction in complications.
Article
Ophthalmology
Ugur Ercin, Yavuz Kemal Aribas, Atike Burcin Tefon Aribas, Kamil Bilgihan, Aye Bilgihan
Summary: The study showed that the accelerated UV-A irradiance group with 2 L/min oxygen assistance had a greater decrease in DPBF absorbance compared to the Dresden protocol. The Dresden protocol also had a greater decrease in DPBF compared to all groups except for accelerated crosslinking with 2 L/min oxygen. Additionally, oxygen-assisted hyper-accelerated crosslinking groups showed a greater reduction in DPBF absorbance compared to standard crosslinking without oxygen groups.
Article
Ophthalmology
Marcony R. Santhiago, J. Bradley Randleman
Summary: Corneal crosslinking (CXL) surgery halts the progression of keratoconus through a photochemical reaction involving UV light and riboflavin-induced apoptosis of corneal cells. The stiffening effect of CXL primarily occurs in the anterior third of the cornea, and shorter irradiation times may not have the same biological effect.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Alex C. Ferdi, Himal Kandel, Vuong Nguyen, Jeremy Tan, Francisco Arnalich-Montiel, Marco Abbondanza, Stephanie L. Watson
Summary: The long-term outcomes of epithelium-off cross-linking (CXL) in keratoconus patients were determined in this study. Most patients showed stable keratoconus up to 5 years after the CXL treatment, but a small proportion experienced reduced vision.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Samantha Bradford, Shangbang Luo, Donald Brown, Tibor Juhasz, James Jester
Summary: This review analyzes the research findings on the effects and mechanisms of using UVA CXL in the treatment of corneal ectasia and Keratoconus. While some effects are widely accepted, others are still controversial. Understanding and analyzing these effects and mechanisms are essential for predicting treatment outcomes.
Article
Biochemical Research Methods
Giuseppe Lombardo, Giuseppe Massimo Bernava, Sebastiano Serrao, Marco Lombardo
Summary: Theranostics is a personalized medicine approach that combines therapy and diagnostics. This study used theranostic-guided corneal cross-linking to treat human sclero-corneal tissues. The theranostic device provided real-time measurement of corneal riboflavin concentration and a theranostic score to estimate treatment efficacy. The study found a significant correlation between the theranostic score and the increase in mean corneal stiffness, with an accuracy and precision of 90% in predicting the induced corneal tissue stiffening.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Medicine, General & Internal
Farhad Hafezi, Nan-Ji Lu, Jad F. Assaf, Nikki L. Hafezi, Carina Koppen, Riccardo Vinciguerra, Paolo Vinciguerra, Mark Hillen, Shady T. Awwad
Summary: This study aimed to evaluate the depth of the demarcation line following accelerated epithelium-off corneal cross-linking (A-CXL) performed at the slit lamp with the patient sitting in an upright position. The results showed that the demarcation line depth achieved with patients sitting upright, receiving CXL at the slit lamp, is similar to published data on CXL performed in the supine position.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Sonia Razafimino, Elias Flockerzi, Elena Zemova, Christian Munteanu, Berthold Seitz
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Editorial Material
Ophthalmology
Doris Fraenkel, Loic Hamon, Isabel Weinstein, Berthold Seitz, Loay Daas
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Haris Sideroudi, Elias Flockerzi, Theresia Jullien, Loic Hamon, Berthold Seitz
Summary: The study investigated the risk factors for keratoconus progression in different age groups. The factors associated with progression were corneal radius, eye rubbing, corneal thinning, contact lens use, and corneal thickness. Further analysis revealed that anterior chamber volume and keratoconus match index were associated with progression in children, while other factors like distance from apex to the thinnest point and Vogt striae were associated with progression in young and middle-aged adults.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Kassandra Xanthopoulou, Georgia Milioti, Loay Daas, Cristian Munteanu, Berthold Seitz, Elias Flockerzi
Summary: The efficacy of accelerated epithelium-off corneal crosslinking was evaluated in keratoconus patients < 18 years of age. The study showed that this treatment can stabilize KC progression even > 2 years postoperatively and leads to a deep demarcation line.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Kolja Berg, Tarek Safi, Berthold Seitz, Loay Daas
Summary: The aim of this study was to measure the endothelial cell density (ECD) of the in toto pre-stripped endothelial Descemet membrane lamellae (EDML) and to describe the impact of pre- and intraoperative endothelial cell loss (ECL) on postoperative midterm clinical outcome. The results showed that despite a significant decrease in ECD up to 6 months postoperatively, visual acuity further improved and thickness further decreased up to 1 year postoperatively, indicating the feasibility of non-invasive ECD measurement technique.
Article
Ophthalmology
Tim Berger, Fidelis Flockerzi, Ursula Loew, Elias Flockerzi, Wissam Aljundi, Alaadin Abdin, Loay Daas, Berthold Seitz
Summary: The purpose of this study is to report a rare and late manifestation of choroidal melanoma in the form of corneal perforation and to highlight the major histopathological findings of this unusual combined clinical presentation. The patient, a 74-year-old male, presented with corneal perforation of the right eye and absence of light perception for 6 months. Primary enucleation was performed due to the prolonged finding and reduced visual prognosis.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Zhen Li, Daniel Boehringer, Tanja Stachon, Mahsa Nastaranpour, Fabian Norbert Fries, Berthold Seitz, Myriam Ulrich, Cristian Munteanu, Achim Langenbucher, Nora Szentmary
Summary: The study assessed the impact of various factors, including donor age, storage time, and corneal ring size, on the outgrowth of human limbal epithelial cells. The results showed that lower donor age, fewer medium changes during storage, shorter medium time, and smaller corneoscleral ring size were associated with higher success rates of LEC outgrowth. A stepwise linear regression algorithm was employed to analyze the influencing parameters.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Ning Chai, Tanja Stachon, Mahsa Nastaranpour, Zhen Li, Berthold Seitz, Myriam Ulrich, Achim Langenbucher, Nora Szentmary
Summary: This study investigated the effect of Rose Bengal photodynamic therapy (RB-PDT) on the viability and proliferation of different human corneal cells. The results showed that RB-PDT did not have an effect on cell viability or proliferation alone, but it significantly decreased viability and proliferation at specific light doses.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Tim Berger, Nora Szentmary, Ning Chai, Elias Flockerzi, Loay Daas, Tanja Stachon, Berthold Seitz
Summary: The purpose of this research is to investigate the expression of cytokines and ROS-related genes in stromal cells of healthy and keratoconus (KC) corneas. Expression analysis was performed for cytokines and ROS-related genes in corneal fibroblasts (HCFs/KC-HCFs) or keratocytes (Keratocytes/KC-Keratocytes) using qPCR and ELISA. The study found that the expression of most inflammatory markers was decreased in keratocytes compared to fibroblasts, and there were no differences in cytokine expression between healthy and keratoconus cells. TNF-alpha expression was increased in KC keratocytes compared to corneal fibroblasts. No differential expression of ROS-related genes was detected between healthy and diseased cells in both fibroblasts and keratocytes.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Fabian Norbert Fries, Annamaria Naray, Cristian Munteanu, Tanja Stachon, Neil Lagali, Berthold Seitz, Nora Szentmary, Barbara Kaesmann-Kellner
Summary: The purpose of this study is to summarize the ophthalmic findings of aniridia subjects examined at the Department of Ophthalmology, Saarland University Medical Center. The main ophthalmic signs of congenital aniridia were found to be AAK, iris malformation, cataract, and macular hypoplasia.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Alaa Din Abdin, Anna Eppinger, Wissam Aljundi, Yaser Abu-Dail, Cristian Munteanu, Isabel Weinstein, Berthold Seitz
Summary: This study aimed to assess the vision-related quality of life of patients with age-related macular degeneration (AMD) and evaluate the differences according to different types of AMD. The results showed that all types of AMD had a negative effect on vision-related quality of life, but the effect was more pronounced in patients with exudative AMD.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Ophthalmology
Ann-Isabel Mattern, Kai Neller, Machteld Devenijn, Hartmut Schwahn, Achim Langenbucher, Berthold Seitz, Hakan Kaymak
Summary: This study assessed the reproducibility and repeatability of biometers in myopic children. The results showed good agreement between the biometers and suggested a minimum six-month interval for measuring axial growth in myopic children.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Article
Health Care Sciences & Services
Madeleine A. Perrault, Gabriele Lauer, Sabine Voss, Berthold Seitz, Barbara Kaesmann-Kellner
Summary: This study aims to compare the etiology and fitting of low vision aids in visually impaired children and adolescents with that of adults. The study found that children had better visual acuity compared to adults and the most common cause of visual impairment in children was albinism while it was age-related macular degeneration in adults. Fitting magnifying visual aids significantly improved near and distance visual acuity, with optical aids being the most commonly prescribed aids.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Burak Mergen, Tim Berger, Loic Hamon, Loay Daas, Berthold Seitz
Summary: This case report demonstrates that quadruple DMEK may be a feasible approach for managing chronic endothelial cell decompensation secondary to iris-claw ACIOL implantation.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Hakan Kaymak, Kai Neller, Birte Graff, Achim Langenbucher, Berthold Seitz, Hartmut Schwahn, Karsten Klabe
Summary: Patients with mild and moderate macular disorders, such as AMD and ERM, show an induced contrast adaptation, i.e. a gain in contrast sensitivity, which is not different from healthy subjects.
CURRENT EYE RESEARCH
(2023)