Article
Multidisciplinary Sciences
Chun Hsiung, Yu-Ting Liu, Chen-Ying Su, Chung-Chuan Hsiung, Kuo-Hsuan Hung, Lung-Kun Yeh
Summary: Human blood-derived topical therapies, such as autologous serum (AS) and platelet-rich plasma (PRP), have greatly benefited clinicians in recent years. These therapies possess growth factors that are essential for corneal wound healing. Autologous conditioned serum (ACS) not only preserves the properties of AS and PRP, but also has immune-modulating properties, which are important for treating inflammatory diseases. However, the lack of standardized protocols and high preparation costs limit the clinical application of ACS.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Ophthalmology
Selma Ozbek-Uzman, Zuleyha Yalniz-Akkaya, Evin Singar Ozdemir, Ayse Burcu
Summary: The study demonstrated that treatment with autologous serum eye drops is effective and safe for persistent corneal epithelial defects. The method of preparation and administration of serum eye drops plays a crucial role in the treatment outcomes.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hyeong Ju Kim, Hyun Chul Youn, Jeong Jae Hyun, Sang Woo Kim
Summary: Autologous serum gel therapy is effective in patients with lagophthalmos combined with neurotrophic persistent corneal epithelial defects. It reduces symptoms and promotes epithelial healing.
OPHTHALMOLOGY AND THERAPY
(2022)
Review
Ophthalmology
Zhang Zhe Thia, Yik To Ho, Kendrick Co Shih, Louis Tong
Summary: A persistent epithelial defect (PED) refers to a corneal epithelial defect that fails to heal within two weeks, with unsatisfactory treatment outcomes. More research is needed to establish reliable treatment modalities and advance new therapies.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Microbiology
Morgan K. Morelli, Amy Kloosterboer, Scott A. Fulton, Jennifer Furin, Nicholas Newman, Ahmed F. Omar, Laura J. Rojas, Steven H. Marshall, Mohamad Yasmin, Robert A. Bonomo
Summary: Resistant Gram-negative bacteria pose a growing concern in the United States, causing significant morbidity and mortality rates. We report a case of a 72-year-old female patient presenting with unilateral vision loss. She was diagnosed with a large corneal ulcer infected by extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of bla(VIM-80), bla(GES-9), and other resistance determinants. This unique organism was linked to an over-the-counter artificial tears product.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Ophthalmology
David Diaz-Valle, Barbara Burgos-Blasco, Daniela Rego-Lorca, Virginia Puebla-Garcia, Pilar Perez-Garcia, Jose M. Benitez-del-Castillo, Rocio Herrero-Vanrell, Marta Vicario-de-la-Torre, Jose A. Gegundez-Fernandez
Summary: Topical insulin is a more effective treatment for persistent epithelial defects (PED) compared to autologous serum, achieving higher epithelization rates and lower recurrence rates. This study suggests that topical insulin can be considered as a first-line treatment for PED.
ACTA OPHTHALMOLOGICA
(2022)
Review
Allergy
David Cui, Gavin Li, Esen K. Akpek
Summary: Tears have various beneficial properties for the corneal and conjunctival epithelium. The use of autologous serum eye drops has been reported as a new treatment for severe ocular surface disorders, showing similar properties to normal tears and better maintenance of corneal epithelial cells compared to pharmaceutical substitutes.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Ophthalmology
Pieter F. van der Meer, Sanne K. Verbakel, Aine Honohan, Jos Lorinser, Rogier M. Thurlings, Joannes F. M. Jacobs, Dirk de Korte, Catharina A. Eggink
Summary: The study evaluated the efficacy and tolerability of autologous and allogeneic SEDs in treating patients with severe dry eyes, showing no significant difference in improving the Ocular Surface Disease Index between the two, with mild and completely resolved adverse events.
ACTA OPHTHALMOLOGICA
(2021)
Article
Engineering, Biomedical
Yi Zhang, Chenglin Li, Qiuwen Zhu, Renjie Liang, Chang Xie, Shufang Zhang, Yi Hong, Hongwei Ouyang
Summary: The study demonstrates a protein coating strategy for promoting corneal regeneration, which accelerates corneal cell migration and repair by providing a favorable environment, resulting in tissue structure more similar to native cornea being regenerated. This molecular coating, used as an eye drop solution, shows promise for corneal regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Ophthalmology
Barbara Burgos-Blasco, David Diaz-Valle, Daniela Rego-Lorca, Pilar Perez-Garcia, Virginia Puebla-Garcia, Jose Ignacio Fernandez-Vigo, Jose Manuel Benitez-del-Castillo, Jose Antonio Gegundez-Fernandez
Summary: The efficacy of topical insulin eye drops in reducing corneal staining and improving symptoms of refractory dry eye disease was evaluated in this retrospective case series. The results showed that topical insulin was a promising treatment option for patients with epithelial damage in dry eye disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Microbiology
Tanmoy Dutta, Jyoti Sangwan, Moumita Mondal, Mehak Vohra, Vatsala Nidhi, Abha Gour, Neha Kapur, Nidhi Gupta, Tuhin Bhowmick, Arun Chandru, Umang Mathur, Virender Singh Sangwan, Manisha Acharya, Anil Tiwari
Summary: This study explores the gene network driving re-epithelialization in persistent corneal epithelial defect (PED). It suggests that tears play a role in creating an acute proinflammatory environment in PED, while the scraped samples from PED patients represent the chronic stage of the disease.
Review
Ophthalmology
Betina Orman, Giovanna Benozzi
Summary: There are currently three different strategies for pharmacological treatment of presbyopia: inducing miosis to improve near visual acuity, restoring lens elasticity lost due to aging, and rehabilitating accommodation for good vision at all distances. These treatments, involving eyedrops with varying compositions, are a new alternative expanding the diversity of existing strategies and are expected to be on the market in the near future. Proper patient selection is crucial for the successful use of any of these three strategies.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Sukhmandeep Kaur, Phulen Sarma, Hardeep Kaur, Manisha Prajapat, Nishant Shekhar, Jaimini Bhattacharyya, Harpinder Kaur, Subodh Kumar, Bikash Medhi, Jagat Ram, Dipankar Das, Pramod Avti, Ajay Prakash, Rahul Singh, Anusuya Bhattacharyya
Summary: This study found that cysteamine performed better than placebo and control in terms of treatment response and improvement, and was more effective in reducing corneal cystine density compared to other formulations.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Waleed K. Alsarhani, Abdullah I. Almater, Majed S. Alkharashi
Summary: The study found that the use of 100% medical grade Manuka honey ointment can be an effective treatment for persistent corneal epithelial defects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Erin S. Ong, Bennie H. Jeng
Summary: This review provides an update on the current and potential future therapeutic options for persistent epithelial defects (PEDs) and neurotrophic keratopathy (NK), focusing on stimulating healing at the cellular level, promoting corneal re-innervation, and restoring corneal sensitivity. Recent research has shown promising results for novel therapies aiming at treating PEDs, suggesting increasing potential for more effective and convenient therapies for these difficult situations.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
