Article
Ophthalmology
Gabor Toth, Barbara Berko-Goettel, Berthold Seitz, Achim Langenbucher, Tanja Stachon, Milan Tamas Pluzsik, Zoltan Zsolt Nagy, Sigrun Smola, Nora Szentmary
Summary: The study aimed to determine the prevalence of HSV DNA in corneal tissue of PKP patients with and without history of herpetic keratitis. Results showed a higher positivity rate in patients with clinical HSK history. Despite lack of clinical suspicion, HSV DNA was detected in some corneal tissues, suggesting the need for additional antiviral treatment in these cases.
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, General & Internal
Dominika Szkodny, Ewa Wroblewska-Czajka, Adam Wylegala, Magdalena Nandzik, Edward Wylegala
Summary: The purpose of this study was to evaluate the frequency of complications related to corneal grafts and identify risk factors. A retrospective analysis was conducted on patients who underwent penetrating keratoplasty between 2016 and 2020. The most common treatment complication was secondary glaucoma, followed by late endothelial failure, perforation, and bacterial keratitis. Ophthalmic and connective tissue diseases were significant factors associated with the occurrence of complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Dermatology
Paul Vance, Saranya Wyles, Afsaneh Alavi
Summary: Pityriasis rubra pilaris (PRP) is a rare, chronic papulosquamous disorder characterized by scaling plaques, palmoplantar keratoderma, and keratotic follicular papules. It has been associated with various immunodeficient states and malignancies. Treatment may involve corticosteroids, immunomodulators, or biologic therapy.
ADVANCES IN SKIN & WOUND CARE
(2022)
Letter
Dermatology
Jose Maria Villa-Gonzalez, Maria Rosario Gonzalez-Hermosa, Xabier Atxutegi-Ayesta, Juan Antonio Raton Nieto, Jesus Gardeazabal Garcia, Olatz Lasa Elgezua
Summary: This article presents two cases of erythrodermic pityriasis rubra pilaris that showed a rapid and almost complete response to tildrakizumab. Treatment of this condition is challenging, and there is limited evidence regarding the use of interleukin-23 blockers. These cases may contribute to expanding the available therapeutic options, particularly when fast clearance of lesions is required.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Pediatrics
Jana Guenther, Danielle Novack, Sonia Kamath, Scott Worswick
Summary: Pityriasis rubra pilaris is a rare disorder of cornification that affects both adult and pediatric patients, making clinical trials and universal treatment approaches challenging. Case reports and case series are the primary means of assessment for treatment options. Topicals are commonly used for pediatric patients, while oral retinoids are generally accepted as a first-line therapy. Interleukin-17 inhibitors and ustekinumab may also become first-line treatments due to their efficacy and relative safety. Second-line and adjunctive therapies such as tumor necrosis factor-alpha inhibitors, methotrexate, and phototherapy can be considered if initial treatments fail.
Article
Medicine, Research & Experimental
Shuai Shao, Jiaoling Chen, William R. Swindell, Lam C. Tsoi, Xianying Xing, Feiyang Ma, Ranjitha Uppala, Mrinal K. Sarkar, Olesya Plazyo, Allison C. Billi, Rachael Wasikowski, Kathleen M. Smith, Prisca Honore, Victoria E. Scott, Emanual Maverakis, J. Michelle Kahlenberg, Gang Wang, Nicole L. Ward, Paul W. Harms, Johann E. Gudjonsson
Summary: Through global transcriptomic profiling, it was found that there is a high overlap between plaque psoriasis and pityriasis rubra pilaris skin lesions, indicating a common molecular signature between these skin disorders. The study highlights the important role of phospholipases as regulators of epidermal barrier homeostasis and inflammation, identifying them as a shared pathogenic mechanism between PRP and psoriasis, and as potential therapeutic targets for both diseases.
Article
Dermatology
Marta Kolt-Kaminska, Antonina Osinska, Ewa Kaznowska, Adam Reich
Summary: Pityriasis rubra pilaris (PRP) is a rare skin disease that is mainly treated based on case reports and expert opinions. Treatment with biologicals, particularly anti-TNF and α, has been reported, but the involvement of the IL-23/Th17 axis may provide a potential therapeutic target. This study presents three pediatric PRP patients successfully treated with risankizumab, showing good efficacy and safety.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Sarah Ringin, Chris Baker, Peter Foley, Benjamin Daniel
Summary: Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory skin condition with limited treatment options. This study retrospectively analyzed data from 13 PRP patients in Australia from 2010 to 2019. Acitretin was the most commonly used systemic agent but resulted in adverse events in some cases. Complete clearance of PRP was achieved in 5 cases without biologic agents, and 2 cases showed marked improvement with biologic agents.
DERMATOLOGIC THERAPY
(2021)
Article
Medicine, General & Internal
Yani Wang, Jun Cheng, Nannan Yang, Ting Li, Yanling Dong, Lixin Xie
Summary: The purpose of this study was to compare the surgical outcomes of combined penetrating keratoplasty (PK) and cataract surgery with those of sequential surgery (cataract surgery after PK) for herpes simplex keratitis (HSK). The results showed that in the active stage, combined surgery had more complications and lower graft survival rate compared to sequential surgery. In the stable stage, combined surgery had better outcomes than sequential surgery. Therefore, sequential surgery has advantages in terms of fewer complications and higher graft survival rate in the active stage, while combined surgery is more effective in the stable stage.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Victor G. Sendra, Julia Tau, Gustavo Zapata, Romina M. Lasagni Vitar, Eduardo Illian, Pablo Chiaradia, Alejandro Berra
Summary: The study found that mice exposed to polluted air developed a severe form of herpes simplex keratitis, with increased corneal neovascularization, viral DNA, and production of various inflammatory cytokines. In polluted air, a large number of corneal immune cells were activated, and there was a significant influx of bone marrow-derived cells during acute herpes simplex keratitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Yahya Dogan
Summary: Pityriasis rubra pilaris (PRP) is a rare hyperkeratotic papulosquamous disorder. Rheumatologic manifestations of PRP are less known and rare compared to psoriasis. This article presents an interesting case of inflammatory arthritis in an adolescent patient successfully treated with adalimumab, supporting the diagnosis of type IV circumscribed juvenile PRP according to the literature.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Dermatology
Takuya Takeichi, Takahiro Hamada, Mayuko Yamamoto, Yasutoshi Ito, Aya Kawaguchi, Haruka Kobashi, Takenori Yoshikawa, Hiroshi Koga, Norito Ishii, Takekuni Nakama, Yoshinao Muro, Tomoo Ogi, Masashi Akiyama
Summary: Pathogenic variants in the ABCA12 gene are important for the development of autosomal recessive congenital ichthyoses. In addition, these variants can also cause a non-congenital form of ichthyosis. This study found patients who carried ABCA12 variants but did not exhibit the typical congenital ichthyosis phenotype. These patients had unaffected geographic areas on their skin, suggesting a milder phenotype.
JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Ophthalmology
Radhika Natarajan, Madhuvanthi Mohan
Summary: This video discusses the challenges and steps involved in corneal transplantation after healed herpes simplex viral keratitis, including diagnosis and classification of HSV keratitis, preoperative, intraoperative, and postoperative considerations, as well as the management of problems that may arise during surgery.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Letter
Dermatology
Yong-Hui Xu, Dan-Dan Dong, Yu-Feng Lin, Qian Wang, Liang-Mei Huang, Jian-Qiang Shi
Summary: This article reports a 3-year-old Chinese boy with severe Type III PRP who was successfully treated with secukinumab alone.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Bisant A. Labib, DeGaulle Chigbu
Summary: Herpes simplex virus (HSV) keratitis is a leading cause of blindness worldwide and affects a large population. Although there are currently no vaccines available, treatment options such as antiviral drugs and steroids can help manage the disease. However, these treatments do not eliminate the virus and are ineffective against recurrent infections, highlighting the need for further research on alternative therapies.
Letter
Clinical Neurology
John J. Chen, Namrata Singh, John J. Brinkley, Amanda C. Maltry, Bruno A. Policeni, Nasreen A. Syed, Richard C. Allen, Reid A. Longmuir, Matthew J. Thurtell
JOURNAL OF NEURO-OPHTHALMOLOGY
(2015)
Article
Ophthalmology
Pavlina S. Kemp, Susannah Q. Longmuir, Kevin R. Gertsch, Scott A. Larson, Richard J. Olson, Anne M. Langguth, Nasreen Syed, Thomas A. Oetting
JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS
(2015)
Article
Ophthalmology
Rachel K. Sobel, Nasreen A. Syed, Keith D. Carter, Richard C. Allen
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2015)
Article
Multidisciplinary Sciences
Demelza Koehn, Kacie J. Meyer, Nasreen A. Syed, Michael G. Anderson
Article
Ophthalmology
Amit K. Reddy, Meredith S. Baker, Amanda C. Maltry, Nasreen A. Syed, Richard C. Allen
BRITISH JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Lindsay K. McConnell, Nasreen A. Syed, Miriam B. Zimmerman, Keith D. Carter, Jeffery A. Nerad, Richard C. Allen, Erin M. Shriver
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Article
Ophthalmology
Erin M. Buckingham, Maria A. Foley, Charles Grose, Nasreen A. Syed, Morton E. Smith, Todd P. Margolis, Matthew J. Thurtell, Randy Kardon
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Ophthalmology
John J. Chen, Natalie L. Kamberos, M. Sue O'Dorisio, Nasreen A. Syed, Culver Boldt
Article
Ophthalmology
Meredith S. Baker, Angela R. McAllister, Nasreen A. Syed, Richard C. Allen
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2014)
Article
Ophthalmology
Christine N. Kay, Ryan M. Tarantola, Karen M. Gehrs, James C. Folk, Vinit B. Mahajan, H. Culver Boldt, Nasreen A. Syed, Stephen R. Russell
OPHTHALMIC SURGERY LASERS & IMAGING
(2011)
Article
Ophthalmology
Susannah Q. Longmuir, Nasreen A. Syed, Culver Boldt
Editorial Material
Ophthalmology
Bryce R. Radmall, Aron D. Sampson, Nasreen A. Syed, Audrey C. Ko
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Review
Ophthalmology
Thonnie Rose O. See, Gustav Stalhammar, Tina Tang, Joshua S. Manusow, David R. Jordan, Jeffrey A. Nerad, Robert C. Kersten, Marc Yonkers, Nasreen A. Syed, Seymour Brownstein, Hans E. Grossniklaus
SURVEY OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Elaine M. Binkley, Aron D. Sampson, Nasreen A. Syed, H. Culver Boldt
OCULAR ONCOLOGY AND PATHOLOGY
(2020)
Article
Ophthalmology
Lorraine M. Provencher, Aaron M. Fairbanks, Michael D. Abramoff, Nasreen A. Syed
JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION
(2018)
