Article
Cell Biology
Yongqiang Zheng, Yan Huang, Xiwen Zheng, Jiangtong Peng, Ying Chen, Kaixu Yu, Yun Yang, Xi Wang, Xue Yang, Jiaxin Qian, Xindi Wang, Xiaolan Gao, Bian Wu
Summary: This study characterized the demographic characteristics and mortality rates of COPD deaths in cancer patients in the United States, finding a nearly two-fold increased risk compared to the general population. The proportion of cancer survivors dying from COPD increased over time, with lung cancer patients having the highest overall risk.
Article
Cardiac & Cardiovascular Systems
Anne Lindberg, Lina Lindberg, Sami Sawalha, Ulf Nilsson, Caroline Stridsman, Bo Lundback, Helena Backman
Summary: This study found that COPD as a cause of death is often underestimated, with only 57.1% of death certificates mentioning it even in individuals with severe disease. Smoking, physician-diagnosed COPD, and male gender were independently associated with COPD as a cause of death.
RESPIRATORY MEDICINE
(2021)
Article
Immunology
Hayoung Choi, Kyungdo Han, Jin-Hyung Jung, Sang Hyun Park, Sang Hyuk Kim, Hyung Koo Kang, Jang Won Sohn, Dong Wook Shin, Hyun Lee
Summary: The long-term mortality risk in this study was significantly higher in tuberculosis survivors than those in the matched controls, even after adjusting for potential confounders, including behavior habits, income level, body mass index, and comorbidities.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Patricia Alupo, Adaeze C. Wosu, Abdallah Mahofa, Levicatus Mugenyi, Daniel Semakula, Winceslaus Katagira, Bruce Kirenga
Summary: This study in Uganda found that the two-year mortality rate among COPD patients is high, with disease severity at baseline being the strongest predictor of mortality. These findings highlight the importance of early and accurate diagnosis and management of COPD to potentially improve patient survival.
Article
Nutrition & Dietetics
Massimo Cirillo, Giancarlo Bilancio, Carmine Secondulfo, Gennaro Iesce, Carmela Ferrara, Oscar Terradura-Vagnarelli, Martino Laurenzi
Summary: The effects of alcohol intake on kidney function are still debated. This population-based study examined the association between alcohol intake and kidney function and mortality. The findings suggest a positive independent association between alcohol intake and kidney function, with moderate alcohol consumption associated with lower mortality rates.
Article
Geriatrics & Gerontology
Miguel A. Sanchez-Lastra, Ding Ding, Knut-Eirik Dalene, Borja del Pozo Cruz, Ulf Ekelund, Jakob Tarp
Summary: Regular stair climbing, especially climbing more than five flights per day at home, is associated with a lower risk of premature all-cause and cancer mortality. However, it does not show significant impact on cardiovascular disease mortality. These findings suggest that at-home stair climbing alone may not be sufficient to reduce the risk of premature death.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cardiac & Cardiovascular Systems
Zhi Du, Min Lin, Yuanmeng Tian, Li Jing, Shuang Liu, Guangxiao Li, Tong Jia, Qun Sun, Lei Shi, Jixu Sun, Wen Tian, Liying Xing
Summary: This study found a high prevalence of atrial fibrillation (AF) in hypertensive individuals, with underuse of oral anticoagulant therapy. Hypertensive individuals with AF had a significantly increased risk of cardiovascular disease-related mortality compared to those without AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Arun J. Sanyal, Mark L. Van Natta, Jeanne Clark, Brent A. Neuschwander-Tetri, AnnaMae Diehl, Srinivasan Dasarathy, Rohit Loomba, Naga Chalasani, Kris Kowdley, Bilal Hameed, Laura A. Wilson, Katherine P. Yates, Patricia Belt, Mariana Lazo, David E. Kleiner, Cynthia Behling, James Tonascia
Summary: In this study involving patients with nonalcoholic fatty liver disease, advanced fibrosis stages F3 and F4 were associated with increased risks of liver-related complications and death over a median of 4 years of follow-up. Advanced fibrosis was also related to an increased incidence of liver decompensation events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Hiroaki Ikezaki, Norihiro Furusyo, Ryoko Nakashima, Makiko Umemoto, Ken Yamamoto, Yuji Matsumoto, Azusa Ohta, Sho Yamasaki, Satoshi Hiramine, Koji Takayama, Eiichi Ogawa, Kazuhiro Toyoda, Masayuki Murata, Nobuyuki Shimono, Jun Hayashi
Summary: The Kyushu and Okinawa Population Study aims to investigate gene-environment interactions in non-communicable diseases in Japan by collecting data and analyzing various factors to understand and assess the occurrence and development of diseases. Researchers have mainly focused on either risk or confounding factors for non-communicable diseases based on the current survey results.
Article
Critical Care Medicine
Andrea S. Gershon, Rachel E. McGihon, Deva Thiruchelvam, Teresa To, Robert Wu, Chaim M. Bell, Shawn D. Aaron
Summary: The study indicates that hospitalization in COPD patients is associated with a higher risk of discontinuation of long-acting inhalers, especially in less adherent patients. Quality improvement efforts should focus on safe transitions and patient medication reconciliation following discharge.
Article
Nutrition & Dietetics
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This population-based prospective cohort study found no association between vitamin D levels and changes in weight and waist circumference at 5- and 10-year follow-up.
Article
Cardiac & Cardiovascular Systems
Henning Nilius, Tamara Mertins, Robin Boss, Matthias Knuchel, Eva Blozik, Johanna Anna Kremer Hovinga, Sabine Eichinger, Michael Nagler
Summary: This study found that long-term survival after the initial treatment of venous thromboembolism (VTE) was significantly reduced compared to the general Swiss population, especially in patients with more severe disease, cardiovascular comorbidities, and longer anticoagulant treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fredrik aberg, Rupesh Rajani, Axel Wester, Linnea Widman, Hanne Hagstrom
Summary: A study in Sweden found that patients with Budd-Chiari syndrome have a 3-fold higher risk of death compared to the general population, with cardiovascular disease being the most common cause of death.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Subramaniam, Susan A. Weston, Jill M. Killian, Phillip J. Schulte, Veronique L. Roger, Margaret M. Redfield, Saul B. Blecker, Shannon M. Dunlay
Summary: This population-based study found that the development of advanced HF is common and associated with significantly increased risks of hospitalization and mortality.
CIRCULATION-HEART FAILURE
(2022)
Article
Immunology
Seilesh Kadambari, Caroline L. Trotter, Paul T. Heath, Michael J. Goldacre, Andrew J. Pollard, Raphael Goldacre
Summary: This study assessed the burden of GBS disease and mortality in young infants in England, finding that there was no significant change in the annual incidence of GBS disease over the years, but a significant decline in GBS-attributable mortality. Infants with GBS had higher rates of visual impairment, cerebral palsy, hydrocephalus, and necrotizing enterocolitis compared to those without GBS.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Jonas Eriksson Strom, Simon Kebede Merid, Jamshid Pourazar, Anders Blomberg, Anne Lindberg, Mikael Ringh, Michael Hagemann-Jensen, Tomas J. Ekstrom, Annelie F. Behndig, Erik Melen
Summary: DNA methylation patterns in chronic obstructive pulmonary disease (COPD) were investigated using an epigenome-wide association study on bronchoalveolar lavage (BAL) cells. The study identified differential methylation sites associated with COPD, and functional analysis revealed biologically plausible pathways and gene relationships. Integration with mRNA data showed a strong functional readout for relevant genes. The study also found colocalization between differential methylation sites and COPD-associated SNPs, suggesting joint genetic and epigenetic pathways related to the disease.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Letter
Respiratory System
Adriana-Maria Hiller, Magnus Ekstrom, Eeva Piitulainen, Anne Lindberg, Eva Ronmark, Hanan Tanash
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Adriana-Maria Hiller, Magnus Ekstrom, Eeva Piitulainen, Anne Lindberg, Eva Ronmark, Hanan Tanash
Summary: Individuals with severe AATD, phenotype PiZZ, may have an increased risk of developing both hepatic and non-hepatic cancer compared with the general population.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Sarowar Muhammad Golam, Christer Janson, Richard Beasley, J. Mark FitzGerald, Tim Harrison, Bradley Chipps, Rod Hughes, Hana Mullerov, Jose Maria Olaguibel, Eleni Rapsomaniki, Helen K. Reddel, Mohsen Sadatsafavi, N. O. V. E. L. T. Y. investigators NOVELTY invest
Summary: The study found that a significant proportion of patients with physician-assessed mild asthma experienced considerable clinical burden and healthcare resource utilization.
RESPIRATORY MEDICINE
(2022)
Article
Anesthesiology
Ylva Stenberg, Ylva Rhodin, Anne Lindberg, Roman Aroch, Magnus Hultin, Jakob Wallden, Tomi Myrberg
Summary: The study showed that a simplified approach using tissue Doppler e'-velocities can be used to identify left ventricular diastolic dysfunction pre-operatively, but together with E/e' ratio the severity of dysfunction may be overestimated.
BMC ANESTHESIOLOGY
(2022)
Article
Allergy
Helena Backman, Caroline Stridsman, Linnea Hedman, Lina Ronnebjerg, Bright Nwaru, Thomas Sandstrom, Hannu Kankaanranta, Anne Lindberg, Eva Ronmark
Summary: Adult-onset asthma and obesity are associated with severe asthma at follow-up. Sensitization to mites and molds, as well as NSAID-related respiratory symptoms, are more common in severe asthma. Participants with severe asthma at follow-up had more severe respiratory symptoms at study entry.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Medicine, General & Internal
Hana Mullerova, Jennie Medin, Matthew Arnold, Hugo Gomes da Silva, Supriya Kumar, Magnus Nord, Richard Hubbard, Simon de Lusignan
Summary: This study aims to report the prepandemic background event rates of thrombosis with thrombocytopaenia syndrome (TTS) in the general population. The study found that the background incidence of TTS was estimated to be 9.8-11.1 per 100,000 person-years in a health insurance claims database. The rates were higher in males and increased with age.
Article
Critical Care Medicine
Lowie E. G. W. Vanfleteren, Anne Lindberg, Caddie Zhou, Fredrik Nyberg, Caroline Stridsman
Summary: Stratifying patients with chronic obstructive pulmonary disease (COPD) based on severity is clinically important. This study examined the association between different GOLD groups (A0, A1, B0, B1, and E) and future exacerbations, hospitalizations, and mortality. The results showed that GOLD group B1 had a significantly higher risk for future exacerbation, hospitalization, and mortality compared to group B0.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Muwada Bashir Awad Bashir, Rani Basna, Linnea Hedman, Helena Backman, Linda Ekerljung, Heidi Andersen, Goran Wennergren, Laxmi Bhatta, Anne Lindberg, Bo Lundback, Hannu Kankaanranta, Eva Ronmark, Bright I. Nwaru
Summary: This study investigated the interaction between social class and smoking in relation to the risk of respiratory diseases in adults. It found that social class and smoking interacted in defining the probability of allergic and non-allergic asthma. The results can provide insight into the interaction and help identify population subgroups in need of public health interventions.
RESPIRATORY MEDICINE
(2023)
Article
Allergy
Katja Warm, Linnea Hedman, Caroline Stridsman, Anne Lindberg, Eva Ronmark, Helena Backman
Summary: This study investigated the associations between clinical characteristics, biomarkers, comorbidities, and control of adult-onset asthma in middle-aged and older individuals. The results showed that comorbidities were strongly associated with uncontrolled asthma among older adults, while clinical biomarkers such as eosinophils and neutrophils in blood were associated with uncontrolled asthma among middle-aged individuals.
Article
Cardiac & Cardiovascular Systems
Axel Sturesson, Linnea Hedman, Caroline Stridsman, Anne Lindberg, Eva Ronmark, Helena Backman
Summary: This study aimed to compare all-cause and cause-specific mortality in obese, overweight, and normal-weight adults with asthma. The results showed that obesity was significantly associated with increased all-cause and cardiovascular mortality, while overweight did not increase the risk of any cause-specific mortality.
RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Stina Selberg, Johanna Karlsson Sundbaum, Jon R. Konradsen, Helena Backman, Linnea Hedman, Anne Lindberg, Caroline Stridsman
Summary: This study aimed to explore the associations between clinical characteristics and multiple manifestations of uncontrolled asthma with severe COVID-19. The findings revealed that obesity was the strongest independent risk factor for severe COVID-19, particularly in men. Multiple manifestations of uncontrolled asthma were more common in patients with severe COVID-19 and were associated with an increased risk of severe outcomes. It is crucial to consider both uncontrolled asthma and obesity when assessing patients with COVID-19.
RESPIRATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sofia Winsa-Lindmark, Caroline Stridsman, Axel Sahlin, Linnea Hedman, Nikolai Stenfors, Tomi Myrberg, Anne Lindberg, Eva Ronmark, Helena Backman
Summary: This study aimed to explore the associations between clinical characteristics, asthma control, and treatment in adult-onset asthma. The study found that severe obesity and elevated levels of blood neutrophils were more common in individuals with uncontrolled asthma. In terms of GINA treatment step classification, uncontrolled asthma patients in step 4-5 treatment showed the highest proportions of blood neutrophils, severe obesity, dyspnea, and impaired lung function.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Nicolas Bermudez Baron, Hannu Kankaanranta, Linnea Hedman, Martin Andersson, Caroline Stridsman, Anne Lindberg, Eva Ronmark, Helena Backman
Summary: This study investigates the impact of BMI change on lung function in patients with asthma. The results show that overweight and obese patients have slower decline in lung function, and BMI increase is closely associated with lung function decline.
Letter
Respiratory System
Helena Backman, Sami Sawalha, Ulf Nilsson, Linnea Hedman, Caroline Stridsman, Lowie E. G. W. Vanfleteren, Bright I. Nwaru, Nikolai Stenfors, Eva Ronmark, Anne Lindberg
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)