Review
Chemistry, Inorganic & Nuclear
Sourav De, Sabnaz Kazi, Sabyasachi Banerjee, Subhasis Banerjee, Nandan Sarkar, Suraj Kumar Shah, Yung-Chih Kuo, S. K. Ashok Kumar
Summary: This article reviews the literature on the cytotoxic effects and cellular uptake of metal complexes such as ruthenium, iridium, rhodium, and rhenium, with a particular focus on recently developed metal-based complexes. These complexes primarily target DNA and mitochondria, inducing cancer cell apoptosis to reduce adverse drug reactions.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Biochemistry & Molecular Biology
Alexander D. Ryabov
Summary: The exchange of cyclometalated ligands is a versatile reaction that can be used for synthesizing cyclopalladated complexes and other metalacyclic derivatives, offering attractive synthetic possibilities and aiding in understanding key mechanistic pathways associated with C-H bond activation and C-M bond cleavage by transition metal complexes.
Article
Chemistry, Inorganic & Nuclear
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Sohnel, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: In this study, organometallic complexes with a piano-stool structure and di- or tridentate ligand systems were reported, showing improved biological activity and impact on cytotoxic activity.
INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Carley Giffert L. Nongpiur, Charlestine Soh, Danny F. Diengdoh, Akalesh Kumar Verma, Renu Gogoi, Venkanna Banothu, Werner Kaminsky, Mohan Rao Kollipara
Summary: A series of half-sandwich complexes containing 3-acetyl chromen-2one-4(N)-substituted thiosemicarbazone derivatives of ruthenium, iridium, and rhodium were synthesized and evaluated for their antibacterial and anticancer activities. The complexes were characterized using various spectral techniques and X-ray crystallography. The results showed that complex 5 exhibited the highest cytotoxicity in Dalton's lymphoma cells, followed by complex 4, 1, and 2.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Engineering, Environmental
A. Arevalo-Bastante, S. Omar, J. Palomar, M. A. Alvarez-Montero, J. Bedia, J. J. Rodriguez, L. M. Gomez-Sainero
Summary: This study investigated the adsorption of chloromethanes and hydrogen on metal clusters of Pd, Pt, Rh, and Ru using molecular simulation. The results showed that dissociative adsorption of chloromethanes is promoted on the zero-valent metal sites while non-dissociative adsorption is favored on the electro-deficient sites. The dechlorination ability followed the order Ru > Rh > Pt > Pd, while hydrogenation ability decreased from Pd and Pt to Rh and Ru. Catalysts with high proportion of zero-valent metal species supported on CeO2-Sm2O3 exhibited outstanding performance in the hydrodechlorination of chloromethanes.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Yan-Bo Peng, Wei He, Qiang Niu, Can Tao, Xiao-Lan Zhong, Cai-Ping Tan, Ping Zhao
Summary: Inorganic medicinal chemistry has largely focused on platinum or ruthenium, with insufficient research on other metal centers such as rhodium. This study synthesized a series of cyclometalated rhodium(iii) complexes, which showed stronger anticancer activity than cisplatin. Mechanistic studies revealed that these complexes induced cellular apoptosis through mitochondrial pathways by causing severe damage and cell cycle arrest.
DALTON TRANSACTIONS
(2021)
Review
Engineering, Biomedical
Shao-Bin He, Liu Yang, Meng-Ting Lin, Paramasivam Balasubramanian, Hua-Ping Peng, Ye Kuang, Hao-Hua Deng, Wei Chen
Summary: With the development of platinum group element-based nanozymes, the application of nanozymes in the field of biomedicine has been expanded, possessing high catalytic efficiency and stability, suitable for applications in bio-detection, biomedical imaging, and other fields. The focus of the research is to reveal their roles and overcome limitations in biomedical applications, and trends and prospects for the future are also provided.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Physical
Merrily Sawkmie, Mayuri Bhattacharyya, Venkanna Banothu, Werner Kaminsky, Paige M. Gannon, Suktilang Majaw, Mohan Rao Kollipara
Summary: A convenient synthesis of twelve complexes of ruthenium(II), rhodium(III), and iridium(III) containing fluorenyl benzohydrazone ligands has been carried out. The complexes were characterized by various analytical techniques. The antibacterial activity of the complexes was tested, and complex 4 and 6 showed significant activity against both Gram-positive and Gram-negative bacteria. In vitro cytotoxicity assessment indicated that complex 9 exhibited promising results with the lowest IC50 value against HeLa cell lines, suggesting its potential as an anticancer agent.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Yan Liu, Zhao Zhang, Xili Yang, Feng Qiu
Summary: In this study, we designed and synthesized two complexes as photosensitizers, which exhibited strong phosphorescence and high toxicity against cancer cells. These complexes rapidly accumulated in lysosomes after entering cancer cells, and when exposed to light irradiation, they produced a large amount of oxidizing stress substances, eventually leading to cancer cell death. This provides promising potential application in photodynamic therapy.
Article
Pharmacology & Pharmacy
Ana R. Rubio, Rocio Gonzalez, Natalia Busto, Monica Vaquero, Ana L. Iglesias, Felix A. Jalon, Gustavo Espino, Ana M. Rodriguez, Begona Garcia, Blanca R. Manzano
Summary: In the field of anticancer chemotherapy, a study has been conducted to synthesize metal complexes with bioactive ligands to overcome drug resistance. The results show that one of the complexes has high cytotoxicity, induces apoptosis, overcomes drug resistance, and displays selectivity towards cancer cells through DNA binding and ROS generation pathways.
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Starha
Summary: In this study, model compounds such as Ru-dca and Ir-dca were used to investigate the behavior of complexes containing bioactive substituents like dichloroacetate (dca) in solution, with characterization done using techniques such as single-crystal X-ray analysis. However, these complexes did not demonstrate antiproliferative activity in four human cancer cell lines.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Mert Olgun Karatas, Guldeniz Sekerci, Suat Tekin, Suleyman Sandal, Hasan Kucukbay
Summary: In this study, a series of lipophilic benzimidazolium chloride complexes of different metals were synthesized and their cytotoxicity was investigated and compared. The results showed that the synthesized complexes exhibited stronger anti-growth effects against different cancer cell lines than cisplatin.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Prinessa Chellan, Vicky M. Avery, Sandra Duffy, Kirkwood M. Land, Christina C. Tam, Jong H. Kim, Luisa W. Cheng, Isolda Romero-Canelon, Peter J. Sadler
Summary: The reaction of dihydroartemisinin (DHA) with 4-methyl-4'-carboxy-2,2'-bipyridine yielded a novel ester derivative L1. Subsequent synthesis of organometallic half-sandwich complexes with pentamethylcyclopentadienyl, tetramethylphenylcyclopentadienyl, or tetramethylbiphenylcyclopentadienyl ligands exhibited potent antiplasmodial and anticancer activities, with iridium complex 3 emerging as a promising candidate for further studies.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Stephanus J. L. Linde, Anja Franken, Johannes L. du Plessis
Summary: This study investigated the simultaneous skin and respiratory exposure of precious metals refinery workers to all six soluble PGMs. The results showed that workers were exposed to quantifiable concentrations of soluble PGMs via both the skin and inhalation, with higher concentrations found on the palm and wrist compared to the neck and forehead. Skin exposure to all soluble PGMs was positively correlated with respiratory exposure, indicating the need for control measures to reduce both skin and respiratory exposure.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Lenka Markova, Vojtech Novohradsky, Jana Kasparkova, Jose Ruiz, Viktor Brabec
Summary: This study investigates the mechanism of the anticancer activity of a photoactivatable Ir(III) compound on highly aggressive and poorly treatable Rhabdomyosarcoma cells. The compound demonstrates potent activity in both differentiated cancer cells and cancer stem cells, and it affects mitochondrial function in a novel way. The findings suggest that this compound could be a promising chemotherapeutic agent for the treatment of hard-to-treat Rhabdomyosarcoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Joaquin Bonelli, Enrique Ortega-Forte, Anna Rovira, Manel Bosch, Oriol Torres, Cristina Cusco, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: Encapsulation of mitochondria-targeted coumarin photosensitizers within nanocapsules improves their photoactivity and reduces cytotoxicity, making them promising agents for nano-photodynamic therapy.
Article
Biochemistry & Molecular Biology
Enrique Ortega-Forte, Samanta Hernandez-Garcia, Gloria Vigueras, Paula Henarejos-Escudero, Natalia Cutillas, Jose Ruiz, Fernando Gandia-Herrero
Summary: This study reports a novel mitochondria-targeted iridium(III) complex, OncoIr3, which exhibits advantageous properties as a bioimaging agent and shows potent anticancer activity in vitro and in vivo through an oncosis process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Applied
Francisco J. Ballester, Enrique Ortega-Forte, Delia Bautista, M. Dolores Santana, Giampaolo Barone, Jose Ruiz
Summary: In this study, a series of compounds with different substituents were synthesized and characterized using NMR and X-ray diffraction. It was found that compounds with stronger electron-donating groups exhibited larger Stokes shift and higher quantum yield. Additionally, some of the compounds showed higher activity in cancer cell lines while displaying low cytotoxicity in healthy cells. One of the compounds also showed the ability to stain the cytoplasm.
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Anna Rovira, Enrique Ortega-Forte, Cormac Hally, Mireia Jorda-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesus I. Martinez, Manel Bosch, Santi Nonell, Jose Ruiz, Vicente Marchan
Summary: Photodynamic therapy shows potential as a non-invasive anticancer tool, but the development of highly effective and non-toxic photosensitizers that can work under hypoxic conditions is still needed. In this study, Ir(III)-COUPY conjugates were developed based on the advantageous properties of COUPY fluorophores and cyclometalated Ir(III) complexes, aiming to explore structure-activity relationships. The structural modifications within the coumarin scaffold had a significant impact on the photophysical properties and cellular uptake of the conjugates. All Ir(III)-COUPY conjugates exhibited high phototoxicity under green light irradiation, attributed to the photogeneration of reactive oxygen species (ROS), while remaining non-toxic in the dark. Two hit conjugates showed excellent phototherapeutic indexes in cisplatin-resistant A2780cis cancer cells, indicating the potential of photoactive therapy approaches based on the conjugation of far-red/NIR-emitting COUPY dyes and transition metal complexes to overcome acquired resistance to cisplatin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, Jose Ruiz, Viktor Brabec
Summary: In this study, a series of new octahedral iridium(III) complexes Ir1-Ir9 were reported, which showed potential for inhibiting metastasis in triple-negative breast cancer. The results demonstrated that the structural modifications within the complexes strongly influenced their anti-metastatic properties, with complex Ir1 exhibiting the highest activity. Contrary to the effects of the conventional chemotherapy drug doxorubicin, which promoted metastatic properties of TNBC cells, the results suggested that doxorubicin therapy may increase the risk of breast cancer metastasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Enrique Ortega-Forte, Anna Rovira, Marta Lopez-Corrales, Alba Hernandez-Garcia, Francisco Jose Ballester, Eduardo Izquierdo-Garcia, Mireia Jorda-Redondo, Manel Bosch, Santi Nonell, Maria Dolores Santana, Jose Ruiz, Vicente Marchan, Gilles Gasser
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method, but it is limited by its oxygen dependency and poor tissue penetration of some photosensitizers (PSs) activatable with short wavelengths. In this study, a novel hypoxia-active PS with operability in the near-infrared (NIR) region was developed, which showed high photoactivity toward cancer cells even under hypoxic environments. This strategy could potentially pave the way for the development of novel NIR- and hypoxia-active Ru(ii)-based theragnostic PSs.
Article
Chemistry, Inorganic & Nuclear
Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista, Jose Ruiz
Summary: New valproate Ir(iii) and Rh(iii) half-sandwich conjugates with a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The conjugation of valproic acid to organometallic fragments appears to enhance the antibacterial activity of the complexes against Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Natalia Busto, Gloria Vigueras, Natalia Cutillas, Begona Garcia, Jose Ruiz
Summary: This study found that a new series of heteroleptic iridium(III) complexes showed remarkable effectiveness against Gram positive strains, especially Ir1 and Ir2, which were even 10 times more active than the fluoroquinolone antibiotic norfioxacin. The antimicrobial activity of these complexes is achieved by inducing ROS generation.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Joaquin Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: By encapsulating poorly soluble cyclometalated Ir(III) complexes using polyurethane-polyurea hybrid nanocapsules, their solubility is improved and the nanocapsules can enhance cellular uptake and cytotoxicity, leading to inhibition of tumor growth.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Enrique Ortega, Francisco J. Ballester, Alba Hernandez-Garcia, Samanta Hernandez-Garcia, M. Alejandra Guerrero-Rubio, Delia Bautista, M. Dolores Santana, Fernando Gandia-Herrero, Jose Ruiz
Summary: This study reported the synthesis and characterization of novel osmium (II) complexes with potential as anticancer drugs, showing effective antiproliferative activity towards ovarian cancer cells and inhibitory effects in tumoral strains in vivo. The mechanism of action involves reduction of proteosynthesis, increase of apoptosis, and regulation of oxidative stress genes, potentially making osmium (II) complexes candidates for novel chemotherapeutic drugs.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)
