Review
Biochemistry & Molecular Biology
Nicole S. Britten, Jonathan A. Butler
Summary: Human parasitic infections are challenging diseases for medical intervention, with a high mortality rate and concerns about resistance. Ruthenium metallotherapeutic agents have shown great efficacy in targeting key parasites while having lower cytotoxicity profiles and multiple target sites, reducing the risk of resistance.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Parasitology
Sajad Rashidi, Reza Mansouri, Mohammad Ali-Hassanzadeh, Antonio Muro, Paul Nguewa, Rail Manzano-Roman
Summary: This study summarizes the most prominent Annexin proteins identified thus far and their relevant functions in parasites and infected host cells during pathogenesis, especially in the most important intracellular protozoan parasitic infections, such as malaria, trypanosomiasis, leishmaniasis, and toxoplasmosis. The study shows that helminth parasites may express and secrete Annexins to develop pathogenesis, while intracellular protozoan parasites may employ the modulation of host Annexins as a crucial strategy. Additionally, the use of analogs of both parasite and host Annexin peptides might suggest novel therapeutic insights into the treatment of parasitic infections, and Annexins could also be potentially relevant as vaccine and diagnostic biomarkers due to their immunoregulatory activities and expression levels in infected tissues.
Review
Biochemistry & Molecular Biology
Orlando Elso, Guadalupe Garcia Linares, Valeria Sulsen
Summary: Infections caused by parasites are a global health issue and pose significant challenges. Current chemotherapy methods for these infections are often ineffective and associated with severe side effects. Drug resistance and varying susceptibility among different strains further complicate the situation. This review focuses on the potential of 1,4-dihydropyridines derivatives as a class of compounds for new drug development, discussing their antiparasitic activities and the development of new derivatives or repurposing of existing drugs for designing effective treatments.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Hamzav Hameed, Elizabeth F. B. King, Katerina Doleckova, Barbara Bartholomew, Jackie Hollinshead, Haddijatou Mbye, Imran Ullah, Karen Walker, Maria Van Veelen, Somaia Saif Abou-Akkada, Robert J. Nash, Paul D. Horrocks, Helen P. Price
Summary: This study screened a library of purified compounds from temperate zone plants against tropical parasitic diseases, identifying potential candidates with significant inhibitory effects on specific parasites.
Review
Biochemistry & Molecular Biology
Paulo A. F. Pacheco, Maria M. M. Santos
Summary: Protozoan diseases pose a significant global health problem, particularly for socially and economically vulnerable populations. Due to limited investment in drug discovery, the available therapeutic options are limited. The emergence of drug-resistant parasite strains further emphasizes the need for safe and effective antiparasitic agents. Indole-based compounds have shown promise as drug candidates for treating important parasitic diseases such as malaria, trypanosomiasis, and leishmaniasis, with recent advancements in the design, optimization, and synthesis of synthetic indole scaffolds.
Review
Biochemistry & Molecular Biology
Santo Previti, Carla Di Chio, Roberta Ettari, Maria Zappala
Summary: Despite efforts in the last decades, malaria and neglected tropical diseases remain significant health problems in developing countries. Outdated drugs, resistance, and limited effectiveness have prompted researchers to identify new targets. Multi-target ligands could potentially overcome the limitations of current antiparasitic drugs.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Isha Saini, Jyoti Joshi, Sukhbir Kaur
Summary: Co-infection between leishmaniasis and other infectious diseases is common and leads to increased disease severity and mortality. The immunology, diagnosis, and treatment options for co-infections are areas that require further research.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Natalya N. Besednova, Tatyana S. Zaporozhets, Boris G. Andryukov, Sergey P. Kryzhanovsky, Svetlana P. Ermakova, Tatyana A. Kuznetsova, Anastasia N. Voronova, Mikhail Y. Shchelkanov
Summary: This review examines the potential of sulfated polysaccharides from marine hydrobionts as means for preventing and treating protozoa and helminthiasis. The high antiparasitic activity, good solubility, and low toxicity of SPS make them attractive candidates for developing drugs and functional food products with antiparasitic properties.
Review
Urology & Nephrology
Elizabeth De Francesco Daher, Geraldo Bezerra da Silva Junior, Mayuri Trivedi, Tarek Fayad, Nattachai Srisawat, Sanjeev Nair, Padet Siriyasatien, Marcus Vinicius Guimaraes de Lacerda, Maria Alice Sperto Ferreira Baptista, Mahesha Vankalakunti, Vivekanand Jha
Summary: Parasitic diseases have been known to cause kidney damage and can lead to increased mortality. Chagas disease, filariasis, leishmaniasis, malaria, and schistosomiasis are important parasitic diseases that can affect the kidney. The mechanisms of kidney injury include direct parasite damage, immune phenomena, and systemic manifestations. Early diagnosis and proper management are crucial for preventing kidney disease progression and optimizing patient recovery.
NATURE REVIEWS NEPHROLOGY
(2022)
Review
Pharmacology & Pharmacy
Leonardo L. G. Ferreira, Josue de Moraes, Adriano D. Andricopulo
Summary: Neglected tropical diseases, such as leishmaniasis and schistosomiasis, continue to be a public health challenge in developing countries. However, advancements in drug discovery using modern strategies have shown promise in addressing these diseases by combining medicinal chemistry and parasite biology.
DRUG DISCOVERY TODAY
(2022)
Article
Plant Sciences
Mariscal Brice Tchatat Tali, Boniface Pone Kamdem, Jean Claude Tchouankeu, Fabrice Fekam Boyom
Summary: This study summarizes the latest information on the antimalarial, antileishmanial, and antitrypanosomal activities of plants from the genus Terminalia, as well as their mechanisms of action. Terminalia plant extracts show a wide range of antiparasitic activities against Plasmodium, Leishmania, and Trypanosoma species, but their in vivo effectiveness is not well known. Overall, Terminalia plants have shown potential as candidates for drug development against malaria, leishmaniasis, and trypanosomiasis, but further in vivo experiments and detailed mechanism studies are needed.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Microbiology
Aadish Rawat, Mrinalini Roy, Anupam Jyoti, Sanket Kaushik, Kuldeep Verma, Vijay Kumar Srivastava
Summary: Cysteine proteases play a critical role in protozoic infections, but have yet to be translated into clinical therapeutic targets. Investigating these enzymes can provide a better insight into the pathogenesis of protozoic diseases.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Microbiology
Mrinalini Roy, Aadish Rawat, Sanket Kaushik, Anupam Jyoti, Vijay Kumar Srivastava
Summary: This article reviews the endogenous inhibitors of cysteine proteases in three major pathogenic parasitic protozoa. The inhibitors target proteases involved in host-parasite interactions and are also involved in other functions of the parasites. They show limited sequence homology and are linked to parasite biology and evolution.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Rodrigo M. S. Justo, Luana Pereira Borba-Santos, Youssef Bacila Sade, Frederico Henrique C. Ferreira, Nathalia M. P. Rosa, Luiz Antonio S. Costa, Gonzalo Visbal, Sonia Rozental, Maribel Navarro
Summary: New copper(I), copper(II), and zinc(II) azasterol derivatives were synthesized using 20-hydrazone-imidazolin-2-yl-5 alpha-pregnan-3 beta-ol (H1) as a ligand. The metal complexes were fully characterized and their molecular structures were investigated using computational methods. In vitro antifungal tests showed that the metal-azasterol complexes were more effective against S. brasiliensis than the ligand H1, with [Zn(H1)(2)(OH)(2)] demonstrating the highest efficiency. These results suggest the potential of metal-azasterol complexes in developing new antifungal compounds.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Richard M. Beteck, Audrey Jordaan, Ronnett Seldon, Dustin Laming, Heinrich C. Hoppe, Digby F. Warner, Setshaba D. Khanye
Summary: A series of lipophilic heterocyclic quinolone compounds were synthesized and evaluated for their anti-TB activity in vitro, showing varied potency against Mycobacterium tuberculosis. Some of the compounds also exhibited activity against protozoan parasites, while showing limited activity against ESKAPE pathogens.
Article
Biochemistry & Molecular Biology
Legna Colina-Vegas, Jocely Lucena Dutra, Wilmer Villarreal, Joao Honorato de A. Neto, Marcia Regina Cominetti, Fernando Pavan, Maribel Navarro, Alzir A. Batista
JOURNAL OF INORGANIC BIOCHEMISTRY
(2016)
Article
Chemistry, Inorganic & Nuclear
Wilmer Villarreal, Legna Colina-Vegas, Gonzalo Visbal, Oscar Corona, Rodrigo S. Correa, Javier Ellena, Marcia Regina Cominetti, Alzir Azevedo Batista, Maribel Navarro
INORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Tais S. Macedo, Wilmer Villarreal, Camila C. Couto, Diogo R. M. Moreira, Maribel Navarro, Marta Machado, Miguel Prudencio, Alzir A. Batista, Milena B. P. Soares
Article
Chemistry, Multidisciplinary
Thalita Gagini, Legna Colina-Vegas, Wilmer Villarreal, Luana Pereira Borba-Santos, Caroline de Souza Pereira, Alzir Azevedo Batista, Marcos Kneip Fleury, Wanderley de Souza, Sonia Rozental, Luiz Antonio S. Costa, Maribel Navarro
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Livia D. Pereira, Taissa Vila, Luana P. Borba-Santos, Wanderley de Souza, Maribel Navarro, Sonia Rozental
CURRENT PHARMACEUTICAL DESIGN
(2020)
Review
Pharmacology & Pharmacy
Maribel Navarro, Rodrigo M. S. Justo, Giset Y. Sanchez Delgado, Gonzalo Visbal
Summary: The evaluation of late transition metal complexes for the treatment of Trypanosomatid diseases and some insights about their mechanism of action are provided.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Chemistry, Inorganic & Nuclear
Camila A. S. R. Conde, Mauro De Almeida, Gabrielle dos Santos Da Silva, Milena Barenco Pires de Abreu Sodre, Juliany Cola Fernandes Rodrigues, Maribel Navarro
Summary: A new series of copper- and zinc-diamine complexes were synthesized and showed significant biological activity against Leishmania amazonensis.
TRANSITION METAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M. Moreira, Nicoletta Basilico, David. L. L. Williams, Miguel Prudencio, Bruno Pradines, Maribel Navarro
Summary: Hybrid-based drugs linked through a transition metal, such as the novel compound [AuAQPQ]PF6, show strong and effective antiplasmodial activity against multiple stages of the Plasmodium life cycle. The compound's mechanism involves inhibiting beta-hematin formation and enzymatic activity of thioredoxin reductases.
Article
Pharmacology & Pharmacy
Gonzalo Visbal, Rodrigo M. S. Justo, Gabrielle dos Santos da Silva e Miranda, Sara Teixeira de Macedo Silva, Wanderley de Souza, Juliany Cola Fernandes Rodrigues, Maribel Navarro
Summary: In this study, a new complex called ZnCl2(H3)(2) was synthesized and evaluated for its efficacy against Leishmania amazonensis. The results showed that this complex exhibited stronger inhibitory effects on the parasite compared to the free ligand H3. Furthermore, it demonstrated higher selectivity. Additionally, the study revealed that H3 could induce depletion of endogenous parasite sterols and their replacement by 24-desalkyl sterols, and the zinc derivative of H3 resulted in a loss of cell viability.
Article
Chemistry, Multidisciplinary
Legna Colina-Vegas, Mariana da Cruz B. Silva, Caroline de Souza Pereira, Ariane Isis Barros, Joaquim Araujo Nobrega, Maribel Navarro, Matthias Rottmann, Sarah D'Alessandro, Nicoletta Basilico, Alzir Azevedo Batista, Diogo R. M. Moreira
Summary: Coordination of metal complexes with antimalarial quinolines shows potential in improving their bioactivity and inhibiting multiple stages of the Plasmodium life cycle.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Rodrigo M. S. Justo, Luana Pereira Borba-Santos, Youssef Bacila Sade, Frederico Henrique C. Ferreira, Nathalia M. P. Rosa, Luiz Antonio S. Costa, Gonzalo Visbal, Sonia Rozental, Maribel Navarro
Summary: New copper(I), copper(II), and zinc(II) azasterol derivatives were synthesized using 20-hydrazone-imidazolin-2-yl-5 alpha-pregnan-3 beta-ol (H1) as a ligand. The metal complexes were fully characterized and their molecular structures were investigated using computational methods. In vitro antifungal tests showed that the metal-azasterol complexes were more effective against S. brasiliensis than the ligand H1, with [Zn(H1)(2)(OH)(2)] demonstrating the highest efficiency. These results suggest the potential of metal-azasterol complexes in developing new antifungal compounds.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Legna Colina-Vegas, Joseane Lima Prado Godinho, Thallita Coutinho, Rodrigo S. Correa, Wanderley de Souza, Juliany Cola Fernandes Rodrigues, Alzir Azevedo Batista, Maribel Navarro
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Legna Colina-Vegas, Katia M. Oliveira, Beatriz N. Cunha, Marcia Regina Cominetti, Maribel Navarro, Alzir Azevedo Batista
Meeting Abstract
Biochemistry & Molecular Biology
Maribel Navarro
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Gonzalo Visbal, Angel Ruben Higuera-Padilla, Luana Pereira Borba-Santos, Wanderley de Souza, Sonia Rozental, Maribel Navarro
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY
(2017)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)
