Review
Nanoscience & Nanotechnology
Ahmed A. H. Abdellatif, Mahmoud A. Younis, Mansour Alsharidah, Osamah Al Rugaie, M. Hesham Tawfeek
Summary: Despite advancements in nanomedicines and associated research, their translation into clinically applicable products still faces challenges. Quantum dots (QDs), a type of semiconductor-based nanomaterial, have diverse biomedical applications but are underestimated in clinics. This article reviews the status of QDs in literature, including their preparation, characterization, and biomedical applications. It also highlights the challenges limiting the clinical translation of QDs and compares QDs to other commercially-available substitutes. Technical aspects that could improve the clinical fate of QDs are discussed.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Infectious Diseases
Yaseen Hussain, Waqas Alam, Hammad Ullah, Marco Dacrema, Maria Daglia, Haroon Khan, Carla Renata Arciola
Summary: Curcumin is a bioactive compound with antimicrobial properties that can effectively combat a wide range of infections caused by bacteria, fungi, and viruses.
Review
Biochemical Research Methods
Ahmed Ghouneimy, Ahmed Mahas, Tin Marsic, Rashid Aman, Magdy Mahfouz
Summary: The COVID-19 pandemic has highlighted the need for decentralized Point of Care (POC) solutions in the diagnostic field. CRISPR-based diagnostics have emerged as promising tools that could revolutionize molecular diagnostics, but there are obstacles to their use in POC applications.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Farolfi, Letizia Calderoni, Francesco Mattana, Riccardo Mei, Sivi Telo, Stefano Fanti, Paolo Castellucci
Summary: PSMA PET shows superior detection capabilities for prostate cancer in both primary and recurrent settings, with significant impact on clinical management. It may also play a crucial role in localization and treatment of PCa patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Food Science & Technology
Eduardo Puertolas, Izaskun Perez, Xabier Murgui
Summary: Laser food processing, especially using CO2 laser, has the potential to revolutionize the industry with its high efficiency, high-power output, and infrared wavelength. Over the past 50 years, CO2 laser has been used for various food processing applications, such as cooking, marking, cutting, and microbial surface decontamination. This review article focuses on the state of the art of CO2 laser in food processing, discussing its characteristics, mechanisms, and challenges in realizing its full potential in the agri-food sector.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Computer Science, Information Systems
Ivan Kulagin, Ming Li, Ville Laitinen, Heikki Handroos
Summary: This paper reviews the current state of magnetic shape memory alloys (MSMAs) and their potential applications in various fields, particularly as actuators. Although research in this area is increasing, the types of actuators and their applications are still relatively limited.
Review
Oncology
Fang-Ying Chiu, Yun Yen
Summary: Biomarker discovery and development play a crucial role in diagnosing diseases, particularly cancer. Imaging biomarkers provide objective information about tumor biology and its environment, aiding in treatment and diagnosis. Neuro-oncology has seen advancements in tumor classification and targeted therapies. The use of biomarkers and diagnostic tools in assessing prognosis and long-term effects is crucial, as is the implementation of personalized precision medicine.
BIOMARKER RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Xue Li, Menglin Wu, Jiang Li, Qi Guo, Yang Zhao, Xuening Zhang
Summary: Atherosclerosis plaques, caused by cerebrovascular and coronary artery disease, are a major cause of death and morbidity worldwide. Accurately assessing and identifying the degree of plaque is crucial for predicting risk and monitoring treatment outcomes. Traditional imaging techniques have limitations, while nanomedicine-based imaging techniques show great potential for characterizing and detecting plaques. This review discusses recent advancements in targeted nanomedicine-based approaches for imaging and risk stratification of atherosclerosis plaques, as well as the challenges and opportunities for future development and clinical translation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiaoxia Liu, Yujia Jiang, Dongli Song, Linlin Zhang, Guang Xu, Rui Hou, Yong Zhang, Jian Chen, Yunfeng Cheng, Longqi Liu, Xun Xu, Gang Chen, Duojiao Wu, Tianxiang Chen, Ao Chen, Xiangdong Wang
Summary: Spatial transcriptomics is important in bridging molecular information with clinical images. This study aims to identify factors that influence the quality of spatial transcriptomics, specifically in lung cancer. The results indicate that the isolated times and dry conditions of samples are critical for the quality of spatial transcriptomic samples. Therefore, further optimization and standardization of clinical procedures are necessary for the development of clinical spatial transcriptome.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Shivaram Selvam, Midhun Ben Thomas, Tuhin Bhowmick, Arun Chandru
Summary: Three-dimensional bioprinting (3DBP) is a promising additive manufacturing technique for fabricating scaffolds that mimic the cues of target tissues. Cell-derived exosomes (EXOs), extracellular vesicles containing diverse cell constituents, have therapeutic potential and can be incorporated and released in a controlled manner using 3DBP. The bioprinting of EXOs holds great promise for tissue engineering and regenerative medicine, allowing the fabrication of complex tissues with native-like microarchitecture and developmental profiles.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Editorial Material
Cell Biology
Sarah H. Elsea, Jennifer E. Posey
Summary: In a recent publication in Nature Medicine, Surendran and colleagues analyzed human plasma metabolomic data for 913 metabolites in 20,000 individuals, identifying 2,599 associations between metabolites and genetic variants, as well as over 400 metabolite signatures. This comprehensive atlas provides novel insights into the genomic mechanisms underlying metabolic phenotypes.
Review
Cell Biology
Ziran Xu, Jiaxu Yang, Xianyi Xin, Chengrun Liu, Lisha Li, Xianglin Mei, Meiying Li
Summary: Induced pluripotent stem cells (iPSCs) have made significant contributions to disease modeling, drug discovery, and regenerative medicine. Combining iPSCs with 3D organoids has further expanded the applications of iPSCs in disease research. Organoids derived from different types of stem cells can replicate developmental processes and tissue regeneration, providing insights into regulatory mechanisms and disease pathophysiology. This article summarizes the production scheme of organ-specific iPSC-derived organoids, their contribution to treating organ-related diseases, particularly in the context of COVID-19, and discusses the current challenges and limitations of these models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medical Informatics
Siddharth Nath, Edward Korot, Dun Jack Fu, Gongyu Zhang, Kapil Mishra, Aaron Y. Lee, Pearse A. Keane
Summary: Reinforcement learning is a type of machine learning that aims to maximize a specific outcome or reward by considering multiple variables and parallel actions. It can be applied to ophthalmology to optimize patient outcomes. However, there are challenges associated with developing and implementing reinforcement learning solutions.
LANCET DIGITAL HEALTH
(2022)
Review
Pharmacology & Pharmacy
Jessica Manoelli Costa Silva, Eliel Barbosa Teixeira, Ronald Matheus da Silva Mourao, Rafaella Sousa Ferraz, Fabiano Cordeiro Moreira, Paulo Pimentel de Assumpcao, Danielle Queiroz Calcagno
Summary: Gastric cancer is a highly prevalent and deadly malignant neoplasm worldwide. Long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Tiansong Liang, Linhui Chen, Xiaojing Liu, Yuanfang Li, Zhikai Li, Daoke Yang, Huizhen Li
Summary: This review discusses the role of extracellular vesicles (EVs) in the progression and treatment of nasopharyngeal carcinoma. EVs can affect the features of target cells and participate in regulating the development process of tumors, making them potential biomarkers for early diagnosis and therapeutic agents for tumors.
