Article
Chemistry, Multidisciplinary
Sellamuthu Anbu, Sabrina H. L. Hoffmann, Fabio Carniato, Lawrence Kenning, Thomas W. Price, Timothy J. Prior, Mauro Botta, Andre F. Martins, Graeme J. Stasiuk
Summary: Manganese-based contrast agents have emerged as potential alternatives to gadolinium-based ones, but their clinical application is limited due to synthetic challenges. This study successfully developed a MnCA with optimized relaxivity, MnLMe, through an innovative synthetic strategy, demonstrating promising performance in both in vitro and in vivo studies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Paolo Arosio, Davide Cicolari, Amedea Manfredi, Francesco Orsini, Alessandro Lascialfari, Elisabetta Ranucci, Paolo Ferruti, Daniela Maggioni
Summary: In this study, a linear polyamidoamine (PAA) named BAC-EDDS was successfully synthesized and showed stable nanoaggregates with negative charge, demonstrating good performance as a contrast agent in magnetic resonance imaging.
Article
Chemistry, Medicinal
Soyeon Kim, Ji-ung Yang, Jae Hun Ahn, In Ok Ko, Jung Young Kim, Yong Jin Lee, Ji-Ae Park
Summary: The study evaluated a tumor-targeting gadolinium complex Gd-TDAP, showing its potential in MR/optical imaging and therapy. The complex exhibited higher longitudinal relaxivity and tumor-targeting characteristics, as well as demonstrated potential inside the cell nucleus and for photodynamic therapy.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Neurosciences
Ece Su Sayin, Jacob Schulman, Julien Poublanc, Harrison T. Levine, Lakshmikumar Venkat Raghavan, Kamil Uludag, James Duffin, Joseph A. Fisher, David J. Mikulis, Olivia Sobczyk
Summary: The assessment of resting perfusion measures currently requires a susceptibility contrast agent such as gadolinium. This study compared the perfusion measures obtained using hypoxia-induced deoxyhemoglobin and gadolinium in healthy participants. The results showed that the perfusion measures calculated using hypoxia-induced deoxyhemoglobin were comparable to those obtained with gadolinium injection.
HUMAN BRAIN MAPPING
(2023)
Review
Chemistry, Inorganic & Nuclear
Rocio Uzal-Varela, Aurora Rodriguez-Rodriguez, Huan Wang, David Esteban-Gomez, Isabel Brandariz, Eric M. Gale, Peter Caravan, Carlos Platas-Iglesias
Summary: This research developed a method for predicting Gd(III)-ligand formation constant and pGd at pH 7.4 using known stability constants and structural descriptors, showing strong predictive power and potential for screening potential ligands.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Medicinal
Casey J. Adams, Thomas J. Meade
Summary: Cisplatin and related Pt(II) chemotherapeutics are essential in treating solid tumors, but challenges like off-target toxicity and chemoresistance exist. A method using MR contrast agents to image accumulation differences in sensitive and resistant cells shows promise in predicting chemotherapy response and monitoring chemoresistance onset.
Article
Biochemistry & Molecular Biology
Wan-Yun Fang, You -Yang Zhan, Chuan-Ling Wan, Xiao-Jing Li, Rong Xue, Feng-Kui Pei
Summary: A glutathione-responsive imaging drug delivery system HA-SS-a-Gd-DOTA was developed using hyaluronic acid as macromolecular drug carriers. The system exhibited higher T1-reflexivity than gadoterate meglumine and showed good biocompatibility with low cytotoxicity. In vivo mouse imaging studies demonstrated significant tumor signaling enhancement and minimal damage to important organs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Viktoria Neubertova, Olga Guselnikova, Yusuke Yamauchi, Anastasia Olshtrem, Silvie Rimpelova, Erik Cizmar, Martin Orendac, Jan Duchon, Lenka Volfova, Jan Lancok, Vit Herynek, Premysl Fitl, Pavel Ulbrich, Ludek Jelinek, Patrik Schneider, Juraj Kosek, Pavel Postnikov, Zdenka Kolska, Vaclav Svorcik, Sergii Chertopalov, Oleksiy Lyutakov
Summary: This study explores the covalent functionalization of MXenes for bioimaging applications. By using a chelating agent and Gd3+ ions, the commonly diamagnetic MXenes were transformed into paramagnetic materials, enabling their use in magnetic resonance imaging. Covalent functionalization not only enhanced the stability and cytocompatibility of MXenes but also prevented the leakage of Gd3+ ions. This work expands the bioapplication of MXenes by introducing an MRI contrast and developing covalent functionalization strategies.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander M. Panich, Moti Salti, Ofer Prager, Evyatar Swissa, Yuri Kulvelis, Elena B. Yudina, Alexander E. Aleksenskii, Shaul D. Goren, Alexander Ya Vul', Alexander Shames
Summary: The study demonstrates that saline suspension of PVP-coated gadolinium-grafted detonation nanodiamonds (DND) serves as a promising contrast agent in MRI, providing higher signal intensities than the commonly used gadoterate meglumin. This novel contrast agent shows potential for safer clinical use based on its performance in ex vivo and in vivo testing.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Danping Zhuang, Huifen Zhang, Genwen Hu, Bing Guo
Summary: This review summarizes the recent advances in MRI contrast agents and dual-modal or triple-modal nanoprobes for glioblastoma (GBM) imaging, and discusses potential obstacles and prospects for future research and clinical translation of these contrast agents.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Jing Zhang, Kang Song, Jing Ping, Jun Du, Yun Sun, Jianping Zhang, Ming Qi, Yuqing Miao, Yuhao Li
Summary: A new nano dual-modal contrast agent BiGd-PVP has been designed for accurate identification and imaging of renal insufficiency, with a longer residence time and metabolic differences between healthy and impaired kidneys, potentially aiding in distinguishing between the two through enhanced MRI contrast abilities.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Divya Rajendran, Judith Elizabeth, Sundar Manoharan, Nagabhushan Vellala, Brahmadathan Kootallur, Abiram Angamuthu, Jebasingh Bhagavathsingh, Prince Makarios Paul
Summary: In this study, a novel Gd(III) complex was reported as a potential contrast agent for high resolution MRI images, and its molecular structure was predicted through DFT calculations. The complex displayed high relaxivity and enhanced image intensity in MRI, paving the way for higher resolution imaging.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Xiangyu Chen, Shiyong Teng, Jinming Li, Xuezhi Qiao, Weidong Zhao, Zhengjie Xue, Xudong Shi, Yuguang Wang, Wensheng Yang, Tie Wang
Summary: Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd-DTPA), have limited blood circulation time due to rapid clearance by the kidney, which hinders the improvement of contrast between tumors and normal tissue. To address this issue, a novel MRI contrast agent using deformable mesoporous organosilica nanoparticles (D-MON) incorporating Gd-DTPA is fabricated. In vivo distribution studies show that the D-MON-based contrast agent can prolong blood circulation time and achieve high-contrast imaging in tumor tissue, surpassing the performance of the clinical contrast agent Gd-DTPA.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hao Li, Dong Luo, Chaonan Yuan, Xinning Wang, Jing Wang, James P. Basilion, Thomas J. Meade
Summary: PSMA is a transmembrane protein highly expressed in aggressive prostate cancer, utilized in various imaging modalities as a biomarker. MR imaging provides detailed information but requires development of molecular contrast agents for improved sensitivity. In this study, targeted and activatable MR contrast agents were successfully used to differentiate between PSMA+ and PSMA- prostate cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Food Science & Technology
Duo Liang, Wentao Su, Mingqian Tan
Summary: The use of microfluidic intestine-on-a-chip offers a novel way to mimic human intestinal pathophysiology, potentially reducing animal testing. However, research on the effect of bioactive food compounds on intestinal inflammation is still largely unexplored. Standardizing key parameters such as cell types and shear stress is essential for accurate modeling.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Engineering, Biomedical
Yannan Chen, Wentao Su, Shanshan Tie, Weina Cui, Xiaoting Yu, Lijuan Zhang, Zheng Hua, Mingqian Tan
Summary: A new kind of sequence-targeted astaxanthin nanoparticles was developed for the treatment of ulcerative colitis (UC). The nanoparticles demonstrated excellent macrophages and mitochondria targeting ability, and significantly alleviated inflammation. Additionally, they also improved the composition of gut microbiota and the production of short chain fatty acid.
Article
Engineering, Biomedical
Xuedi Zhang, Xue Zhao, Zheng Hua, Shanghua Xing, Jiaxuan Li, Siyuan Fei, Mingqian Tan
Summary: This study successfully designed and constructed astaxanthin nanoparticles with reactive oxygen species (ROS) and pH dual-response capability. In vitro and in vivo experiments demonstrated that these nanoparticles showed significant effects in antioxidation, protection of intestinal tissue integrity, and improvement of gut microbiota.
Article
Engineering, Biomedical
Duo Liang, Chenyue Liu, Yu Li, Caiyun Wu, Yuling Chen, Mingqian Tan, Wentao Su
Summary: A large-scale engineering preparation strategy has been developed to produce synthetic probiotic membrane vesicles (FX-MVs) for encapsulating fucoxanthin, which can be used for treating colitis. The engineering membrane vesicles showed a significantly higher yield and richer protein content compared to naturally secreted vesicles. FX-MVs exhibited improved gastrointestinal stability of fucoxanthin and effectively inhibited oxidative damage and inflammatory response in vivo.
Review
Food Science & Technology
Shanghua Xing, Shasha Cheng, Mingqian Tan
Summary: Food contamination and spoilage are global concerns that have a negative impact on public health and food security. Real-time monitoring of food quality can reduce the risk of foodborne diseases. The emergence of multi-emitter luminescent metal-organic frameworks (LMOFs) as ratiometric sensory materials has provided a high sensitivity and selectivity for food quality and safety detection. These sensors offer excellent sensing performance including self-calibration, multi-dimensional recognition, and visual signal readout, meeting the rigorous requirements of food safety evaluation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Jia Song, Hongliang Li, Wenbo Shang, Haitao Wang, Mingqian Tan
Summary: In this study, gliadin/starch nanocomposites (G/SNPs) with different gliadin/starch ratios were prepared and used to stabilize Pickering emulsion gels (PEGs). The interaction between gliadin and gelatinized starch was confirmed by fluorescence and Fourier transform infrared (FTIR) spectra. The stable PEGs stabilized by G/SNPs showed promising potential as carriers for the delivery of hydrophobic bioactive compounds.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Shan Sun, Zhuyi Lin, Shasha Cheng, A. M. Abd El-Aty, Mingqian Tan
Summary: Repeated freeze-thaw cycles can cause changes in the water distribution, physicochemical characteristics, and microstructure of Scomberomorus niphonius surimi. Water retention agents (phosphate and trehalose) were found to decrease water loss and improve surimi quality during these cycles. The combination of low-field nuclear magnetic resonance (LF-NMR) and magnetic resonance imaging (MRI) analysis provided important insights into the effects of water retention agents on surimi after freeze-thaw cycles.
INTERNATIONAL JOURNAL OF FOOD ENGINEERING
(2023)
Article
Engineering, Chemical
Yin Zhang, Haitao Wang, Yitong Hou, Jia Song, Wenbo Shang, Pengjing Zhang, Shuai Hou, Mingqian Tan
Summary: Konjac glucomannan was introduced to improve the wettability of gliadin and fabricate oil-in-water Pickering emulsions stabilized by konjac glucomannan/gliadin colloidal particles (GKPs) with algal oil as internal oil phase. The major force between konjac glucomannan and gliadin was hydrogen bonding and GKPs appeared as independently dispersed spheres. The Pickering emulsion stabilized by GKPs showed high stability and increased bioaccessibility of astaxanthin.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Analytical
Jie Song, Bing Yin, Mingqian Tan
Summary: This study reported the fabrication of an all-in-one wearable system with a UV photodetector and VC sensor powered by a micro-supercapacitor. The system exhibited outstanding energy storage ability, high areal capacitance, and good mechanical flexibility, and was able to simultaneously monitor the UV intensity of the external environment and the VC level in the human body.
Article
Chemistry, Applied
Lijuan Zhang, Chengfu Zhou, Shanghua Xing, Yannan Chen, Wentao Su, Haitao Wang, Mingqian Tan
Summary: This study demonstrated the protective effect of sea bass protein (SBP)-(-)-epigallocatechin-3-gallate (EGCG) covalent complex-stabilized high internal phase (algal oil) Pickering emulsions (HIPPEs) on astaxanthin and algal oils. The formation of the SBP-EGCG complex improved the wettability and antioxidant activity, leading to the stabilization of HIPPEs. The incorporation of SBP-EGCG complex resulted in dense particle shells surrounding the oil droplets and a network structure, providing HIPPEs with high viscoelasticity and thermal stability for 3D printing applications.
Article
Chemistry, Applied
Wenbo Shang, Yuanda Sun, Jia Song, Pengjing Zhang, Yitong Hou, Haitao Wang, Mingqian Tan
Summary: Stable and tailorable high internal phase emulsions (HIPEs) solely stabilized by whey protein isolate (WPI) were prepared using oil phase gelatinization by glycerol monostearate (GM). These HIPEs exhibited small oil droplet size and gel-like network structure in the oil phase, resulting in superior stability and desirable rheological properties. The addition of GM improved the freezing-thawing stability of the HIPEs and increased the half-life of fucoxanthin, suggesting the potential of oil gelation in designing novel HIPEs for numerous food applications.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Jia Song, Yuanda Sun, Haitao Wang, Mingqian Tan
Summary: This paper demonstrated a facile route to prepare oil in water high internal phase Pickering emulsions (HIPEs) by centrifuging gliadin/gelatinized starch nanocomposites (G/SNPs) stabilized pre-emulsions. The engineered surface properties of G/SNPs prevented oil coalescence during centrifugation and resulted in HIPEs with oil phase fractions up to 77.3%. These HIPEs exhibited shear-thinning behavior and high solid viscoelasticity. Furthermore, HIPEs with internal phase fraction above 80% were successfully prepared by adjusting the ionic strength. The rheological properties of these HIPEs were suitable for 3D printing, and their enhanced viscoelasticity and thixotropic recovery could be attributed to the electrostatic shielding under higher ionic strength. Additionally, HIPEs significantly improved the light stability and bioaccessibility of astaxanthin, with more than 90% astaxanthin retained after heating at 95 degrees C for 30 min. These results present a new route for producing HIPEs with improved performance, opening possibilities for future food manufacturing and delivery of hydrophobic bioactive molecules.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Ronggang Liu, Yu Li, Chengfu Zhou, Mingqian Tan
Summary: This study developed Pickering emulsions using a SP-CS complex as an emulsifier, which demonstrated improved stability, release rate, and bioavailability of AXT, a hydrophobic compound.
Article
Biochemistry & Molecular Biology
Duo Liang, Chenyue Liu, Jiaxuan Li, Yu Li, Jiashu Li, Mingqian Tan, Wentao Su
Summary: Synthetic probiotic membrane vesicles can be used as safe delivery carriers to improve the stability and bioavailability of hydrophobic food bioactive ingredients.
Review
Food Science & Technology
Jiacong Man, A. M. Abd El-Aty, Zuzhe Wang, Mingqian Tan
Summary: Sea cucumber is a precious and nutritious food with abundant protein and other bioactive compounds, and sea cucumber peptide (SCP) has shown various beneficial functions. However, the translation of research findings into industrial practice and new products is currently immature. This review focuses on the production, characterization, and bioactive properties of SCP, as well as the challenges and prospects of its development in scientific research and commercialization. Although SCP has great potential for health promotion, there are still challenges that need to be addressed, such as the validation of health claims, clarification of its mechanisms, improvement of bioavailability, and enhancement of industrial production and sensory properties of end-products.