Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander M. Panich, Moti Salti, Ofer Prager, Evyatar Swissa, Yuri Kulvelis, Elena B. Yudina, Alexander E. Aleksenskii, Shaul D. Goren, Alexander Ya Vul', Alexander Shames
Summary: The study demonstrates that saline suspension of PVP-coated gadolinium-grafted detonation nanodiamonds (DND) serves as a promising contrast agent in MRI, providing higher signal intensities than the commonly used gadoterate meglumin. This novel contrast agent shows potential for safer clinical use based on its performance in ex vivo and in vivo testing.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Staszak, Karolina Wieszczycka, Anna Bajek, Maciej Staszak, Bartosz Tylkowski, Krzysztof Roszkowski
Summary: According to the World Health Organization (WHO), cancer is the second leading cause of death globally. This review focuses on recent developments of chemical compounds in cancer angiogenesis imaging and monitoring, providing insights into active agents structures involved in various imaging techniques. The aim is to provide the journal audience with a comprehensive understanding of chemistry policy in tumor angiogenesis imaging.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Chemistry, Medicinal
Marzena Wyskocka-Gajda, Lukasz Przypis, Monika Olesiejuk, Tomasz Krawczyk, Anna Kuznik, Krzysztof Nawara, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi, Nikodem Kuznik
Summary: Investigation into iron(III) chelates with N,O-aminophenol showed high versatility and tuning potential, with functionalization with galactose providing a bioresponsive character sensitive to enzyme activity. The resulting complexes exhibited extremely high relaxivity and could change relaxivity by over 80% through enzymatic hydrolysis. MRI and cytotoxicity studies confirmed the bioresponsive character and good biocompatibility of these iron-based chelates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Michael Haimerl, Kirsten Utpatel, Andrea Goetz, Florian Zeman, Claudia Fellner, Dominik Nickel, Lukas Luerken, Frank Brennfleck, Christian Stroszczynski, Alexander Scheiter, Niklas Verloh
Summary: This study aimed to assess the differentiation degree of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted MRI with T1 relaxometry. The results suggest that the uptake of Gd-EOB-DTPA in HCCs correlates with tumor grade, indicating that Gd-EOB-DTPA-assisted T1 relaxometry can aid in further differentiating HCC.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Sylviane Chevreux, Mickael Four, Gilles Lemercier
Summary: This preliminary study demonstrates the potential use of O-3(2) as a magnetic Contrast Agent for monitoring photodynamic treatments, showing significant changes in T-1 (and R-1) values of water protons when combined with a Photo-Sensitizer (PS). The results suggest that transposition to Magnetic Resonance Imaging (MRI) under relevant conditions should be achievable.
HELVETICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Enza Di Gregorio, Mariangela Boccalon, Chiara Furlan, Eliana Gianolio, Attila Benyei, Silvio Aime, Zsolt Baranyai, Giuseppe Ferrauto
Summary: This study investigates the hydrophobic interaction between HPTS and the gadolinium(iii)-complex of tetra-aza macrocyclic ligand HP-DO3A (Gd(HP-DO3A)) in vivo and in vitro. The results show that the interaction is not influenced by the protonation state of HPTS. The formation of binary and ternary adducts between HPTS and Gd(iii)-complexes is supported by UV spectra and X-ray solid-state structures. The strong hydrophobic interaction is utilized to detect the in vivo distribution of Gd(HP-DO3A) in tumor-bearing mice through fluorescence optical imaging.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Iryna Antal, Oliver Strbak, Vlasta Zavisova, Jana Vojtova, Martina Kubovcikova, Alena Jurikova, Iryna Khmara, Vladimir Girman, Robert Dzunda, Karol Koval, Martina Koneracka
Summary: A colloidal solution of magnetic nanoparticles modified with biocompatible PLL and OL layer was produced as a potential MRI contrast agent. The optimal mass ratio for MNPs' surface coating was found to be 0.5. The PLL coating significantly enhanced the relaxivity of MNPs in MRI relaxometry, leading to excellent MRI contrast enhancement properties.
Article
Radiology, Nuclear Medicine & Medical Imaging
Evan C. Norris, Guenther Schneider, Toshimasa J. Clark, Miles A. Kirchin, Gregory J. Wilson, Jeffrey H. Maki
Summary: This study validates the theory describing the behavior of R-1 and R-2* in blood using an animal model. Results show that incorporating sub-linear R-1 and high blood R-2* effects allows accurate prediction of SPGR SI, while simplified models show poorer correlation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Jongeun Kang, Eunha Hwang, Hyunseung Lee, Mi Young Cho, Sanu Karan, Hak Nam Kim, Jong Seung Kim, Jonathan L. Sessler, Sankarprasad Bhuniya, Kwan Soo Hong
Summary: This article presents a new type of MRI T-1 contrast agent that can activate the recognition of the cellular vicinal thiol motifs of the protein thioredoxin, showing significant effects on the binding to thioredoxin at 60 MHz.
Article
Chemistry, Inorganic & Nuclear
Riya Mallik, Mahmuda Khannam, Muktashree Saha, Shivani Marandi, Sachin Kumar, Chandan Mukherjee
Summary: A high relaxivity T-1-weighted MRI contrast agent was developed by incorporating Gd(iii) complex 1 into porous silica nanoparticles, leading to a significant increase in relaxivity value for lesion imaging and tumor detection. The nanomaterial showed potential diagnostic applications as a biocompatible contrast agent, promising early-stage tumor detection.
DALTON TRANSACTIONS
(2022)
Article
Pharmacology & Pharmacy
Eirik A. L. Rustad, Susannah von Hofsten, Robin Kumar, Eirik A. Laensman, Gerd Berge, Natasa Skalko-Basnet
Summary: Nanomedicine has been successful in developing superior anticancer therapies, but there are still challenges in treating certain tumors, such as glioblastoma. In this study, pH-responsive liposomes were used to deliver drugs to glioblastoma cells, taking advantage of the acidic extracellular environment. The results showed improved intracellular uptake of drugs in glioblastoma cells compared to non-pH-responsive liposomes, regardless of the length of PEG.
Article
Biophysics
Muhammad Asim Farooq, Huang Xinyu, Amna Jabeen, Anam Ahsan, Theodora Amanda Seidu, Perpetua Takunda Kutoka, Bo Wang
Summary: The study demonstrated that TPGS-coated liposomes enhanced cytotoxicity and cellular uptake of VOR in breast cancer cells, with improved stability and encapsulation efficiency. TPGS-coated liposomes also improved solubility of VOR and showed sustained release, making them promising drug carriers for effective delivery of hydrophobic drugs in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Siavash Iravani, Rajender S. Varma
Summary: Magnetic resonance imaging (MRI) is a widely used noninvasive clinical imaging modality in bio- and nanomedicine, especially for tumor detection and high-quality three-dimensional imaging. The design of efficient nanoscale contrast agents (NCAs) is crucial for specific detection and imaging of tumors. However, there are still challenges to be addressed in the clinical applications of these agents, including nanotoxicology and biosafety issues.
ACS APPLIED NANO MATERIALS
(2022)
Article
Multidisciplinary Sciences
S. A. Amali S. Subasinghe, Caitlyn J. Ortiz, Jonathan Romero, Cassandra L. Ward, Alexander G. Sertage, Lyazat Kurenbekova, Jason T. Yustein, Robia G. Pautler, Matthew J. Allen
Summary: Hypoxia is a prognostic biomarker of rapidly growing cancers and can be mapped using contrast-enhanced MRI. However, quantification of hypoxia is challenging due to the dependence on oxygen and EuII concentration. This study presents a ratiometric method using fluorinated EuII/III-containing probes to eliminate concentration dependence and quantify hypoxia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Respiratory System
Jeroen N. Wessels, Sophia A. Mouratoglou, Jessie van Wezenbeek, M. Louis Handoko, J. Tim Marcus, Lilian J. Meijboom, Berend E. Westerhof, Harm Jan Bogaard, Gustav J. Strijkers, Anton Vonk Noordegraaf, Frances S. de Man
Summary: This study assessed the impact of RV diastolic stiffness on RA-RV interaction in pulmonary arterial hypertension (PAH) patients. The results showed that increased RV diastolic stiffness resulted in reduced RA and RV passive strain. Treatment that reduced RV diastolic stiffness led to improvements in RV active filling and decreased vena cava backflow.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Lukas Christian Sebeke, Juan Daniel Castillo Gomez, Edwin Heijman, Pia Rademann, Alexandra Claudia Simon, Sandra Ekdawi, Susan Vlachakis, Dennis Toker, Ben Lasse Mink, Claudia Schubert-Quecke, Sin Yuin Yeo, Patrick Schmidt, Christina Lucas, Susanne Brodesser, Martin Hossann, Lars H. Lindner, Holger Gruell
Summary: In this article, the localized release of doxorubicin (DOX) from thermosensitive liposomes was achieved using MR-HIFU mediated hyperthermia in a swine model. The study showed a significant increase in DOX concentration in the muscle tissue after hyperthermia treatment, and there was a correlation between the pharmacokinetics of DOX in the bloodstream and its accumulation in the target tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen P. A. Baas, Bram F. Coolen, Esben T. Petersen, Bart J. Biemond, Gustav J. Strijkers, Aart J. Nederveen
Summary: This study compared T-2-TRIR with TRUST in measuring T(2)b, Yv, and OEF. The results showed that T-2-TRIR-derived T(2)b values were higher, resulting in higher Yv estimates and lower OEF estimates.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Laura Secondulfo, Melissa T. Hooijmans, Joep J. Suskens, Valentina Mazzoli, Mario Maas, Johannes L. Tol, Aart J. Nederveen, Gustav J. Strijkers
Summary: This study developed a DTI-based method for quantitatively assessing fiber angles and changes in leg muscles, allowing for longitudinal studies on muscle fiber architectural adaptations in healthy individuals. The results showed that the method was feasible and repeatable, and it was able to detect changes in lower-leg muscle fiber angles with varying ankle angles.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Gustav J. Strijkers
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Sport Sciences
Jozef J. M. Suskens, Laura Secondulfo, Ozgur Kilic, Melissa T. Hooijmans, Gustaaf Reurink, Martijn Froeling, Aart J. Nederveen, Gustav J. Strijkers, Johannes L. Tol
Summary: This study evaluated the effect of Nordic hamstring exercise and Diver hamstring exercise on the fascicle length and orientation of hamstrings using DTI MRI. The results showed that the Nordic exercise increased the length of the semitendinosus, while the Diver exercise changed the orientation of the biceps femoris long head. Both exercises are important for preventing hamstring injuries.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Environmental Sciences
Julia Simoes Correa Galendi, Ann-Cathrine Siefen, Debora M. M. Moretti, Sin Yuin Yeo, Holger Gruell, Grischa Bratke, Alessio Giuseppe Morganti, Alberto Bazzocchi, Chiara Gasperini, Francesca De Felice, Roberto Blanco Sequeiros, Mira Huhtala, Ingrid M. M. Nijholt, Martijn F. F. Boomsma, Clemens Bos, Helena M. M. Verkooijen, Dirk Mueller, Stephanie Stock
Summary: Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is an innovative treatment for painful bone metastases. However, its adoption is influenced by various factors, and addressing these factors from different clusters is crucial for its widespread use.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Oncology
Sin Yuin Yeo, Grischa Bratke, Holger Gruell
Summary: High Intensity Focused Ultrasound (HIFU) is a non-invasive method for ablating tumors and treating painful bone lesions. It has been used for pain relief in bone metastases and primary tumors for 20 years, as well as for local treatment of bone tumors. This review summarizes 20 years of literature on HIFU treatment of bone malignancies, focusing on pain palliation, treatment efficacy, and safety.
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen P. A. Baas, Chau Vu, Jian Shen, Bram F. F. Coolen, Bart J. J. Biemond, Gustav J. J. Strijkers, John C. C. Wood, Aart J. J. Nederveen
Summary: This study compared the measurements of blood T2 values, venous blood oxygenation, oxygen extraction fraction, and cerebral metabolic rate of oxygen obtained using TRUST and T2-TRIR methods under different respiratory challenges. The results showed a significant bias between TRUST and T2-TRIR, but this bias remained constant across different oxygen saturations. The correlation between hemoglobin concentration measured by T2-TRIR and venipuncture was weak.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Koen P. A. Baas, Albert J. Everard, Simon Korver, Laura van Dussen, Bram F. Coolen, Gustav J. Strijkers, Carla E. M. Hollak, Aart J. Nederveen
Summary: This study found that changes in diffusion occur before the formation of white matter lesions in patients with Fabry disease, and that microstructural changes progress faster in men compared with women. These findings suggest that DWI may be of predictive value for white matter lesion formation in Fabry disease.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bobby A. Runderkamp, Thomas Roos, Wietske van der Zwaag, Gustav J. Strijkers, Matthan W. A. Caan, Aart J. Nederveen
Summary: This study aimed to achieve homogeneous signal throughout the human liver at 7 T. By using subject-specific multichannel absolute B-1(+) maps and parallel-transmit k(T)-point pulses for flip angle (FA) shimming, homogeneous whole-liver images were obtained.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Nina G. Smets, Gustav J. Strijkers, Vegard Vinje, Erik N. T. P. Bakker
Summary: Cerebrospinal fluid (CSF) not only clears brain waste, but also interacts intensively with brain tissue through perivascular spaces. Cardiac pulsations, vasomotion, and respiration can drive CSF flow in these spaces, enhancing waste clearance. The intrinsic relationship between CSF production and its distribution volume is not explicitly addressed in recent concepts of brain clearance.
NMR IN BIOMEDICINE
(2023)
Review
Cell Biology
Fatimah M. Al Darwish, Lotte Meijerink, Bram F. Coolen, Gustav J. Strijkers, Mireille Bekker, Titia Lely, Fieke Terstappen
Summary: Placental hypoxia during pregnancy poses risks to both the fetus and the mother, emphasizing the need for early detection and monitoring. Reliable biomarkers are crucial for effectively identifying placental hypoxia and evaluating placental function deterioration. Non-invasive imaging techniques, such as photoacoustic and magnetic resonance imaging, show promising potential for directly assessing placental condition over time. Integrating molecular and imaging biomarkers may revolutionize placental hypoxia detection and monitoring, leading to improved pregnancy outcomes and reduced long-term health complications.
Article
Oncology
Sven Nouwens, Maarten Paulides, Johannes Lindemeyer, Lukas Sebeke, Ricky van Kampen, Holger Gruell, Maurice Heemels
Summary: This study proposes a new frequency-domain estimation method for quality assurance in thermal therapy, which can provide unbiased estimates of specific absorption rate (SAR) and thermal diffusivity. By periodically modulating the power of focused ultrasound and recording the response with MRI thermometry, spatial Fourier coefficients are used to estimate the thermal response and parameters. The experimental results show that this method has a high signal-to-noise ratio (SNR) and reproducible estimates, with insensitivity to B 0 drift and non-steady-state initial temperature distributions.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Biophysics
Melissa T. Hooijmans, Thom T. J. Veeger, Valentina Mazzoli, Hans C. van Assen, Jurriaan H. de Groot, Lukas M. Gottwald, Aart J. Nederveen, Gustav J. Strijkers, Hermien E. Kan
Summary: This study evaluated the elastic function of muscles using magnetic resonance imaging technology and found that muscles exhibit cyclic fiber strain rate patterns during dorsi-/plantarflexion exercise, with amplitudes varying between different muscles and within proximodistal segments of the muscles.
NMR IN BIOMEDICINE
(2023)