期刊
CONTRAST MEDIA & MOLECULAR IMAGING
卷 4, 期 2, 页码 73-80出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/cmmi.264
关键词
biodistribution; whole-body autoradiography; WBSFI; optical imaging; fluorescence
资金
- GE Healthcare AS, Oslo, Norway
The present study demonstrates the usefulness of whole body section fluorescence imaging, a novel technique used in optical imaging drug discovery. This method is in principle an analog of whole body autoradiography, except that fluorescence is measured instead of radioactivity. The method was shown to have a linear concentration-response relationship over a 1000-fold concentration range. Densitometric image analysis allowed semiquantitative studies of drug disposition and selective tumor retention of an optical imaging drug candidate. Copyright (C) 2009 John Wiley & Sons, Ltd.
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