Article
Health Care Sciences & Services
Jing Yu, Hong-Wen Yao, Ting-Ting Liu, Di Wang, Jian-Hong Shi, Guang-Wen Yuan, Sai Ma, Ling-Ying Wu
Summary: This study developed a novel estrogen/progesterone-related gene signature for predicting the prognosis of endometrial cancer (EC) and identified potential molecular targets for EC therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Sylvia C. Hewitt, San-Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Summary: The study demonstrates that uterine cells respond to estrogen and progesterone through their nuclear receptors ESR1 and PGR, with the involvement of chromatin structures. The organoids model provides insights into the regulatory mechanisms of hormone responsiveness.
Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Masahiro Tsutsumi, Isao Yamaguchi, Akimoto Nimura, Hajime Utsunomiya, Keiichi Akita, Shintarou Kudo
Summary: This study investigated the soft tissue characteristics of the hip in the flexion abduction external rotation (FABER) position using magnetic resonance imaging. The results showed that the joint cavity area and its ratio to the femoral neck were largest in the FABER position. Additionally, the fat pad in the inter-pericapsular muscle space was larger in the FABER position compared to hip flexion and extension. This is the first in-vivo study to demonstrate the interrelationship among the joint capsule, pericapsular muscles, and fat pad in the FABER position.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact through Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of-function CTCF mutation in endometrial tumors indicates its importance in uterine homeostasis. Our study reveals that uterine Ctcf plays a key role in progesterone-dependent expression of uterine genes underlying optimal post-pubertal uterine development.
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact via Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of- function CTCF mutation indicates its importance in uterine homeostasis. Deleting Ctcf gene in female reproductive tissues of mice resulted in reduced uterine glands and hypoplastic uteri with decreased endometrial stroma. Ctcf deletion also altered the expression of progesterone-responsive genes, including Ihh, Fst, and Errfi1. Our findings highlight the key role of uterine Ctcf in progesterone-dependent expression and optimal post-pubertal uterine development.
Article
Sport Sciences
Tine Vrist Dam, Line Barner Dalgaard, Vassilis Sevdalis, Bo Martin Bibby, Xanne Janse De Jonge, Claus H. Gravholt, Mette Hansen
Summary: Variations in strength and power performance were observed during the menstrual cycle and the pill cycle in women. These variations were associated with lower psychological well-being, but not sex hormone fluctuations.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Oncology
Yi Jiang, Qinli Xie, Rong Chen
Summary: Hormone replacement therapy is associated with increased risk of breast cancer, especially for slim postmenopausal women.
CLINICAL BREAST CANCER
(2022)
Article
Endocrinology & Metabolism
Elisa Rossini, Mariangela Tamburello, Andrea Abate, Silvia Beretta, Martina Fragni, Manuela Cominelli, Deborah Cosentini, Constanze Hantel, Federica Bono, Salvatore Grisanti, Pietro Luigi Poliani, Guido A. M. Tiberio, Maurizio Memo, Sandra Sigala, Alfredo Berruti
Summary: Research showed that ER expression was low in ACC cell models, while PgR expression was higher, limiting the clinical approach targeting ER.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Victoria Peer, Khitam Muhsen, Moshe Betser, Manfred S. Green
Summary: Pregnant women have lower immune response to pertussis vaccination compared to non-pregnant women, possibly due to higher levels of hormones during pregnancy. Sex hormones during pregnancy, such as progesterone and estrogen, are negatively associated with anti-pertussis toxin antibody levels.
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Koushik Bhattacharya, Pallav Sengupta, Sulagna Dutta, Alak Kumar Syamal
Summary: This study aims to determine the minimum dose of estradiol required to induce uterine receptivity for successful implantation in mice. The results showed that a single dose of 50.0 ng of estradiol can effectively induce uterine receptivity for implantation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biology
Amani A. Mahbub
Summary: Several epidemiological studies have suggested that the use of female sex steroid hormones can reduce the risk of colon cancer. This review summarizes the available data on the effects of estradiol and progesterone treatments in male and female in vitro and in vivo models of colon cancer, along with their potential molecular mechanisms. The studies showed that estradiol treatment and activation of its beta receptor inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis through molecular pathway modulation. Similarly, the inhibition of the alpha receptor also had antitumorigenic effects. Limited studies on progesterone revealed promising tumoricidal actions. Furthermore, the combination of estradiol and progesterone showed enhanced anticancer activities compared to monotherapy. Overall, these studies suggest that female sex steroid hormones could be a novel and effective therapeutic strategy against colon cancer.
Article
Agriculture, Dairy & Animal Science
Harender Singh, Anand Kumar Pandey, Sandeep Kumar, Gitesh Saini, Rakesh Duggal, Yogesh Chandrakant Bangar, Ravinder Saini, Hitesh Kumar
Summary: This study investigated whether increasing estradiol (E-2) levels during the preovulatory period would improve estrous expression, luteal profiles, and conception rate in a 5-day CIDR-based timed artificial insemination (AI) protocol. The results showed that the addition of estradiol increased estradiol concentrations, estrus induction, and conception rate compared to the control group. Estrus response and progesterone concentrations were found to be indicators of pregnancy probability.
ANIMAL BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Akimasa Adachi, Tetsuya Honda
Summary: Psoriasis is a chronic inflammatory skin disease associated with the interleukin-23/interleukin-17 axis, and female sex hormones, specifically estrogens, play a significant role in its development by suppressing the production of psoriasis-related cytokines.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Primary Health Care
David Nolan, Kirsty J. Elliott-Sale, Brendan Egan
Summary: This study investigated the prevalence and side effects of hormonal contraceptive use in powerlifters and rugby players. The results showed that a large proportion of athletes, regardless of HC use, experienced negative side effects of the menstrual cycle. The symptoms varied between HC users and nonusers, which may have an impact on athletic performance.
PHYSICIAN AND SPORTSMEDICINE
(2023)
Article
Nutrition & Dietetics
Tommy Slater, William J. A. Mode, Mollie G. Pinkney, John Hough, Ruth M. James, Craig Sale, Lewis J. James, David J. Clayton
Summary: This study assessed the effects of 7-hr fasting before evening exercise on energy intake, metabolism, and performance. The study found that fasted evening exercise reduced net energy intake and increased fat oxidation, but also decreased exercise performance, motivation, and enjoyment.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Behavioral Sciences
William J. A. Mode, Tommy Slater, Mollie G. Pinkney, John Hough, Ruth M. James, Ian Varley, Lewis J. James, David J. Clayton
Summary: This study compared the effects of morning and evening exercise on appetite, post-exercise energy intake, and voluntary performance. The findings suggest that exercise might offset circadian variations in appetite and that post-exercise ad-libitum energy intake is greater following evening exercise.
Review
Nutrition & Dietetics
David J. J. Clayton, Ian Varley, Maria Papageorgiou
Summary: Intermittent fasting (IF) is a promising strategy for weight loss and improving metabolic health, but its effects on bone health are less clear. Animal studies and limited observational studies suggest a potential link between certain IF practices and compromised bone health, while interventional studies show no adverse effects on bone outcomes for time-restricted eating (TRE) regimens and alternate-day fasting (ADF). However, the interpretation of existing data is challenging due to the limitations of available studies. Further research with well-controlled protocols and clinically relevant assessments is needed.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Ian Varley, Marcus Ward, Chris Thorpe, Nathan Beardsley, Julie Greeves, Craig Sale, Chris Saward
Summary: This study explored the association between training load and changes in body composition and bone characteristics during a competitive season. The results showed significant changes in lean mass, fat mass, and bone mineral density (BMD) at different phases of the season, indicating the impact of training load on these factors.
Article
Sport Sciences
Reece Scott, Ruth James, Cleveland T. Barnett, Craig Sale, Ian Varley
Summary: This study aimed to investigate the external load measuring tools used by support staff to estimate bone load and assess if these methodologies were supported in research. The results showed that although most support staff (92%) monitored external load, only 28% used it to estimate bone load. GPS was the most commonly used method, but there is a lack of research on its association with bone load. Further research is needed to determine the best method of estimating bone load in an applied setting.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Article
Sport Sciences
Ian Varley, Craig Sale, Julie P. Greeves, John G. Morris, Caroline Sunderland, Chris Saward
Summary: We investigated the relationship between football-specific training and changes in bone structural properties in 15 male football players aged 16 years over a 12-week period. Tibial scans were performed before and after increased football-specific training, and training parameters were analyzed using GPS. The results suggest that while football training is associated with increased bone characteristics in male academy footballers, the specific training variables influencing bone structural properties may vary over a 12-week period. Further research is needed to fully understand the time-course of how certain football-specific training characteristics affect bone adaptation.
Editorial Material
Biochemistry & Molecular Biology
Eimear Dolan, Craig Sale, Michael S. Hedrick
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Physiology
Gabriel P. Esteves, Paul Swinton, Craig Sale, Bruno Gualano, Hamilton Roschel, Eimear Dolan
Summary: Bone mass and quality decline with age, and this study investigated the associations between bone and physical, dietary, and metabolic factors. The results showed that body composition (lean) and strength were positively associated with bone, while dietary intake relative to body mass was negatively associated with bone. Resistance training programs that improve lean mass and strength may benefit bone in older individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Daniel F. Mcwilliams, Bin Yue, Stephanie L. Smith, Joanne Stocks, Michael Doherty, Ana M. Valdes, Weiya Zhang, Aliya Sarmanova, Gwen S. Fernandes, Kehinde Akin-Akinyosoye, Michelle Hall, David A. Walsh
Summary: Knee pain is associated with lower muscle strength, and both peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help future treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell & Tissue Engineering
Janelle Tarum, Hans Degens, Mark D. Turner, Claire Stewart, Craig Sale, Livia Santos
Summary: Healthy skeletal muscle has the ability to regenerate after injury, but this ability is impaired in aging muscle due to dysfunctional satellite cells and reduced myogenic capacity. This study developed a high-throughput in vitro model to assess muscle regeneration in young and aged muscle cell cultures. The results suggest that aged muscle cells have reduced regeneration capacity and show significant changes in signalling pathways associated with muscle development and contraction. Understanding these mechanisms can aid in the development of new therapies for impaired muscle regeneration in older age.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paul A. Swinton, Kirsty J. Elliott-Sale, Craig Sale
Summary: This large cohort study examined the reliability and validity of heel ultrasound for estimating bone mineral density. The reliability between left and right heels was poor, as was the agreement with dual-energy X-ray absorptiometry. Heel ultrasound should be used cautiously for estimating bone mineral density.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Cell Biology
K. Habra, J. R. D. Pearson, P. Le Vu, C. Puig-Saenz, M. J. Cripps, M. A. Khan, M. D. Turner, C. Sale, S. E. B. McArdle
Summary: Carnosine has a significant inhibitory effect on the proliferation of prostate cancer cells and does not have detrimental effects on healthy cells. Further in vivo research is needed to determine the potential use of carnosine as a treatment for prostate cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Sport Sciences
Rita Civil, Eimear Dolan, Paul A. Swinton, Livia Santos, Ian Varley, Philip J. Atherton, Kirsty J. Elliott-Sale, Craig Sale
Summary: This study aimed to investigate the responses and variability of P1NP and beta-CTX-1 after prolonged, continuous running in young healthy adult males. The results showed that the increase in P1NP was likely due to biological artifacts, and the small decrease in beta-CTX-1 was related to the markers' circadian rhythm rather than the running intervention.
SPORTS MEDICINE-OPEN
(2023)
Article
Sport Sciences
Kirsty J. Elliott-Sale, Kathryn E. Ackerman, Constance M. Lebrun, Clare Minahan, Craig Sale, Trent Stellingwerff, Paul A. Swinton, Anthony Hackney
Summary: This article highlights the lack of sufficient high-quality studies in sport science using women as participants, which limits our understanding of female athletes in relation to their ovarian hormone profiles. The authors propose the use of consortia to accelerate learning and reduce research waste through collaboration. They also describe the formation of an international multisite team to investigate the effects of the menstrual cycle and contraceptive pill phase on exercise physiology and sports performance in female athletes, aiming to produce a well-powered, high-quality dataset to inform practices in this field.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
