Article
Oncology
Henri Malaize, Thomas Samoyeau, Marc Zanello, Alexandre Roux, Joseph Benzakoun, Sophie Peeters, Gilles Zah-Bi, Myriam Edjlali, Arnault Tauziede-Espariat, Edouard Dezamis, Eduardo Parraga, Fabrice Chretien, Pascale Varlet, Genevieve Plu-Bureau, Catherine Oppenheim, Johan Pallud
Summary: The number of patients with progestin-associated meningiomas has increased over time, with a growing trend towards conservative management and discontinuation of progestin treatment. MRI follow-up has shown promising results in terms of efficacy for conservatively managed meningiomas after discontinuation of progestin treatment.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Medicine, General & Internal
Naama Vilk Ayalon, Lior Segev, Abraham O. Samson, Simcha Yagel, Sarah M. Cohen, Tamar Green, Hila Hochler
Summary: This study found that adding 5 mg of norethisterone acetate to progesterone-only pills can significantly reduce the frequency and quantity of bleeding and spotting associated with contraception.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Antoine Devalckeneer, Rabih Aboukais, Philippe Bourgeois, Olivier De Witte, Judith Racape, Sabine Caron, Romain Perbet, Claude-Alain Maurage, Jean-Paul Lejeune
Summary: The relationship between meningioma and progestins remains unclear. Meningioma regression after progestin withdrawal has been reported. Results suggest a strong association between CA treatment and development of intracranial meningioma, with potential regression after withdrawal. Further studies are needed for NA and ChlA groups.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Pedro-Antonio Regidor, Enrico Colli
Summary: This study aimed to examine the effects of two contraceptive drugs on dysmenorrhea and mastodynia after nine months of use. The results showed that these drugs had a significant impact in reducing the symptoms of these two gynecologic conditions, offering new possibilities for treatment.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Antoine Devalckeneer, Rabih Aboukais, Maxime Faisant, Philippe Bourgeois, Vannod-Michel Quentin, Claude-Alain Maurage, Fabienne Escande, Jean-Paul Lejeune
Summary: In this retrospective study, 9 patients with high-grade progestin-related intracranial meningioma who underwent surgery and long-term exposure to progestin were followed up for an average of 8.1 years. The study found that patients with grade II progestin-related meningiomas had lower tumor recurrence rates after surgery, especially after progestin withdrawal. Factors such as edema presence, absence of cleft sign on MRI, and PR expression levels were key in the surgical management of these patients.
NEUROSURGICAL REVIEW
(2022)
Article
Obstetrics & Gynecology
Samia Ouasti, Margot Bucau, Elise Larouzee, Sebastien Clement De Givry, Nathalie Chabbert-Buffet, Martin Koskas
Summary: The study confirms that the use of chlormadinone acetate for 6 months is comparable to other fertility-sparing treatments in achieving remission of atypical hyperplasia or endometrial carcinoma. It is an effective and well-tolerated treatment option, with the added benefit of allowing some patients to achieve live births.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Anesthesiology
T. Devoy, M. Hunter, N. A. Smith
Summary: A study found no evidence of hormone level changes that might threaten contraceptive efficacy in women on hormonal contraception receiving sugammadex.
Article
Obstetrics & Gynecology
Rohan R. Chodankar, Alison Murray, Moira Nicol, H. R. Whitaker, Alistair R. W. Williams, Hilary O. D. Critchley
Summary: This study investigated the impact of the progesterone receptor modulator ulipristal acetate (UPA) on endometrial morphology and function. The results showed that the effects on hormone receptors, cell proliferation, and progesterone-regulated genes were reversible after cessation of treatment.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Kayla Tanya Patel, Saira Adeel, Joanna Rodrigues Miragaya, Vin Tangpricha
Summary: The use of progestogens in gender-affirming hormone therapy for transgender women has been controversial. This systematic review found significant effects of progestogens on decreased high-density lipoprotein levels and increased thromboembolism risk in transgender women. However, there is no conclusive evidence regarding improved quality of life or breast development. Further research is needed.
ENDOCRINE PRACTICE
(2022)
Article
Health Care Sciences & Services
Stefano Restaino, Matilde Degano, Diana Padovani, Anna Biasioli, Valentina Capodicasa, Giuseppe Vizzielli, Lorenza Driul
Summary: This case report presents a rare case of an advanced ectopic pregnancy in a healthy 41-year-old woman after emergency contraception with Ulipristal Acetate. The patient presented with amenorrhea and ultrasound examination revealed an unruptured tubal pregnancy. The patient underwent laparoscopic surgery without complications.
Article
Reproductive Biology
Kianna M. Spencer, Giorgia Podico, Ameer A. Megahed, Kristi L. Jones, Joao H. J. Bittar, Igor F. Canisso
Summary: This study evaluated the ovulatory response of mares to deslorelin acetate during the fall and their response to PGF2 alpha 8 days post-ovulation. The results showed that mares displayed a highly efficacious response to deslorelin acetate and apparently normal luteal function during the fall, despite lower edema scores in late fall.
Article
Obstetrics & Gynecology
Sena Shibasaki, Hiromitsu Hattori, Masae Koizumi, Satoko Nagaura, Mayumi Toya, Hideki Igarashi, Koichi Kyono
Summary: This study aimed to investigate whether progestin-primed ovarian stimulation (PPOS) with chlormadinone acetate (CMA) adversely affects clinical results and neonatal outcomes or causes congenital deformities. The results showed that using CMA for ovarian stimulation did not have a negative impact on clinical outcomes, suggesting that PPOS with CMA is an appropriate ovarian stimulation method for normal ovarian responders.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Silvia Vannuccini, Chiara Biagiotti, Maria Celeste Esposto, Francesco La Torre, Sara Clemenza, Gretha Orlandi, Tommaso Capezzuoli, Felice Petraglia
Summary: This study evaluated the effects of desogestrel (DSG) and combined oral contraceptives (COCs) on treating endometriosis-related pain. The results showed that both treatments were effective in reducing pain, but patients treated with DSG experienced lower levels of dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Alexis J. Bick, Renate Louw-du Toit, Salndave B. Skosana, Donita Africander, Janet P. Hapgood
Summary: This study discusses the impact of different forms of hormonal contraception and progestins on side effects, reproductive cancers, and susceptibility to infectious diseases. The research highlights the lack of study on progestins used in hormonal contraception and emphasizes the need for greater understanding of these topics.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Obstetrics & Gynecology
Kathryn L. Shaia, Benjamin S. Harris, Jessica H. Selter, Thomas M. Price
Summary: The classic transcriptional regulation by nuclear progesterone receptors A and B has been well-studied, but the mitochondrial progesterone receptor (PR-M) responsible for non-nuclear activities has received less attention. PR-M, derived from the progesterone receptor gene, binds to the mitochondrial outer membrane and increases cellular respiration to meet the metabolic demands of pregnancy, spermatozoa activation, and myometrial growth. Its presence may play a role in extended gestation and brain development in primates.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
A. Cagnacci, A. Gambera, G. Bonaccorsi, A. Xholli
Summary: In women across the menopausal age, genito-urinary symptoms, especially vaginal dryness, vaginal atrophy, and recurrent urinary infection, are associated with higher blood pressure, heart rate, and hypertension, while dyspareunia is related to heart rate. Risk factors for hypertension include vaginal atrophy, recurrent urinary infection, and hot flushes.
Article
Obstetrics & Gynecology
A. Xholli, E. Cavalli, U. Scovazzi, A. Cagnacci
Summary: This case series evaluates the clinical outcomes and sonographic features of symptomatic enhanced myometrial vascularity developed after first trimester medical abortion or miscarriage management. The results indicate that ultrasonography, along with persistent low serum beta-HCG levels, can be used for diagnosis and expectant management.
Article
Obstetrics & Gynecology
C. Massarotti, G. Asinaro, M. G. Schiaffino, C. Ronzini, I. Vacca, M. Lambertini, P. Anserini, L. Del Mastro, A. Cagnacci
Summary: This study aimed to evaluate the efficacy of vaginal oxygen and hyaluronic acid on genito-urinary symptoms of breast cancer survivors. Treatment with vaginal oxygen and hyaluronic acid every 15 days improved genito-urinary symptoms of breast cancer patients. However, additional studies are needed to determine the optimal treatment interval, duration, and long-term benefits.
Review
Endocrinology & Metabolism
Stefano Lello, Ida Paris, Angelo Cagnacci, Donata Sartori, Salvatore Caruso, Aldo Iop
Summary: This review discusses the epidemiology, pathophysiology, and clinical features of vasomotor symptoms (VMS) in breast cancer patients and provides an overview of complementary and alternative medicine (CAM) approaches for relieving VMS, with a focus on purified cytoplasm of pollen (PCP). VMS are common in breast cancer patients undergoing hormonal treatment and have a significant impact on quality of life. CAM approaches for VMS include vitamin E, phytoestrogens, and black cohosh, but there is limited evidence to guide treatment choices. PCP, produced according to good manufacturing practices, has a clear pharmacological mechanism, no estrogen activity, and has shown clinical efficacy with a favorable safety profile for menopause-associated symptoms.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Developmental Biology
Irene Gazzo, Claudia Massarotti, Sandra Chiodi, Simonetta Spinelli, Francesca Gualandi, Ubaldo Passamonti, Ezio Fulcheri, Emanuele Angelucci, Angelo Cagnacci
Summary: Hematopoietic stem cell transplantation (HSCT) is a treatment option for various blood diseases. With the increasing use of reproductive technologies, more patients who have undergone HSCT are conceiving, but the pathogenesis of obstetrical complications in these cases is not fully understood. This study presents data on two pregnancies in women who had undergone HSCT, showing that both pregnancies had intrauterine growth retardation due to defective implantation and placenta development, possibly caused by uterine vessel damage from irradiation. Further research is needed to understand the factors influencing placenta development post total body irradiation and HSCT for better pregnancy outcomes in this population.
Editorial Material
Public, Environmental & Occupational Health
Angelo Cagnacci, Vincenzina Bruni, Costantino Di Carlo, Franca Fruzzetti
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Article
Obstetrics & Gynecology
Anjeza Xholli, Ambrogio Pietro Londero, Ludovica Camacho Mattos, Sonja Vujosevic, Angelo Cagnacci
Summary: The objective of this study was to understand the needs for gynecological emergency department (ED) visits and plan measures to reduce these visits. A retrospective anonymized chart review analysis of ED visits for gynecological disturbances was conducted, and it was found that chronic pathologies such as adenomyosis, endometriosis, and leiomyomas significantly impacted ED use.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
A. Xholli, F. Molinari, F. Oppedisano, U. Scovazzi, I Vacca, M. G. Schiaffino, E. Cavalli, A. Cagnacci
Summary: This study suggests that there is a possible link between cervical stiffness and adenomyosis, with women affected by adenomyosis having a stiffer internal cervical os. Further investigation is needed to fully understand the relationship between cervical stiffness and the development of adenomyosis.
HUMAN REPRODUCTION
(2023)
Review
Medicine, General & Internal
Serena Bertozzi, Ambrogio P. Londero, Anjeza Xholli, Guglielmo Azioni, Roberta Di Vora, Michele Paudice, Ines Bucimazza, Carla Cedolini, Angelo Cagnacci
Summary: This narrative review examines the role of breast and gynecological risk-reduction surgery in BRCA mutation carriers. It discusses the indications, contraindications, complications, technical aspects, timing, economic impact, ethical issues, and prognostic benefits of the most common prophylactic surgical options. BRCA1/2 mutation carriers have a significantly higher risk of developing breast, ovarian, and serous endometrial cancer. Risk-reducing mastectomy and risk-reducing salpingo-oophorectomy are effective in reducing the risk of breast and ovarian cancer but have side effects such as impact on fertility and early menopause. A multidisciplinary team should inform women considering prophylactic surgery about the implications and hormonal therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Arrigo Fruscalzo, Alice Novak, Camilla Somma, Anjeza Xholli, Virginia Michelerio, Federico Prefumo, Ambrogio P. Londero, Angelo Cagnacci
Summary: The study aimed to assess the correlation between maternal and fetal anthropometric characteristics and third- and fourth-degree perineal tears. It included all consecutive pregnancies from 2011 to 2017 at a single institution. Nulliparity and feto-maternal BMI were found to be the best predictors for perineal tears. Confirming this association in future research and integrating it into delivery timing decisions could reduce obstetric damage.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Geriatrics & Gerontology
Petra Stute, Jo Marsden, Noor Salih, Angelo Cagnacci
Summary: Menopausal hormone treatment (MHT) is recommended for managing menopause symptoms, but the Women's Health Initiative (WHI) study showed an increased risk of breast cancer with MHT, leading to a decrease in its use globally. However, further evaluation considering different MHT regimens has shed light on a more nuanced understanding of the risk-benefit profile, particularly regarding progestogen type, prescription pattern, duration of use, and timing of initiation. This review provides a contextual interpretation of the WHI study and evaluates the impact of bioidentical MHT on the risk of chronic non-communicable diseases in post-menopausal women.
Article
Health Care Sciences & Services
Ambrogio P. Londero, Claudia Massarotti, Anjeza Xholli, Arrigo Fruscalzo, Angelo Cagnacci
Summary: This study reevaluated the association between assisted reproduction technologies (ART) and breech presentation, and found that both ART and other subfertility treatments (OST) were independent risk factors for breech at delivery. The prevalence of breech remained stable during the study period for both ART and OST.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biology
Serena Xodo, Ambrogio P. Londero, Maria Orsaria, Stefania Marzinotto, Gianluca Colussi, Angelo Cagnacci, Laura Mariuzzi, Giorgia Gri
Summary: This study investigates the involvement of the aryl hydrocarbon receptor (AhR) and its associated pathway in pre-eclampsia. It finds decreased levels of AhR, IDO1, ARNT, TiPARP, and S100A4 expression in the placental tissues of individuals with pre-eclampsia. The study highlights the need for further research to validate and expand these findings for better management of this complex pregnancy condition.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anjeza Xholli, Ambrogio Pietro Londero, Marina Jakimovska, Silvia Zermano, Laura Puma, Enrico Maria Pasqual, Borut Kobal, Angelo Cagnacci
Summary: The LC-CUSUM test was used to evaluate the skill acquisition process for ultrasound staging of endometrial cancer, showing the feasibility of quantitatively assessing performance.
Article
Obstetrics & Gynecology
Ambrogio P. Londero, Anjeza Xholli, Claudia Massarotti, Arrigo Fruscalzo, Angelo Cagnacci
Summary: This study aimed to assess the factors associated with the success and failure rate of external cephalic version (ECV) in breech fetuses. The results found factors such as nulliparity, maternal race, maternal age, female fetal sex, low fetal weight, and maternal anthropometric features to be correlated with ECV results.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)