期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1099, 期 -, 页码 135-141出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2015.06.055
关键词
Phenothiazines; Chemical reactivity; Protein binding; Biological activities
资金
- UGC India under the Rajiv Gandhi National Fellowship [RGNF-SC-HIM-1223]
- UGC Start-up grant [F. 30-70/2014]
- SATE Punjab University Chandigarh
A noble biologically active compound Ag(I)-PTZ metal complex (1) with spherical morphology was synthesized first time. Entire characterization tool (spectral, elemental, mass and thermal analysis) was supported a distorted tetrahedral structure, where two water compounds were coordinated with Ag(I) including one phenothiazine and one nitrate group. For the better insight, obtained spectral/structural results were supported by 3D molecular modeling. Compound 1 had shown excellent activities against the Salmonella typhimurium and Aspergillus fumigatus with minimum inhibitory concentration (MIC) value 20 mg/L and 25 mg/L. The observed antioxidant radical scavenging activity (in %) of compound 1 (62.74%) was more than control ascorbic acid (28.58%). The observed protein (BSA) binding constant of 1 was 8.86 x 10(4) M-1, which is similar to binding constant of salicylic acid with BSA protein. Initial studies have revealed that synthesized compound 1 may act as multipurpose drug analogue in future. (C) 2015 Elsevier B.V. All rights reserved.
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