Article
Medicine, General & Internal
Keren Ladin, Thalia Porteny, Julia M. Perugini, Kristina M. Gonzales, Kate E. Aufort, Sarah K. Levine, John B. Wong, Tamara Isakova, Dena Rifkin, Elisa J. Gordon, Ana Rossi, Susan Koch-Weser, Daniel E. Weiner
Summary: Older patients, care partners, and kidney clinicians have divergent views on patient-centered telehealth care, especially in terms of clinical effectiveness, patient experience, access to care, and clinician-patient relationship. Understanding these perceptions can help identify barriers that need to be addressed to promote high-quality care and telehealth utilization.
Article
Multidisciplinary Sciences
Silvia Marcela Ballesteros, Jose Moreno-Montoya, Wilhelmus Johannes Andreas Grooten, Pedro Barrera-Lopez, Jose A. De la Hoz-Valle
Summary: The study investigated the prevalence of multimorbidity among older adults in Colombia and found associations between age, sex, functional limitations, ethnicity, body mass index, income, physical activity, and urban residence with multimorbidity. It also demonstrated a strong association between infectious diseases mortality and poverty in a low-middle income country.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Ajay Kolli, Rebecca S. Mozaffarian, Erica L. Kenney
Summary: This study found a correlation between food insecurity and the prevalence of vision impairment through a nationally representative survey. The lower the food security level, the higher the odds of vision impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Alongkorn Pekalee, Rossarin Soottipong Gray
Summary: This study aimed to construct and test a structural equation model describing the relationship among personal aspects, in-home environment, and happiness among older adults in Thailand. The results showed that living alone did not directly influence happiness, physical disability had a significant negative direct effect on happiness, and in-home environment not only had a direct impact on happiness, but also moderated the relationship between physical disability and happiness. These findings suggest that interventions to improve happiness among older adults should focus on adapting their housing, including sleeping place and toilet design.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Minye Dong, Yuyin Xiao, Chenshu Shi, Wu Zeng, Fan Wu, Guohong Li
Summary: This study is based on data collected from electronic medical records (EMR), surveys on person-environment fit (P-E fit), and academic outputs from personnel files of 244 ward clinicians in public hospitals who sought career progression in Shanghai in 2020. The study found that promoted clinicians had higher academic outputs than non-promoted clinicians, but there was no difference in clinical performance between the two groups. Regression analysis showed that academic outputs were not related to clinical performance, while higher P-E fit was associated with improvement in various clinical performances.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Chan Mi Park, Gahee Oh, Heayon Lee, Hee-Won Jung, Eunju Lee, Il-Young Jang, Dae Hyun Kim
Summary: A 24-week multicomponent intervention program was associated with a slower progression of disability in socioeconomically vulnerable older adults. However, the association attenuated over time, indicating the need for reassessment and further intervention. The findings should be interpreted with caution due to the lack of randomization.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Psychology, Clinical
Sarah Dorrington, Ewan Carr, Sharon A. M. Stevelink, Alex Dregan, Charlotte Woodhead, Jayati Das-Munshil, Mark Ashworth, Matthew Broadbent, Ira Madan, Stephani L. Hatch, Matthew Hotopf
Summary: Previous studies on sickness absence have focused on single diagnoses, but there is increasing recognition that long-term health conditions often involve multiple coexisting mental and physical conditions, leading to poorer clinical and functional outcomes. The digitisation of sickness certification in the UK provides an opportunity to address sickness absence in a large primary care population. An analysis of primary care data revealed significant variation in multimorbidity by demographic variables, particularly self-defined ethnicity. Multimorbid health conditions were associated with increased sickness certification.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Ene M. Enogela, Taylor Buchanan, Christy S. Carter, Ronit Elk, Shena B. Gazaway, Burel R. Goodin, Elizabeth A. Jackson, Raymond Jones, Richard E. Kennedy, Emma Perez-Costas, Lisa Zubkoff, Emily L. Zumbro, Alayne D. Markland, Thomas W. Buford
Summary: Disability prevention and preservation of independence are important for successful aging. Little is known about disparities in independent aging in disadvantaged older adult population. This review highlights unique barriers to independent aging in the Deep South and discusses potential strategies and opportunities to address these barriers.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2022)
Article
Geriatrics & Gerontology
Saila M. Kyronlahti, Sari Stenholm, Jani Raitanen, Subas Neupane, Seppo Koskinen, Kristina Tiainen
Summary: In the general Finnish population aged 55 years and older, decline in maximum gait speed was found to be greater in low and intermediate education groups compared to the high education group. As age increases, the association between lower education and greater decline in gait speed becomes more prominent. Body mass index and physical workload were identified as the most significant mediators contributing to educational disparities in age-related decline in maximum gait speed.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
S. L. Choi, F. Men
Summary: The study found that during the pandemic, households experiencing food insecurity had higher rates of COVID-19 infection compared to food-secure households, and food insecurity due to non-financial barriers was associated with COVID-19 infection.
Article
Geriatrics & Gerontology
Kendra D. Sims, Ellen Smit, G. David Batty, Perry W. Hystad, Michelle C. Odden
Summary: Associations between multiple forms of discrimination and blood pressure control in older populations remain unestablished.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Estella Musacchio, Pierluigi Binotto, Egle Perissinotto, Giuseppe Sergi, Sabina Zambon, Maria-Chiara Corti, Anna-Chiara Frigo, Leonardo Sartori
Summary: Research shows a strong relationship between oral health and physical well-being and disability, with dental status closely linked to various comorbidities, lifestyle factors, and socioeconomic indicators. Good dental health is significantly associated with better physical functioning and lower disability rates.
Article
Public, Environmental & Occupational Health
Laura B. Zahodne, Neika Sharifian, A. Zarina Kraal, Emily P. Morris, Ketlyne Sol, Afsara B. Zaheed, Lindsey Meister, Richard Mayeux, Nicole Schupf, Jennifer J. Manly, Adam M. Brickman
Summary: Non-Hispanic Black older adults have a higher risk of Alzheimer's disease and related dementias (ADRD) than non-Hispanic Whites, reflecting racial disparities in brain and cognitive health. Research suggests that racial discrimination may be detrimental to brain aging among non-Hispanic Black older adults, contributing to their disproportionate dementia burden. Further studies that disaggregate discrimination by attribution may provide a clearer understanding of racial inequalities in brain and cognitive aging.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Qian Song, Haowei Wang, Jeff A. Burr
Summary: This study investigated the impact of high outmigration on the psychological health of older adults in rural China. The results showed that older adults living in low-income rural communities may experience aggravated mental health issues. Higher older adult density was also associated with more depressive symptoms, particularly in less wealthy communities. Differences in community economic conditions played a key role in buffering the negative effects of high outmigration on the psychological health of older Chinese adults.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Gerontology
Tyrone C. Hamler, Ann W. Nguyen, Dawne M. Mouzon, Harry O. Taylor, Weidi Qin, Ryon J. Cobb
Summary: This study examines the psychological effects of COVID-19 on older adults, focusing on the interplay between perceptions of the outbreak, race, and psychological distress. The findings suggest that greater perceptions of COVID-19 as a threat to daily life are associated with higher levels of distress, although Black individuals reported lower distress compared to White individuals. The study also identifies race differences in the association between COVID-19 threat and distress among men. This research contributes to understanding the impact of COVID-19-related stressors on older adults and highlights the importance of considering intersecting identities in mental health during the pandemic.
Article
Geriatrics & Gerontology
Christine E. Haugen, Alden Gross, Nadia M. Chu, Silas P. Norman, Daniel C. Brennan, Qian-Li Xue, Jeremy Walston, Dorry L. Segev, Mara McAdams-DeMarco
Summary: Measurement of IL6-frailty at transplantation can inform which patients should be targeted for pre-KT interventions. However, the traditional physical frailty phenotype is sufficient for post-KT mortality risk prediction.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Minhui Liu, Qian-Li Xue, Laura N. Gitlin, Jennifer L. Wolff, Jack Guralnik, Bruce Leff, Sarah L. Szanton
Summary: The study aimed to evaluate the effects of a home-based disability prevention program on life-space and falls efficacy among low-income older adults. Findings showed that participants who received the intervention had improved life-space in various areas and an increase in falls efficacy during daily activities. Thus, this intervention can effectively promote independent living among older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Qian-Li Xue, Karen Bandeen-Roche, Jing Tian, Judith D. Kasper, Linda P. Fried
Summary: The study found an association between the number and rate of accumulation of frailty criteria with mortality risk, with a notable increase in risk after accumulating all five criteria. Individuals with all five frailty criteria had triple the one-year mortality risk compared to those with three or four criteria, and a 50% increase in mortality risk was associated with frailty onset without a prior history of pre-frailty.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Sameera A. Talegawkar, Yichen Jin, Qian-Li Xue, Toshiko Tanaka, Eleanor M. Simonsick, Katherine L. Tucker, Luigi Ferrucci
Summary: This study found that improving diet quality in middle age may contribute to better physical function in older age. The results showed an association between dietary trajectories improvement and subsequent improvement in physical function.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Marcela D. Blinka, Brian Buta, Kevin D. Bader, Casey Hanley, Nancy L. Schoenborn, Matthew McNabney, Qian-Li Xue
Summary: The study revealed that older adults of different frailty statuses expressed high interest and acceptance of sensor-based technologies for frailty assessment. Sensor-based technologies show promise for assessing frailty in older adults with care needs, but concerns regarding data management and technology replacing in-person visits with healthcare providers need to be addressed.
Article
Geriatrics & Gerontology
J. K. Chhetri, Q-L Xue, L. Ma, P. Chan, R. Varadhan
Summary: The traditional disease-oriented model of healthcare is inadequate for older populations, greater focus on healthy aging strategies is needed. The concepts of intrinsic capacity (IC) and physical resilience (PR) have the potential to reshape geriatric medicine and aging research. IC encompasses all physical and mental capacities, while PR is the ability to successfully cope with stressors.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Nadia M. Chu, Jessica Ruck, Xiaomeng Chen, Qian-Li Xue, Silas P. Norman, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: This study evaluated the long-term trajectories of the physical frailty phenotype (PFP) in adult kidney transplant recipients. The results showed that frailty improved in the first 2.5 years post-transplant, but worsened after 2.5 years. Specifically, recipients experienced increases in strength, activity, and exhaustion in the first 2.5 years, but declined in strength and activity after 2.5 years while experiencing persistent slowness. Clinicians should monitor recipients for worsening frailty after 2.5 years despite short-term improvements.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Amal A. Wanigatunga, Yurun Cai, Jacek K. Urbanek, Christine M. Mitchell, David L. Roth, Edgar R. Miller, Erin D. Michos, Stephen P. Juraschek, Jeremy Walston, Qian-Li Xue, Lawrence J. Appel, Jennifer A. Schrack
Summary: This study examined the association between accelerometer-derived patterns of routine daily physical activity and frailty, and found that higher amounts and intensity of daily activity, as well as lower activity fragmentation, were associated with lower odds of frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Caglar Cosarderelioglu, Lolita S. Nidadavolu, Claudene J. George, Ruth Marx-Rattner, Laura Powell, Qian-Li Xue, Jing Tian, Joy Salib, Esther S. Oh, Luigi Ferrucci, Pervin Dincer, David A. Bennett, Jeremy D. Walston, Peter M. Abadir
Summary: Aging is a key risk factor in the development and progression of Alzheimer's dementia. This study identifies changes in AT(1)R in the brains of AD patients, which are associated with inflammation, oxidative stress, lower cognitive performance, and higher levels of amyloid-beta and tangle pathologies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Patrick T. Donahue, Qian-Li Xue, Michelle C. Carlson
Summary: A study found that there is an association between peak expiratory flow (PEF) and incident dementia in older adults. Higher PEF categories were found to have a lower risk of dementia. Improving PEF may reduce the risk of dementia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Mei-Ling Ge, Nadia M. Chu, Eleanor M. Simonsick, Judith D. Kasper, Qian-Li Xue
Summary: This study examined the association between the onset of physical frailty before, after, or in concert with cognitive impairment and fall incidence in older adults. The results showed that older adults experiencing both cognitive impairment and frailty had the greatest risk of repeated falls. Fall risk screening should take into account the order and timing of onset of physical frailty and cognitive impairment.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Reyhan Westbrook, Cissy Zhang, Huanle Yang, Jing Tian, Shenghao Guo, Qian-Li Xue, Jeremy Walston, Anne Le, Peter M. Abadir
Summary: This study found that dysregulation of energy producing metabolic pathways is associated with frailty in older adults. Elevated levels of TCA cycle and glycolytic intermediates were observed in frail subjects, while the differences in ATP and other energy metabolites between young, nonfrail, and frail adults were not significant. Additionally, serum levels of neurotransmitters were significantly elevated in older adults with frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Public, Environmental & Occupational Health
Alice F. Yan, Zhuo Chen, Yang Wang, Jennifer A. Campbell, Qian-Li Xue, Michelle Y. Williams, Lance S. Weinhardt, Leonard E. Egede
Summary: This systematic review examines the process of integrating social determinants of health (SDOH) or social needs screening into electronic health records (EHRs) and the intervention effects in the United States. A total of 28 studies were included in the review, showing mixed results on the effects of interventions on health and healthcare costs, with improved access to resources for patients.
Article
Gerontology
Melissa Hladek, Jessica M. Gill, Chen Lai, Karen Bandeen-Roche, Qian-Li Xue, Jerilyn Allen, Christine Leyden, Rebekah Kanefsky, Sarah L. Szanton
Summary: A study found a significant association between social coping self-efficacy and IL-6, which may help reduce the inflammatory burden of chronic diseases in older adults. The results suggest that enhancing self-efficacy could be an effective nonpharmacological treatment to lower inflammatory burden in older adults.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Article
Gerontology
Minhui Liu, Qian-Li Xue, Laura Samuel, Laura N. Gitlin, Jack Guralnik, Bruce Leff, Sarah L. Szanton
Summary: The CAPABLE program has been shown to reduce disability in low-income older adults. Participants with financial strain benefit more from the program in reducing activities of daily living and instrumental activities of daily living difficulties.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Article
Medicine, Research & Experimental
Hongjin Li, Judith M. Schlaeger, Crystal L. Patil, Oana Danciu, Zhengjia Chen, Natalie Lif, Shuang Gao, Ardith Z. Doorenbos
Summary: Nearly 94% of breast cancer survivors experience symptoms or side effects during or after endocrine therapy, and acupuncture offers a comprehensive solution to address these issues. However, medically underserved breast cancer survivors often lack access to acupuncture. To promote equal access and evidence-based treatment, a randomized controlled trial is being conducted to investigate the effectiveness of acupuncture for symptom management among this population.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
JoAnn M. Sperl-Hillen, Jacob L. Haapala, Steven P. Dehmer, Lilian N. Chumba, Heidi L. Ekstrom, Anjali R. Truitt, Stephen E. Asche, Ann M. Werner, Dan J. Rehrauer, Melissa A. Pankonin, Pamala A. Pawloski, Patrick J. O'Connor
Summary: This article describes the original and adapted protocols of a randomized trial to improve medication adherence for cardiometabolic conditions. Protocol adaptation became imperative in response to major implementation challenges.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Connor Celum, Bethany Jablonski Horton, Mark Conaway
Summary: This paper proposes a phase-I clinical trial design that uses ordinal toxicity to locate group-specific doses. The proposed method avoids dose-reversals and is compared with two other methods through simulations.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Tanya Knutzen, Eileen Bulger, Matt Iles-Shih, Alexandra Hernandez, Allison Engstrom, Lauren Whiteside, Navneet Birk, Khadija Abu, Jake Shoyer, Cristina Conde, Paige Ryan, Jin Wang, Joan Russo, Patrick Heagerty, Larry Palinkas, Douglas Zatzick
Summary: This study aims to investigate how trauma centers in the US can effectively conduct mental health screening, intervention, and referral services to help injured patients recover. The study will randomly assign patients to different intervention groups and compare the impact of different interventions on PTSD symptoms and emergency department/inpatient utilization.
CONTEMPORARY CLINICAL TRIALS
(2024)