Review
Neurosciences
Xiaohuan Zhao, Rou Sun, Xueting Luo, Feng Wang, Xiaodong Sun
Summary: Glaucoma, a neurodegenerative disease that leads to irreversible vision loss, is typically associated with elevated intraocular pressure (IOP) but can also occur in patients with normal IOP, with unclear underlying mechanisms. Recent studies have highlighted the significant roles of retinal glia, particularly microglia and macroglia, in the initiation and progression of glaucoma, suggesting potential therapeutic targets for prevention and treatment. The interaction between microglia and macroglia in the context of glaucoma, including their roles in neuroinflammation and neuroprotection, may offer new insights into developing treatment options.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Worawat Songjang, Chatchai Nensat, Nitirut Nernpermpisooth, Porrnthanate Seenak, Panyupa Pankhong, Noppadon Jumroon, Sarawut Kumphune, Arunya Jiraviriyakul
Summary: Damage-associated molecular patterns (DAMPs) are the molecular signature of immunogenic cell death (ICD). The expression of drug-induced DAMPs and their role in tumor progression are crucial for evaluating the efficacy of chemotherapy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Evren Onay Ucar, Aslihan Sengelen, Elif Mertoglu Kamali
Summary: The study reveals that heat shock response (HSR) is closely related to therapeutic resistance of gliomas. Resveratrol (RSV) shows potential as an experimental agent for glioblastoma (GB) therapy, but the role of heat shock proteins (Hsps) in RSV efficacy remains unclear. The findings suggest that silencing Hsp27, Hsp60, Hsp70, and Hsp90 makes glioma cells more sensitive to RSV treatment, making these Hsps potential therapeutic targets for GB treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexey S. Kazakov, Evgenia Deryusheva, Maria E. Permyakova, Andrey S. Sokolov, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov
Summary: S100 proteins are versatile calcium-binding proteins that interact with four-helical cytokines, potentially serving as inhibitors of their action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Christian Tibor Josef Magyar, Yogesh K. Vashist, Deborah Stroka, Corina Kim-Fuchs, Martin D. Berger, Vanessa M. Banz
Summary: HSP90 inhibitors may have potential efficacy in the treatment of gastrointestinal cancers, but more research is needed to determine which patient subgroups and at what time point these inhibitors may be beneficial.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Angelo Mandarino, Swetha Thiyagarajan, Allana C. F. Martins, Roberto da Silva Gomes, Stefan W. Vetter, Estelle Leclerc
Summary: Pancreatic cancer is difficult to treat, and S100 proteins and HMGB1 protein play important roles in the tumorigenesis process. By analyzing the transcript levels of 13 cancer-related S100 genes and HMGB1 in 19 pancreatic cancer tumor samples and 8 human pancreatic cancer cell lines, statistically significant positive correlations were found in 5.5% (5 out of 91) and 37.4% (34 of 91) of the possible S100/S100 or S100/HMGB1 pairs in cells and tumors, respectively. These findings suggest that S100 proteins may interact with each other and with HMGB1, providing valuable insights for further characterization of pancreatic tumors based on S100 and HMGB1 transcription profiles.
Article
Biochemistry & Molecular Biology
Alexey S. Kazakov, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov
Summary: S100 is a family of structurally homologous regulatory proteins that play diverse functions in vertebrates. Recent studies have shown that S100 proteins can modulate cell signaling by directly interacting with cytokines. This study reveals that S100A6, a member of the S100 family, specifically binds numerous four-helical cytokines. The findings suggest the presence of cytokine-binding sites in some promiscuous members of the S100 family, allowing them to regulate the activity of these cytokines.
Review
Medicine, General & Internal
Eleonora Di Salvo, Mario Di Gioacchino, Alessandro Tonacci, Marco Casciaro, Sebastiano Gangemi
Summary: The role of alarmins in patients affected by COVID-19 disease and their relationship with commonly reported comorbidities are the focus of current research. There is limited literature on this specific topic, but preliminary evidence confirms the involvement of danger signals in amplifying the inflammatory reaction associated with SARS-CoV-2 infection.
ANNALS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alexey S. Kazakov, Evgenia I. Deryusheva, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov
Summary: The study found that S100A2, S100A6 and S100P proteins in the S100 protein family can specifically recognize EPO, which may have important implications for the progression of cancer and other diseases.
Review
Cell Biology
Linqiang Zhang, Tingting Zhu, Huilai Miao, Bin Liang
Summary: The S100 family in humans consists of 21 known members, each with a molecular weight between 10 and 14 kDa. S100A11, a member of this family, plays various roles in diseases and functions as a chemotactic agent. Research focuses on the tissue and organ expression of S100A11, as well as its roles in diseases and signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martin Salzmann, Alexander H. Enk, Jessica C. Hassel
Summary: Our study examined the usefulness of the S100 protein in monitoring the progression of uveal melanoma. We found that S100 levels in the blood varied depending on the stage of the disease and the expression of S100 in metastases. Patients with strong S100 expression in metastases always had rising S100 levels in their blood, while patients without S100 expression in metastases never showed rising S100 levels. Therefore, S100 levels can be predicted by examining S100 expression in metastases and may be useful in monitoring disease progression.
Article
Biochemistry & Molecular Biology
Pia Grotegut, Philipp Johannes Hoerdemann, Sabrina Reinehr, Nupur Gupta, H. Burkhard Dick, Stephanie C. Joachim
Summary: The intravitreal injection of HSP27 leads to neuronal damage in the retina and optic nerve mainly by activating apoptotic pathways, increasing NF kappa B, and inducing an immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Antonio J. Figueira, Guilherme G. Moreira, Joana Saavedra, Isabel Cardoso, Claudio M. Gomes
Summary: The hallmark of Alzheimer's disease (AD) includes the aggregation of amyloid-beta (A beta), tau, and neuroinflammation. In this study, the researchers found that S100B protein, which is upregulated in AD, can inhibit the aggregation of A beta 42, and this activity is dependent on Ca2+ binding. They also discovered that S100B exists in tetrameric form, and tetrameric S100B is more effective in inhibiting A beta 42 aggregation. These findings highlight the importance of S100B protein in regulating AD proteotoxicity.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexey S. Kazakov, Marina Y. Zemskova, Gleb K. Rystsov, Alisa A. Vologzhannikova, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov
Summary: S100A11, S100A12, and S100A13 interact with soluble TNF and may affect the clinical efficacy of anti-TNF drugs. This interaction could interfere with the recognition of TNF by anti-TNF drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Haopeng Wang, Xiang Mao, Lei Ye, Hongwei Cheng, Xingliang Dai
Summary: Members of the S100 protein family play important roles in various diseases, especially in the progression, diagnosis, and prognosis of tumors. Some S100 proteins show abnormal expression in gliomas, which may affect patients' survival and prognosis. They are involved in regulating cell functions and signaling pathways through various mechanisms, impacting the development of gliomas.
Correction
Biochemistry & Molecular Biology
Natalie Wagner, Sabrina Reinehr, Marina Palmhof, David Schuschel, Teresa Tsai, Emely Sommer, Viktoria Frank, Gesa Stute, H. Burkhard Dick, Stephanie C. Joachim
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Ophthalmology
Marco Zschoche, Sergej Skosyrski, Neele Babst, Mahdy Ranjbar, Felix Rommel, Maximilian Kurz, Aysegul Tura, Stephanie C. Joachim, Norbert Kociok, Vinodh Kakkassey
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2023)
Editorial Material
Cell Biology
Teresa Tsai, Stephanie C. Joachim
NEURAL REGENERATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Daniel Hunziker, Sabrina Reinehr, Marina Palmhof, Natalie Wagner, Thomas Biniasch, Gesa Stute, Patrizio Mattei, Petra Schmitz, Patrick DiGiorgio, Jerome Hert, Markus G. Rudolph, Joerg Benz, Martine Stihle, Bernard Gsell, Stephan Mueller, Rodolfo Gasser, Nina Schonhoven, Christoph Ullmer, Stephanie C. Joachim
Summary: The dysregulation of the autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway is suggested to contribute to glaucoma pathogenesis. In this study, a new ATX-inhibitor was developed and shown to reduce retinal ganglion cell (RGC) loss in two glaucoma models. These findings suggest that the dysregulation of the ATX-LPA axis may be an additional factor contributing to RGC loss in glaucoma patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Laura Petrikowski, Sabrina Reinehr, Steffen Haupeltshofer, Leonie Deppe, Florian Graz, Ingo Kleiter, H. Burkhard Dick, Ralf Gold, Simon Faissner, Stephanie C. Joachim
Summary: In this study, inflammation and degeneration of the visual system were investigated in a spontaneous encephalomyelitis animal model. The findings showed concurrent inflammatory and degenerative mechanisms in the retina and optic nerve, involving the complement system.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Ma Maria Mueller-Buehl, Sabrina Reinehr
NEURAL REGENERATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Teresa Tsai, Mohannad Alwees, Mohammad Ali Asaad, Janine Theile, Vinodh Kakkassery, H. Burkhard Dick, Tim Schultz, Stephanie C. Joachim
Summary: This study aimed to elucidate the pathophysiology of diabetic retinopathy by comparing protein alterations in the vitreous of patients at different stages. The results showed up-regulated levels of various proteins in the vitreous of proliferative diabetic retinopathy patients, including VEGF-A, PIGF, Angiopoietin-1, Angiopoietin-2, IL-1β, and IL-8. Correlation analysis revealed a strong positive correlation between Angiopoietin-2 and VEGF-A levels, as well as a positive correlation between Angiopoietin-1 and VEGF-A. These findings contribute to the future detection and treatment of the disease.
Editorial Material
Pharmacology & Pharmacy
Kyriaki Thermos, Stephanie C. Joachim
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Benedikt P. Langenbach, Andreas Thieme, Raquel van der Veen, Sabrina Reinehr, Nina R. Neuendorff
Summary: This study assessed the attitudes and knowledge of healthcare providers in Germany towards sex workers and their specific health risks. The results showed that German healthcare professionals have prejudices against sex workers and tend to overestimate the prevalence of disorders among them. This bias may affect the healthcare provided to sex workers. Future interventions, such as better training on marginalized societal groups, are needed to improve the attitudes and knowledge of healthcare providers.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Ophthalmology
Friederike Schaub, Birgit Mele, Philip Gass, Marius Ader, Horst Helbig, Wolf A. Lagreze, Ursula Schloetzer-Schrehardt, Marius Ueffing, Claus Cursiefen
Summary: The German Ophthalmological Society (DOG) has published a research map to showcase the performance of scientific ophthalmology in Germany, including the increase in research centers, research projects, and scientific publications. However, there is still a high demand for ophthalmology research.
Meeting Abstract
Ophthalmology
Kim Karla Schulte, Renee M. Girbig, Rudolf Fuchshofer, H. Bukhard Dick, Stephanie C. Joachim, Sabrina Reinehr
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Sabrina Reinehr, Renee M. Girbig, Janine Theile, Rudolf Fuchshofer, H. Bukhard Dick, Stephanie C. Joachim
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Natalie Wagner, Armin Safaei, Pia A. Vogt, Maurice R. Gammel, H. Burkhard Dick, Sven Schnichels, Stephanie C. Joachim
Summary: Coculturing porcine neural retina explants with human RPE-derived ARPE-19 cells provides a more realistic ex vivo model for investigating retinal diseases and reveals beneficial effects on retinal thickness, photoreceptors, and synaptic structure.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
(2022)