期刊
CONGENITAL ANOMALIES
卷 53, 期 1, 页码 42-45出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1741-4520.2012.00381.x
关键词
bisphenol A; brain-derived neurotrophic factor; embryonic hypothalamic cell; gonadotropin-releasing hormone 1; neurotrophic tyrosine kinase; receptor; type 2
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [21791037]
- Grants-in-Aid for Scientific Research [21791037] Funding Source: KAKEN
We evaluated the effects of bisphenol A (BPA) on embryonic mouse hypothalamic cells. Real-time reverse transcription polymerase chain reaction (RT-PCR) indicated that gonadotropin-releasing hormone 1 (Gnrh1) expression in 0.0220M BPA-treated cells did not differ from that in control cells but decreased significantly in 200M BPA-treated cells. The mRNA level for brain-derived neurotrophic factor (Bdnf), which participates in GNRH1 secretory system development, decreased significantly in 200M BPA-treated cells, but that for neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2), did not change. This indicates that Gnrh1 gene expression in mice fetuses is not affected by exposure to <20M BPA and that the adverse effects of BPA on the BDNF-NTRK2 neurotrophin system are induced by decrease in the mRNA level of the ligand, not of its receptor.
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